Abstract:
:Resistance of tumour cells to methylating and monochloroethylating agents in vitro and in vivo has been linked to levels of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). In a clinical trial of temozolomide in advanced malignant melanoma, the relationship between pretreatment MGMT levels in biopsies of cutaneous tumours and involved lymph nodes and clinical response to the drug has been studied. Among 50 evaluable patients, there were three complete responses (CR), four partial responses (PR), six with stable disease (SD) and 37 with progressive disease (PD), with an overall response rate of 14%. In 33 patients in whom MGMT level and clinical response could be evaluated, the tumour MGMT levels (fmol mg(-1) protein) were: CR, 158 +/- 119; PR, 607 +/- 481; NC, 171 +/- 101; PD, 185 +/- 42.3. Thus, measurements of pretreatment levels of MGMT in melanoma did not predict for response to temozolomide.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Middleton MR,Lunn JM,Morris C,Rustin G,Wedge SR,Brampton MH,Lind MJ,Lee SM,Newell DR,Bleehen NM,Newlands ES,Calvert AH,Margison GP,Thatcher Ndoi
10.1038/bjc.1998.654subject
Has Abstractpub_date
1998-11-01 00:00:00pages
1199-202issue
9eissn
0007-0920issn
1532-1827journal_volume
78pub_type
临床试验,杂志文章abstract::We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, partic...
journal_title:British journal of cancer
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pub_type: 杂志文章
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journal_title:British journal of cancer
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