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Tumour cell detection in the bone marrow of breast cancer patients at primary therapy: results of a 3-year median follow-up.

Abstract：

:We examined bone marrow aspirates from 100 metastasis-free primary breast cancer patients. In 38/100 patients (38%), tumour cells were detected in the marrow using an immunocytochemical technique with a cocktail of two monoclonal antibodies: anti-EMA and anti-cytokeratin. Median follow-up was 34 months: 15/38 (39%) tumour cell-positive patients have since relapsed, but only 9/62 (15%) tumour cell-negative patients. The median interval between tumour cell detection and relapse was 11.4 months. No statistically significant correlation existed between tumour cell presence and 'established' prognostic factors. However, relapse-free survival was significantly shorter in tumour cell-positive patients. Multivariate analysis showed tumour cell presence as a strong, significant prognostic factor for relapse-free as well as overall survival. We conclude that screening for tumour cells in bone marrow of primary breast cancer patients identifies high-risk patients for early relapse. In particular, patients with node-negative tumours who have tumour cells in their bone marrow may require subsequent systemic therapy.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Harbeck N,Untch M,Pache L,Eiermann W

doi

10.1038/bjc.1994.103

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

566-71

issue

3

eissn

0007-0920

issn

1532-1827

journal_volume

69

pub_type

杂志文章

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