Type I and type III collagen metabolites in adult osteosarcoma patients.

abstract：:This study was undertaken to investigate the intracellular induction of reactive oxygen species (ROS) by cis-dichlorodiammineplatinum (CDDP) and the augmentation of their cytotoxicity in bladder cancer cells (KU7) by enhancement of ROS generation by the glutathione (GSH) depletors buthionine sulphoximine (BSO) and die...

journal_title：British journal of cancer

authors： Miyajima A,Nakashima J,Yoshioka K,Tachibana M,Tazaki H,Murai M

更新日期：1997-01-01 00:00:00

abstract：:Although CD133 has been shown to be a marker for cancer stem cells in various tumours, its expression in pancreatic cancer has not yet been clinically reported. In this study, we investigated the relationship between CD133 expression and clinicopathological factors in pancreatic cancer. Pancreatic head carcinoma speci...

journal_title：British journal of cancer

authors： Maeda S,Shinchi H,Kurahara H,Mataki Y,Maemura K,Sato M,Natsugoe S,Aikou T,Takao S

更新日期：2008-04-22 00:00:00

abstract：BACKGROUND:Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. However, clinical trials testing anti-FOLR1 therapies in OvCa show mixed results and require better understanding of the prognostic relevance of FOLR1 expression. We conducted a la...

journal_title：British journal of cancer

authors： Köbel M,Madore J,Ramus SJ,Clarke BA,Pharoah PD,Deen S,Bowtell DD,Odunsi K,Menon U,Morrison C,Lele S,Bshara W,Sucheston L,Beckmann MW,Hein A,Thiel FC,Hartmann A,Wachter DL,Anglesio MS,Høgdall E,Jensen A,Høgdall C

更新日期：2014-12-09 00:00:00

abstract：:Anti-inflammatory corticosteroids administered to rats in high dosages before intravenous injection of allogeneic tumour cells caused 5-10 fold reductions in "take" and clonogenic growth of the cells in lung and kidney and decreased growth and spread of the cells transplanted to leg muscle. Steroid therapy also reduce...

journal_title：British journal of cancer

authors： Van Den Brenk HA,Kelly H,Orton C

更新日期：1974-05-01 00:00:00

abstract：BACKGROUND:Dichloroacetate (DCA), through the inhibition of aerobic glycolysis (the 'Warburg effect') and promotion of pyruvate oxidation, induces growth reduction in many tumours and is now undergoing several clinical trials. If aerobic glycolysis is active in multiple myeloma (MM) cells, it can be potentially targete...

journal_title：British journal of cancer

authors： Sanchez WY,McGee SL,Connor T,Mottram B,Wilkinson A,Whitehead JP,Vuckovic S,Catley L

更新日期：2013-04-30 00:00:00

abstract：:Metastatic variant sublines of the murine large-cell lymphoma cell line RAW117 were tested for their growth and migration properties in vitro in medium conditioned by soluble factors released from syngeneic mouse liver-, lung-, and brain-derived microvessel endothelial cells. Medium conditioned with hepatic sinusoidal...

journal_title：British journal of cancer

authors： Hamada J,Cavanaugh PG,Lotan O,Nicolson GL

更新日期：1992-08-01 00:00:00

abstract：:Pancreatic cancer is the fifth most common cause of cancer death. Identification of defined patient groups based on a prognostic index may improve the prediction of survival and selection of therapy. Many prognostic factors have been identified often based on retrospective, underpowered studies with unclear analyses. ...

journal_title：British journal of cancer

authors： Stocken DD,Hassan AB,Altman DG,Billingham LJ,Bramhall SR,Johnson PJ,Freemantle N

更新日期：2008-09-16 00:00:00

abstract：:We analysed the molecular genetic profiles of breast cancer samples before and after neoadjuvant chemotherapy with combination doxorubicin and cyclophosphamide (AC). DNA was obtained from microdissected frozen breast core biopsies from 44 patients before chemotherapy. Additional samples were obtained before the second...

journal_title：British journal of cancer

authors： Pierga JY,Reis-Filho JS,Cleator SJ,Dexter T,Mackay A,Simpson P,Fenwick K,Iravani M,Salter J,Hills M,Jones C,Ashworth A,Smith IE,Powles T,Dowsett M

更新日期：2007-01-29 00:00:00

abstract：:The co-injection of extracellular matrix components, such as Matrigel, with human tumour cells into nude mice has been reported to facilitate tumour formation and growth, but it is unknown whether such components exert similar effects on tumour progression and metastasis. Metastatic behaviour is known to be enhanced w...

journal_title：British journal of cancer

authors： Bao L,Matsumura Y,Baban D,Sun Y,Tarin D

更新日期：1994-08-01 00:00:00

abstract：:In the years 1979-1982, 83 patients with malignant teratoma of the testis who had retroperitoneal adenopathy at presentation or after a period of surveillance were treated. Complete radiological resolution of disease was obtained in 34 patients and a residual mass remained in 26, the remainder having progression of th...

journal_title：British journal of cancer

authors： Read G,Johnson RJ,Wilkinson PM

更新日期：1986-05-01 00:00:00

abstract：:To determine the maximum-tolerated dose (MTD), dose-limiting toxicities and pharmacokinetic of semisynthetic homoharringtonine (ssHHT), given as a twice daily subcutaneous (s.c.) injections for 9 days, in patients with advanced acute leukaemia, 18 patients with advanced acute myeloid leukaemia were included in this se...

journal_title：British journal of cancer

authors： Lévy V,Zohar S,Bardin C,Vekhoff A,Chaoui D,Rio B,Legrand O,Sentenac S,Rousselot P,Raffoux E,Chast F,Chevret S,Marie JP

更新日期：2006-08-07 00:00:00

abstract：:Primary liver cancer, predominantly consisting of hepatocellular carcinoma (HCC), is one of the most common and aggressive human malignancies worldwide. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression post-transcriptionally. Emerging evidence indicates that miRNAs are often deregu...

journal_title：British journal of cancer

authors： Huang S,He X

更新日期：2011-01-18 00:00:00

abstract：:We studied 5555 seminoma patients and 3733 patients with nonseminomatous testicular cancers diagnosed in Southeast England between 1960 and 2004. For both groups survival improved over time: 10-year relative survival increased from 78% in 1960-1969 to 99% in 1990-2004 for seminomas, and from 55 to 95% for nonseminomas...

journal_title：British journal of cancer

authors： Robinson D,Møller H,Horwich A

更新日期：2007-02-12 00:00:00

abstract：BACKGROUND:The role of further hormone therapy in castration-resistant prostate cancer (CRPC) remains unclear. We performed a multi-centre randomised phase III study comparing the use of Dexamethasone, Aspirin, and immediate addition of Diethylstilbestrol (DAiS) vs Dexamethasone, Aspirin, and deferred (until disease pr...

journal_title：British journal of cancer

authors： Shamash J,Powles T,Sarker SJ,Protheroe A,Mithal N,Mills R,Beard R,Wilson P,Tranter N,O'Brien N,McFaul S,Oliver T

更新日期：2011-02-15 00:00:00

abstract：:In recent years, large discrepancies were described in the success rate of the tyrosinase reverse transcription polymerase chain reaction (RT-PCR) for detecting melanoma cells in the peripheral blood of melanoma patients. We present a quality control study in which we analysed the reproducibility of detection of tyros...

journal_title：British journal of cancer

authors： de Vries TJ,Fourkour A,Punt CJ,van de Locht LT,Wobbes T,van den Bosch S,de Rooij MJ,Mensink EJ,Ruiter DJ,van Muijen GN

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:To evaluate the possible association between paediatric head computed tomography (CT) examination and increased subsequent risk of malignancy and benign brain tumour. METHODS:In the exposed cohort, 24 418 participants under 18 years of age, who underwent head CT examination between 1998 and 2006, were ident...

journal_title：British journal of cancer

authors： Huang WY,Muo CH,Lin CY,Jen YM,Yang MH,Lin JC,Sung FC,Kao CH

更新日期：2014-04-29 00:00:00

abstract：:In a prospective study we determined the frequency and causes of delay in the diagnosis of breast cancer after suspicious screening mammography. We included all women aged 50-75 years who underwent biennial screening mammography in the southern breast cancer screening region of the Netherlands between 1 January 1996 a...

journal_title：British journal of cancer

authors： Duijm LE,Groenewoud JH,Jansen FH,Fracheboud J,van Beek M,de Koning HJ

更新日期：2004-11-15 00:00:00

abstract：:Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on th...

journal_title：British journal of cancer

authors： Workman P,Aboagye EO,Balkwill F,Balmain A,Bruder G,Chaplin DJ,Double JA,Everitt J,Farningham DA,Glennie MJ,Kelland LR,Robinson V,Stratford IJ,Tozer GM,Watson S,Wedge SR,Eccles SA,Committee of the National Cancer Researc

更新日期：2010-05-25 00:00:00

abstract：:Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA acts in vivo by binding to a membrane receptor known as uPAR. In this study, uPA and uPAR levels were semiquantitated by immunocytochemistry in 36 primary breast carcinomas. Using monoclonal antibody HD-UK 1, uPA...

journal_title：British journal of cancer

authors： Kennedy S,Duffy MJ,Duggan C,Barnes C,Rafferty R,Kramer MD

更新日期：1998-05-01 00:00:00

abstract：:Recombinant single-chain fragments (scFv) of the murine anti-MUC1 monoclonal antibody C595 have been produced using the original hybridoma cells as a source of variable heavy (V(H))- and variable light (V(L))-chain-encoding antibody genes. The use of the polymerase chain reaction (PCR), bacteriophage (phage) display t...

journal_title：British journal of cancer

authors： Denton G,Sekowski M,Spencer DI,Hughes OD,Murray A,Denley H,Tendler SJ,Price MR

更新日期：1997-01-01 00:00:00

abstract：:This paper describes the results of a study set up to investigate factors associated with the high proportions of 'death certificate only' registrations (DCOs) for all cancers registered in south-east England between 1987 and 1989 and to identify those which might be subject to registry intervention. DCOs as a proport...

journal_title：British journal of cancer

authors： Pollock AM,Vickers N

更新日期：1995-03-01 00:00:00

abstract：:Collagen breakdown, and thus bone resorption, can now be assessed by measuring the urinary excretion of the collagen crosslinks, pyridinoline (Pyd) and deoxypyridinoline (Dpd). In a pilot study we measured Pyd and Dpd in 20 patients with breast cancer, ten with known bone metastases and ten with no recognised metastas...

journal_title：British journal of cancer

authors： Paterson CR,Robins SP,Horobin JM,Preece PE,Cuschieri A

更新日期：1991-11-01 00:00:00

abstract：:Throughout the world there are problems recruiting ethnic minority patients into cancer clinical trials. A major barrier to trial entry may be distrust of research and the medical system. This may be compounded by the regulatory framework governing research with an emphasis on written consent, closed questions and con...

journal_title：British journal of cancer

authors： Symonds RP,Lord K,Mitchell AJ,Raghavan D

更新日期：2012-09-25 00:00:00

abstract：:Our recent genome-wide allelotyping analysis of gallbladder carcinoma identified 3p, 8p, 9q and 22q as chromosomal regions with frequent loss of heterozygosity. The present study was undertaken to more precisely identify the presence and location of regions of frequent allele loss involving those chromosomes in gallbl...

journal_title：British journal of cancer

authors： Wistuba II,Maitra A,Carrasco R,Tang M,Troncoso P,Minna JD,Gazdar AF

更新日期：2002-08-12 00:00:00

abstract：:The 5T4 oncofetal antigen is a 72 kDa glycoprotein defined by a monoclonal antibody raised against human placental trophoblast and is expressed in many different carcinomas but detected only at low levels in some normal epithelia. Immunohistochemical analysis of the patterns of expression in colorectal carcinomas has ...

journal_title：British journal of cancer

authors： Starzynska T,Marsh PJ,Schofield PF,Roberts SA,Myers KA,Stern PL

更新日期：1994-05-01 00:00:00

abstract：:The geographical distribution of mortality from mesothelioma of the pleura during the years 1968-78 in England and Wales has been studied using extracts from the death records held by the Office of Population Censuses and Surveys. Using the national death rate as standard, Local Authority areas with raised mortality a...

journal_title：British journal of cancer

authors： Gardner MJ,Acheson ED,Winter PD

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:Laboratory studies suggest a possible role of magnesium intake in colorectal carcinogenesis but epidemiological evidence is inconclusive. METHOD:We tested magnesium-colorectal cancer hypothesis in the Nurses' Health Study, in which 85 924 women free of cancer in 1980 were followed until June 2008. Cox propo...

journal_title：British journal of cancer

authors： Zhang X,Giovannucci EL,Wu K,Smith-Warner SA,Fuchs CS,Pollak M,Willett WC,Ma J

更新日期：2012-03-27 00:00:00

abstract：:Metallothioneins are ubiquitous low molecular weight proteins characterised by high cysteine content and affinity for binding heavy metals. Abnormal metallothionein function and expression have been implicated in various disease states, including neoplasia. The aim of this study was to investigate metallothionein expr...

journal_title：British journal of cancer

authors： Goulding H,Jasani B,Pereira H,Reid A,Galea M,Bell JA,Elston CW,Robertson JF,Blamey RW,Nicholson RA

更新日期：1995-10-01 00:00:00

abstract：:Histochemical studies on the cell surface and intercellular matrix of normal cervical epithelium, and squamous cell carcinomata have shown the mucosubstances present may be symbolized by the descriptive formula:C(G) mucosubstance; B 3.5; A 2.5 (0.6m MgCl(2)); T; S.This indicates that sulphate groups are absent and tha...

journal_title：British journal of cancer

authors： Bradbury S,Wiernik G,Williams EA,Cowdell RH

更新日期：1970-12-01 00:00:00

abstract：:The combination effect of docetaxel and capecitabine on tumour response rate and survival was demonstrated recently in metastatic breast cancer patients. This combination was based on an experimental hypothesis that taxane can increase tumour sensitivity to the effect of capecitabine through the upregulation of thymid...

journal_title：British journal of cancer

authors： Toi M,Bando H,Horiguchi S,Takada M,Kataoka A,Ueno T,Saji S,Muta M,Funata N,Ohno S

更新日期：2004-06-14 00:00:00