Abstract：
:High-mol.-wt levan injected locally inhibits the growth of Lewis lung carcinoma in C57BL mice. The inhibition is dependent on the number of tumour cells injected and on the dose of levan. The inhibition decreases tumour incidence and size as well as prolonging survival. The polysaccharide is most effective when injected daily beginning on the day of tumour-cell inoculation. Treatment begun on later dates is less effective. Treatment begun one day before tumour-cell inoculation enhances tumour growth. Histological studies showed that levan induces an intense polymorphonuclear (PMN) reaction followed by accumulation of vacuolated, levan-laden macrophages. Both PMN and activated macrophages seemed to have an inhibitory effect upon the growth of the tumour. The effector role of PMN was not explained by the histological study. Tumour cells in close contact with levan-laden macrophages appeared mostly necrotic. Administration of levan begun one day before tumour-cell inoculation produced a similar reaction, but the infiltrating cells did not appear to approach and damage the tumour cells.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Leibovici J,Borit A,Sandbank U,Wolman Mdoi
10.1038/bjc.1979.225subject
Has Abstractpub_date
1979-10-01 00:00:00pages
597-607issue
4eissn
0007-0920issn
1532-1827journal_volume
40pub_type
杂志文章abstract：:Novel synthetic antagonists of retinoic acid receptors (RARs) have been developed. To avoid interference by serum retinoids when testing these compounds, we established serum-free grown sub-lines (>3 years) of the prostate carcinoma lines LNCaP, PC3 and DU145. A high affinity pan-RAR antagonist (AGN194310, K(d) for bi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1939
更新日期：2001-08-03 00:00:00
abstract：:The management of older patients with aggressive non-Hodgkin's lymphoma presents a challenge to the physician. Age is a poor prognostic indicator, due to reduced ability to tolerate and maintain dose-intensive chemotherapy. Generally, older patients demonstrate a lower response rate, reduced survival and increased tox...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.bjc.6602975
更新日期：2006-03-27 00:00:00
abstract：:Comorbid diseases can affect breast cancer prognosis. We conducted a population-based study of Danish women diagnosed with a first primary breast cancer from 1995 to 2005 (n=9300), using hospital discharge registry data to quantify comorbidities by Charlson score. We examined the influence of comorbidities on survival...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6603717
更新日期：2007-05-07 00:00:00
abstract：:Expression of the wild-type p53 gene has an important role in cell differentiation, maturation and apoptosis. Mutation of the p53 gene is associated with tumour development and mutant p53 can promote cell proliferation. Recently wild-type p53 has been demonstrated to exist in two conformational variants: one acting as...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.444
更新日期：1993-11-01 00:00:00
abstract：:Detailed data were provided by the Oxford Survey of Childhood Cancer OSCC on deaths from childhood cancer in Britain after irradiation of the fetus during diagnostic radiology of the mother. In each age group at death, 0-5, 6-9 and 10-15 years, excess cancer deaths decreased suddenly for births in and after 1958. A ma...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.1990.249
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND:Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local microenvironment. These intercellular interactions, modulated by the microenvironm...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.517
更新日期：2012-01-03 00:00:00
abstract：:The aetiologic fractions due to smoking and chewing tobacco have been quantified for the first time, for cancers of the oral cavity, oropharynx, hypopharynx, larynx and oesophagus. The overall aetiologic fractions due to smoking and/or chewing tobacco have been found to be 70% for cancer of the oral cavity, 84% for th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.31
更新日期：1977-02-01 00:00:00
abstract：BACKGROUND:Soft tissue sarcomas are heterogeneous and a major complication in their management is that the existing classification scheme is not definitive and is still evolving. Leiomyosarcomas, a major histologic category of soft tissue sarcomas, are malignant tumours displaying smooth muscle differentiation. Althoug...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.280
更新日期：2016-10-11 00:00:00
abstract：:The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected inf...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604989
更新日期：2009-04-07 00:00:00
abstract：:The endocrine effects of 125 mg (low dose) aminoglutethimide (AG) twice daily (b.d.) were compared with those of 125 mg AG + 20 mg hydrocortisone (HC) b.d. in 23 and 45 postmenopausal patients with advanced breast cancer, respectively. The patients in each group were drawn from two separate populations, but the mean a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.223
更新日期：1985-10-01 00:00:00
abstract：:Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that develop from distinct epithelial sub-types; however, they are both related to chronic inflammation of differing aetiologies. Inflammation leads to somatically inherited genetic mutations altering control of the cell cycle, DNA replication an...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605126
更新日期：2009-07-07 00:00:00
abstract：:This corrects the article DOI: 10.1038/bjc.2017.85. ...
journal_title：British journal of cancer
pub_type： 杂志文章,已发布勘误
doi：10.1038/bjc.2017.437
更新日期：2018-03-20 00:00:00
abstract：:The influence on heat sensitivity of interactions between HT29 human colon adenocarcinoma cells grown in two- or three-dimensional contact was investigated. No evidence for intercellular cooperation affecting cellular sensitivity to hyperthermia was found. Cells grown in monolayer were found to be more heat sensitive ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.268
更新日期：1985-12-01 00:00:00
abstract：BACKGROUND:Whether red and processed meat consumption is a risk factor for pancreatic cancer remains unclear. We conducted a meta-analysis to summarise the evidence from prospective studies of red and processed meat consumption and pancreatic cancer risk. METHODS:Relevant studies were identified by searching PubMed an...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2011.585
更新日期：2012-01-31 00:00:00
abstract：:This phase II study was designed to evaluate the activity and safety of a combination of irinotecan, docetaxel and oxaliplatin in metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. Forty patients with measurable distant metastasis received irinotecan 150 mg m(-2) and docetaxel 60 mg m(-2) on day 1, ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603917
更新日期：2007-09-03 00:00:00
abstract：:The association of endometrial thickness with the risk of developing endometrial cancer (EC) within 2 years was investigated in a consecutive cohort of 1205 breast cancer patients under tamoxifen treatment, undergoing transvaginal ultrasonography (TVUS) for follow-up purpose (asymptomatic, 1068) or for abnormal uterin...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600894
更新日期：2003-04-22 00:00:00
abstract：:Prostate cancer is the second leading cause of male death from malignant disease in Europe and in the USA. Failure to prevent or eliminate metastatic dissemination is a fundamental problem underlying the current inadequate treatment of prostate cancer, and novel therapeutic strategies are required if this disease is t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.45
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Glomerular filtration rate (GFR) is used in the calculation of carboplatin dose. Glomerular filtration rate is measured using a radioisotope method (radionuclide GFR (rGFR)), however, estimation equations are available (estimated GFR (eGFR)). Our aim was to assess the accuracy of three eGFR equations and the...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.393
更新日期：2012-10-09 00:00:00
abstract：:Information on exposure and reaction to sunlight, together with the history of exposure to fluorescent lighting, was elicited by postal questionnaire. Case-control analysis from 58 patients with malignant melanoma, 182 matched controls and 151 unmatched controls showed associations between malignant melanoma and (i) b...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.255
更新日期：1985-11-01 00:00:00
abstract：BACKGROUND:Efficacy and safety are the two considerations when characterising the effects of a new therapy. We sought to apply an innovative method of assessing the benefit-risk balance using data from a completed randomised controlled trial that compared erlotinib vs placebo added to gemcitabine in patients with advan...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2015.55
更新日期：2015-03-17 00:00:00
abstract：BACKGROUND:This first-in-human, phase I clinical trial of p28 (NSC745104), a 28-amino-acid fragment of the cupredoxin azurin, investigated the safety, tolerability, pharmacokinetics and preliminary activity of p28 in patients with p53(+) metastatic solid tumours. METHODS:A total of 15 patients were administered p28 i....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.74
更新日期：2013-03-19 00:00:00
abstract：:Squamous cell carcinomas of the anus are rare neoplasias that account for about 3% of large bowel tumours. Infections with human papillomaviruses are frequently detected in these cancers, suggesting that pathogenic pathways in anal carcinomas and in carcinomas of the uterine cervix are similar. Little is known regardi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.547
更新日期：1997-01-01 00:00:00
abstract：:Non-small-cell lung cancer (NSCLC) prognosis is strictly related to well-established clinicopathological parameters which have unfortunately become insufficient in the prognostic evaluation of this type of cancer. As p53 and bcl-2 gene deregulations are frequently involved in several types of epithelial malignancies, ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.193
更新日期：1995-05-01 00:00:00
abstract：:In a study of 157 patients with lymphoid malignancy, the phenotype of the tumour cells was correlated with the histological classification of the tumour using the Rappaport and the Kiel classifications. The markers used included E, Fc gamma, Fc micron (IgM) and C3d rosetting, estimation of SIg and CyIg, and tests for ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.137
更新日期：1979-07-01 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumour and has poor prognosis. Currently, systematic chemotherapy is the only approach to prolong survival. Thus the development of new treatment regimens is urgently needed to improve the therapeutic efficacy. Our study intended to ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.55
更新日期：2017-04-11 00:00:00
abstract：:Monocyte-macrophage series have an important role in host surveillance against cancer. The cytotoxic/cytostatic activity of macrophages is, to a great extent, attributed to the up-regulation of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO). Here, in 28 patients with primary lung cancer and...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.528
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the plasma/serum. We hypothesised that miR-18a in the plasma is a potential biomarker in patients with pancreatic cancer. METHODS:miR-18a is located in the miR-17-92 cluster and reported to be highly expressed in pancr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.453
更新日期：2011-11-22 00:00:00
abstract：:The objective of this paper is to compare the hospital costs of treating patients with colorectal cancers detected as a result of a faecal occult blood screening programme with those of patients whose cancers present symptomatically (control group). Patient-specific cost estimates are made, using case records and hosp...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.462
更新日期：1993-11-01 00:00:00
abstract：:To investigate liver cancer-associated genes and to explore the molecular basis of liver cancer genesis, we have cloned a novel hepatocellular carcinoma (HCC)-related gene with a transcript of 2520 base pairs in length named HCCA2 by mRNA differential display polymerase chain reaction (DDPCR) and screening a placenta ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2059
更新日期：2001-10-19 00:00:00
abstract：:Hepatic arterial floxuridine (HAI) in 35 patients with systemic fluorouracil/folinic acid-resistant colorectal liver metastases achieved a 14% partial response and 26% disease stabilization rate, with a median response duration of 7 months from onset of HAI. ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1998.627
更新日期：1998-10-01 00:00:00
