Abstract：
:The endocrine effects of 125 mg (low dose) aminoglutethimide (AG) twice daily (b.d.) were compared with those of 125 mg AG + 20 mg hydrocortisone (HC) b.d. in 23 and 45 postmenopausal patients with advanced breast cancer, respectively. The patients in each group were drawn from two separate populations, but the mean age and weight of the groups were similar and there were no significant differences between the pretreatment serum levels of the hormones investigated. Serum oestrone and oestradiol levels were suppressed by both treatments, but there was a significantly greater suppression by AG + HC. This greater suppression is probably due to the observed increase in serum androstenedione (i.e. precursor) levels with AG alone, whilst with AG + HC these levels were found to be reduced. In terms of suppression of serum oestrogen levels it is of benefit to combine low dose AG with HC.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Dowsett M,Harris AL,Stuart-Harris R,Hill M,Cantwell BM,Smith IE,Jeffcoate SLdoi
10.1038/bjc.1985.223subject
Has Abstractpub_date
1985-10-01 00:00:00pages
525-9issue
4eissn
0007-0920issn
1532-1827journal_volume
52pub_type
杂志文章abstract：:Somatostatin analogues may be useful novel agents in the systemic treatment of advanced colorectal cancer, as somatostatin inhibits proliferation in a wide variety of cell types. Here, we report the expression profiles of somatostatin receptor mRNAs in 32 pairs of malignant and normal colonic epithelia. Receptor subty...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.59
更新日期：1997-01-01 00:00:00
abstract：:A population-based, case-control study was conducted in Los Angeles County, California, to investigate the inter-relationships of obesity, hypertension and medications in relation to renal cell carcinoma (RCC) risk. A total of 1204 RCC patients and an equal number of neighbourhood controls were included. Obesity was a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.248
更新日期：1998-05-01 00:00:00
abstract：:A clinical trial conducted according to a schedule of interim analyses written into the protocol, and stopped according to a predetermined rule, is known to statisticians as a sequential clinical trial. This methodology is becoming more widely used in trials concerning life-threatening diseases because of its ability ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.500
更新日期：1993-12-01 00:00:00
abstract：:One hundred cancer patients undergoing active treatment were interviewed to determine how they perceived their illness and how their perceptions compared with those of their attending physicians. Ninety-eight patients recognized that they had cancer and 87 correctly identified the tumour type. Sixty-four of 67 patient...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.218
更新日期：1988-09-01 00:00:00
abstract：BACKGROUND:The clinical utility of machine-learning (ML) algorithms for breast cancer risk prediction and screening practices is unknown. We compared classification of lifetime breast cancer risk based on ML and the BOADICEA model. We explored the differences in risk classification and their clinical impact on screenin...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0937-0
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Vitamin D has been linked with improved cancer outcome. This systematic review and meta-analysis investigates the relationship between cancer outcomes and both vitamin D-related genetic variation and circulating 25-hydroxyvitamin D (25OHD) concentration. METHODS:A systematic review and meta-analysis of pape...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1038/bjc.2017.44
更新日期：2017-04-11 00:00:00
abstract：:Over a wide range of pH, the semiquinone free radicals formed by reduction of adriamycin exist as a form which is strongly stabilised by internal hydrogen bonding and resonance. They protonate with pKa = 2.9. Below this pH they exhibit absorption maxima at 430 nm (Emax = 13,200 dm3 mol-1 cm-1) and approximately 720 nm...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.74
更新日期：1985-04-01 00:00:00
abstract：:In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenol...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.125
更新日期：1979-06-01 00:00:00
abstract：:The therapeutic efficacy of gemcitabine, a new nucleoside analogue, was assessed in a variety of well-established human soft tissue sarcoma and ovarian cancer xenografts grown s.c. in nude mice. Tumour lines selected had different histological subtypes, growth rates and sensitivities to conventional cytostatic agents....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.285
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:The current analysis was performed to evaluate the impact of PIK3CA hotspot mutations on everolimus efficacy in BOLERO-2 participants, using cell-free DNA (cfDNA) from plasma samples collected at the time of patient randomisation. METHODS:PIK3CA H1047R, E545K, and E542K mutations in plasma-derived cfDNA wer...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2017.25
更新日期：2017-03-14 00:00:00
abstract：BACKGROUND:Tumour hypoxia is associated with impaired apoptosis, resistance to therapy and poor prognosis. We previously reported that high stromal expression of the endogenous marker of hypoxia, carbonic anhydrase IX (CAIX), is associated with significantly reduced survival in oral squamous cell carcinoma (OSCC). In a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.533
更新日期：2013-10-01 00:00:00
abstract：:The depression of the immunological status of BALB/c mice treated during infancy with two different doses of urethane, alone or combined with cortisone, was evaluated by counting the number of plaque forming cells at 30 or 50 days of age. The incidence of lung adenomatous nodules was directly related to the degree of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.42
更新日期：1973-05-01 00:00:00
abstract：:Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The beta-actin promoter-driven KrasRz ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1363
更新日期：2000-09-01 00:00:00
abstract：:Survival data on female invasive breast cancer with 9-year follow-up from five French cancer registries were analysed by logistic regression for prognostic factors of cancer stage. The Kaplan-Meier method and log-rank test were used to estimate and compare the overall survival probability at 5 and 7 years, and at the ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604163
更新日期：2008-01-15 00:00:00
abstract：:The registered incidence rate of childhood central nervous system (CNS) tumours has increased in several countries. It is uncertain whether these increases are biologically real or owing to improved diagnostic methods. We explored the medical records of 626 CNS tumours diagnosed in Danish children between 1980 and 199...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603278
更新日期：2006-08-07 00:00:00
abstract：:A study involving the measurement of glutathione S-transferase activities and isoenzyme distributions in human ovarian tumours has been carried out. These tumours have been obtained either at initial debulking surgery, prior to cytotoxic chemotherapy, or at second look laparotomy following chemotherapy. The response r...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.389
更新日期：1992-11-01 00:00:00
abstract：:Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents and adults (TGCTs). To study this in more detail, we screened exons 2 and 3 of this gene for mutations in a larger series of cel...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690563
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:To quantify the benefits (cancer prevention and down-staging) and harms (recall and excess treatment) of cervical screening starting from age 20 years rather than from age 25 years. METHODS:We use routine screening and cancer incidence statistics from Wales (for screening from age 20 years) and England (scr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.65
更新日期：2014-04-02 00:00:00
abstract：:The effect of the combined administration of doxorubicin (DX) and verapamil (VRP) on the induction of DX resistance of B16 melanoma cells, was investigated both in vitro and in vivo. Cells grown in the presence of increasing concentrations of DX and of 1 microM VRP, tested at several passages, were more resistant than...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.79
更新日期：1988-04-01 00:00:00
abstract：:The feasibility of combination irinotecan, carboplatin and docetaxel chemotherapy as first-line treatment for advanced epithelial ovarian carcinoma was assessed. One hundred patients were randomised to receive four 3-weekly cycles of carboplatin (area under the curve (AUC) 7) followed by four 3-weekly cycles of doceta...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.bjc.6602910
更新日期：2006-01-16 00:00:00
abstract：:Pulmonary metastasectomy is widely and increasingly practiced in the belief that this intervention can cure patients with colorectal cancer, and that without it few survive 5 years. No good evidence exists supporting such convictions, indeed recent trial results challenge them. What evidence underpins this acceptance ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0927-2
更新日期：2020-08-01 00:00:00
abstract：:Although patients with superficial bladder cancer (Ta, T1) have a generally good prognosis, those patients who develop muscle-invasive tumours or metastatic disease at recurrence do poorly clinically. In the current study 69 patients undergoing complete transurethral resection for superficial transitional cell cancer ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.41
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:The percentage of tumour stroma (TSP) has recently been reported to be a novel independent predictor of outcome in patients with a variety of common solid organ tumours. The aim of this study was to examine the relationship between TSP, clinicopathological characteristics and outcome in patients with invasiv...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.279
更新日期：2014-07-08 00:00:00
abstract：:The relationship between melanoma incidence and latitude was investigated in North American and Europe, using the data collected by 43 population-based cancer registries. In North America melanoma incidence increased with decreasing latitude, supporting the role of UV light in the induction of melanoma. Within England...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.260
更新日期：1979-11-01 00:00:00
abstract：:A multicentric, prospective phase III study was carried out with the aim of testing the so-called 'worst drug rule' hypothesis, which suggests the use of an effective but 'less active' regimen that first eradicates tumoral cells resistant to a second effective and 'more active' regimen. With respect to this hypothesis...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.1997.586
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Administration of interleukin-2 (IL-2) has shown some effects on malignant pleural mesothelioma (MPM) tumour regression. The purpose of this study was to investigate the ability of IL-2 to modify immunological effector cells and angiogenesis in MPM patients and their prognostic value. METHODS:Tumour-infiltr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605438
更新日期：2009-12-01 00:00:00
abstract：:Window of opportunity trials exploit the 'window' of time after cancer diagnosis, typically prior to initiation of cancer therapy. In recent years this study design has become a more regular feature of drug development, as this 'window' provides an opportunity to carry out a thorough pharmacodynamic assessment of a th...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/s41416-019-0621-4
更新日期：2020-01-01 00:00:00
abstract：:Sublines of a human myeloid leukaemia cell line, KBM-3, with increasing degrees of resistance to the antileukaemic agent 4'-(9-acridinlylamino) methanesulphon-m-anisidide (m-AMSA) were evaluated for their response to this drug using a clonogenic assay to measure cell survival and alkaline elution to assess m-AMSA indu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.11
更新日期：1990-01-01 00:00:00
abstract：:Magnetic resonance spectroscopy was used to study intracellular pH and compounds which contain phosphorus in normal human brain and primary brain tumours non-invasively. In normal subjects (n = 7) intracellular pH (pHi) of the brain was 7.03 +/- 0.02 (mean +/- s.e.m.). The pHi did not vary between superficial (2 cm, m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.300
更新日期：1989-09-01 00:00:00
abstract：:Patient participation in medical consultations has been demonstrated to benefit their subsequent psychological well being. Question asking is one way in which patients can be active. We investigated 2 means of promoting cancer patient question asking. One was the provision of a question prompt sheet to patients prior ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1054/bjoc.2001.2073
更新日期：2001-11-02 00:00:00
