Abstract：
BACKGROUND:Previous studies have reported up to 50% of ductal carcinoma in situ (DCIS), is HER2 positive, but the frequency of HER2-positive invasive breast cancer (IBC) is lower. The aim of this study is to characterise HER2 status in DCIS and assess its prognostic value. METHODS:HER2 status was evaluated in a large series of DCIS (n = 868), including pure DCIS and DCIS associated with IBC, prepared as tissue microarrays (TMAs). HER2 status was assessed using immunohistochemistry (IHC) and chromogenic in situ hybridisation (CISH). RESULTS:In pure DCIS, HER2 protein was over-expressed in 9% of DCIS (3+), whereas 15% were HER2 equivocal (2+). Using CISH, the final HER2 status was positive in 20%. In mixed DCIS, HER2 amplification of the DCIS component was detected in 15% with amplification in the invasive component of only 12%. HER2-positive DCIS was associated with features of aggressiveness (p < 0.0001) and more frequent local recurrence (p = 0.03). On multivariate analysis, combined HER2+/Ki67+ profile was an independent predictor of local recurrence (p = 0.006). CONCLUSIONS:The frequency of HER2 positivity in DCIS is comparable to IBC- and HER2-positive DCIS is associated with features of poor prognosis. The majority of HER2 over-expression in DCIS is driven by gene amplification.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Miligy IM,Toss MS,Gorringe KL,Lee AHS,Ellis IO,Green AR,Rakha EAdoi
10.1038/s41416-019-0436-3subject
Has Abstractpub_date
2019-05-01 00:00:00pages
1075-1082issue
11eissn
0007-0920issn
1532-1827pii
10.1038/s41416-019-0436-3journal_volume
120pub_type
杂志文章abstract：:In vivo models of acquired resistance to the platinum-based agents cisplatin (CDDP), carboplatin (CBDCA), iproplatin (CHIP) and tetraplatin have been established using a panel of six parent human ovarian carcinoma lines, two (HX/110 and PXN/87) being derived from previously untreated patients. Resistance has been gene...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.5
更新日期：1993-01-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is one of the most malignant human tumours because of its high incidence of metastasis. The mechanisms underlying the metastasis of HCC, however, remain poorly understood. In this study, we performed cDNA microarray analysis to profile gene expression patterns in two subtypes of HCC, sol...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601749
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journal_title：British journal of cancer
pub_type： 杂志文章,评审
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journal_title：British journal of cancer
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doi：10.1054/bjoc.2000.1620
更新日期：2001-02-02 00:00:00
abstract：:Imatinib mesilate (Glivec), Novartis Pharmaceuticals) is a novel therapy for the treatment of chronic myeloid leukaemia (CML). We evaluated the cost-effectiveness of imatinib (600 mg daily) when used for the treatment of patients in advanced stages of CML (accelerated phase and blast crisis) against conventional thera...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601151
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.9
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journal_title：British journal of cancer
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.575
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601614
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doi：10.1038/sj.bjc.6690467
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pub_type： 杂志文章,评审
doi：10.1038/bjc.2014.384
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journal_title：British journal of cancer
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doi：10.1038/bjc.1989.333
更新日期：1989-11-01 00:00:00
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journal_title：British journal of cancer
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doi：10.1038/bjc.2014.631
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更新日期：1977-03-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
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更新日期：2013-10-01 00:00:00
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