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Expression of oncofoetal pancreatic antigens in hamster adult pancreas during experimental carcinogenesis.

Abstract：

:Foetal acinar components associated with the development of the hamster pancreas have been previously defined with the aid of an antifoetal pancreas serum. In immunohistology this antiserum also stained malignant ductal cells in N-nitrobis (2-oxopropyl) amine (BOP)-induced pancreatic adenocarcinoma. It did not stain adult pancreas structures including acini, ducts and islets of Langerhans. In this study, re-expression of foetal acinar antigens was disclosed before formation of tumours. Adenocarcinomas were not detected by conventional histology before the 24th week following initiation of the chemical treatment. However, staining with the antiserum was observed from the 7th week appearing in the apex of some acini cells having an almost normal histological appearance. Later, foetal acinar expression was frequently associated with evident morphological alterations in acini like dyskaryosis, enlarged cytoplasm or lumina. Staining of ducts with marked atypical epithelium and (as already reported) of neoplastic ducts was also observed. It was not detected in other pancreatic lesions viz. cystadenomas, mucoid glands and regular hyperplastic ducts. Acinar dedifferentiation as assessed by expression of foetal components preceded formation of tumours in all instances.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Escribano MJ,Carré-Llopis A,Loridon-Rosa B

doi

10.1038/bjc.1985.28

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

187-93

issue

2

eissn

0007-0920

issn

1532-1827

journal_volume

51

pub_type

杂志文章

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