Abstract：
:We evaluated the interaction between hepatitis C virus (HCV) and cigarette smoking on death from hepatocellular cancer in The Japan Collaborative Cohort Study. The odds ratio of death from HCC for smoking was 9.60 (1.50-61.35) and 1.71(0.58-5.08) among anti-HCV positive and negative individuals, respectively.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Fujita Y,Shibata A,Ogimoto I,Kurozawa Y,Nose T,Yoshimura T,Suzuki H,Iwai N,Sakata R,Ichikawa S,Tamakoshi Adoi
10.1038/sj.bjc.6602981subject
Has Abstractpub_date
2006-03-13 00:00:00pages
737-9issue
5eissn
0007-0920issn
1532-1827pii
6602981journal_volume
94pub_type
杂志文章abstract：:The incidence of B cell leukaemia in 186 consecutive untreated patients with histologically defined B cell neoplasms is described. The lymphomas were classified by the Kiel convention. B cell leukaemia in the context of this paper refers to the situation where a neoplastic clone of B cells in the blood greatly outnumb...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1983.174
更新日期：1983-08-01 00:00:00
abstract：:The use of oncolytic viruses has received considerable attention in recent years and many viruses have proved to be effective against a variety of cancer models and a few are currently being used in clinical trials. However, the possible emergence and outcome of virus-resistant tumour cells has not been addressed. We ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603363
更新日期：2006-10-23 00:00:00
abstract：BACKGROUND:Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wid...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.50
更新日期：2016-04-12 00:00:00
abstract：BACKGROUND:Ewing sarcoma is a paradigm of solid tumour -bearing chromosomal translocations resulting in fusion proteins that act as deregulated transcription factors. Ewing sarcoma translocations fuse the EWS gene with an ETS transcription factor, mainly FLI1. Most of the EWS-FLI1 target genes still remain unknown and ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605104
更新日期：2009-07-07 00:00:00
abstract：:To determine the maximum-tolerated dose (MTD), dose-limiting toxicities and pharmacokinetic of semisynthetic homoharringtonine (ssHHT), given as a twice daily subcutaneous (s.c.) injections for 9 days, in patients with advanced acute leukaemia, 18 patients with advanced acute myeloid leukaemia were included in this se...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.bjc.6603265
更新日期：2006-08-07 00:00:00
abstract：BACKGROUND:Dysregulation of microRNAs (miRNAs) has been found in human epithelial ovarian cancer (EOC). However, the role and mechanism of action of miR-23a in EOC remain unclear. METHODS:The roles of miR-23a, IKKα, and ST7L in EOC were determined by MTT, colony formation, wounding healing, transwell, flow cytometry, ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.244
更新日期：2016-09-06 00:00:00
abstract：:This article was originally published under a standard license to Publish, but has now been made available under a CC BY license. The PDF and HTML versions of the paper have been modified accordingly.An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：British journal of cancer
pub_type： 已发布勘误
doi：10.1038/s41416-019-0534-2
更新日期：2019-10-01 00:00:00
abstract：:We have purified epithelial cells from human colonic tumours by velocity sedimentation in an isokinetic density gradient of Ficoll in tissue culture medium. In frozen sections of colonic carcinoma, histochemically demonstrable N-acetyl-beta-D-glucosaminidase (HDAG) was observed primarily in epithelial cells. We used t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.128
更新日期：1977-06-01 00:00:00
abstract：BACKGROUND:Testing for high-risk human papillomavirus (HPV) in primary screening for cervical cancer is considered more sensitive, but less specific, in comparison with Pap-smear cytology. Women with persistent HPV infections have a higher risk of developing cervical intraepithelial neoplasia 2+ (CIN2+) lesions. This s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.277
更新日期：2011-08-23 00:00:00
abstract：:The integrin alpha(v)beta6 is not detectable on normal keratinocytes in vivo but expression is increased significantly in oral squamous cell carcinoma where this heterodimer has been shown to play a role in cell migration, invasion and protease expression. Although regarded initially as a fibronectin receptor, alpha(v...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600545
更新日期：2002-10-07 00:00:00
abstract：:The prostate cancer cell lines PC3 and LNCaP have been shown to lack expression of the tumour suppressor gene MMAC1/PTEN, in contrast to the immortalized non-tumorigenic epithelial lines PNT1a and PNT2. We have measured the effects of reintroduction of wild type (wt) and mutant MMAC1 genes on to these genetic backgrou...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1400
更新日期：2000-10-01 00:00:00
abstract：:Germline mutations in the LKB1 (STK11) gene (chromosome sub-band 19p13.3) cause characteristic hamartomas and pigmentation to develop in patients with Peutz-Jeghers syndrome. Peutz-Jeghers syndrome carries an overall risk of cancer that may be up to 20 times that of the general population and Peutz-Jeghers patients ar...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690323
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Clinical heterogeneity reflects the complexity of genetic events associated with neuroblastoma (NB). To identify the status of all described genetic loci with possible prognostic interest, high-throughput approaches have been used, but only with tumour cell content >60%. In some tumours, necrotic, haemorrhag...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.188
更新日期：2011-06-28 00:00:00
abstract：:Delta-aminolevulinic acid (ALA) is the precursor in the biosynthesis of porphyrins. The knowledge of both the regulation of ALA entrance and efflux from the cells and the control of porphyrin biosynthesis is essential to improve ALA-mediated photodynamic therapy. In this work, we studied the regulation of ALA uptake a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601066
更新日期：2003-07-07 00:00:00
abstract：:The relationship between colony numbers and concentration of cells plated is an important parameter of clonogenic assay systems. The cloning efficiency for an ideal sample should be independent of cell concentration, thus giving a straight line through the origin when colony numbers are plotted against cell concentrat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.195
更新日期：1985-09-01 00:00:00
abstract：:No published data are available concerning the activity and tolerability of intramuscularly administered granulocyte colony-stimulating factor (G-CSF) in humans. To fill this gap, 19 patients with advanced ovarian cancer previously treated with at least one first-line chemotherapy cycle received the following myelosup...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1994.186
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:There is growing evidence that history of allergic or autoimmune disease is associated with reduced risk of glioma, but few prospective studies have explored the biological basis. To assess associations with immune conditions and levels of 14 cytokines in serial prediagnostic serum samples, we conducted a st...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0272-x
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%, next-generation sequencing (NGS)must be narrowed to target only clinically relevant genes. In this proof-of-concept study, we developed a panel to use ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.8
更新日期：2017-03-14 00:00:00
abstract：:Alcohol consumption has been inconsistently associated with breast cancer risk. Recent studies suggest that genetic polymorphisms of glutathione S-transferases (GSTs) may modify this relation. To determine if breast cancer risk is associated with GSTM1 and GSTT1 genetic polymorphisms, and to evaluate the effect modifi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600708
更新日期：2003-01-13 00:00:00
abstract：:Hypoxic cells in KHT sarcomas were characterized using fluorescence activated cell sorting based on the diffusion properties of the fluorochrome Hoechst 33342. Tumour-bearing female C3H/HeJ mice were injected i.v. with 10 micrograms g-1 Hoechst 33342 and the cells derived from the tumours sorted on the basis of their ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.207
更新日期：1988-09-01 00:00:00
abstract：BACKGROUND:Alternative treatments are needed for elderly patients with acute myeloid leukaemia, as the disease prognosis is poor and the current treatment is unsuitable for many patients. METHODS:In this study, we investigated whether combining the nucleoside analogue sapacitabine with histone deacetylase (HDAC) inhib...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605922
更新日期：2010-10-26 00:00:00
abstract：:The pathophysiology of Raynaud's phenomenon after Cisplatin-Bleomycin-Vinblastine combination chemotherapy, its relationship to polyneuropathy, and response to transcutaneous nerve stimulation (TNS), was studied in eight patients previously treated for testicular cancer. Peripheral circulation in the index finger was ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.129
更新日期：1991-04-01 00:00:00
abstract：BACKGROUND:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. METHODS:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.339
更新日期：2013-07-23 00:00:00
abstract：:This is the first study to investigate the associations of IGF-1, IGF-2 and IGFBP-3 concentrations with the risk of colorectal cancer in prospectively collected blood samples from an Oriental population. Between 1986 and 1989 serum samples were collected at baseline from 18 244 men, aged 45-65 years, without a history...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2172
更新日期：2001-11-30 00:00:00
abstract：BACKGROUND:Several microRNA (miRNA) molecules have emerged as important post-transcriptional regulators of tumour suppressor and oncogene expression. Ras association domain family member 1 (RASSF1) is a critical tumour suppressor that controls multiple aspects of cell proliferation such as cell cycle, cell division and...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.110
更新日期：2017-05-23 00:00:00
abstract：:Women referred to a familial breast cancer clinic completed questionnaires before and after counselling and at annual follow-up to assess their risk estimate and psychological characteristics. The aims were to determine whether those who attended the clinic overestimated their risk or were highly anxious and whether c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690078
更新日期：1999-02-01 00:00:00
abstract：:Two soft-agar methods for assaying chemosensitivity of human cancers in vitro were compared with respect to colony morphology, plating efficiency (PE) and chemosensitivity of human melanomas. In 9 xenografts and 9 patients' biopsy specimens Method A (essentially that of Courtenay & Mills, 1978) gave considerably highe...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.223
更新日期：1981-10-01 00:00:00
abstract：:Benzo[b]thiophenesulphonamide 1,1-dioxide (BTS) derivatives are strong cytotoxic agents that induce reactive oxygen species (ROS) overproduction and apoptosis in tumour cells. Although the precise origin of BTS-induced ROS is not known, a clear correlation between their cytotoxic effect and ability to inhibit a tumour...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602383
更新日期：2005-02-28 00:00:00
abstract：:Sera from 182 newly diagnosed breast cancer patients were assayed for antibodies to p53 using an enzyme-linked immunosorbent assay (ELISA) method, and antibodies were detected in 48 (26%) compared with 1 out of 76 (1.3%) normal control volunteers (P = 0.0001). In breast cancer patients, autoantibodies were found in al...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.219
更新日期：1994-06-01 00:00:00
abstract：:We have previously shown that epidermal growth factor (EGF) enhances the in vitro and in vivo sensitivity of human ovarian carcinoma 2008 cells to cisplatin. EGF was found to enhance selectively the in vivo toxicity of cisplatin to 2008 cell xenografts without altering the toxicity of cisplatin to non-malignant target...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.382
更新日期：1995-09-01 00:00:00
