Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: a systematic literature review.

abstract：:Dendritic cells (DC) are professional antigen-presenting cells that play a pivotal role in the induction of immunity. Ex vivo-generated, tumour antigen-loaded mature DC are currently exploited as cancer vaccines in clinical studies. However, antigen loading and maturation of DC directly in vivo would greatly facilitat...

journal_title：British journal of cancer

authors： den Brok MH,Sutmuller RP,Nierkens S,Bennink EJ,Frielink C,Toonen LW,Boerman OC,Figdor CG,Ruers TJ,Adema GJ

更新日期：2006-10-09 00:00:00

abstract：:HER2 / neu is a potential antigen candidate for immunotherapy because of its correlation to a poor prognosis and high expressions in many kinds of epithelial tumours. Especially in the colorectal carcinomas, the higher expression of HER2 / neu is recognized in metastatic regions as well as in primary sites. Several CT...

journal_title：British journal of cancer

authors： Tanaka H,Tsunoda T,Nukaya I,Sette A,Matsuda K,Umano Y,Yamaue H,Takesako K,Tanimura H

更新日期：2001-01-05 00:00:00

abstract：:The humanised form of an antagonistic anti-IGF-1R mAb (AVE1642) selectively inhibits the growth of CD45(neg) myeloma cells. AVE1642 strongly increased bortezomib-induced apoptosis, correlated with an increase of Noxa expression. These results support the therapeutic use of anti-IGF-1R/bortezomib in CD45(neg) Myeloma p...

journal_title：British journal of cancer

authors： Descamps G,Gomez-Bougie P,Venot C,Moreau P,Bataille R,Amiot M

更新日期：2009-01-27 00:00:00

abstract：:Magnetic resonance spectroscopy is increasingly used as a non-invasive method to investigate apoptosis. Apoptosis was induced in Jurkat T-cells by Fas mAb. (1)H magnetic resonance spectra of live cells showed an increase in methylene signal as well as methylene/methyl ratio of fatty acid side chains at 5 and 24 h foll...

journal_title：British journal of cancer

authors： Al-Saffar NM,Titley JC,Robertson D,Clarke PA,Jackson LE,Leach MO,Ronen SM

更新日期：2002-03-18 00:00:00

abstract：BACKGROUND:Non-epithelial gonadal tumours largely comprise sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Specific somatic mutations in DICER1, a microRNA maturation pathway gene, have been identified in these tumours. We conducted a study that aimed to confirm, refine and extend the previous observatio...

journal_title：British journal of cancer

authors： Witkowski L,Mattina J,Schönberger S,Murray MJ,Choong CS,Huntsman DG,Reis-Filho JS,McCluggage WG,Nicholson JC,Coleman N,Calaminus G,Schneider DT,Arseneau J,Stewart CJ,Foulkes WD

更新日期：2013-11-12 00:00:00

abstract：:Activation of Met by its ligand HGF has been shown to elicit both mitogenic and motogenic responses in thyrocytes in vitro. In the present study we have investigated the expression of Met in human anaplastic thyroid carcinoma cells in culture. There was a variation in expression level and size of Met in the different ...

journal_title：British journal of cancer

authors： Bergström JD,Hermansson A,Diaz de Ståhl T,Heldin NE

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Successful introduction of new anticancer agents into the clinic is often hampered by a lack of qualified biomarkers. Studies have been conducted of 17 ELISAs representing a potential panel of pharmacodynamic/predictive biomarkers for drugs targeted to tumour vasculature. METHODS:The fit-for-purpose approac...

journal_title：British journal of cancer

authors： Brookes K,Cummings J,Backen A,Greystoke A,Ward T,Jayson GC,Dive C

更新日期：2010-05-11 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) is highly expressed in adenoid cystic carcinoma (ACC). The efficacy and toxicity of cetuximab with concomitant platinum-based chemoradio- or chemotherapy in patients with locally advanced or metastatic ACC, respectively, was evaluated. METHODS:Eligible patients (9 wit...

journal_title：British journal of cancer

authors： Hitre E,Budai B,Takácsi-Nagy Z,Rubovszky G,Tóth E,Remenár É,Polgár C,Láng I

更新日期：2013-09-03 00:00:00

abstract：:Cancer survival rates decrease in the presence of disseminated disease. However, there are few therapies that are effective at eliminating the primary tumour while providing control of distant stage disease. Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumours, resulting in cure...

journal_title：British journal of cancer

authors： Kabingu E,Vaughan L,Owczarczak B,Ramsey KD,Gollnick SO

更新日期：2007-06-18 00:00:00

abstract：BACKGROUND:The somatic molecular profiles of basal-like breast cancers and high-grade serous ovarian cancers share many similarities, leading to the hypothesis that they have similar aetiologies, in which case they should occur together in the same patient more often than expected. METHODS:We identified 545 women with...

journal_title：British journal of cancer

authors： Begg CB,Rice MS,Zabor EC,Tworoger SS

更新日期：2017-04-11 00:00:00

abstract：:Radiographically occult bronchogenic squamous cell carcinomas are early lung cancers that localize mainly in the bronchial wall, and are thought to be a good model for investigating genetic alterations through lung cancer progression. In order to elucidate sequential genetic changes in lung cancers, we analysed the in...

journal_title：British journal of cancer

authors： Endo C,Sagawa M,Sato M,Chen Y,Sakurada A,Aikawa H,Takahashi S,Usuda K,Saito Y,Fujimura S

更新日期：1998-09-01 00:00:00

abstract：:The ability of human tumour cells to form colonies in soft agar is enhanced by the presence of autologous phagocytic/adherent cells. We investigated the effect of irradiation on the ability of the adherent cells to support human tumour colony formation. Relatively low doses of irradiation significantly increased the g...

journal_title：British journal of cancer

authors： Hamburger AW,White CP,Dunn FE

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Abiraterone and enzalutamide are novel endocrine treatments that abrogate androgen receptor (AR) signalling in castration-resistant prostate cancer (CRPC). Here, we developed a circulating tumour cells (CTCs)-based assay to evaluate AR expression in real-time in CRPC and investigated nuclear AR expression in...

journal_title：British journal of cancer

authors： Crespo M,van Dalum G,Ferraldeschi R,Zafeiriou Z,Sideris S,Lorente D,Bianchini D,Rodrigues DN,Riisnaes R,Miranda S,Figueiredo I,Flohr P,Nowakowska K,de Bono JS,Terstappen LW,Attard G

更新日期：2015-03-31 00:00:00

abstract：:A monoclonal antibody recognizing the blood group H type 2 antigen has been obtained from a BALB/c mouse immunized with MCF-7 (human mammary carcinoma) cells. The specificity of this antibody (A46-B/B10, IgM, kappa) has been identified by haemagglutination tests, immunohistochemistry, binding inhibition studies, and a...

journal_title：British journal of cancer

authors： Karsten U,Pilgrim G,Hanisch FG,Uhlenbruck G,Kasper M,Stosiek P,Papsdorf G,Pasternak G

更新日期：1988-08-01 00:00:00

abstract：:ICI 182,780 (Fulvestrant) is the first in a new class of novel, steroidal, 'pure' antioestrogens--the oestrogen receptor (ER) down-regulators. Its unique mode of action and the absence of partial agonist activity make it a candidate for the treatment of advanced breast cancer in both pre- and postmenopausal women. Tam...

journal_title：British journal of cancer

authors： Robertson JF

更新日期：2001-11-01 00:00:00

abstract：:Docetaxel has been reported to show promising anti-tumour activity in pancreatic ductal cancer (PC). This study was conducted to evaluate the activity and toxicity of moderate-dose (60 mg m(-2)) docetaxel in Japanese chemo-naive patients with measurable metastatic PC. The patients had a performance status of 0-2. They...

journal_title：British journal of cancer

authors： Okada S,Sakata Y,Matsuno S,Kurihara M,Sasaki Y,Ohashi Y,Taguchi T

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance (Mcm) 2-7 proteins is an early event in epithelial multistep carcinogenesis and thus MCM proteins represent powerful ca...

journal_title：British journal of cancer

authors： Dudderidge TJ,Kelly JD,Wollenschlaeger A,Okoturo O,Prevost T,Robson W,Leung HY,Williams GH,Stoeber K

更新日期：2010-08-24 00:00:00

abstract：:Three hundred and nineteen patients with primary adenocarcinoma of the ovary were studied to define those factors, many of them histopathological, which influence survival. The paper considers the stage of spread at the time of operation, the histological type of the tumour, its grade and in particular its mitotic act...

journal_title：British journal of cancer

authors： Dyson JL,Beilby JO,Steele SJ

更新日期：1971-06-01 00:00:00

abstract：:Selection of cytostatic agents for intrathecal administration is the subject of this paper.Both the toxic side effects-destruction of blood-brain barrier and change of body weight-and the cytostatic effects on intracranially transplanted Yoshida ascites sarcoma were investigated of intrathecal administration of variou...

journal_title：British journal of cancer

authors： Hayakawa T,Yamada R,Kanai N,Kuroda R,Ushio Y,Higashi H,Mogami H

更新日期：1970-09-01 00:00:00

abstract：BACKGROUND:Men diagnosed with localised prostate cancer (LPC) face difficult choices between treatment options that can cause persistent problems with sexual, urinary and bowel function. Controlled trial evidence about the survival benefits of the full range of treatment alternatives is limited, and patients' views on ...

journal_title：British journal of cancer

authors： King MT,Viney R,Smith DP,Hossain I,Street D,Savage E,Fowler S,Berry MP,Stockler M,Cozzi P,Stricker P,Ward J,Armstrong BK

更新日期：2012-02-14 00:00:00

abstract：BACKGROUND:Tumour stromal cells differ from its normal counterpart. We have shown that tumour endothelial cells (TECs) isolated from tumour tissues are also abnormal. Furthermore, we found that mRNAs of vascular endothelial growth factor-A (VEGF-A) and cyclooxygenase-2 (COX-2) were upregulated in TECs. Vascular endothe...

journal_title：British journal of cancer

authors： Kurosu T,Ohga N,Hida Y,Maishi N,Akiyama K,Kakuguchi W,Kuroshima T,Kondo M,Akino T,Totsuka Y,Shindoh M,Higashino F,Hida K

更新日期：2011-03-01 00:00:00

abstract：:In Vaud, Switzerland, the incidence of carcinoids based on 218 malignant and 215 benign cases rose from 19.6/10(6)in 1974-85 to 28. 2/10(6)in 1986-97, more so among males and malignant neoplasms. Lung was the commonest site for malignant and large intestine for benign carcinoids. Sixty-eight (16%) carcinoids had anoth...

journal_title：British journal of cancer

authors： Levi F,Te VC,Randimbison L,Rindi G,La Vecchia C

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Childhood cancer survival estimates from developing nations are rare. METHODS:Using the US SEER and the Manila and Rizal Cancer Registry databases in the Philippines, 5-year survival for childhood leukaemia and lymphoma in 2001-2005 among Asian Americans were compared with both Filipinos and Caucasians in t...

journal_title：British journal of cancer

authors： Redaniel MT,Laudico A,Mirasol-Lumague MR,Alcasabas AP,Pulte D,Brenner H

更新日期：2010-06-29 00:00:00

abstract：:5-fluorouracil (5FU) is activated intracellularly to cytotoxic 5-fluoronucleotides (FNuct). These were detected non-invasively in rats bearing the Walker carcinosarcoma by 19F-magnetic resonance spectroscopy (MRS) following an i.v. bolus dose of 5FU (50 mg kg-1). Pre-treatment of the rats (3 to 24 h earlier) by methot...

journal_title：British journal of cancer

authors： McSheehy PM,Prior MJ,Griffiths JR

更新日期：1992-03-01 00:00:00

abstract：:To: (1) estimate the prevalence of clinically significant emotional distress in patients attending a cancer outpatient department and (2) determine the associations between distress and demographic and clinical variables, we conducted a survey of outpatients attending selected clinics of a regional cancer centre in Ed...

journal_title：British journal of cancer

authors： Strong V,Waters R,Hibberd C,Rush R,Cargill A,Storey D,Walker J,Wall L,Fallon M,Sharpe M

更新日期：2007-03-26 00:00:00

abstract：:The orally administered tubulin-binding agent 1069C85 was developed with the hope of overcoming the multidrug resistance associated with existing anti-tubulin agents, such as the vinca alkaloids. A phase I study was performed using a single oral dose every 3 weeks, administered as a suspension reconstituted in 0.1% Tw...

journal_title：British journal of cancer

authors： Judson I,Briasoulis E,Raynaud F,Hanwell J,Berry C,Lacey H

更新日期：1997-01-01 00:00:00

abstract：:We analysed antibodies specific for human p53 in sera from primary breast cancer patients using three different immunoassays and we related these results to the p53 level in tumour tissue detected by immunohistochemistry. Only 44% (11/25) of apparently enzyme-linked immunosorbent assay (ELISA)-positive sera were from ...

journal_title：British journal of cancer

authors： Vojtesek B,Kovarik J,Dolezalova H,Nenutil R,Havlis P,Brentani RR,Lane DP

更新日期：1995-06-01 00:00:00

abstract：:Angiogenesis and extracellular matrix degradation are key events in tumour progression, and factors regulating stromal-epithelial interactions and matrix composition are potential targets for the development of novel anti-invasive/antiangiogenic therapies. Here, we examine the expression of ADAMTS-8, a secreted protea...

journal_title：British journal of cancer

authors： Dunn JR,Reed JE,du Plessis DG,Shaw EJ,Reeves P,Gee AL,Warnke P,Walker C

更新日期：2006-04-24 00:00:00

abstract：:Discrete masses are commonly detected during mammographic screening and most such lesions are benign. For lesions without pathognomonically benign imaging features that are still regarded likely to be non-malignant (Tabar grade 3) reliable biopsy results would be a clinically useful alternative to mammographic surveil...

journal_title：British journal of cancer

authors： Farshid G,Downey P,Gill P,Pieterse S

更新日期：2008-04-08 00:00:00

abstract：:The effect of the synthetic progesterone, megestrol acetate, on weight loss induced by both tumour necrosis factor alpha (TNF) as a model for the cachexia accompanying the acquired immunodeficiency syndrome and by a cachexia-inducing tumour (MAC16) has been studied in NMRI mice. Megestrol acetate was effective in prev...

journal_title：British journal of cancer

authors： Beck SA,Tisdale MJ

更新日期：1990-09-01 00:00:00