Epidemiology of carcinoid neoplasms in Vaud, Switzerland, 1974-97.

abstract：:Angiogenesis and extracellular matrix degradation are key events in tumour progression, and factors regulating stromal-epithelial interactions and matrix composition are potential targets for the development of novel anti-invasive/antiangiogenic therapies. Here, we examine the expression of ADAMTS-8, a secreted protea...

journal_title：British journal of cancer

authors： Dunn JR,Reed JE,du Plessis DG,Shaw EJ,Reeves P,Gee AL,Warnke P,Walker C

更新日期：2006-04-24 00:00:00

abstract：:From 1,211 breast cancers, 15 oestrogen receptor (ER) negative-progesterone receptor (PgR) positive breast cancers by conventional dextran coated charcoal steroid binding assays in cytosol were reassessed using Elisa techniques with monoclonal antireceptors antibodies in the cytosolic and nuclear fractions, and immuno...

journal_title：British journal of cancer

authors： Pichon MF,Milgrom E

更新日期：1992-06-01 00:00:00

abstract：:The relationship between hormone replacement treatment (HRT) and breast cancer risk was analysed using data from a case-control study conducted between June 1991 and February 1994 in six Italian centres on 2569 patients aged below 75 with histologically confirmed breast cancer and 2588 controls admitted to hospital fo...

journal_title：British journal of cancer

authors： La Vecchia C,Negri E,Franceschi S,Favero A,Nanni O,Filiberti R,Conti E,Montella M,Veronesi A,Ferraroni M

更新日期：1995-07-01 00:00:00

abstract：:In vivo DNA damage and repair was induced by nicotinamide (NAM) in adenotype 12 virus-induced mouse sarcoma A12B3 and sarcoma F inoculated into CBA mice. DNA damage, NAM and NAD concentrations were measured after in vivo exposure to NAM, in tumours and spleens by alkaline elution and by HPLC analysis. Our results indi...

journal_title：British journal of cancer

authors： Olsson AR,Sheng Y,Pero RW,Chaplin DJ,Horsman MR

更新日期：1996-08-01 00:00:00

abstract：:In a case-control study using a large UK primary care database, we found that non-steroidal anti-inflammatory drugs had no protective effect against biliary carcinomas (cholangiocarcinoma and gall bladder cancer). Increased risks were observed for cigarette smoking, diabetes, gallstone disease and obesity. ...

journal_title：British journal of cancer

authors： Grainge MJ,West J,Solaymani-Dodaran M,Aithal GP,Card TR

更新日期：2009-01-13 00:00:00

abstract：:Peutz-Jeghers syndrome (PJS) and juvenile polyposis (JPS) are both characterized by the presence of hamartomatous polyps and increased risk of malignancy in the gastrointestinal tract. Mutations of the LKB1 and SMAD4 genes have been shown recently to cause a number of PJS and JPS cases respectively, but there remains ...

journal_title：British journal of cancer

authors： Woodford-Richens KL,Halford S,Rowan A,Bevan S,Aaltonen LA,Wasan H,Bicknell D,Bodmer WF,Houlston RS,Tomlinson IP

更新日期：2001-05-18 00:00:00

abstract：:The S-phase fraction (SPF) in flow cytometric DNA histograms in soft tissue sarcoma (STS) can be calculated in various ways. The traditional planimetric method of Baisch has been shown to be prognostic, but is hampered by a failure rate of around 40%. We therefore tested other models to see if this rate could be decre...

journal_title：British journal of cancer

authors： Gustafson P,Baldetorp B,Fernö M,Akerman M

更新日期：1999-03-01 00:00:00

abstract：:In the years before human immunodeficiency virus (HIV) infection, the incidence of Kaposi's sarcoma varied markedly across the African continent, and it was a disease primarily affecting men. In contrast, the evidence reviewed here shows that the causal virus-Kaposi's sarcoma associated herpesvirus (KSHV)-is prevalent...

journal_title：British journal of cancer

authors： Dedicoat M,Newton R

更新日期：2003-01-13 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is associated with poor survival. To identify prognostic and diagnostic markers and therapeutic targets, we studied ANO1, a recently identified calcium-activated chloride channel (CaCC). METHODS:High-resolution genomic and transcriptomic microarray analysis and ...

journal_title：British journal of cancer

authors： Ayoub C,Wasylyk C,Li Y,Thomas E,Marisa L,Robé A,Roux M,Abecassis J,de Reyniès A,Wasylyk B

更新日期：2010-08-24 00:00:00

abstract：:We investigated whether dietary intakes of total fat, monounsaturated fat (MUFA), polyunsaturated fat (PUFA) and saturated fat (SFA) were associated with breast cancer risk in a prospective cohort of 49 261 Swedish women (30-49 years at enrolment), which yielded 974 breast cancer cases by December 2005. Further, we ev...

journal_title：British journal of cancer

authors： Löf M,Sandin S,Lagiou P,Hilakivi-Clarke L,Trichopoulos D,Adami HO,Weiderpass E

更新日期：2007-12-03 00:00:00

abstract：:Three hundred and nineteen patients with primary adenocarcinoma of the ovary were studied to define those factors, many of them histopathological, which influence survival. The paper considers the stage of spread at the time of operation, the histological type of the tumour, its grade and in particular its mitotic act...

journal_title：British journal of cancer

authors： Dyson JL,Beilby JO,Steele SJ

更新日期：1971-06-01 00:00:00

abstract：BACKGROUND:Appreciating variation in the length of pre- or post-presentation diagnostic intervals can help prioritise early diagnosis interventions with either a community or a primary care focus. METHODS:We analysed data from the first English National Audit of Cancer Diagnosis in Primary Care on 10 953 patients with...

journal_title：British journal of cancer

authors： Lyratzopoulos G,Saunders CL,Abel GA,McPhail S,Neal RD,Wardle J,Rubin GP

更新日期：2015-03-31 00:00:00

abstract：:The hypothesis is advanced that abnormalities of the chromosome group 17,18 play a special role in the genesis and/or evolution of some reticuloendothelial neoplasms. Aberrations of the group 17,18 chromosomes in tumour cells exceed in variety the reported anomaliesof any other chromosome. Both the frequency of these ...

journal_title：British journal of cancer

authors： Spiers AS,Baikie AG

更新日期：1970-03-01 00:00:00

abstract：BACKGROUND:In the phase III AVAGAST trial, the addition of bevacizumab to chemotherapy improved progression-free survival (PFS) but not overall survival (OS) in patients with advanced gastric cancer. We studied the role of Angiopoietin-2 (Ang-2), a key driver of tumour angiogenesis, metastasis and resistance to antiang...

journal_title：British journal of cancer

authors： Hacker UT,Escalona-Espinosa L,Consalvo N,Goede V,Schiffmann L,Scherer SJ,Hedge P,Van Cutsem E,Coutelle O,Büning H

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Panobinostat, a pan-deacetylase inhibitor, overcomes imatinib resistance in preclinical models of gastrointestinal stromal tumours (GIST). Here we determined the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of panobinostat in combination with imatinib (IM) for treatment of patients with re...

journal_title：British journal of cancer

authors： Bauer S,Hilger RA,Mühlenberg T,Grabellus F,Nagarajah J,Hoiczyk M,Reichardt A,Ahrens M,Reichardt P,Grunewald S,Scheulen ME,Pustowka A,Bock E,Schuler M,Pink D

更新日期：2014-03-04 00:00:00

abstract：:The objective of this study was to examine the relationship between educational level and mortality from cancer in the city of Barcelona. The data were derived from a record linkage between the Barcelona Mortality Registry and the Municipal Census. The relative risks (RR) of death and 95% confidence intervals (CIs) ac...

journal_title：British journal of cancer

authors： Fernandez E,Borrell C

更新日期：1999-02-01 00:00:00

abstract：:The aim of this study was to assess the relationship between haemoglobin level and quality-of-life in anaemic cancer patients. Patients, diagnosed with one of four cancers, were recruited if their haemoglobin level was <12 g dl(-1) (female) or <13 g dl(-1) (male). The condition-specific Functional Assessment of Cancer...

journal_title：British journal of cancer

authors： Lind M,Vernon C,Cruickshank D,Wilkinson P,Littlewood T,Stuart N,Jenkinson C,Grey-Amante P,Doll H,Wild D

更新日期：2002-04-22 00:00:00

abstract：BACKGROUND:Evidence suggests that dysregulation of energy-sensing pathways closely associates with renal cell carcinoma (RCC) development. The metabolic regulation is largely controlled by 5'-AMP activated protein kinase (AMPK) which is activated through phosphorylation by LKB1. METHODS:The expression of LKB1 was dete...

journal_title：British journal of cancer

authors： Duivenvoorden WC,Beatty LK,Lhotak S,Hill B,Mak I,Paulin G,Gallino D,Popovic S,Austin RC,Pinthus JH

更新日期：2013-02-05 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most malignant human tumours because of its high incidence of metastasis. The mechanisms underlying the metastasis of HCC, however, remain poorly understood. In this study, we performed cDNA microarray analysis to profile gene expression patterns in two subtypes of HCC, sol...

journal_title：British journal of cancer

authors： Wang W,Yang LY,Huang GW,Lu WQ,Yang ZL,Yang JQ,Liu HL

更新日期：2004-06-14 00:00:00

abstract：:Erbicin is a human anti-ErbB2 single-chain antibody fragment with high affinity and selectivity for ErbB2-positive cancer cells. Two anti-ErbB2 immunoconjugates, called Erb-hRNase and Erb-hcAb, have been prepared and found to be selectively cytotoxic on ErbB2-positive cancer cells in vitro and vivo. In Erb-hRNase, Erb...

journal_title：British journal of cancer

authors： De Lorenzo C,Troise F,Cafaro V,D'Alessio G

更新日期：2007-11-19 00:00:00

abstract：:The prognostic value of flow cytometric parameters and tumour growth rate of melanoma metastases under the mouse renal capsule was investigated for tumours from 117 consecutive patients referred to the Helsinki University Central Hospital Melanoma Team. DNA flow cytometry (FCM) was interpretable for the tumours of 114...

journal_title：British journal of cancer

authors： Muhonen T,Pyrhönen S,Laasonen A,Wasenius VM,Asko-Seljavaara S,Franssila K,Kangas L

更新日期：1992-09-01 00:00:00

abstract：:In addition to new tumour antigens, new prognostic and diagnostic markers are needed for common cancers. In this study, we report the expression of Dickkopf-1 (DKK1) in multiple common cancers. This constitutes a comprehensive analysis of the DKK1 expression profile. Dickkopf-1 expression was evaluated by classical an...

journal_title：British journal of cancer

authors： Forget MA,Turcotte S,Beauseigle D,Godin-Ethier J,Pelletier S,Martin J,Tanguay S,Lapointe R

更新日期：2007-02-26 00:00:00

abstract：:Our purpose was to determine the response rate and median and overall survival of gemcitabine as monotherapy versus gemcitabine plus irinotecan in advanced or metastatic pancreatic cancer. Patients with histologically or cytologically confirmed adenocarcinoma who were chemotherapy and radiotherapy naive were enrolled....

journal_title：British journal of cancer

authors： Stathopoulos GP,Syrigos K,Aravantinos G,Polyzos A,Papakotoulas P,Fountzilas G,Potamianou A,Ziras N,Boukovinas J,Varthalitis J,Androulakis N,Kotsakis A,Samonis G,Georgoulias V

更新日期：2006-09-04 00:00:00

abstract：BACKGROUND:A Population-Based Cancer Registry (PBCR) was set up in Sikkim (a state in the North Eastern India) in 2003. We examined incidence rates by ethnic groups from 2003-2008. METHODS:Age-adjusted incidence rates (AARs) per 100,000 person-years were calculated by direct method using the world standard population,...

journal_title：British journal of cancer

authors： Verma Y,Pradhan PK,Gurung N,Sapkota SD,Giri P,Sundas P,Bhattarai BN,Nadayil D,Ramnath T,Nandakumar A

更新日期：2012-02-28 00:00:00

abstract：:This study explored the relationships of serum insulin-like growth factors, IGF-I and IGF-II, and their binding proteins (IGFBP)-2 and IGFBP-3, with key clinicopathological parameters in 92 patients with colorectal cancer (cases). Comparisons were made with 57 individuals who had a normal colonoscopy (controls). Seria...

journal_title：British journal of cancer

authors： Renehan AG,Jones J,Potten CS,Shalet SM,O'Dwyer ST

更新日期：2000-11-01 00:00:00

abstract：:Neurofilaments (NFs) are specific intermediate filaments to neural cells. Mammalian NFs are protein triplets composed of three major subunits with respective molecular weights of approximately 70, 150 and 200 kD. Using an immunohistochemical method, 13 carcinoid tumours from different sites were examined for the prese...

journal_title：British journal of cancer

authors： Astarloa R,Sánchez-Franco F,Cacicedo L,García-Villanueva M

更新日期：1991-05-01 00:00:00

abstract：:The levels of CA 242, a new tumour marker of carbohydrate nature, were measured in sera of 185 patients with malignancies of the digestive tract and of 123 patients with benign digestive tract diseases. High percentages of elevated CA 242 levels (greater than 20 U ml-1) were recorded in patients with pancreatic and bi...

journal_title：British journal of cancer

authors： Kuusela P,Haglund C,Roberts PJ

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients. METHODS:The study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model...

journal_title：British journal of cancer

authors： Staff S,Aaltonen M,Huhtala H,Pylvänäinen K,Mecklin JP,Mäenpää J

更新日期：2016-07-26 00:00:00

abstract：:The pharmacokinetics (PK) and pharmacodynamics (PD) of metronomic irinotecan have not been studied in cancer patients. The aim of the study is to investigate the PK/PD profile of irinotecan/SN-38 administered by metronomic schedule. Twenty chemotherapy-refractory or chemotherapy-resistant patients with metastatic colo...

journal_title：British journal of cancer

authors： Allegrini G,Falcone A,Fioravanti A,Barletta MT,Orlandi P,Loupakis F,Cerri E,Masi G,Di Paolo A,Kerbel RS,Danesi R,Del Tacca M,Bocci G

更新日期：2008-04-22 00:00:00

abstract：:Up to 60% of gastro-oesophageal junction (GEJ) adenocarcinomas show nuclear beta-catenin expression, pointing to activated T-cell factor (TCF)/beta-catenin-driven gene transcription. We demonstrate in five human GEJ adenocarcinoma cell lines that nuclear beta-catenin expression indeed correlates with enhanced TCF-medi...

journal_title：British journal of cancer

authors： Koppert LB,van der Velden AW,van de Wetering M,Abbou M,van den Ouweland AM,Tilanus HW,Wijnhoven BP,Dinjens WN

更新日期：2004-02-23 00:00:00