Abstract：
:In Vaud, Switzerland, the incidence of carcinoids based on 218 malignant and 215 benign cases rose from 19.6/10(6)in 1974-85 to 28. 2/10(6)in 1986-97, more so among males and malignant neoplasms. Lung was the commonest site for malignant and large intestine for benign carcinoids. Sixty-eight (16%) carcinoids had another neoplasm.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Levi F,Te VC,Randimbison L,Rindi G,La Vecchia Cdoi
10.1054/bjoc.2000.1394subject
Has Abstractpub_date
2000-10-01 00:00:00pages
952-5issue
7eissn
0007-0920issn
1532-1827pii
S0007092000913946journal_volume
83pub_type
杂志文章abstract：:Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.71
更新日期：1987-04-01 00:00:00
abstract：:We conducted a national, retrospective population-based cohort study of 705 patients hospitalized with a first diagnosis of dermatomyositis (DM) or polymyositis (PM) during 1982-1996 based on linkage of hospital discharge, cancer registration, and death records in Scotland. Risks of cancer were assessed by calculating...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1699
更新日期：2001-07-06 00:00:00
abstract：BACKGROUND:Doxorubicin and cyclophosphamide (AC) therapy is an effective treatment for early-stage breast cancer. Doxorubicin is a substrate for ABCB1 and SLC22A16 transporters. Cyclophosphamide is a prodrug that requires oxidation to 4-hydroxycyclophosphamide, which yields a cytotoxic alkylating agent. The initial oxi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605587
更新日期：2010-03-16 00:00:00
abstract：:Human glioma usually shows intrinsic multidrug resistance because of the blood-brain barrier (BBB), in which membrane-associated P-glycoprotein (P-gp), encoded by the human multidrug resistance gene MDR1, plays a role. We studied drug sensitivity to vincristine (VCR), doxorubicin (DOX) and nimustine (ACNU) in both int...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.408
更新日期：1997-01-01 00:00:00
abstract：:A multicentric, prospective phase III study was carried out with the aim of testing the so-called 'worst drug rule' hypothesis, which suggests the use of an effective but 'less active' regimen that first eradicates tumoral cells resistant to a second effective and 'more active' regimen. With respect to this hypothesis...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.1997.586
更新日期：1997-01-01 00:00:00
abstract：:Methotrexate (MTX)-based chemotherapy extends survival in patients with primary brain lymphomas, but it is not clear whether multiagent chemotherapy is superior to MTX alone. Treatment options for patients with recurrent primary brain lymphoma are limited; there is no standard second-line chemotherapy. New chemotherap...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603660
更新日期：2007-03-26 00:00:00
abstract：:The MIB-1 antibody has been raised against recombinant parts of the Ki-67 antigen and, unlike Ki-67, has wider application to routinely fixed specimens. The aim of this study was to compare the usefulness of MIB-1 with S-phase fraction (SPF) as a measure of proliferation. A total of 75 patients with operable breast ca...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.111
更新日期：1996-03-01 00:00:00
abstract：BACKGROUND:Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used antihypertensives. Recently, these drugs have been associated with a protective effect against pancreatic cancer, but data on this putative association remain limited. Thus, the objective of this study...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.375
更新日期：2017-01-03 00:00:00
abstract：BACKGROUND:It has been reported that although young patients present with more advanced disease, when adjusted for stage, cancer-specific survival is not different after surgery for colorectal cancer. However, few studies have examined non-cancer survival in young patients and 10-year survival has rarely been reported....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605222
更新日期：2009-08-18 00:00:00
abstract：:From 1984 to 1989, 63 patients with diffuse, malignant mesothelioma of the pleura were treated with 4-8 courses of high-dose methotrexate (HDMTX, 3 g total dose) and citrovorum factor rescue. There were 61 male and two female patients of median age 60 years. CT scan was performed before and after treatment and used fo...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1992.200
更新日期：1992-06-01 00:00:00
abstract：:Bryostatin 1 is a novel antitumour agent derived from Bugula neritina of the marine phylum Ectoprocta. Nineteen patients with advanced solid tumours were entered into a phase I study to evaluate the toxicity and biological effects of bryostatin 1. Bryostatin 1 was given as a one hour intravenous infusion at the beginn...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1993.352
更新日期：1993-08-01 00:00:00
abstract：BACKGROUND:CA-125 as a tumour progression criterion in relapsing ovarian cancer (ROC) trials remains controversial. CALYPSO is a large randomised trial incorporating CA-125 (GCIG criteria) and symptomatic deterioration in addition to Response Evaluation Criteria in Solid Tumours (RECIST) criteria (radiological) to dete...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2011.593
更新日期：2012-02-14 00:00:00
abstract：BACKGROUND:Inconsistencies between mitotic index (MI) and Ki67 measures have been identified in many breast tumour samples. The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2- tumours having discrepant MI and Ki67. METHODS:We included a cohort of breast cancer patients initiall...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.239
更新日期：2015-09-29 00:00:00
abstract：:Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first tumour-associated antigens identified, it has never received the same level of attention as other target proteins for therapy of cancer. It is also striking that ever since its discovery in the late 1970s the actual contribution of...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6603494
更新日期：2007-02-12 00:00:00
abstract：:Wnt-5a is one of the most highly investigated non-canonical Wnts and has been implicated in almost all aspects of non-canonical Wnt signalling. In terms of cancer development, Wnt-5a has, until recently, lived in the shadow of its better-characterised relatives. This was largely because of its apparent inability to tr...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605174
更新日期：2009-07-21 00:00:00
abstract：BACKGROUND:To compare the imaging and clinical features of temporal lobe necrosis (TLN) in nasopharyngeal carcinoma (NPC) patients treated with two-dimensional radiotherapy (2D-RT) or those with intensity-modulated radiotherapy (IMRT). METHODS:We retrospectively analysed NPC patients who underwent 2D-RT (72 patients, ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.243
更新日期：2014-05-27 00:00:00
abstract：BACKGROUND:Exploring variation in patients' experiences of involvement in treatment decision making can identify groups needing extra support, such as additional consultation time, when considering treatment options. METHODS:We analysed data from the 2010 English National Cancer Patient Experience Survey, a national s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.316
更新日期：2013-08-06 00:00:00
abstract：:It has been shown that some types of tumour cells produce activated transforming growth factor beta-1 (TGF-beta 1). However, the mechanism for the activation of TGF-beta 1 derived from tumour cells has not been fully elucidated. The present study was undertaken to characterise an activator of latent TGF-beta 1 secrete...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.393
更新日期：1995-09-01 00:00:00
abstract：:The serum CA125 level was determined by a one-step immunoradiometric assay method in patients with lung cancer. Increased serum CA125 levels were observed in 37.8% of patients with squamous cell cancer, in 30.0% of those with adenocarcinoma and in 60.0% of those with small call cancer. Most patients with increased ser...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.355
更新日期：1990-10-01 00:00:00
abstract：:The metabolism of serotonin was studied in cancer patients of their first day of their first course of chemotherapeutic drugs either with strongly or moderately emetogenic regimens. It was observed that strongly emetogenic treatments induce greater increases in serotonin release than moderately emetogenic regimens. Hi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.242
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:Accumulating evidence demonstrates high levels of aldehyde dehydrogense (ALDH) activity in human cancer types, in part, because of its association with cancer stem cells. Whereas ALDH1A1 and ALDH7A1 isoforms were reported to associate with prostate tumorigenesis, whether other ALDH isoforms are associated wi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.201
更新日期：2014-05-13 00:00:00
abstract：:Loss of the short arm of chromosome 1 is a hallmark of oligodendroglial tumours (OTs). Deletion mapping studies in OTs have revealed multiple commonly deleted regions on chromosome 1p, suggesting that there are more than one tumour suppressor gene. To map critical deletion regions on 1p, a series of 25 OTs were examin...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602093
更新日期：2004-09-13 00:00:00
abstract：BACKGROUND:Previous studies have demonstrated that senescent cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), unlike non-senescent CAFs from genetically stable carcinomas (GS-OSCC), promoted keratinocyte invasion in vitro in a paracrine manner. The mechanis...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.438
更新日期：2014-09-09 00:00:00
abstract：:Serum levels of the soluble epidermal growth factor receptor (sEGFR) and its ligands epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha) and amphiregulin (AR) were measured in healthy donors and patients with non-small cell lung cancer (NSCLC) and head and neck carcinoma (HNC). In NSCLC, we fou...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603770
更新日期：2007-05-21 00:00:00
abstract：:Temozolomide, an oral cytotoxic agent with approximately 100% bioavailability after one administration, has demonstrated schedule-dependent clinical activity against highly resistant cancers. Thirty patients with minimal prior chemotherapy were enrolled in this phase I trial to characterize the drug's safety, pharmaco...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6690802
更新日期：1999-11-01 00:00:00
abstract：:Platinum diamine dichloride and tetrachloride inhibit the formation of antibody-forming cells in the mouse spleen after injection of sheep red cells. The dichloride is the more effective agent. It acts best when given 2 days after the antigen, which suggests that cells are more sensitive to its action when they are ra...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1971.27
更新日期：1971-03-01 00:00:00
abstract：:Using a recently developed model for studying the biology of locally recurrent (LR) mammary tumours in the 13762NF rat mammary adenocarcinoma system, we examined the sensitivity to polymorphonuclear cell, macrophage and natural killer cell cytolysis. The parental MTF7(T20) cell line; the 'primary' tumours which arose ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.302
更新日期：1988-12-01 00:00:00
abstract：:Supplementary Table 1 and the Supplementary Figure legends were not included when this manuscript was first published. The files are now available here. ...
journal_title：British journal of cancer
pub_type： 已发布勘误
doi：10.1038/s41416-018-0130-x
更新日期：2018-08-01 00:00:00
abstract：:A study was conducted on the effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on peroxisomal enzyme activities in mouse embryo fibroblasts C3H/10T1/2 C18 cells and chemically transformed C3H/10T1/2 MCA16 cells. TPA is a potent tumour promoter and treatment with this compound of the two cell lines induced peroxis...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.17
更新日期：1986-01-01 00:00:00
abstract：:We studied 5555 seminoma patients and 3733 patients with nonseminomatous testicular cancers diagnosed in Southeast England between 1960 and 2004. For both groups survival improved over time: 10-year relative survival increased from 78% in 1960-1969 to 99% in 1990-2004 for seminomas, and from 55 to 95% for nonseminomas...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603589
更新日期：2007-02-12 00:00:00
