A new monoclonal antibody (A46-B/B10) highly specific for the blood group H type 2 epitope: generation, epitope analysis, serological and histological evaluation.


:A monoclonal antibody recognizing the blood group H type 2 antigen has been obtained from a BALB/c mouse immunized with MCF-7 (human mammary carcinoma) cells. The specificity of this antibody (A46-B/B10, IgM, kappa) has been identified by haemagglutination tests, immunohistochemistry, binding inhibition studies, and absorption experiments performed with synthetic oligosaccharides. The antibody is virtually nonreactive with H type 1 antigen or with closely related type 2 structures (e.g., Y antigen). A46-B/B10 strongly agglutinates human erythrocytes according to the amount of H substance expressed and can, therefore, easily discriminate between blood groups A1 and A2 as well as A1B and A2B (A1 and A1B are not or only weakly agglutinated). In immunohistochemistry, this antibody seems to provide a highly specific reagent for a restricted number of carcinomas and epithelial lineages in tissue sections and in vitro.


Br J Cancer


Karsten U,Pilgrim G,Hanisch FG,Uhlenbruck G,Kasper M,Stosiek P,Papsdorf G,Pasternak G




Has Abstract


1988-08-01 00:00:00












  • Role of immunologic disturbance in human oncogenesis: some facts and fancies.

    abstract::A brief review is presented of the evidence linking the development of certain types of neoplasms, and of the malignant lymphomas in particular, to chronic immunosuppression in animals and man and to the naturally occurring human immunologic deficiency states. The discussion then focuses on Hodgkin's disease and consi...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审


    authors: Kaplan HS

    更新日期:1971-12-01 00:00:00

  • Selective cytotoxic activity of immunotoxins composed of a monoclonal anti-Thy 1.1 antibody and the ribosome-inactivating proteins bryodin and momordin.

    abstract::The ribosome-inactivating proteins, bryodin, from Bryonia dioica, and momordin, from Momordica charantia, were coupled by a disulphide bond to a monoclonal anti-Thy 1.1 antibody (OX7). Both immunotoxins were specifically cytotoxic to the Thy 1.1-expressing mouse lymphoma cell line AKR-A in vitro. The OX7-bryodin immun...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Stirpe F,Wawrzynczak EJ,Brown AN,Knyba RE,Watson GJ,Barbieri L,Thorpe PE

    更新日期:1988-11-01 00:00:00

  • A simple, reproducible method for monitoring the treatment of tumours using dynamic contrast-enhanced MR imaging.

    abstract::Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respirato...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Morgan B,Utting JF,Higginson A,Thomas AL,Steward WP,Horsfield MA

    更新日期:2006-05-22 00:00:00

  • Baseline and early lymphopenia predict for the risk of febrile neutropenia after chemotherapy.

    abstract::A risk model for febrile neutropenia (FN) after conventional cytotoxic chemotherapy, based on early (day 5) lymphopenia and the dose of chemotherapy, has been described. A risk index based on parameters available at day 1 would be easier in daily practice. The objectives of this work were (1) to investigate a risk mod...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Ray-Coquard I,Borg C,Bachelot T,Sebban C,Philip I,Clapisson G,Le Cesne A,Biron P,Chauvin F,Blay JY,ELYPSE study group.

    更新日期:2003-01-27 00:00:00

  • Porphyrin synthesis from ALA derivatives for photodynamic therapy. In vitro and in vivo studies.

    abstract::The aim of this work was to test in vitro and in vivo the efficacy of the derivatives of 5-aminolevulinic acid (ALA): hexyl-ALA (He-ALA), undecanoyl-ALA and R,S-2-(hydroximethyl)tetrahydropyranyl-ALA (THP-ALA) as pro-photosensitising agents. The compounds were assayed in a cell line derived from a murine mammary tumou...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Perotti C,Fukuda H,DiVenosa G,MacRobert AJ,Batlle A,Casas A

    更新日期:2004-04-19 00:00:00

  • Insulin-like growth factor 1 receptors in human breast tumour: localisation and quantification by histo-autoradiographic analysis.

    abstract::To assess the precise role of IGF1 in benign and malignant breast diseases, we analysed the tissular localisation, characterised, and quantified specific insulin-like growth factor 1 (IGF1) binding sites in these heterogenous tissues, using histo-autoradiographic analysis (HAA). The 125I-IGF1 binding was performed on ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Jammes H,Peyrat JP,Ban E,Vilain MO,Haour F,Djiane J,Bonneterre J

    更新日期:1992-08-01 00:00:00

  • Collagen production by macrophages in tumour encapsulation and dormancy.

    abstract::Dormant and regressing implants of C3H mammary carcinoma MC2 were always found to be surrounded by a cellular fibrous capsule where macrophages and T cells predominated as the cellular elements. Macrophages were always closely associated with the collagen deposition, and stained with anti-collagen type I immuno-peroxi...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Vaage J,Harlos JP

    更新日期:1991-05-01 00:00:00

  • In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cells.

    abstract::In this study we investigated the tumorigenicity, growth pattern and spontaneous metastatic ability of a series of nine human colorectal carcinoma cell lines after subcutaneous and intracaecal xenografting in nude mice. CaCo2 cells were found to be poorly tumorigenic to non-tumorigenic in either site; the other cell l...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: de Vries JE,Dinjens WN,De Bruyne GK,Verspaget HW,van der Linden EP,de Bruïne AP,Mareel MM,Bosman FT,ten Kate J

    更新日期:1995-02-01 00:00:00

  • Intra-tumoral heterogeneity of tumour potential doubling times (Tpot) in colorectal cancer.

    abstract::Intra-tumoural heterogeneity of proliferation has been assessed by taking multiple biopsies from 30 colorectal cancers. Following in vivo IUDR labelling, dual parameter flow cytometry was used to measure tumour DNA index (DI) and labelling index (LI) and to derive DNA synthesis time (Ts) and potential doubling time (T...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Wilson MS,West CM,Wilson GD,Roberts SA,James RD,Schofield PF

    更新日期:1993-09-01 00:00:00

  • Establishment of a murine leukaemia cell line resistant to the growth-inhibitory effect of bryostatin 1.

    abstract::Bryostatin 1 is a novel macrocyclic lactone activator of protein kinase C (PKC) which has clinical potential as an anti-cancer agent. The mechanism of action of this agent is unknown, but protein kinase C has been implicated. In order to investigate this possibility, we have developed P388 sublines resistant to bryost...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Prendiville J,McGown AT,Gescher A,Dickson AJ,Courage C,Pettit GR,Crowther D,Fox BW

    更新日期:1994-10-01 00:00:00

  • Lithium enhances the antitumour effect of temozolomide against TP53 wild-type glioblastoma cells via NFAT1/FasL signalling.

    abstract:BACKGROUND:We previously showed that activation of the nuclear factor of activated T cells (NFAT)1/Fas ligand (FasL) pathway induces glioma cell death. Lithium (Li) is an inhibitor of glycogen synthase kinase (GSK)-3 that activates NFAT1/FasL signalling. Temozolomide (TMZ) inhibits GSK-3 and activates Fas in tumour pro...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Han S,Meng L,Jiang Y,Cheng W,Tie X,Xia J,Wu A

    更新日期:2017-05-09 00:00:00

  • Rural and urban differences in stage at diagnosis of colorectal and lung cancers.

    abstract::There is evidence that patients living in outlying areas have poorer survival from cancer. This study set out to investigate whether they have more advanced disease at diagnosis. Case notes of 1323 patients in north and northeast Scotland who were diagnosed with lung or colorectal cancer in 1995 or 1996 were reviewed....

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Campbell NC,Elliott AM,Sharp L,Ritchie LD,Cassidy J,Little J

    更新日期:2001-04-06 00:00:00

  • Augmentation of cytotoxic drug action and X-irradiation by antibodies.

    abstract::The effect of an antiserum containing antibodies against cell surface components of PyBHK cells on the action of certain anticancer agents has been studied using a colony formation inhibition assay. The effects of x-rays, chlorambucil, CCNU and possibly ICRF 159 are augmented by the antiserum whereas methotrexate and ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Rubens RD,Vaughan-Smith S,Dulbecco R

    更新日期:1975-09-01 00:00:00

  • Diagnostic accuracy systematic review of rectal bleeding in combination with other symptoms, signs and tests in relation to colorectal cancer.

    abstract:BACKGROUND:Rectal bleeding is a recognised early symptom of colorectal cancer. This study aimed to assess the diagnostic accuracy of symptoms, signs and diagnostic tests in patients with rectal bleeding in relation to risk of colorectal cancer in primary care. METHODS:Diagnostic accuracy systematic review. Medline (19...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Olde Bekkink M,McCowan C,Falk GA,Teljeur C,Van de Laar FA,Fahey T

    更新日期:2010-01-05 00:00:00

  • Human primary brain tumour metabolism in vivo: a phosphorus magnetic resonance spectroscopy study.

    abstract::Magnetic resonance spectroscopy was used to study intracellular pH and compounds which contain phosphorus in normal human brain and primary brain tumours non-invasively. In normal subjects (n = 7) intracellular pH (pHi) of the brain was 7.03 +/- 0.02 (mean +/- s.e.m.). The pHi did not vary between superficial (2 cm, m...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Cadoux-Hudson TA,Blackledge MJ,Rajagopalan B,Taylor DJ,Radda GK

    更新日期:1989-09-01 00:00:00

  • Identification of a transforming growth factor beta-1 activator derived from a human gastric cancer cell line.

    abstract::It has been shown that some types of tumour cells produce activated transforming growth factor beta-1 (TGF-beta 1). However, the mechanism for the activation of TGF-beta 1 derived from tumour cells has not been fully elucidated. The present study was undertaken to characterise an activator of latent TGF-beta 1 secrete...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Horimoto M,Kato J,Takimoto R,Terui T,Mogi Y,Niitsu Y

    更新日期:1995-09-01 00:00:00

  • Intravenous interleukin-2 in patients over 65 with metastatic renal carcinoma.

    abstract::The present study was designed in order to evaluate the response rate and the toxicity of continuous infusion of Interleukin 2 (IL2) in patients over 65 with metastatic renal cell carcinoma. Twenty-five patients, median age 69 (range 65-77), without any prior systemic anticancer therapy received a continuous infusion ...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Négrier S,Mercatello A,Bret M,Thiesse P,Blay JY,Coronel B,Merrouche Y,Oskam R,Franks CR,Clavel M

    更新日期:1992-05-01 00:00:00

  • Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo.

    abstract::Isomerisation to all-trans-retinoic acid (ATRA) is widely accepted as the key mechanism underlying the favourable clinical properties of 13-cis-retinoic acid (13cisRA). As intracellular metabolism of ATRA by CYP26 may result in clinical resistance to 13cisRA, an increase in efficacy may be achieved through modulation ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Armstrong JL,Taylor GA,Thomas HD,Boddy AV,Redfern CP,Veal GJ

    更新日期:2007-06-04 00:00:00

  • The mechanisms of action of the carcinogenic nitroso and related compounds.

    abstract::It is suggested that the proximate carcinogenic forms of dialkylnitrosamines are their oxidation products, which retain the alkylnitrosamino moiety, but have acquired a carbonyl function as a result of omega or beta oxidation of an alkyl group. Such metabolites resemble the locally acting carcinogenic "nitrosamides" a...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Schoental R

    更新日期:1973-11-01 00:00:00

  • Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation.

    abstract:BACKGROUND:Heat shock protein 90 (HSP90) has a key role in the maintenance of the cellular proteostasis. However, HSP90 is also involved in stabilisation of oncogenic client proteins and facilitates oncogene addiction and cancer cell survival. The development of HSP90 inhibitors for cancer treatment is an area of growi...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Zhang Y,Dayalan Naidu S,Samarasinghe K,Van Hecke GC,Pheely A,Boronina TN,Cole RN,Benjamin IJ,Cole PA,Ahn YH,Dinkova-Kostova AT

    更新日期:2014-01-07 00:00:00

  • Vascular endothelial growth factor-C (VEGF-C) expression in human colorectal cancer tissues.

    abstract::Vascular endothelial growth factor-C (VEGF-C) functions specifically to induce lymphangiogenesis. We examined the relationship between expression of VEGF-C and clinicopathological features in patients with colorectal cancer. The expression of VEGF-C in the 99 primary tumours and 18 metastatic lymph nodes from colorect...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Akagi K,Ikeda Y,Miyazaki M,Abe T,Kinoshita J,Maehara Y,Sugimachi K

    更新日期:2000-10-01 00:00:00

  • A novel form of constitutively active farnesylated Akt1 prevents mammary epithelial cells from anoikis and suppresses chemotherapy-induced apoptosis.

    abstract::Protein kinase B/Akt has been described as a central mediator of anti-apoptotic signals transduced by the PI3 kinase. Although the role of Akt in the suppression of apoptosis is well elucidated, a potential function of Akt in tumorigenesis and chemoresistance is less intensively documented. In this study, we describe ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Schmidt M,Hövelmann S,Beckers TL

    更新日期:2002-10-07 00:00:00

  • Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein.

    abstract::Serum protein induced by vitamin K absence or antagonist II (PIVKAII), hepatoma-specific band of serum gamma-glutamyl transferase (GGTII), and alpha-fetoprotein (AFP) levels were determined in 120 patients with hepatocellular carcinoma (HCC) and 90 patients with cirrhosis. The mean serum concentration of PIVKAII in HC...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Cui R,He J,Zhang F,Wang B,Ding H,Shen H,Li Y,Chen X

    更新日期:2003-06-16 00:00:00

  • The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations.

    abstract::Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome of a workshop that ...

    journal_title:British journal of cancer

    pub_type: 指南,杂志文章


    authors: Leach MO,Brindle KM,Evelhoch JL,Griffiths JR,Horsman MR,Jackson A,Jayson GC,Judson IR,Knopp MV,Maxwell RJ,McIntyre D,Padhani AR,Price P,Rathbone R,Rustin GJ,Tofts PS,Tozer GM,Vennart W,Waterton JC,Williams SR,Work

    更新日期:2005-05-09 00:00:00

  • Prognostic significance of methyl-p-hydroxy-phenyllactate-esterase activity in laryngeal squamous cell carcinoma.

    abstract::We assayed methyl-p-hydroxyphenyllactate esterase (MeHPLAase) activity in 63 cases of primary laryngeal squamous cell carcinoma. MeHPLAase activity did not show any correlation with oestrogen, progesterone and epidermal growth factor (EGF) receptor levels. No significant relationship was found between MeHPLAase activi...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Maurizi M,Ferrandina G,Almadori G,Scambia G,Cadoni G,D'Agostino G,Serra FG,Piantelli M,Mancuso S,Ranelletti FO

    更新日期:1998-04-01 00:00:00

  • BCL-6 and other genomic alterations in non-Hodgkin's lymphoma (NHL).

    abstract::This study reports on the frequency and disease association pattern of a number of gene rearrangements in a large panel of lymphoid tumours (n = 94). We detected the t(11;14) translocation, involving rearrangement of the BCL-1 locus, in 60% of mantle cell lymphomas. The BCL-2 gene, located at band 18q21, was rearrange...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Butler M,Corbally N,Dervan PA,Carney DN

    更新日期:1997-01-01 00:00:00

  • Global methylation levels in peripheral blood leukocyte DNA by LUMA and breast cancer: a case-control study in Japanese women.

    abstract:BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kuchiba A,Iwasaki M,Ono H,Kasuga Y,Yokoyama S,Onuma H,Nishimura H,Kusama R,Tsugane S,Yoshida T

    更新日期:2014-05-27 00:00:00

  • Oestrogen receptor negative-progesterone receptor positive phenotype in 1,211 breast tumours.

    abstract::From 1,211 breast cancers, 15 oestrogen receptor (ER) negative-progesterone receptor (PgR) positive breast cancers by conventional dextran coated charcoal steroid binding assays in cytosol were reassessed using Elisa techniques with monoclonal antireceptors antibodies in the cytosolic and nuclear fractions, and immuno...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Pichon MF,Milgrom E

    更新日期:1992-06-01 00:00:00

  • Costs and consequences of different chemotherapy regimens in metastatic colorectal cancer.

    abstract::An economic sub-study was run alongside a large multi-centre randomised trial (MRC-CR06) comparing three chemotherapy regimens; de Gramont, Lokich and raltitrexed in patients with metastatic colorectal cancer. Patients in six of 45 centres in the main trial were approached to take part in the sub-study. Chemotherapy d...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Hale JP,Cohen DR,Maughan TS,Stephens RJ

    更新日期:2002-06-05 00:00:00

  • Expression of laminin 5-γ2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion.

    abstract:BACKGROUND:Laminin-5 (Ln5), a heterotrimer composed of three chains (α3, β3, and γ2), is a major component of the basement membrane in most adult tissues. One of the chains, Ln5-γ2, is a marker of invasive tumours because it is frequently expressed as a monomer in malignant tumours. Recent studies from our laboratories...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hamasaki H,Koga K,Aoki M,Hamasaki M,Koshikawa N,Seiki M,Iwasaki H,Nakayama J,Nabeshima K

    更新日期:2011-09-06 00:00:00