当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan.

Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan.

Abstract：

:To understand the role of p53 tumour suppressor gene in the carcinogenesis of arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan, we collected tumour samples from 23 patients with Bowen's disease, seven patients with basal cell carcinomas (BCC) and nine patients with squamous cell carcinomas (SCC). The result showed that p53 gene mutations were found in 39% of cases with Bowen's disease (9/23), 28.6% of cases with BCC (2/7) and 55.6% of cases with SCC (5/9). Most of the mutation sites were located on exon 5 and exon 8. Moreover, the results from direct sequencing indicated that missense mutations were found at codon 149 (C-->T) in one case, codon 175 (G-->A) in three cases, codon 273 (G-->C) in three cases, codon 292 (T-->A) in one case, codon 283 (G-->T) in one case, codon 172 (T-->C) in one case and codon 284 (C-->A) in one case. In addition, silent mutations were also found in four cases. These mutations were located at codons 174, 253, 289 and 298 respectively. In immunohistochemistry analysis, p53 overexpression was found in 43.5% (10/23) of cases with Bowen's disease, 14% (1/7) of cases with BCC and 44% (4/9) of cases with SSC. These findings showed that p53 gene mutation rate in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan is high and that the mutation types are different from those in UV-induced skin cancers.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Hsu CH,Yang SA,Wang JY,Yu HS,Lin SR

doi

10.1038/sj.bjc.6690467

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

1080-6

issue

7

eissn

0007-0920

issn

1532-1827

journal_volume

80

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Paediatric germ cell tumours and congenital abnormalities: a Children's Oncology Group study.

    abstract：METHODS:Maternally reported congenital abnormalities (CAs) were examined in a case-control study of 278 cases of paediatric germ cell tumours (GCTs) and 423 controls. RESULTS AND CONCLUSIONS:Germ cell tumours were significantly associated with cryptorchidism in males (OR=10.8, 95% CI: 2.1-55.1), but not with any other...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605169

    authors： Johnson KJ,Ross JA,Poynter JN,Linabery AM,Robison LL,Shu XO

    更新日期：2009-08-04 00:00:00

  • Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity.

    abstract：:Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme of 5-fluorouracil (5-FU) catabolism. We report lymphocytic DPD data concerning a group of 53 patients (23 men, 30 women, mean age 58, range 36-73), treated by 5-FU-based chemotherapy in different French institutions and who developed unantic...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690098

    authors： Milano G,Etienne MC,Pierrefite V,Barberi-Heyob M,Deporte-Fety R,Renée N

    更新日期：1999-02-01 00:00:00

  • Expression of oncofoetal pancreatic antigens in hamster adult pancreas during experimental carcinogenesis.

    abstract：:Foetal acinar components associated with the development of the hamster pancreas have been previously defined with the aid of an antifoetal pancreas serum. In immunohistology this antiserum also stained malignant ductal cells in N-nitrobis (2-oxopropyl) amine (BOP)-induced pancreatic adenocarcinoma. It did not stain a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1985.28

    authors： Escribano MJ,Carré-Llopis A,Loridon-Rosa B

    更新日期：1985-02-01 00:00:00

  • Neoadjuvant modified FOLFIRINOX followed by postoperative gemcitabine in borderline resectable pancreatic adenocarcinoma: a Phase 2 study for clinical and biomarker analysis.

    abstract：BACKGROUND:Patients with borderline resectable pancreatic cancer (BRPC) have poor prognosis with upfront surgery. METHODS:This was a single-arm Phase 2 trial for clinical and biomarker analysis. The primary endpoint is 1-year progression-free survival (PFS) rate. Patients received 8 cycles of neoadjuvant modified (m) ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-0867-x

    authors： Yoo C,Lee SS,Song KB,Jeong JH,Hyung J,Park DH,Song TJ,Seo DW,Lee SK,Kim MH,Lee SS,Kim JH,Jin HS,Park JH,Hwang DW,Lee JH,Lee W,Chang HM,Kim KP,Ryoo BY,Kim SC

    更新日期：2020-08-01 00:00:00

  • The induction of rat bladder cancer by 2-naphthylamine.

    abstract：:The widely held belief that 2-naphthylamine is not carcinogenic for the rat has been re-examined. Twenty female Wistar rats were dosed by gastric intubation weekly for 57 weeks with 2-naphthylamine, 300 mg/kg body wt, in arachis oil and 20 controls were given arachis oil alone. Animals which became moribund were kille...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1982.250

    authors： Hicks RM,Wright R,Wakefield JS

    更新日期：1982-10-01 00:00:00

  • Radiotherapy for stage I Hodgkin's disease: 20 years experience at St Bartholomew's Hospital.

    abstract：:One hundred and one consecutive patients with newly diagnosed stage I Hodgkin's disease (HD) received treatment at St Bartholomew's Hospital, between 1968 and 1987, with a median follow-up of 12 years. Eleven patients have been excluded from detailed analysis because they either received involved field radiotherapy (R...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.285

    authors： Ganesan TS,Wrigley PF,Murray PA,Stansfeld AG,d'Ardenne AJ,Arnott S,Jones A,Shand WS,Malpas JS,Lister TA

    更新日期：1990-08-01 00:00:00

  • Electrophoretic mobility of mouse T-cell hybrids.

    abstract：:The hybrid cell line BH2 was derived by fusion between an AKR thymoma BW5147 (HGPRT-) and C57BL thymoma EL-4R (TK-). The hybrid cells showed a near-tetraploid modal number of chromosomes, in contrast to the near-diploid stem-lines of both parental cell populations; most of the BH2 hybrid cells acquired marker chromoso...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1981.255

    authors： Bubeník J,Perlmann P,Jónsdóttir I,Kypĕnová H,Bubeníková D,Símová J

    更新日期：1981-11-01 00:00:00

  • Involvement of chromosome 6 in endometrial cancer.

    abstract：:Cytogenetic investigation was performed on direct preparations of 15 endometrial cancers showing different histotypes. Clonal abnormalities were found in 11 out of 13 analysable cases. The modal chromosome number was near diploid in all cases. The abnormal karyotypes contained relatively simple numerical or structural...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.312

    authors： Tibiletti MG,Bernasconi B,Taborelli M,Furlan D,Fabbri A,Franchi M,Taramelli R,Trubia M,Capella C

    更新日期：1997-01-01 00:00:00

  • Vinorelbine and gemcitabine vs vinorelbine and carboplatin as first-line treatment of advanced NSCLC. A phase III randomised controlled trial by the Norwegian Lung Cancer Study Group.

    abstract：BACKGROUND:Platinum-based doublet chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC), but earlier studies have suggested that non-platinum combinations are equally effective and better tolerated. We conducted a national, randomised study to compare a non-platinum with a pl...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/bjc.2012.284

    authors： Fløtten Ø,Grønberg BH,Bremnes R,Amundsen T,Sundstrøm S,Rolke H,Hornslien K,Wentzel-Larsen T,Aasebø U,von Plessen C

    更新日期：2012-07-24 00:00:00

  • Assessment of bone response to systemic therapy in an EORTC trial: preliminary experience with the use of collagen cross-link excretion. European Organization for Research and Treatment of Cancer.

    abstract：:This study was designed to evaluate new bone resorption and tumour markers as possible alternatives to serial plain radiographs for the assessment of response to treatment. Thirty-seven patients with newly diagnosed bone metastases from breast cancer, randomized to receive oral pamidronate or placebo tablets in additi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690506

    authors： Vinholes J,Coleman R,Lacombe D,Rose C,Tubiana-Hulin M,Bastit P,Wildiers J,Michel J,Leonard R,Nortier J,Mignolet F,Ford J

    更新日期：1999-04-01 00:00:00

  • Development and characterization of a tamoxifen-resistant breast carcinoma xenograft.

    abstract：:A human tamoxifen-resistant mammary carcinoma, MaCa 3366/TAM, originating from a sensitive parental xenograft 3366 was successfully established by treatment of tumour-bearing nude mice with 1-50 mg kg(-1) tamoxifen for 3 years during routine passaging. Both tumours did not differ significantly in OR- and PR-positivity...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1156

    authors： Naundorf H,Becker M,Lykkesfeldt AE,Elbe B,Neumann C,Büttner B,Fichtner I

    更新日期：2000-06-01 00:00:00

  • ZD 1839 in patients with brain metastases from non-small-cell lung cancer (NSCLC): report of four cases.

    abstract：:The activity of ZD 1839 on brain metastases (BM) from Non-Small-Cell Lung Cancer (NSCLC) is unknown. We report four cases of BM responding to ZD 1839 theraphy. ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601116

    authors： Cappuzzo F,Calandri C,Bartolini S,Crinò L

    更新日期：2003-07-21 00:00:00

  • Fern spore extracts can damage DNA.

    abstract：:The carcinogenicity of the vegetative tissues of bracken fern (Pteridium) has long been established. More recently, the carcinogenic effects of the spores of bracken have also been recognized. Both vegetative tissues and spores of bracken can induce adducts in DNA in animal tissues, but the possible genotoxic or carci...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1204

    authors： Simán SE,Povey AC,Ward TH,Margison GP,Sheffield E

    更新日期：2000-07-01 00:00:00

  • Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types.

    abstract：BACKGROUND:Alternative treatments are needed for elderly patients with acute myeloid leukaemia, as the disease prognosis is poor and the current treatment is unsuitable for many patients. METHODS:In this study, we investigated whether combining the nucleoside analogue sapacitabine with histone deacetylase (HDAC) inhib...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605922

    authors： Green SR,Choudhary AK,Fleming IN

    更新日期：2010-10-26 00:00:00

  • Geographic and ethnic differences in childhood leukaemia and lymphoma survival: comparisons of Philippine residents, Asian Americans and Caucasians in the United States.

    abstract：BACKGROUND:Childhood cancer survival estimates from developing nations are rare. METHODS:Using the US SEER and the Manila and Rizal Cancer Registry databases in the Philippines, 5-year survival for childhood leukaemia and lymphoma in 2001-2005 among Asian Americans were compared with both Filipinos and Caucasians in t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605703

    authors： Redaniel MT,Laudico A,Mirasol-Lumague MR,Alcasabas AP,Pulte D,Brenner H

    更新日期：2010-06-29 00:00:00

  • Identification and characterization of a novel human hepatocellular carcinoma-associated gene.

    abstract：:To investigate liver cancer-associated genes and to explore the molecular basis of liver cancer genesis, we have cloned a novel hepatocellular carcinoma (HCC)-related gene with a transcript of 2520 base pairs in length named HCCA2 by mRNA differential display polymerase chain reaction (DDPCR) and screening a placenta ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2001.2059

    authors： Wang ZX,Wang HY,Wu MC

    更新日期：2001-10-19 00:00:00

  • Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules.

    abstract：BACKGROUND:Enzastaurin, an oral serine-threonine kinase inhibitor, was initially developed as an ATP-competitive selective inhibitor against protein kinase Cβ. However, the mechanism by which enzastaurin contributes to tumourigenesis remains unclear. METHODS:We analysed the anti-tumour effects of enzastaurin in 22 lun...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.7

    authors： Shimokawa T,Seike M,Soeno C,Uesaka H,Miyanaga A,Mizutani H,Kitamura K,Minegishi Y,Noro R,Okano T,Yoshimura A,Gemma A

    更新日期：2012-02-28 00:00:00

  • Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours.

    abstract：:This corrects the article DOI: 10.1038/bjc.2017.327. ...

    journal_title：British journal of cancer

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/bjc.2017.438

    authors： Infante JR,Korn RL,Rosen LS,LoRusso P,Dychter SS,Zhu J,Maneval DC,Jiang P,Shepard HM,Frost G,Von Hoff DD,Borad MJ,Ramanathan RK

    更新日期：2018-01-01 00:00:00

  • Pharmacokinetic considerations in testing hypoxic cell radiosensitizers in mouse tumours.

    abstract：:Bilateral kidney ligation of mice immediately before injection of misonidazole (MIS) prolongs the plasma half-life of this radiosensitizer from about 2 h (in normal mice) to 10-11 h, similar to that in man. Kidney ligation does not, however, change the relative proportions of MIS and its O-demethylated metabolite, Ro-...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1979.55

    authors： Brown JM,Yu NY,Workman P

    更新日期：1979-03-01 00:00:00

  • Breast cancer risk among first-generation migrants in the Netherlands.

    abstract：:We investigated breast cancer incidence in migrants in the Netherlands in 1988-1998. The standardised incidence ratio for breast cancer in Northwest-Netherlands was statistically significantly reduced for women born in Surinam (0.56), Turkey (0.29) and Morocco (0.22). The proportion of women with advanced stages (III ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601821

    authors： Visser O,van der Kooy K,van Peppen AM,Ory FG,van Leeuwen FE

    更新日期：2004-06-01 00:00:00

  • Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytarabine.

    abstract：:DepoCyte is a slow-release formulation of cytarabine designed for intrathecal administration. The goal of this multi-centre cohort study was to determine the safety and efficacy of DepoCyte for the intrathecal treatment of neoplastic meningitis due to breast cancer. DepoCyte 50 mg was injected once every 2 weeks for o...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1054/bjoc.2000.1574

    authors： Jaeckle KA,Phuphanich S,Bent MJ,Aiken R,Batchelor T,Campbell T,Fulton D,Gilbert M,Heros D,Rogers L,O'Day SJ,Akerley W,Allen J,Baidas S,Gertler SZ,Greenberg HS,LaFollette S,Lesser G,Mason W,Recht L,Wong E,Chamber

    更新日期：2001-01-01 00:00:00

  • Prognostic value of histological and biological markers in pharyngeal squamous cell carcinoma: a case-control study.

    abstract：:Between 1980 and 1985, 914 patients with head and neck squamous cell carcinoma underwent lymph node dissection in our institution. The prognostic value of clinical factors has already been reported (Mamelle et al, 1994, Am J Surg 168: 494-498). We present here a comparison of biological characteristics of pharyngeal t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.320

    authors： Guerry M,Vabre L,Talbot M,Mamelle G,Leridant AM,Hill C,Bosq J,Luboinski B,Janot F

    更新日期：1998-06-01 00:00:00

  • Childhood indicators of susceptibility to subsequent cervical cancer.

    abstract：:Common warts could indicate cervical cancer susceptibility, as both are caused by human papillomavirus (HPV). Eczema was also investigated, as atopic eczema has been negatively associated with warts, but non-atopic eczema may be associated with compromised host defences, as observed in patients with HIV, suggesting in...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600585

    authors： Montgomery SM,Ehlin AG,Sparén P,Björkstén B,Ekbom A

    更新日期：2002-10-21 00:00:00

  • Randomised double-blind trial of megestrol acetate vs placebo in treatment-naive advanced hepatocellular carcinoma.

    abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. We tested megestrol acetate (MA) against placebo in the treatment of advanced HCC. METHODS:From 2002 through 2007, this randomised double-blind trial enrolled 204 patients with treatment-naive advanced HCC (Eastern Coopera...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2011.333

    authors： Chow PK,Machin D,Chen Y,Zhang X,Win KM,Hoang HH,Nguyen BD,Jin MY,Lobo R,Findlay M,Lim CH,Tan SB,Gandhi M,Soo KC,Asia-Pacific Hepatocellular Carcinoma Trials Group.

    更新日期：2011-09-27 00:00:00

  • Long-term results and recurrence patterns from SCALOP: a phase II randomised trial of gemcitabine- or capecitabine-based chemoradiation for locally advanced pancreatic cancer.

    abstract：BACKGROUND:SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. METHODS:Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks o...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2017.95

    authors： Hurt CN,Falk S,Crosby T,McDonald A,Ray R,Joseph G,Staffurth J,Abrams RA,Griffiths G,Maughan T,Mukherjee S

    更新日期：2017-05-09 00:00:00

  • Childhood rhabdomyosarcoma: experience of the Children's Solid Tumour Group.

    abstract：:Seventy three children with rhabdomyosarcoma were treated by members of the Children's Solid Tumour Group during the period, 1974-1981. The extent of disease at diagnosis was found to be the major influence affecting outcome. Children with tumours confined to the tissue of origin with no evidence of nodal or metastati...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1983.175

    authors： Kingston JE,McElwain TJ,Malpas JS

    更新日期：1983-08-01 00:00:00

  • Reactivity to human papillomavirus type 16 L1 virus-like particles in sera from patients with genital cancer and patients with carcinomas at five different extragenital sites.

    abstract：:A retrospective seroepidemiologic study was performed to examine the association between human papillomaviruses (HPV) 16 infection and carcinomas of the oropharynx, the oesophagus, penis and vagina. Sera were selected from the serum bank from the Antoni van Leeuwenhoek Hospital (Netherlands Cancer Institute) and the S...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600870

    authors： Van Doornum GJ,Korse CM,Buning-Kager JC,Bonfrer JM,Horenblas S,Taal BG,Dillner J

    更新日期：2003-04-07 00:00:00

  • Long-term results of screening with magnetic resonance imaging in women with BRCA mutations.

    abstract：BACKGROUND:The addition of breast magnetic resonance imaging (MRI) to screening mammography for women with BRCA mutations significantly increases sensitivity, but there is little data on clinical outcomes. We report screening performance, cancer stage, distant recurrence rate, and breast cancer-specific mortality in ou...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.204

    authors： Passaperuma K,Warner E,Causer PA,Hill KA,Messner S,Wong JW,Jong RA,Wright FC,Yaffe MJ,Ramsay EA,Balasingham S,Verity L,Eisen A,Curpen B,Shumak R,Plewes DB,Narod SA

    更新日期：2012-06-26 00:00:00

  • Collection of circulating progenitor cells after epirubicin, paclitaxel and filgrastim in patients with metastatic breast cancer.

    abstract：:The efficacy of high-dose chemotherapy (HDC) and circulating progenitor cell (CPC) transplantation in metastatic breast cancer (MBC) relies mainly on giving this treatment after a response to conventional induction chemotherapy has been achieved. For this reason an optimal mobilization regimen should be therapeuticall...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.231

    authors： Pedrazzoli P,Perotti C,Da Prada GA,Bertolini F,Gibelli N,Torretta L,Battaglia M,Pavesi L,Preti P,Salvaneschi L,Robustelli della Cuna G

    更新日期：1997-01-01 00:00:00

  • Regulation of monocyte MMP-9 production by TNF-alpha and a tumour-derived soluble factor (MMPSF).

    abstract：:The matrix metalloprotease MMP-9 localizes to tumour-associated macrophages in human ovarian cancer but little is known of its regulation. Co-culture of human ovarian cancer cells (PEO-1) and a monocytic cell line (THP-1) led to production of 92-kDa proMMP-9. PEO-1-conditioned medium (CM) also stimulated THP-1 cells o...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.568

    authors： Leber TM,Balkwill FR

    更新日期：1998-09-01 00:00:00