Abstract：
:Seventy three children with rhabdomyosarcoma were treated by members of the Children's Solid Tumour Group during the period, 1974-1981. The extent of disease at diagnosis was found to be the major influence affecting outcome. Children with tumours confined to the tissue of origin with no evidence of nodal or metastatic spread, had a predicted actuarial 5-year survival rate of 86%. However children with 'unconfined' tumours, i.e. those with extension of disease outside the tissue of origin, had a much poorer prognosis with an actuarial 5-year survival rate of only 21%. Two other factors, histological type and site of primary tumour, appeared to affect prognosis but were not independent of the extent of disease at diagnosis. All children were treated according to protocol. Fifty-two patients showed a complete response to initial therapy and 4 of the 11 partial responders achieved a full remission after additional therapy. The overall complete response rate was therefore 77%. Nineteen children who achieved a complete response on initial treatment subsequently relapsed. Only 3 of these children were alive with no evidence of disease 3 years later, a salvage rate of 15%. "Late" relapses, defined as those occurring more than 2 years after diagnosis, were seen in only 5 children, 4 in boys with primary paratesticular tumours.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Kingston JE,McElwain TJ,Malpas JSdoi
10.1038/bjc.1983.175subject
Has Abstractpub_date
1983-08-01 00:00:00pages
195-207issue
2eissn
0007-0920issn
1532-1827journal_volume
48pub_type
杂志文章abstract：BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. METHODS:Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosi...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2017.68
更新日期：2017-04-25 00:00:00
abstract：:Evidence in the literature suggests that hyperthermia (HT) or inhibitors of calmodulin can increase the sensitivity of rodent cells to bleomycin (BLM) by interfering with DNA repair functions. In an attempt to explore methods of improving the efficacy of thermochemotherapy we have investigated the individual and combi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.14
更新日期：1986-01-01 00:00:00
abstract：:Nerve growth factor (NGF) administration to athymic mice with transplanted human bromocriptine-resistant prolactinoma, results in the expression of dopamine D-2 receptors in the tumour and restores sensitivity to subsequent treatment with bromocriptine, which then produces normalisation of plasma prolactin and tumour ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.520
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Cytochrome P450 2D6 (CYP2D6) has a crucial role in the metabolic conversion of tamoxifen into the active metabolite endoxifen. In this cohort study, the effect of CYP2D6-predicted phenotype, defined as the combined effect of CYP2D6 genetic variation and concomitant use of CYP2D6-inhibiting medication, on tim...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605800
更新日期：2010-09-07 00:00:00
abstract：:We have examined the genetic aberrations in two near-diploid glioblastoma multiforme cell lines that appear to have arisen from different glial lineages. One cell line, Hu-O-2A/Gb1, expresses antigens and metabolic profiles characteristic of the oligodendrocyte-type-2 astrocyte (0-2A) lineage of the rat central nervou...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690116
更新日期：1999-02-01 00:00:00
abstract：:A total of 165 adult patients with Hodgkin's disease (HD) were questioned following treatment to examine their perceptions of actual and desired involvement and provision of information in the treatment decision-making process. Irrespective of the degree to which patients felt they had been involved in the decision-ma...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.39
更新日期：1996-01-01 00:00:00
abstract：:The role of secreted frizzled-related protein (SFRP) genes in gastric cancer remains largely unknown. We determined the frequency and functional significance of SFRPs hypermethylation in human gastric cancer. The expression and methylation status of four SFRP members (SFRP1, 2, 4, and 5) in primary gastric cancer samp...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603968
更新日期：2007-10-08 00:00:00
abstract：:An apparently unique circulating common oncofoetal protein has been identified in rat small-bowel, colonic and pancreatic adenocarcinomas. The tumours were induced by ionizing radiation (small bowel), an alkyl hydrocarbon, 1,2-dimethylhydrazine (colon) and a polyaromatic hydrocarbon, 7,12-dimethylbenz[a]anthracene (pa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.120
更新日期：1981-06-01 00:00:00
abstract：METHODS:Maternally reported congenital abnormalities (CAs) were examined in a case-control study of 278 cases of paediatric germ cell tumours (GCTs) and 423 controls. RESULTS AND CONCLUSIONS:Germ cell tumours were significantly associated with cryptorchidism in males (OR=10.8, 95% CI: 2.1-55.1), but not with any other...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605169
更新日期：2009-08-04 00:00:00
abstract：BACKGROUND:Anti-PD-1 antibodies and BRAF/MEK inhibitors are the two main groups of systemic therapy in the treatment of BRAFV600-mutant advanced melanoma. Until now, data are inconclusive on which therapy to use as first-line treatment. The aim of this study was to use propensity score matching to compare first-line an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01229-1
更新日期：2021-01-26 00:00:00
abstract：:The survival and clonogenic growth (measured in terms of colony forming efficiency (CFE) of intravenously injected (i.v.) Walker (W256) tumour cells in the lungs of rats was greatly enhanced by states of topical and systemic stress induced by the intraperitoneal (i.p.) injection of rats with a single dose of 10(-5)-10...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.7
更新日期：1976-01-01 00:00:00
abstract：:An analysis of the occurrence of breast cancer in this long-term prospective cohort study shows a significant relative risk (RR) in women who have ever used oral contraceptives (OC) of 3.33 in women age 30 to 34 years at diagnosis and an RR of 5.88 (P = 0.0011) in women who were parity 1 at the time of diagnosis. In w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.285
更新日期：1988-11-01 00:00:00
abstract：BACKGROUND:MSMB, a gene coding for beta-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605485
更新日期：2010-01-19 00:00:00
abstract：BACKGROUND:To date, there are few reports on gene products contributing to colon cancer progression. METHODS:We used a gene trap comprised of an enhanced retroviral mutagen (ERM) cassette that includes a tetracycline-responsive promoter upstream of a haemagglutinin (HA) tag and a splice donor site. Integration of the ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605536
更新日期：2010-02-16 00:00:00
abstract：:Extracellular proteases of the matrix metalloproteinase (MMP) and serine protease families participate in many aspects of tumour growth and metastasis. Using quantitative real-time RT-PCR analysis, we have undertaken a comprehensive survey of the expression of these enzymes and of their natural inhibitors in 44 cases ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602630
更新日期：2005-06-20 00:00:00
abstract：BACKGROUND:On theoretical grounds, the age of the grandmother and the age of the mother at delivery of her daughter may affect the breast cancer risk of the granddaughter. METHODS:We used the data relating to the Diagnostic Research Mamma-carcinoma cohort (DOM (Diagnostisch Onderzoek Mammacarcinoom) 3), which comprise...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605639
更新日期：2010-04-27 00:00:00
abstract：:Photodynamic therapy (PDT) using Photofrin was used in combination with a hypoxic toxin (mitomycin C, MMC) to treat four patients with recurrent skin metastasis of a mammary carcinoma. In preclinical experiments an additive effect was found for the combination of MMC and PDT for treating subcutaneous RIF1 tumours in m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.186
更新日期：1996-04-01 00:00:00
abstract：:Serine proteases, such as alpha-chymotrypsin or elastase, caused an aggregation of rat ascites tumour cell lines, AH-130, AH-109A and YS, in a protein free medium which preserved the cell viability. This aggregation, which was monitored spectrophotometrically, was dependent upon the protease activities and was resista...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.339
更新日期：1990-10-01 00:00:00
abstract：:Colorectal tumours from MYH polyposis patients display an excess of somatic G : C --> T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.0...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601747
更新日期：2004-04-19 00:00:00
abstract：:The relationship between hepatic arterial albumin microsphere distribution and hepatic arterial blood flow and the effects of regional angiotensin II were studied in a rat liver metastases model. Hooded-Lister rats were inoculated subcapsularly with 2 x 10(6) HSN sarcoma cells. At 20 days, hepatic arterial blood flow ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.258
更新日期：1992-08-01 00:00:00
abstract：:Diffuse invasion of the brain, an intrinsic property of gliomas, renders these tumours incurable, and is a principal determinant of their spatial and temporal growth. Knowledge of the invasive potential of gliomas is highly desired in order to understand their behaviour in vivo. Comprehensive ex vivo invasion studies ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602048
更新日期：2004-08-16 00:00:00
abstract：:Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross ela...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.98
更新日期：1979-05-01 00:00:00
abstract：BACKGROUND:We investigated whether pazopanib maintenance following first-line chemotherapy would improve survival in patients with extensive disease small-cell lung cancer (ED-SCLC). METHODS:This study is a randomised, placebo-controlled, phase II study that enroled ED-SCLC patients who had not progressed after four c...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2017.465
更新日期：2018-03-06 00:00:00
abstract：:Eleven human bladder carcinomata of different degrees of differentiation were implanted in mice immunosuppressed by thymectomy, anti-thymocyte serum and x-rays. Seven carcinomata grew well and one poorly and 3 produced mainly fibrous nodules in the mice. Normal human bladder tissues were grown from 4 other patients. T...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.30
更新日期：1975-02-01 00:00:00
abstract：:The present study was designed to examine whether different p53 haplotypes of exon 4-intron 3-intron 6 affect the frequency of mutations and loss of heterozygosity (LOH) of the p53 gene in male oral squamous cell carcinomas (OSCCs) in Taiwan. We found that individuals without two Pro-W-G alleles had significantly high...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602271
更新日期：2005-01-17 00:00:00
abstract：:Endogamous groups in Western India have been known to have a wide degree of genetic diversity. Analysis of the data available on some of the endogamous groups belonging to two main communities attending the Tata Memorial Hospital, Bombay, viz. Hindus from Maharashtra, and Hindus from Gujarat show that one of the endog...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1971.77
更新日期：1971-12-01 00:00:00
abstract：:ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied. We investigated whether ApoE polymorphisms alone or in combination with dietary factor...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605097
更新日期：2009-06-16 00:00:00
abstract：:The primary aim of this study was to investigate if the expression of the DNA damage identifying protein DNA-PKcs known to be involved in DNA repair after treatment with ionising radiation can be used as a predictive marker for radiotherapy (RT) response in cervical cancer. Formalin-fixed primary tumour biopsies from ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603153
更新日期：2006-06-05 00:00:00
abstract：BACKGROUND:CYFRA 21-1 serves as biomarker in several epithelial malignancies. However, its role in pancreatic cancer (PC) has not yet been investigated. METHODS:Within a prospective single-centre study serial blood samples were collected from patients with confirmed advanced PC. Pre-treatment values and weekly measure...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.2013.158
更新日期：2013-04-30 00:00:00
abstract：:We used data from a prospective cohort study of twins to investigate the influence of unmeasured genetic and measured and unmeasured environmental factors on the smoking behaviour of adolescents and young adults. Twins were surveyed in 1988 (aged 11-18 years), 1991, 1996 and 2004 with data from 1409, 1121, 732 and 758...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604250
更新日期：2008-04-22 00:00:00
