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Expression of DNA damage response proteins and complete remission after radiotherapy of stage IB-IIA of cervical cancer.

Abstract：

:The primary aim of this study was to investigate if the expression of the DNA damage identifying protein DNA-PKcs known to be involved in DNA repair after treatment with ionising radiation can be used as a predictive marker for radiotherapy (RT) response in cervical cancer. Formalin-fixed primary tumour biopsies from 109 patients with cervical cancer, FIGO-stage IB-IIA, treated with preoperative brachytherapy followed by radical surgery were analysed by immunohistochemistry. In addition, correlation studies between early pathological tumour response to radiation and expression of Ku86, Ku70, Mdm-2, p53 and p21 in primary tumours were also performed. We found that tumour-transformed tissue shows positive immunostaining of DNA-PKcs, Ku86 and Ku70, while non-neoplastic squamous epithelium and tumour-free cervix glands show negative immunoreactivity. Expression of DNA-PKcs positively correlated with both Ku86 and Ku70, and a statistically significant correlation between the Ku subunits was also found. After RT, 85 patients demonstrated pathologic complete remission (pCR), whereas 24 patients had residual tumour in the surgical specimen (non-pCR). The main finding of our study is that there was no correlation between the outcome of RT and the expression of DNA-PK subunits. Positive p53 tumours were significantly more common among non-pCR cases than in patients with pCR (P=0.031). Expression of p21 and Mdm-2 did not correlate with the outcome of RT.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Beskow C,Kanter L,Holgersson A,Nilsson B,Frankendal B,Avall-Lundqvist E,Lewensohn R

doi

10.1038/sj.bjc.6603153

subject

Has Abstract

pub_date

2006-06-05 00:00:00

pages

1683-9

issue

11

eissn

0007-0920

issn

1532-1827

pii

6603153

journal_volume

94

pub_type

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