Abstract：
:The hybrid cell line BH2 was derived by fusion between an AKR thymoma BW5147 (HGPRT-) and C57BL thymoma EL-4R (TK-). The hybrid cells showed a near-tetraploid modal number of chromosomes, in contrast to the near-diploid stem-lines of both parental cell populations; most of the BH2 hybrid cells acquired marker chromosomes from both parental cell lines. Inoculation of the parental and hybrid cells into C57BL and AKR mice revealed that the possible admixture of revertant parental cells in the hybrid cell population was less than 10(-4). Anodic electrophoretic mobilities (AEM) of the mouse thymoma lines and their hybrids were compared with each other and with normal mouse lymphoid cells. The AEM of the parental and hybrid T-cell lines was slower than that of mouse T LNC and comparable with AEM of some thymocyte subsets. The mean AEM of parental and hybrid cell lines was 0.69 micrometers/sec/V/cm for BW5147 cells, 0.96 for EL-4R cells and 0.83 for BH2 cells, the mean AEM of the hybrid cell population being identical with the mean of the parental AEM values. The mean AEM was found to be a relatively stable characteristic of each cell line.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Bubeník J,Perlmann P,Jónsdóttir I,Kypĕnová H,Bubeníková D,Símová Jdoi
10.1038/bjc.1981.255subject
Has Abstractpub_date
1981-11-01 00:00:00pages
692-9issue
5eissn
0007-0920issn
1532-1827journal_volume
44pub_type
杂志文章abstract：BACKGROUND:New prognostic markers are needed to identify patients with Ewing sarcoma (EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the incidence and association with outcome of circulating tumour DNA (ctDNA) using next-generation sequencing (NGS) assays. METHODS:A NGS hybrid capture ass...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0212-9
更新日期：2018-08-01 00:00:00
abstract：:In a prospective cohort study, a close to two-fold elevated risk of bladder cancer was found among men reporting a history of gonorrhoea (relative risk=1.92, 95% CI=1.10-3.33). Our finding warrants further examination of the role of gonorrhoea in bladder carcinogenesis. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603510
更新日期：2007-01-15 00:00:00
abstract：:Steroid receptor was assessed immunohistochemically in 158 samples of normal breast for variation through the menstrual cycle. Patterns and intensity of reaction were used in a semi-quantitative scoring system to examine the influence of cycle phase, cycle type, parity and age. The changes in oestrogen receptor for na...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.122
更新日期：1992-04-01 00:00:00
abstract：:Comparison of 9 and 35 GHz spectra, obtained from frozen and lyophilized tissues, with those from model systems containing ascorbic acid, confirm that the major component of the "lyophilization signal" of tissue is the ascorbyl radical, stabilized by adsorption on an inert matrix. The magnitude of the signal under ano...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.10
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to evaluate the number of ovarian cancer and primary peritoneal cancer (PPC) progressive disease cases identified via routine follow-up procedures and the corresponding cost throughout a 16-year period at a single medical institution. METHODS:Previously undiagnosed epithelial o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605963
更新日期：2010-11-23 00:00:00
abstract：:The addition of lapatinib (Tykerb/Tyverb) to capecitabine (Xeloda) delays disease progression more effectively than capecitabine monotherapy in women with previously treated HER2+ metastatic breast cancer (MBC). The quality-adjusted time without symptoms of disease or toxicity of treatment (Q-TWiST) method was used to...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.bjc.6604501
更新日期：2008-09-02 00:00:00
abstract：:A cohort study was conducted to investigate the mortality of individuals employed by biological research institutes in the UK. The inclusion criteria were met by 12,703 individuals, of whom 95% were traced (11,502 alive, 395 deaths, 246 embarkations). All-cause mortality was significantly reduced in men (standardised)...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.221
更新日期：1996-05-01 00:00:00
abstract：:A number of rare human inherited syndromes are associated with apparent defects in DNA repair and a greatly increased frequency of cancer. Cell lines derived from such individuals phenotypically resemble certain bacterial mutant strains that have increased sensitivity to radiation or chemical agents and well character...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.1987.163
更新日期：1987-08-01 00:00:00
abstract：:All hospital-treated cases of Burkitt's lymphoma (BL), with onset of symptoms in the period 1963-68 and resident in the Lango and Acholi districts of Uganda, were identified. The average annual incidence of BL in the 6-year period was 1-87 X 10(-5), similar to that in the adjacent West Nile district. Contrary to findi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.102
更新日期：1977-05-01 00:00:00
abstract：:A cytofluorometric assay allowing the measurement of thymidine phosphorylation in single cells had been established (Hengstschläger & Wawra, 1993). This assay enables us to correlate intracellular thymidine kinase (TK) activity with the DNA content of single cells. Enzyme activity levels from neuroblastoma cells and n...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.187
更新日期：1993-05-01 00:00:00
abstract：BACKGROUND:The natural history of prostate cancer is highly variable and difficult to predict accurately. Better markers are needed to guide management and avoid unnecessary treatment. In this study, we validate the prognostic value of a cell cycle progression score (CCP score) independently and in a prespecified linea...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.223
更新日期：2015-07-28 00:00:00
abstract：:Metastatic spread of some solid tumours is thought to depend upon the adhesion of tumour cells to the vascular endothelium followed by extravasation into surrounding tissues. We investigated the role of beta 1 integrins in the adhesion of the breast adenocarcinoma cell line MDA-MB-231 and the melanoma cell line RPMI-7...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.627
更新日期：1996-12-01 00:00:00
abstract：:The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas. We performed immunohistochemical analysis of p16(INK4a) and pRb expression and correlated with survival in a series of 300 patients w...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.bjc.6603531
更新日期：2007-01-29 00:00:00
abstract：:A regional cancer network has been set up in the Rhône-Alpes region in France. The aim of the project is to improve the quality of care and to rationalize prescriptions in the network. In this network, we assessed the impact of the implementation of a clinical practice guidelines project by assessing the conformity of...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600057
更新日期：2002-02-01 00:00:00
abstract：:Reports are available on the studies of the cell cycle of several normal cell populations and of neoplastic effusions in man and experimental animals in vitro and in vivo at various stages of the growth. In the present work the cell cycle of 5 solid human tumours in vitro and the duration of their various intermitotic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1970.32
更新日期：1970-06-01 00:00:00
abstract：:In clinically organ-confined prostate cancer patients, bloodstream tumour cell dissemination generally occurs, and may be enhanced by surgical prostate manipulation. To evaluate cancer-cell seeding impact upon patient recurrence-free survival, 155 patients were prospectively enrolled then followed. Here, 57 patients p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604912
更新日期：2009-02-24 00:00:00
abstract：:Thyroid carcinomas of an additional series of 34 children exposed to radioactive fall-out after the Chernobyl reactor accident were analysed for mutations in the H-, K- and N-RAS and the p53 gene. Allele-specific oligonucleotide hybridization, single-strand conformation polymorphism (SSCP) and direct sequencing did no...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.157
更新日期：1998-03-01 00:00:00
abstract：:Epidemiologic evidence has recently identified an association between an endemic outbreak of pleural and peritoneal mesothelioma in the Urgup region of Turkey and exposure to zeolite fibres. This malignancy is usually associated with exposure to asbestos dusts whose mineralogical characteristics differ from those of z...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.158
更新日期：1986-07-01 00:00:00
abstract：:The photodynamic effects of sulphonated aluminium phthalocyanine (SALPC) have been compared on cultured AR4-2J cells of a pancreatic carcinoma cell line and on exocrine cells of the normal phenotype freshly isolated from the rat pancreas; a multi-channel perifusion system was used for this kinetic study in vitro. Wher...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.157
更新日期：1990-05-01 00:00:00
abstract：:The therapeutic efficacy of gemcitabine, a new nucleoside analogue, was assessed in a variety of well-established human soft tissue sarcoma and ovarian cancer xenografts grown s.c. in nude mice. Tumour lines selected had different histological subtypes, growth rates and sensitivities to conventional cytostatic agents....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.285
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:Malignancy alters cellular complex lipid metabolism and membrane lipid composition and turnover. Here, we investigated whether tumorigenesis in cancer-derived prostate epithelial cell lines influences protein kinase C-linked turnover of ethanolamine phosphoglycerides (EtnPGs) and alters the pattern of ethano...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.457
更新日期：2014-10-14 00:00:00
abstract：:High experienced continuity of care in patients with cancer is associated with lower needs for care, better quality of life and better psychological outcomes. We developed and evaluated an intervention to improve experienced continuity. The intervention, consisted of (1) a 17-item patient-completed continuity assessme...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.bjc.6604836
更新日期：2009-01-27 00:00:00
abstract：:Genomic alterations in the p53 tumour-suppressor gene and overexpression of p53 protein, resulting from gene mutations, are frequently found in pancreatic cancer. In this study we analysed the sera of 160 patients with malignant and benign pancreatic diseases for the presence of circulating antibodies to the p53 prote...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.443
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND:The interaction between human prostate cancer (PCa) cells and bone marrow (BM) endothelium follows a rolling-and-adhesion cascade mediated by E-selectin ligand (ESL): E-selectin. This adhesion is enabled by elevated expression of α-1,3-fucosyltransferases (FTs), enzymes responsible for ESL-mediated bone meta...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.690
更新日期：2013-12-10 00:00:00
abstract：BACKGROUND:The somatic molecular profiles of basal-like breast cancers and high-grade serous ovarian cancers share many similarities, leading to the hypothesis that they have similar aetiologies, in which case they should occur together in the same patient more often than expected. METHODS:We identified 545 women with...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.73
更新日期：2017-04-11 00:00:00
abstract：BACKGROUND:The intestinal uptake of the taxanes paclitaxel and docetaxel is seriously hampered by drug efflux through P-glycoprotein (P-gp) and drug metabolism via cytochrome P450 (CYP) 3A. The resulting low oral bioavailability can be boosted by co-administration of P-gp or CYP3A4 inhibitors. METHODS:Paclitaxel or do...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.222
更新日期：2014-05-27 00:00:00
abstract：:A total of 152 non-small cell lung cancers (NSCLC) were studied retrospectively to determine the relationship between epidermal growth factor receptor (EGF-R) status and the histological type, tumour size, nodal status and prognosis. EGF-R status was assessed on routinely embedded paraffin sections with an antibody to...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.156
更新日期：1989-05-01 00:00:00
abstract：:The objective of this study was to document the occurrence and to correlate the prevalence of different human papillomavirus (HPV) types with the cytological results on simultaneously performed thin-layer preparations in a large population of Flemish women. During 1 year, 69 290 thin-layer preparations were interprete...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600756
更新日期：2003-02-24 00:00:00
abstract：BACKGROUND:Epithelial ovarian cancer (EOC) cells are prone to metastasise throughout the peritoneal cavity. The epithelial-to-mesenchymal transition (EMT) is a necessary step towards metastatic tumour progression. CA125/MUC16 mucin is a high-molecular-weight glycoprotein overexpressed in the majority of serous carcinom...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.34
更新日期：2011-03-15 00:00:00
abstract：BACKGROUND:We aimed to analyse clinical and gene expression profiles to predict pathologic complete response and disease-free survival using two consecutive, prospective, preoperative chemotherapy trial cohorts. METHODS:Clinicopathological and gene expression data were evaluated in a cohort from two consecutive phase ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.184
更新日期：2016-08-09 00:00:00
