Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.

abstract：BACKGROUND:Cancer survival statistics are typically reported by using measures discounting the impact of other-cause mortality, such as net survival. This is a hypothetical measure and is interpreted as excluding the possibility of cancer patients dying from other causes. Crude probability of death partitions the all-c...

journal_title：British journal of cancer

authors： Wong KF,Lambert PC,Mozumder SI,Broggio J,Rutherford MJ

更新日期：2019-11-01 00:00:00

abstract：:Raltitrexed, a thymidylate synthase inhibitor, was given to 21 patients with advanced small-cell lung cancer, at a dose of 3 mg m(-2) as a 15-min intravenous infusion at 21-day intervals. All of the patients had extensive disease and 17 had received prior therapy. Patients with disease refractory to primary chemothera...

journal_title：British journal of cancer

authors： Woll PJ,Basser R,Le Chevalier T,Drings P,Perez Manga G,Adenis A,Seymour L,Smith F,Thatcher N

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT's different functional aspects in non-small cell lung cancer (NSCLC). Thymidylate synthase (TS) has been previously correlated with EMT t...

journal_title：British journal of cancer

authors： Siddiqui MA,Gollavilli PN,Ramesh V,Parma B,Schwab A,Vazakidou ME,Natesan R,Saatci O,Rapa I,Bironzo P,Schuhwerk H,Asangani IA,Sahin O,Volante M,Ceppi P

更新日期：2021-01-01 00:00:00

abstract：:Canine transmissible venereal sarcoma (CTVS) is a naturally occurring contagious neoplasm which can be transplanted with intact viable cells across major histocompatibility (MHC) barriers within the species and even to other members of the canine family, such as foxes, coyotes, and wolves. After 2 to 4 months of progr...

journal_title：British journal of cancer

authors： Yang TJ,Chandler JP,Dunne-Anway S

更新日期：1987-02-01 00:00:00

abstract：:Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome of a workshop that ...

journal_title：British journal of cancer

authors： Leach MO,Brindle KM,Evelhoch JL,Griffiths JR,Horsman MR,Jackson A,Jayson GC,Judson IR,Knopp MV,Maxwell RJ,McIntyre D,Padhani AR,Price P,Rathbone R,Rustin GJ,Tofts PS,Tozer GM,Vennart W,Waterton JC,Williams SR,Work

更新日期：2005-05-09 00:00:00

abstract：:The cisplatin analogue 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) (DAP) is a DNA-damaging agent that will be entering clinical trials for its potent cytotoxic effects against cisplatin-resistant tumour cells. This cytotoxicity may reside in its ability to selectively activate G1-phase checkpoint r...

journal_title：British journal of cancer

authors： He G,Kuang J,Huang Z,Koomen J,Kobayashi R,Khokhar AR,Siddik ZH

更新日期：2006-12-04 00:00:00

abstract：:The vaso-active drug hydralazine causes a considerable increase in the cytotoxic effect of melphalan towards the KHT tumour in mice. The enhancement in response, measured as the concentration of melphalan required to achieve a given tumour response, is 3.0 and 2.35 when determined using the regrowth delay assay and th...

journal_title：British journal of cancer

authors： Stratford IJ,Adams GE,Godden J,Nolan J,Howells N,Timpson N

更新日期：1988-08-01 00:00:00

abstract：:A number of growth factors have been implicated in the control of the proliferation of breast cancer cells and some have been reported to mediate the proliferative effects of oestradiol. MCF-7 cells were treated with growth factors in the presence and absence of oestradiol. Oestradiol increased the response of cells t...

journal_title：British journal of cancer

authors： Stewart AJ,Westley BR,May FE

更新日期：1992-10-01 00:00:00

abstract：:Some cancer cells depend on the function of specific molecules for their growth, survival, and metastatic potential. Targeting of these critical molecules has arguably been the best therapy for cancer as demonstrated by the success of tamoxifen and trastuzumab in breast cancer. This review will evaluate the type I IGF...

journal_title：British journal of cancer

authors： Yee D

更新日期：2006-02-27 00:00:00

abstract：:ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied. We investigated whether ApoE polymorphisms alone or in combination with dietary factor...

journal_title：British journal of cancer

authors： Mrkonjic M,Chappell E,Pethe VV,Manno M,Daftary D,Greenwood CM,Gallinger S,Zanke BW,Knight JA,Bapat B

更新日期：2009-06-16 00:00:00

abstract：:Recently, apoptosis has been implicated as one of the end points of cells exposed to chemotherapeutic agents. The p53 and Bcl-2 family of proteins are involved in chemotherapy-induced apoptosis, but in a cell type-dependent manner. We sought to determine the roles played by the p53 and Bcl-2 family of proteins in 5-fl...

journal_title：British journal of cancer

authors： Nita ME,Nagawa H,Tominaga O,Tsuno N,Fujii S,Sasaki S,Fu CG,Takenoue T,Tsuruo T,Muto T

更新日期：1998-10-01 00:00:00

abstract：:The registered incidence rate of childhood central nervous system (CNS) tumours has increased in several countries. It is uncertain whether these increases are biologically real or owing to improved diagnostic methods. We explored the medical records of 626 CNS tumours diagnosed in Danish children between 1980 and 199...

journal_title：British journal of cancer

authors： Raaschou-Nielsen O,Sørensen M,Carstensen H,Jensen T,Bernhardtsen T,Gjerris F,Schmiegelow K

更新日期：2006-08-07 00:00:00

abstract：:The in vitro metabolisms of [14C]7,12-dimethylbenz(a)anthracene (DMBA) by post-mitochondrial supernates and microsomes from intact and regenerating rat livers were compared. Both cell fractions from regenerating livers at 48, 72, and 96 h after partial hepatectomy metabolized less [14C]DMBA than similar fractions from...

journal_title：British journal of cancer

authors： Tomsak RL,Cook RT

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND:Currently, none of the available colorectal adenocarcinoma (CAC) testing has been established as a well-accepted diagnosis tool, particularly for the early stage of CAC. The recent discovery of serum microRNA (miRNA) profile has provided a new auxiliary approach for tumour diagnosis. Our study is involved in...

journal_title：British journal of cancer

authors： Zheng G,Du L,Yang X,Zhang X,Wang L,Yang Y,Li J,Wang C

更新日期：2014-11-11 00:00:00

abstract：:The aim of this study was to investigate whether immunohistochemical staining patterns of tissue inhibitor of metalloproteinases TIMP-2 and matrix metalloproteinases MMP-2 and MMP-9 can be predictors of tumour stage and survival time in colorectal cancer. Frozen tumour sections from 212 patients operated on between Ja...

journal_title：British journal of cancer

authors： Ring P,Johansson K,Höyhtyä M,Rubin K,Lindmark G

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Abiraterone and enzalutamide are novel endocrine treatments that abrogate androgen receptor (AR) signalling in castration-resistant prostate cancer (CRPC). Here, we developed a circulating tumour cells (CTCs)-based assay to evaluate AR expression in real-time in CRPC and investigated nuclear AR expression in...

journal_title：British journal of cancer

authors： Crespo M,van Dalum G,Ferraldeschi R,Zafeiriou Z,Sideris S,Lorente D,Bianchini D,Rodrigues DN,Riisnaes R,Miranda S,Figueiredo I,Flohr P,Nowakowska K,de Bono JS,Terstappen LW,Attard G

更新日期：2015-03-31 00:00:00

abstract：:Vascular endothelial growth factor-A (VEGF-A) has been demonstrated to play an important role in tumour angiogenesis and to influence prognosis in many cancers. However its prognostic value in head and neck squamous cell carcinomas (HNSCCs) remains controversial. Therefore, we investigated the clinical relevance of VE...

journal_title：British journal of cancer

authors： Onesto C,Hannoun-Lévi JM,Chamorey E,Formento JL,Ramaioli A,Pagès G

更新日期：2006-05-22 00:00:00

abstract：:Changes in the buccal mucosa of 296 Indian and Malay betel-nut chewers in Perak, West Malaysia, were studied clinically. 167 out of 212 Indian subjects incorporated tobacco in their quids, while 45 out of 84 Malay subjects incorporated. "Gambir". The Indians appeared to show a higher proportion of mucosal changes, par...

journal_title：British journal of cancer

authors： Chin CT,Lee KW

更新日期：1970-09-01 00:00:00

abstract：:High expression of thymidylate synthase (TS) and inactivation of p53 are allegedly associated with chemoresistance. The authors evaluated TS and p53 expression in gastric cancer treated with neoadjuvant S-1/cisplatin chemotherapy. Paraffin sections of pretreatment biopsy and surgical specimens from 41 gastric cancers ...

journal_title：British journal of cancer

authors： Kamoshida S,Suzuki M,Shimomura R,Sakurai Y,Komori Y,Uyama I,Tsutsumi Y

更新日期：2007-01-29 00:00:00

abstract：BACKGROUND:Bcl-xL has an important role in the control of cell death through its inhibition of apoptosis. The aim of this study was to investigate the clinicopathological significance of Bcl-xL in upper urinary tract urothelial carcinoma (UTUC) and the therapeutic effect of targeting Bcl-xL protein in urothelial carcin...

journal_title：British journal of cancer

authors： Yoshimine S,Kikuchi E,Kosaka T,Mikami S,Miyajima A,Okada Y,Oya M

更新日期：2013-06-11 00:00:00

abstract：:The results of treating two series of patients with Burkitt's lymphoma are presented in the form of survival curves. The second series shows an improved survival rate which seems to be due to a potentiating effect by potassium iodide on oral cyclophosphamide. So far no reason for this effect has been found. ...

journal_title：British journal of cancer

authors： Williams EH

更新日期：1971-03-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) regulate colon cancer growth and metastasis. Previous studies utilizing antibodies against the VEGF receptor (DC101) or EGF receptor (C225) have demonstrated independently that these agents can inhibit tumour growth and induce apoptosis in col...

journal_title：British journal of cancer

authors： Shaheen RM,Ahmad SA,Liu W,Reinmuth N,Jung YD,Tseng WW,Drazan KE,Bucana CD,Hicklin DJ,Ellis LM

更新日期：2001-08-17 00:00:00

abstract：:One hundred cancer patients undergoing active treatment were interviewed to determine how they perceived their illness and how their perceptions compared with those of their attending physicians. Ninety-eight patients recognized that they had cancer and 87 correctly identified the tumour type. Sixty-four of 67 patient...

journal_title：British journal of cancer

authors： Mackillop WJ,Stewart WE,Ginsburg AD,Stewart SS

更新日期：1988-09-01 00:00:00

abstract：:The Type 1 family of growth factor receptors includes epidermal growth factor receptor (EGFR), c-erbB-2, c-erbB-3 and c-erbB-4. Overexpression of the first two members is associated with poorer prognosis in patients with breast carcinoma. In this study we examined the expression of c-erbB-4 protein using the monoclona...

journal_title：British journal of cancer

authors： Kew TY,Bell JA,Pinder SE,Denley H,Srinivasan R,Gullick WJ,Nicholson RI,Blamey RW,Ellis IO

更新日期：2000-03-01 00:00:00

abstract：:Elderly patients are recommended to have a reduced starting dose (300 mg m(-2) once every 3 weeks) of irinotecan monotherapy. The aims of this analysis are to compare toxicity and survival according to age, performance status (PS), gender and prior radical pelvic radiotherapy (RT). The primary end points were overall ...

journal_title：British journal of cancer

authors： Chau I,Norman AR,Cunningham D,Waters JS,Topham C,Middleton G,Hill M,Ross PJ,Katopodis R,Stewart G,Oates JR

更新日期：2004-10-18 00:00:00

abstract：:The records of 610 consecutive patients with small cell lung cancer, treated on a common protocol in a multicentre trial, were reviewed and 24 (4%) cases of spinal cord compression identified. Five hundred patients had isotope bone scans performed at presentation, and in 131 (26%) there was abnormal isotope uptake in ...

journal_title：British journal of cancer

authors： Goldman JM,Ash CM,Souhami RL,Geddes DM,Harper PG,Spiro SG,Tobias JS

更新日期：1989-04-01 00:00:00

abstract：:Detailed data were provided by the Oxford Survey of Childhood Cancer OSCC on deaths from childhood cancer in Britain after irradiation of the fetus during diagnostic radiology of the mother. In each age group at death, 0-5, 6-9 and 10-15 years, excess cancer deaths decreased suddenly for births in and after 1958. A ma...

journal_title：British journal of cancer

authors： Mole RH

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:CA-125 as a tumour progression criterion in relapsing ovarian cancer (ROC) trials remains controversial. CALYPSO is a large randomised trial incorporating CA-125 (GCIG criteria) and symptomatic deterioration in addition to Response Evaluation Criteria in Solid Tumours (RECIST) criteria (radiological) to dete...

journal_title：British journal of cancer

authors： Alexandre J,Brown C,Coeffic D,Raban N,Pfisterer J,Mäenpää J,Chalchal H,Fitzharris B,Volgger B,Vergote I,Pisano C,Ferrero A,Pujade-Lauraine E

更新日期：2012-02-14 00:00:00

abstract：:The development of an altered stromal microenvironment is a common feature of many tumours including squamous cell carcinoma (SCC), and there is increasing evidence that these changes in the stroma, which include increased expression of proteases and cytokines, may actually promote tumour progression. A common finding...

journal_title：British journal of cancer

authors： Lewis MP,Lygoe KA,Nystrom ML,Anderson WP,Speight PM,Marshall JF,Thomas GJ

更新日期：2004-02-23 00:00:00

abstract：:In the search for effective chemotherapy regimens which can be used in multimodality treatment programmes for patients with cancer of the oesophagus, we conducted a phase II trial to determine the activity and toxicity of the combination of cisplatin and etoposide in patients with advanced squamous cell carcinoma of t...

journal_title：British journal of cancer

authors： Kok TC,Van der Gaast A,Dees J,Eykenboom WM,Van Overhagen H,Stoter G,Tilanus HW,Splinter TA

更新日期：1996-09-01 00:00:00