Abstract：
:Changes in the buccal mucosa of 296 Indian and Malay betel-nut chewers in Perak, West Malaysia, were studied clinically. 167 out of 212 Indian subjects incorporated tobacco in their quids, while 45 out of 84 Malay subjects incorporated. "Gambir". The Indians appeared to show a higher proportion of mucosal changes, particularly when tobacco was used. "Gambir" did not appear to be potent in the production of mucosal changes. Comparison with studies in other parts of the world suggested comparable findings with respect to both tobacco and non-tobacco chewing samples, and there would appear to be some evidence that tobacco-containing quids are likely to produce a higher proportion of mucosal changes as compared to non-tobacco-containing quids. An attempt to demonstrate a dose-effect relationship by dividing the subjects into "slight" and "heavy" chewers did not yield significant differences between these two categories in each of the groups.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Chin CT,Lee KWdoi
10.1038/bjc.1970.50subject
Has Abstractpub_date
1970-09-01 00:00:00pages
427-32issue
3eissn
0007-0920issn
1532-1827journal_volume
24pub_type
杂志文章abstract：:A cytofluorometric assay allowing the measurement of thymidine phosphorylation in single cells had been established (Hengstschläger & Wawra, 1993). This assay enables us to correlate intracellular thymidine kinase (TK) activity with the DNA content of single cells. Enzyme activity levels from neuroblastoma cells and n...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.187
更新日期：1993-05-01 00:00:00
abstract：BACKGROUND:Accumulating evidence demonstrates high levels of aldehyde dehydrogense (ALDH) activity in human cancer types, in part, because of its association with cancer stem cells. Whereas ALDH1A1 and ALDH7A1 isoforms were reported to associate with prostate tumorigenesis, whether other ALDH isoforms are associated wi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.201
更新日期：2014-05-13 00:00:00
abstract：:The patterns of early and late relapses (those occurring later than 3 years after diagnosis) in 432 patients achieving complete remission after treatment for stage I and II Hodgkin's disease at the Royal Marsden Hospital between 1964 and 1983 were studied to identify factors predicting for late relapse. The incidence ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.257
更新日期：1989-08-01 00:00:00
abstract：:Increased expression of tumour-associated trypsin inhibitor (TATI) in tumour tissue and/or serum has been associated with poor survival in various cancer forms. Moreover, a proinvasive function of TATI has been shown in colon cancer cell lines. In this study, we have examined the prognostic significance of tumour-spec...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605047
更新日期：2009-05-19 00:00:00
abstract：:Currently the only tumour marker to have a well-defined and validated role in the management of ovarian cancer is CA125. Changes in the level of CA125 can be used as a reliable indication of response or progression according to various criteria, but it does not yet have a clear place in diagnosis or prognosis. Its val...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1054/bjoc.2000.1174
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:Colorectal cancer (CRC) diagnoses and disease-specific survival (DSS) vary between ethnic groups in the United States. However, few studies have assessed differences among Asian subgroups. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients with invasive CRC...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.97
更新日期：2013-04-16 00:00:00
abstract：:We analysed two case-control studies of women from Italy and Switzerland, including 195 cases of oral and pharyngeal cancers and 1113 controls. The multivariate odds ratio was 4.6 for heavy smokers and 2.7 for high alcohol intake. Vegetables, fruit, beta-carotene and wholegrain foods were inversely, butter and retinol...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.0900
更新日期：2000-01-01 00:00:00
abstract：:The aim of this study was to evaluate serum midkine (S-MK) concentrations as a prognostic tumour marker in oral squamous cell carcinoma (OSCC). We measured S-MK concentrations in patients with OSCC and healthy volunteers. In addition, we performed real-time quantitative reverse transcription-PCR analysis and immunohis...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604539
更新日期：2008-08-19 00:00:00
abstract：:Analysis of data from 1434 children with primary renal tumours revealed 57 who developed bone metastases. Of these, 54 were initially recorded as nephroblastoma. Fifty-two of the 57 cases were reviewed histologically, and only 18 were found to be Wilms' tumours. Twenty-three were classified as "Bone-Metastasizing Rena...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.163
更新日期：1980-06-01 00:00:00
abstract：:As of June 1998, four randomized trials have been completed comparing the combination of paclitaxel and cisplatin with a cisplatin-based control arm. The results of three of these trials are available; one has been published as a full paper, the other two in abstract form only. Two of the reported trials (GOG-111 and ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.709
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:Currently, none of the available colorectal adenocarcinoma (CAC) testing has been established as a well-accepted diagnosis tool, particularly for the early stage of CAC. The recent discovery of serum microRNA (miRNA) profile has provided a new auxiliary approach for tumour diagnosis. Our study is involved in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.489
更新日期：2014-11-11 00:00:00
abstract：:This study evaluates the overall survival and disease free survival of melanoma patients that were treated with an autologous melanoma cell vaccine, administered as a post-operative adjuvant. Included are 43 patients with totally resected metastatic melanoma (28-AJCC stage III, 15-AJCC stage IV), with a median follow ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6600251
更新日期：2002-05-20 00:00:00
abstract：:Lipoxygenase metabolites of arachidonic acid can act as growth promoting factors for various cancer cell lines. Here we demonstrate that the 5-lipoxygenase inhibitor nordihydroguaiaretic acid potently inhibits anchorage-independent growth of human pancreatic and cervical cancer cells in soft agar and delays growth of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600186
更新日期：2002-04-08 00:00:00
abstract：:Van Trommel et al have previously shown that serum human chorionic gonadotropin (hCG) cutoff levels can provide early prediction of resistance to first-line methotrexate (MTX) in patients with persistent trophoblastic disease (PTD). In this study, we validate this approach of prediction of resistance to single-agent c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604849
更新日期：2009-03-24 00:00:00
abstract：:Exposure to the fibrous mineral erionite is known to induce mesothelioma in man and laboratory animals. Previous studies demonstrated the presence of a trypsin-like protease associated with tumour cells. This protease could be demonstrated by the use of fluorescent probes which located cells possessing this enzyme. We...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.269
更新日期：1988-11-01 00:00:00
abstract：:Benzo[b]thiophenesulphonamide 1,1-dioxide (BTS) derivatives are strong cytotoxic agents that induce reactive oxygen species (ROS) overproduction and apoptosis in tumour cells. Although the precise origin of BTS-induced ROS is not known, a clear correlation between their cytotoxic effect and ability to inhibit a tumour...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602383
更新日期：2005-02-28 00:00:00
abstract：BACKGROUND:The aim was to evaluate whether this gastric cancer-screening programme was effective in reducing oesophageal cancer mortality. METHODS:A population-based retrospective cohort study was conducted using the Korean National Cancer Screening Programme (NCSP) database. The study cohort comprised 16,969 oesophag...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0883-x
更新日期：2020-08-01 00:00:00
abstract：:Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that develop from distinct epithelial sub-types; however, they are both related to chronic inflammation of differing aetiologies. Inflammation leads to somatically inherited genetic mutations altering control of the cell cycle, DNA replication an...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605126
更新日期：2009-07-07 00:00:00
abstract：BACKGROUND:Enzastaurin, an oral serine-threonine kinase inhibitor, was initially developed as an ATP-competitive selective inhibitor against protein kinase Cβ. However, the mechanism by which enzastaurin contributes to tumourigenesis remains unclear. METHODS:We analysed the anti-tumour effects of enzastaurin in 22 lun...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.7
更新日期：2012-02-28 00:00:00
abstract：BACKGROUND:Immune checkpoint blockade (ICB) therapy improved the prognosis of cancer patients, but general administration of ICBs occasionally induces side effects that include immune-related adverse events and tumour hyper-progression. Here, we established a protein-based system, by which endogenous expression of IC m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0708-y
更新日期：2020-03-01 00:00:00
abstract：:The use of cytotoxic drug vincristine (VCR) is limited by the occurrence of peripheral neuropathy. A neurotrophic ACTH(4-9) analogue, ORG 2766, is being studied for its protective effect. Possible modulatory effects of ORG 2766 on tumour cell growth and interference with the cytotoxic efficacy of VCR were studied in t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.90
更新日期：1994-03-01 00:00:00
abstract：:The aim of our analysis was to assess retrospectively the effect on local relapse, overall survival (OS) and disease-free survival (DFS) of a limited or an extended lymphadenectomy in radically resected gastric cancer patients. This study was performed in order to identify a subgroup of patients possibly not benefitin...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602468
更新日期：2005-03-28 00:00:00
abstract：BACKGROUND:Gram-negative bacteria mediated gemcitabine resistance in pre-clinical models. We determined if intratumoural lipopolysaccharide (LPS) detection by immunohistochemistry is associated with outcome in advanced pancreatic ductal adenocarcinoma (PDAC) treated with gemcitabine and non-gemcitabine containing 1st-l...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01029-7
更新日期：2020-10-01 00:00:00
abstract：:Dipyridamole has been shown to enhance the in vitro activity of antimetabolite anticancer drugs through the inhibition of nucleoside transport. However, the clinical potential of dipyridamole has not been realized because of the avid binding of the drug to the plasma protein alpha1-acid glycoprotein (AGP). Dipyridamol...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690591
更新日期：1999-08-01 00:00:00
abstract：BACKGROUND:Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods. METHODS:We analysed 41 lymph nodes from 19 patients with oral squamous cell carcinoma (OSCC)...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.408
更新日期：2018-02-06 00:00:00
abstract：:In a study involving 50 breast cancer tumours, we compared two oestrogen receptor (ER) detection methods developed by us--a microplate immunoenzymometric assay (EIA96) and an immunohistochemistry kit (HistoCIS-ER)--with the radioligand assay (RLA), the Abbott immunoenzymometric assay ER-EIA and the reverse transcripta...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.418
更新日期：1997-01-01 00:00:00
abstract：:We screened 145 HIV-infected non-pregnant women at a tertiary care centre in Lusaka, Zambia. Liquid-based cytology and human papillomavirus (HPV) genotyping with PGMY09/11 biotinylated primers (Roche Linear Array HPV genotyping test) maximised sensitivity of cytology and HPV assessments. Among high-risk (HR) types, HP...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603737
更新日期：2007-05-07 00:00:00
abstract：:The influence on heat sensitivity of interactions between HT29 human colon adenocarcinoma cells grown in two- or three-dimensional contact was investigated. No evidence for intercellular cooperation affecting cellular sensitivity to hyperthermia was found. Cells grown in monolayer were found to be more heat sensitive ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.268
更新日期：1985-12-01 00:00:00
abstract：:Screen-detected (SD) breast cancers are smaller and biologically more indolent than clinically presenting cancers. An often debated question is: if left undiagnosed during their preclinical phase, would they become more aggressive or would they only increase in size? This study considered a registry-based series (1988...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602289
更新日期：2005-01-17 00:00:00
abstract：:The bioreductive antitumour agent, mitomycin C (MMC), requires activation by reductive enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1). We used a novel approach to increase MMC efficacy by selectively inducing NQO1 in tumour cells in vivo. CD-1 nude mice were implanted with HCT116 cells, and fed control diet or d...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602171
更新日期：2004-10-18 00:00:00
