Comparative analysis of lifestyle factors, screening test use, and clinicopathologic features in association with survival among Asian Americans with colorectal cancer.


BACKGROUND:Colorectal cancer (CRC) diagnoses and disease-specific survival (DSS) vary between ethnic groups in the United States. However, few studies have assessed differences among Asian subgroups. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients with invasive CRC between 1988 and 2008. Differences in clinicopathologic features, and DSS rates were compared among Asian subgroups. The California Health Interview Survey was used to examine risk factors and screening patterns for CRC. RESULTS:The study included 359 374 patients with 8.4% Asian. Patients in all Asian subgroups were younger (median: 68 years) at diagnosis than non-Hispanic white (NHW) patients (median: 72 years). Most Asian subgroups, except Hawaiians, had better DSS than NHW patients although Asian subgroups had more advanced disease than NHW. Indian/Pakistani patients had a higher 5-year DSS than other Asian subgroups. Obesity proportions were lower in Asian subgroups (<50.2%) than in NHW (59.8%). Vietnamese men and Korean women had the lowest proportions of CRC screening. Advance tumour stages were highly associated with worse DSS in each ethnicity group. High tumour grades were associated with worse DSS in NHW, Filipino, and Chinese. Older age at diagnosis was associated with worse DSS in most ethnicity groups except Hawaiian and Vietnamese. CONCLUSION:Disparities exist between Asians and NHW with CRC, and among various Asian subgroups. Differences in cancer clinicopathologic features, patients' behavioural habits, lifestyle, and screening patterns may explain some differences in CRC survival observed among ethnic groups.


Br J Cancer


Yi M,Xu J,Liu P,Chang GJ,Du XL,Hu CY,Song Y,He J,Ren Y,Wei Y,Yang J,Hunt KK,Li X




Has Abstract


2013-04-16 00:00:00














  • Mechanisms of relapse in acute leukaemia: involvement of p53 mutated subclones in disease progression in acute lymphoblastic leukaemia.

    abstract::Mutations of the p53 tumour suppressor gene are infrequent at presentation of both acute myeloblastic leukaemia (AML) and acute lymphoblastic leukaemia (ALL), being found in between 5-10% of AML and 2-3% of ALL. Here we have studied the frequency of detection of p53 mutations at relapse of both AML and B-precursor ALL...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Zhu YM,Foroni L,McQuaker IG,Papaioannou M,Haynes A,Russell HH

    更新日期:1999-03-01 00:00:00

  • Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation.

    abstract:BACKGROUND:The intestinal uptake of the taxanes paclitaxel and docetaxel is seriously hampered by drug efflux through P-glycoprotein (P-gp) and drug metabolism via cytochrome P450 (CYP) 3A. The resulting low oral bioavailability can be boosted by co-administration of P-gp or CYP3A4 inhibitors. METHODS:Paclitaxel or do...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hendrikx JJ,Lagas JS,Wagenaar E,Rosing H,Schellens JH,Beijnen JH,Schinkel AH

    更新日期:2014-05-27 00:00:00

  • Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma.

    abstract::Following an i.p. dose of 150 mg x kg(-1) 5-fluorouracil (5-FU), drug uptake and metabolism over a 2-h period were studied by in vivo (19)F magnetic resonance spectroscopy (MRS) for the murine colon carcinoma lines C26-B (5-FU-insensitive; n=11) and C26-10 (5-FU-sensitive; n=15) implanted s.c. in Balb/C mice. Time cou...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kamm YJ,Peters GJ,Hull WE,Punt CJ,Heerschap A

    更新日期:2003-08-18 00:00:00

  • Clinical and microarray analysis of breast cancers of all subtypes from two prospective preoperative chemotherapy studies.

    abstract:BACKGROUND:We aimed to analyse clinical and gene expression profiles to predict pathologic complete response and disease-free survival using two consecutive, prospective, preoperative chemotherapy trial cohorts. METHODS:Clinicopathological and gene expression data were evaluated in a cohort from two consecutive phase ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Okuma HS,Koizumi F,Hirakawa A,Nakatochi M,Komori O,Hashimoto J,Kodaira M,Yunokawa M,Yamamoto H,Yonemori K,Shimizu C,Fujiwara Y,Tamura K

    更新日期:2016-08-09 00:00:00

  • Increased risk of hepatocellular carcinoma after cholecystectomy.

    abstract:BACKGROUND:The association between gall bladder removal (cholecystectomy) and hepatocellular carcinoma warrants investigation. An increased intrahepatic bile duct pressure following cholecystectomy might cause chronic inflammation in the surrounding liver tissue, which might induce cancer development. METHODS:A nation...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Lagergren J,Mattsson F,El-Serag H,Nordenstedt H

    更新日期:2011-06-28 00:00:00

  • Mutations of K-ras oncogene in human adrenal tumours in Taiwan.

    abstract::Recently, we have found a high frequency of p53 gene mutations in human functional adrenal tumours. As the tumorigenesis is a multigene defect, we believe that other oncogenes may also be involved in the initiation or progression of adrenal tumours. Using the single-strand conformational polymorphism (SSCP) method, we...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Lin SR,Tsai JH,Yang YC,Lee SC

    更新日期:1998-04-01 00:00:00

  • Age-dependent prevalence of 14 high-risk HPV types in the Netherlands: implications for prophylactic vaccination and screening.

    abstract::We determined the prevalence of type-specific hrHPV infections in the Netherlands on cervical scrapes of 45 362 women aged 18-65 years. The overall hrHPV prevalence peaked at the age of 22 with peak prevalence of 24%. Each of the 14 hrHPV types decreased significantly with age (P-values between 0.0009 and 0.03). The p...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Coupé VM,Berkhof J,Bulkmans NW,Snijders PJ,Meijer CJ

    更新日期:2008-02-12 00:00:00

  • A key genomic subtype associated with lymphovascular invasion in invasive breast cancer.

    abstract:BACKGROUND:Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, using available large transcriptomic datasets, aims to identify genes assoc...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kurozumi S,Joseph C,Sonbul S,Alsaeed S,Kariri Y,Aljohani A,Raafat S,Alsaleem M,Ogden A,Johnston SJ,Aleskandarany MA,Fujii T,Shirabe K,Caldas C,Ashankyty I,Dalton L,Ellis IO,Desmedt C,Green AR,Mongan NP,Rakha EA

    更新日期:2019-06-01 00:00:00

  • MutSbeta exceeds MutSalpha in dinucleotide loop repair.

    abstract:BACKGROUND:The target substrates of DNA mismatch recognising factors MutSalpha (MSH2+MSH6) and MutSbeta (MSH2+MSH3) have already been widely researched. However, the extent of their functional redundancy and clinical substance remains unclear. Mismatch repair (MMR)-deficient tumours are strongly associated with microsa...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kantelinen J,Kansikas M,Korhonen MK,Ollila S,Heinimann K,Kariola R,Nyström M

    更新日期:2010-03-16 00:00:00

  • High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma.

    abstract::Telomerase, an enzyme related with cellular immortality, has been extensively studied in many kinds of malignant tumours for clinical diagnostic or prognostic utilities. Telomerase activity is mainly regulated by the expression of hTERT (human telomerase reverse transcriptase), which is a catalytic component of human ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hiyama E,Yamaoka H,Matsunaga T,Hayashi Y,Ando H,Suita S,Horie H,Kaneko M,Sasaki F,Hashizume K,Nakagawara A,Ohnuma N,Yokoyama T

    更新日期:2004-08-31 00:00:00

  • Cancer risk in Swedish women: the relation to size at birth.

    abstract::The relationship between fetal growth as indicated by weight and length at birth, and cancer risk in 1080 adult Swedish women was examined. Birth factors were retrieved from original midwife records for the years 1914, 1918, 1922 and 1930, and primary cancer cases were identified by matching with national and regional...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Andersson SW,Bengtsson C,Hallberg L,Lapidus L,Niklasson A,Wallgren A,Hulthén L

    更新日期:2001-05-04 00:00:00

  • Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer.

    abstract::The role of secreted frizzled-related protein (SFRP) genes in gastric cancer remains largely unknown. We determined the frequency and functional significance of SFRPs hypermethylation in human gastric cancer. The expression and methylation status of four SFRP members (SFRP1, 2, 4, and 5) in primary gastric cancer samp...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Cheng YY,Yu J,Wong YP,Man EP,To KF,Jin VX,Li J,Tao Q,Sung JJ,Chan FK,Leung WK

    更新日期:2007-10-08 00:00:00

  • The use of drugs acting on the renin-angiotensin system and the incidence of pancreatic cancer.

    abstract:BACKGROUND:Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used antihypertensives. Recently, these drugs have been associated with a protective effect against pancreatic cancer, but data on this putative association remain limited. Thus, the objective of this study...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Mandilaras V,Bouganim N,Yin H,Asselah J,Azoulay L

    更新日期:2017-01-03 00:00:00

  • Divergence between the high rate of p53 mutations in skin carcinomas and the low prevalence of anti-p53 antibodies.

    abstract::Circulating anti-p53 antibodies have been described and used as tumoural markers in patients with various cancers and strongly correlate with the p53 mutated status of the tumours. No study has yet looked at the prevalence of such antibodies in skin carcinoma patients although these tumours have been shown to be frequ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Moch C,Moysan A,Lubin R,de la Salmonière P,Soufir N,Galisson F,Vilmer C,Venutolo E,Le Pelletier F,Janin A,Basset-Séguin N

    更新日期:2001-12-14 00:00:00

  • Sex ratio among offspring of childhood cancer survivors treated with radiotherapy.

    abstract::It has been postulated that paternal gonadal exposure would increase the sex ratio by inducing X-chromosomal dominant lethals but that maternal gonadal exposure would decrease the sex ratio by inducing recessive sex-linked lethals. We therefore evaluated the sex ratio (male-to-female ratio) of children born to survivo...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Winther JF,Boice JD Jr,Thomsen BL,Schull WJ,Stovall M,Olsen JH

    更新日期:2003-02-10 00:00:00

  • EGFR mutation status in tumour-derived DNA from pleural effusion fluid is a practical basis for predicting the response to gefitinib.

    abstract::Epidermal growth factor receptor (EGFR) mutations are strong determinants of tumour response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC). Pleural effusion is a common complication of lung cancer. In this study, we assessed the feasibility of detection of EGFR mutations in samples of pleura...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kimura H,Fujiwara Y,Sone T,Kunitoh H,Tamura T,Kasahara K,Nishio K

    更新日期:2006-11-20 00:00:00

  • Infant vaccinations and risk of childhood acute lymphoblastic leukaemia in the USA.

    abstract::Previous studies have suggested that infant vaccinations may reduce the risk of subsequent childhood leukaemia. Vaccination histories were compared in 439 children (ages 0-14) diagnosed with acute lymphoblastic leukaemia (ALL) in nine Midwestern and Mid-Atlantic states (USA) between 1 January 1989 and 30 June 1993 and...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Groves FD,Gridley G,Wacholder S,Shu XO,Robison LL,Neglia JP,Linet MS

    更新日期:1999-09-01 00:00:00

  • Chemotherapy-induced neutropenia as a prognostic factor in advanced non-small-cell lung cancer: results from Japan Multinational Trial Organization LC00-03.

    abstract:BACKGROUND:Neutropenia is a common adverse reaction of chemotherapy. We assessed whether chemotherapy-induced neutropenia could be a predictor of survival for patients with non-small-cell lung cancer (NSCLC). METHODS:A total of 387 chemotherapy-naïve patients who received chemotherapy (vinorelbine and gemcitabine foll...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kishida Y,Kawahara M,Teramukai S,Kubota K,Komuta K,Minato K,Mio T,Fujita Y,Yonei T,Nakano K,Tsuboi M,Shibata K,Atagi S,Kawaguchi T,Furuse K,Fukushima M

    更新日期:2009-11-03 00:00:00

  • Molecular effects of Lapatinib in the treatment of HER2 overexpressing oesophago-gastric adenocarcinoma.

    abstract:BACKGROUND:Lapatinib, a dual EGFR and HER2 inhibitor has shown disappointing results in clinical trials of metastatic oesophago-gastric adenocarcinomas (OGAs), and in vitro studies suggest that MET, IGFR, and HER3 confer resistance. This trial applied Lapatinib in the curative neoadjuvant setting and investigated the f...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: De Silva N,Schulz L,Paterson A,Qain W,Secrier M,Godfrey E,Cheow H,O'Donovan M,Lao-Sirieix P,Jobanputra M,Hochhauser D,Fitzgerald R,Ford H

    更新日期:2015-11-03 00:00:00

  • Factors affecting stimulation of natural cytotoxicity to a rat lymphoma by Corynebacterium parvum.

    abstract::Differences were seen in the ability of 2 strains of C. parvum to augment cytotoxicity attributable to NK cells towards a rat lymphoma. Furthermore, 2 batches of the same strain of C. parvum prepared by different methods also differed in their ability to augment cytotoxicity. Other factors influencing cytotoxicity wer...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Flexman JP,Shellam GR

    更新日期:1980-07-01 00:00:00

  • Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.

    abstract::The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Bellamy D,Hinsull SM

    更新日期:1978-01-01 00:00:00

  • Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans.

    abstract::Chemical structures of the sugar chains of various human alpha-fetoprotein (AFP) species with different affinity for Concanavalin A (Con A) and Lens culinaris agglutinin (LCA) were examined by pyridylamination of their oligosaccharides and stepwise exoglycosidase digestion. Using reversed-phase and size-fractionation ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Aoyagi Y,Suzuki Y,Igarashi K,Saitoh A,Oguro M,Yokota T,Mori S,Suda T,Isemura M,Asakura H

    更新日期:1993-03-01 00:00:00

  • Separable growth and migration factors for large-cell lymphoma cells secreted by microvascular endothelial cells derived from target organs for metastasis.

    abstract::Metastatic variant sublines of the murine large-cell lymphoma cell line RAW117 were tested for their growth and migration properties in vitro in medium conditioned by soluble factors released from syngeneic mouse liver-, lung-, and brain-derived microvessel endothelial cells. Medium conditioned with hepatic sinusoidal...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hamada J,Cavanaugh PG,Lotan O,Nicolson GL

    更新日期:1992-08-01 00:00:00

  • The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells.

    abstract::Bispecific antibodies (bsAb) are considered as promising tools for the elimination of disseminated tumour cells in a minimal residual disease situation. The bsAb-mediated recruitment of an immune effector cell in close vicinity of a tumour cell is thought to induce an antitumoural immune response. However, classical b...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Zeidler R,Mysliwietz J,Csánady M,Walz A,Ziegler I,Schmitt B,Wollenberg B,Lindhofer H

    更新日期:2000-07-01 00:00:00

  • Lung cancer among women in north-east China.

    abstract::A case-control study of lung cancer involving interviews with 965 female patients and 959 controls in Shenyang and Harbin, two industrial cities which have among the highest rates of lung cancer in China, revealed that cigarette smoking is the main causal factor and accounted for about 35% of the tumours among women. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Wu-Williams AH,Dai XD,Blot W,Xu ZY,Sun XW,Xiao HP,Stone BJ,Yu SF,Feng YP,Ershow AG

    更新日期:1990-12-01 00:00:00

  • How should cancer presenting as a malignant pleural effusion be managed?

    abstract::The objective of the study was to review the natural history of patients with a malignant pleural effusion but without obvious evidence of a primary, to assess the value of investigations used to look for a primary and to assess the response to palliative chemotherapy. This was done by a retrospective study of patient...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Bonnefoi H,Smith IE

    更新日期:1996-09-01 00:00:00

  • Impact of non-axillary sentinel node biopsy on staging and treatment of breast cancer patients.

    abstract::The purpose of this study was to evaluate the occurrence of lymphatic drainage to non-axillary sentinel nodes and to determine the implications of this phenomenon. A total of 549 breast cancer patients underwent lymphoscintigraphy after intratumoural injection of (99m)Tc-nanocolloid. The sentinel node was intraoperati...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Tanis PJ,Nieweg OE,Valdés Olmos RA,Peterse JL,Rutgers EJ,Hoefnagel CA,Kroon BB

    更新日期:2002-09-23 00:00:00

  • HPV type-specific risks of high-grade CIN during 4 years of follow-up: a population-based prospective study.

    abstract::We followed a population-based cohort of 5696 women, 32-38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2+ development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Naucler P,Ryd W,Törnberg S,Strand A,Wadell G,Hansson BG,Rylander E,Dillner J

    更新日期:2007-07-02 00:00:00

  • Author Correction: The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients.

    abstract::The author Sara Lonardi was incorrectly listed as Sara Leonardi. The correct name is listed above. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,已发布勘误


    authors: Rampazzo E,Del Bianco P,Bertorelle R,Boso C,Perin A,Spiro G,Bergamo F,Belluco C,Buonadonna A,Palazzari E,Lonardi S,De Paoli A,Pucciarelli S,De Rossi A

    更新日期:2018-06-01 00:00:00

  • Over-DI dissection may question the value of radiotherapy as a part of an adjuvant programme in high-risk radically resected gastric cancer patients.

    abstract::The aim of our analysis was to assess retrospectively the effect on local relapse, overall survival (OS) and disease-free survival (DFS) of a limited or an extended lymphadenectomy in radically resected gastric cancer patients. This study was performed in order to identify a subgroup of patients possibly not benefitin...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Scartozzi M,Galizia E,Graziano F,Catalano V,Berardi R,Baldelli AM,Testa E,Mari D,Silva RR,Cascinu S

    更新日期:2005-03-28 00:00:00