Activation of cyclin D1-related kinase in human lung adenocarcinoma.

abstract：:A bispecific monoclonal antibody recognising both carcinoembryonic antigen (CEA) and ricin toxin A chain (RTA) was tested for its ability to target recombinant RTA (r-RTA) to CEA-expressing tumour cells, alone and in combination with ricin B chain (RTB). The antibody, 636 (Robins et al., 1990), induced significant RTA...

journal_title：British journal of cancer

authors： Embleton MJ,Charleston A,Robins RA,Pimm MV,Baldwin RW

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) is mainly related to human papillomavirus (HPV) infection. As OPSCCs are often diagnosed at an advanced stage, mortality and morbidity remain high. There are no diagnostic biomarkers for early detection of OPSCC. METHODS:Serum from 25...

journal_title：British journal of cancer

authors： Tuhkuri A,Saraswat M,Mäkitie A,Mattila P,Silén R,Dickinson A,Carpén T,Tohmola T,Joenväärä S,Renkonen S

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients. METHODS:The study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model...

journal_title：British journal of cancer

authors： Staff S,Aaltonen M,Huhtala H,Pylvänäinen K,Mecklin JP,Mäenpää J

更新日期：2016-07-26 00:00:00

abstract：:We have investigated the production, growth and inactivation of gastrin-releasing peptide (GRP)-like peptides in human breast cancer cell lines. Radioimmunoassay detected GRP-like immunoreactivity (GRP-LI) in T47D breast cancer cells but not in the conditioned medium, indicating rapid clearance. No GRP-LI was found in...

journal_title：British journal of cancer

authors： Burns DM,Walker B,Gray J,Nelson J

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:This phase 1 study examined the safety, maximum-tolerated dose (MTD) and antitumour activity of E7449, a novel PARP 1/2 and tankyrase 1/2 inhibitor. METHODS:E7449 was orally administered once daily in 28-day cycles to patients with advanced solid tumours (50-800-mg doses). Archival tumour samples from conse...

journal_title：British journal of cancer

authors： Plummer R,Dua D,Cresti N,Drew Y,Stephens P,Foegh M,Knudsen S,Sachdev P,Mistry BM,Dixit V,McGonigle S,Hall N,Matijevic M,McGrath S,Sarker D

更新日期：2020-08-01 00:00:00

abstract：:The bioreductive antitumour agent, mitomycin C (MMC), requires activation by reductive enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1). We used a novel approach to increase MMC efficacy by selectively inducing NQO1 in tumour cells in vivo. CD-1 nude mice were implanted with HCT116 cells, and fed control diet or d...

journal_title：British journal of cancer

authors： Begleiter A,Leith MK,Thliveris JA,Digby T

更新日期：2004-10-18 00:00:00

abstract：BACKGROUND:Based on the microRNA (miRNA) signature of bladder cancer (BC) by deep sequencing, we recently found that several double-stranded mature miRNAs derived from the same pre-miRNAs were sufficiently expressed and acted as tumour suppressors by regulating common target genes in BC. Our deep-sequencing signature o...

journal_title：British journal of cancer

authors： Sakaguchi T,Yoshino H,Yonemori M,Miyamoto K,Sugita S,Matsushita R,Itesako T,Tatarano S,Nakagawa M,Enokida H

更新日期：2017-04-11 00:00:00

abstract：:The prevalence (lifetime occurrence) rate of cancers of the reproductive system (uterus, ovary, cervix and vagina) and breast cancer was determined for 5,398 living alumnae, 2,622 of whom were former college athletes and 2,776 non-athletes, from data on medical and reproductive history, athletic training and diet. The...

journal_title：British journal of cancer

authors： Frisch RE,Wyshak G,Albright NL,Albright TE,Schiff I,Jones KP,Witschi J,Shiang E,Koff E,Marguglio M

更新日期：1985-12-01 00:00:00

abstract：:The distribution of labelled cells through 5 different mouse tumours was measured after a single injection of [3H]-thymidine [( 3H]-TdR) or [3H]-deoxyuridine [( 3H]-UdR). All the tumours had areas where the percentage of labelled cells (the labelling index, LI) was high and areas where the LI was very low. The total a...

journal_title：British journal of cancer

authors： Hamilton E,Dobbin J

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Tumour budding has been reported to reflect invasiveness, metastasis and unfavourable prognosis in colorectal cancer. The aim of the study was to examine the relationship between tumour budding and clinicopathological characteristics, tumour microenvironment and survival in patients with primary operable col...

journal_title：British journal of cancer

authors： van Wyk HC,Park JH,Edwards J,Horgan PG,McMillan DC,Going JJ

更新日期：2016-07-12 00:00:00

abstract：:In a blind study, 518 serum samples were assayed for serum levels of mammary serum antigen (MSA) by an enzyme immunoassay (EIA) using the 3E1.2 monoclonal antibody. Using 300 IU as the arbitrary cut off to distinguish normal from abnormal individuals, 75% of patients with primary Stage I carcinoma of the breast (n = 1...

journal_title：British journal of cancer

authors： Stacker SA,Sacks NP,Golder J,Tjandra JJ,Thompson CH,Smithyman A,McKenzie IF

更新日期：1988-03-01 00:00:00

abstract：:Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associ...

journal_title：British journal of cancer

authors： Lecot P,Alimirah F,Desprez PY,Campisi J,Wiley C

更新日期：2016-05-24 00:00:00

abstract：:To determine the maximum-tolerated dose (MTD), dose-limiting toxicities and pharmacokinetic of semisynthetic homoharringtonine (ssHHT), given as a twice daily subcutaneous (s.c.) injections for 9 days, in patients with advanced acute leukaemia, 18 patients with advanced acute myeloid leukaemia were included in this se...

journal_title：British journal of cancer

authors： Lévy V,Zohar S,Bardin C,Vekhoff A,Chaoui D,Rio B,Legrand O,Sentenac S,Rousselot P,Raffoux E,Chast F,Chevret S,Marie JP

更新日期：2006-08-07 00:00:00

abstract：:Women referred to a familial breast cancer clinic completed questionnaires before and after counselling and at annual follow-up to assess their risk estimate and psychological characteristics. The aims were to determine whether those who attended the clinic overestimated their risk or were highly anxious and whether c...

journal_title：British journal of cancer

authors： Cull A,Anderson ED,Campbell S,Mackay J,Smyth E,Steel M

更新日期：1999-02-01 00:00:00

abstract：:Canine transmissible venereal sarcoma (CTVS) is a naturally occurring contagious neoplasm which can be transplanted with intact viable cells across major histocompatibility (MHC) barriers within the species and even to other members of the canine family, such as foxes, coyotes, and wolves. After 2 to 4 months of progr...

journal_title：British journal of cancer

authors： Yang TJ,Chandler JP,Dunne-Anway S

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide. Accurately identifying stage II CRC patients at risk for recurrence is an unmet clinical need. KCNQ1 was previously identified as a tumour suppressor gene and loss of expression was associated with poor survival in patients with CRC liver met...

journal_title：British journal of cancer

authors： den Uil SH,Coupé VM,Linnekamp JF,van den Broek E,Goos JA,Delis-van Diemen PM,Belt EJ,van Grieken NC,Scott PM,Vermeulen L,Medema JP,Bril H,Stockmann HB,Cormier RT,Meijer GA,Fijneman RJ

更新日期：2016-12-06 00:00:00

abstract：:The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis fou...

journal_title：British journal of cancer

authors： Jenkins V,Shilling V,Deutsch G,Bloomfield D,Morris R,Allan S,Bishop H,Hodson N,Mitra S,Sadler G,Shah E,Stein R,Whitehead S,Winstanley J

更新日期：2006-03-27 00:00:00

abstract：BACKGROUND:Accurate assessment of the prevalence of the human papilloma virus (HPV) in oropharyngeal tumours (OpSCC) is important because HPV-positive OpSCC are consistently associated with an improved overall survival. Recently, an algorithm has become available that reliably detects clinically relevant HPV in tumour ...

journal_title：British journal of cancer

authors： Melchers LJ,Mastik MF,Samaniego Cameron B,van Dijk BA,de Bock GH,van der Laan BF,van der Vegt B,Speel EJ,Roodenburg JL,Witjes MJ,Schuuring E

更新日期：2015-04-14 00:00:00

abstract：BACKGROUND:We evaluated the efficacy and safety of the modified FOLFOX6 (mFOLFOX6) regimen as a neoadjuvant chemotherapy in gastric cancer patients. METHODS:Seventy-three patients with T2-T4 or N+ were enroled. Preoperative chemotherapy consisted of three cycles of mFOLFOX6. The primary end points were the response ra...

journal_title：British journal of cancer

authors： Wang X,Zhao L,Liu H,Zhong D,Liu W,Shan G,Dong F,Gao W,Bai C,Li X

更新日期：2016-06-14 00:00:00

abstract：:To investigate whether parents of children with congenital malformations more often developed cancer after birth of the child, a population-based case-control study in Denmark was undertaken. By linking the Cancer Registry with the Central Population Registry, we identified 8783 cancer patients having their first chil...

journal_title：British journal of cancer

authors： Zhu JL,Basso O,Hasle H,Winther JF,Olsen JH,Olsen J

更新日期：2002-08-27 00:00:00

abstract：BACKGROUND:Cetuximab plus FOLFIRI improved overall survival compared with bevacizumab plus FOLFIRI in KRAS wild-type metastatic colorectal cancer (mCRC) in FIRE-3, but no corresponding benefit was found for progression-free survival. This analysis aimed to determine whether cetuximab improves response and survival vers...

journal_title：British journal of cancer

authors： Heinemann V,von Weikersthal LF,Decker T,Kiani A,Kaiser F,Al-Batran SE,Heintges T,Lerchenmüller C,Kahl C,Seipelt G,Kullmann F,Moehler M,Scheithauer W,Held S,Miller-Phillips L,Modest DP,Jung A,Kirchner T,Stintzing S

更新日期：2020-11-06 00:00:00

abstract：BACKGROUND:Random error in the numbers of avoidable deaths among cancer patients has not been considered in earlier studies. METHODS:Methods to obtain valid confidence intervals (CIs) for numbers of avoidable deaths were developed. The excess mortality rates were estimated for patients diagnosed with colon cancer in f...

journal_title：British journal of cancer

authors： Seppä K,Hakulinen T,Läärä E

更新日期：2012-05-22 00:00:00

abstract：:Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours, including 47 epitheli...

journal_title：British journal of cancer

authors： Gabra H,Taylor L,Cohen BB,Lessels A,Eccles DM,Leonard RC,Smyth JF,Steel CM

更新日期：1995-08-01 00:00:00

abstract：:I.p. or i.v. administration of Corynebacterium parvum (CP) to MF1 mice induces a generalized inflammatory response, associated with marked hepatosplenomegaly and accompanied by a pronounced granulomatous response in the liver. Injection of the Landschütz ascites carcinoma (LAC) 24 h after CP substantially reduced the ...

journal_title：British journal of cancer

authors： McIntosh LC,Pugh-Humphreys RG,Fraser RA,Thomson AW

更新日期：1982-04-01 00:00:00

abstract：:Many theories mention hypersensitive, promiscuous, outlaw or bypass signalling pathways to explain the acquisition of hormone independence in prostate cancer. Hormonal escape of prostate tumours is marked by many biological changes, including mucinous and neuroendocrine differentiation. Since expression of several muc...

journal_title：British journal of cancer

authors： Legrier ME,de Pinieux G,Boyé K,Arvelo F,Judde JG,Fontaine JJ,Bara J,Poupon MF

更新日期：2004-02-09 00:00:00

abstract：:A central role in anal carcinogenesis of high-risk types of human papillomaviruses (hrHPV) was recently established, but the possible role of benign anal lesions has not been addressed in hrHPV-positive and -negative anal cancers. As part of a population-based case-control study in Denmark and Sweden, we interviewed 4...

journal_title：British journal of cancer

authors： Frisch M,Glimelius B,van den Brule AJ,Wohlfahrt J,Meijer CJ,Walboomers JM,Adami HO,Melbye M

更新日期：1998-12-01 00:00:00

abstract：:Combination chemotherapy with cytosine arabinoside, cyclophosphamide and L-asparaginase (Asnase) was given to 22 children with acute lymphocytic leukaemia (ALL) with a white-cell count greater than 30 X 10(9)/1, and other features suggestive of poor prognosis. Complete remission was induced in all patients--in 19 afte...

journal_title：British journal of cancer

authors： Ekert H,Waters KD,Smith PJ,Matthews RN,Ellis WM

更新日期：1978-11-01 00:00:00

abstract：:Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is conc...

journal_title：British journal of cancer

authors： Selby PJ,Heyderman E,Gibbs J,Peckham MJ

更新日期：1979-05-01 00:00:00

abstract：:We investigated the effects of individual fatty acids on breast cancer in a prospective study of 35,298 Singapore Chinese women aged 45-74 years, who were enrolled during April 1993 to December 1998 (The Singapore Chinese Health Study). At recruitment, each study subject was administered, in-person, a validated, semiq...

journal_title：British journal of cancer

authors： Gago-Dominguez M,Yuan JM,Sun CL,Lee HP,Yu MC

更新日期：2003-11-03 00:00:00

abstract：:Neuroendocrine tumours (NETs) comprise a heterogenous group of malignancies with an often unpredictable course, and with limited treatment options. Thus, new diagnostic, prognostic, and therapeutic markers are needed. To shed new lights into the biology of NETs, we have by cDNA transcript profiling, sought to identify...

journal_title：British journal of cancer

authors： Hofsli E,Wheeler TE,Langaas M,Laegreid A,Thommesen L

更新日期：2008-10-21 00:00:00