Breast cancer cell-associated endopeptidase EC 24.11 modulates proliferative response to bombesin.

abstract：:Fifteen human glioma cell lines were examined for their sensitivity to 1,3-bis(chloroethyl)-nitrosourea (BCNU, carmustine) and cis-dichlorodiamminoplatinum (cisplatin), the induction of DNA interstrand cross-linking (DNA-ISC) induced by the two agents and cellular O6-alkylguanine alkyltransferase (ATase) activity. Cel...

journal_title：British journal of cancer

authors： Beith J,Hartley J,Darling J,Souhami R

更新日期：1997-01-01 00:00:00

abstract：METHODS:Maternally reported congenital abnormalities (CAs) were examined in a case-control study of 278 cases of paediatric germ cell tumours (GCTs) and 423 controls. RESULTS AND CONCLUSIONS:Germ cell tumours were significantly associated with cryptorchidism in males (OR=10.8, 95% CI: 2.1-55.1), but not with any other...

journal_title：British journal of cancer

authors： Johnson KJ,Ross JA,Poynter JN,Linabery AM,Robison LL,Shu XO

更新日期：2009-08-04 00:00:00

abstract：:The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiat...

journal_title：British journal of cancer

authors： Janot F,Klijanienko J,Russo A,Mamet JP,de Braud F,El-Naggar AK,Pignon JP,Luboinski B,Cvitkovic E

更新日期：1996-02-01 00:00:00

abstract：:To investigate possible relationships between genetic alterations and hormonal deregulation during breast cancer development and/or progression, we examined 616 primary breast cancers for loss of heterozygosity (LOH) at chromosomal regions 16q24, 17p13.3 and 17q21, and for amplifications of the ERBB2 and c-MYC loci. A...

journal_title：British journal of cancer

authors： Ito I,Yoshimoto M,Iwase T,Watanabe S,Katagiri T,Harada Y,Kasumi F,Yasuda S,Mitomi T,Emi M

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:There is growing evidence that spleen tyrosine kinase (SYK) is critical for acute myeloid leukaemia (AML) transformation and maintenance of the leukemic clone in AML patients. It has also been found to be over-expressed in AML patients, with activating mutations in foetal liver tyrosine kinase 3 (FLT3), part...

journal_title：British journal of cancer

authors： Yang J,Meng C,Weisberg E,Case A,Lamberto I,Magin RS,Adamia S,Wang J,Gray N,Liu S,Stone R,Sattler M,Buhrlage S,Griffin JD

更新日期：2020-04-01 00:00:00

abstract：:Currently, there are no effective biomarkers for ovarian cancer prognosis or prediction of therapeutic response. The objective of this study was to examine a panel of 10 serum biochemical parameters for their ability to predict response to chemotherapy, progression and survival of ovarian cancer patients. Sera from ov...

journal_title：British journal of cancer

authors： Oikonomopoulou K,Li L,Zheng Y,Simon I,Wolfert RL,Valik D,Nekulova M,Simickova M,Frgala T,Diamandis EP

更新日期：2008-10-07 00:00:00

abstract：:The fluorometric microculture cytotoxicity assay (FMCA) was employed for analysing the effect of different chemotherapeutic drug combinations and their single constituents in 44 cases of acute myelocytic leukaemia (AML). A large heterogeneity with respect to cell kill was observed for all combinations tested, the inte...

journal_title：British journal of cancer

authors： Larsson R,Fridborg H,Kristensen J,Sundström C,Nygren P

更新日期：1993-05-01 00:00:00

abstract：:We have established a novel ascites tumour model (MDA435/LCC6) from the oestrogen receptor-negative, invasive and metastatic MDA-MB-435 human breast cancer cell line. MDA435/LCC6 cells grow as both malignant ascites and solid tumours in vivo in nude mice and nude rats, with a tumour incidence of approximately 100%. Un...

journal_title：British journal of cancer

authors： Leonessa F,Green D,Licht T,Wright A,Wingate-Legette K,Lippman J,Gottesman MM,Clarke R

更新日期：1996-01-01 00:00:00

abstract：:The nature of the invasive growth pattern and microvessel density (MVD) have been suggested to be predictors of prognosis in primary colorectal cancer (CRC) and colorectal liver metastases. The purpose of the present study was to determine whether these two histological features were interrelated and to assess their r...

journal_title：British journal of cancer

authors： Rajaganeshan R,Prasad R,Guillou PJ,Chalmers CR,Scott N,Sarkar R,Poston G,Jayne DG

更新日期：2007-04-10 00:00:00

abstract：:The evolution and structure of adenomatous polyps and adenocarcinomata of the colon in NMRI mice induced by dimethylhydrazine are described. Severe toxic reactions in the liver and other organs are produced by dimethylhydrazine (DMH), but tumours are induced only in the colon and around the anus. The 100% incidence an...

journal_title：British journal of cancer

authors： Haase P,Cowen DM,Knowles JC,Cooper EH

更新日期：1973-12-01 00:00:00

abstract：:To clarify the mechanism of acquired CDDP resistance in ovarian cancer, we compared the microsatellite instability (MSI) by the amplification of 10 microsatellite loci and immunohistochemical detection of hMSH2 and hMLH1 expression between the primary resected tumours and the secondary resected residual tumours after ...

journal_title：British journal of cancer

authors： Watanabe Y,Koi M,Hemmi H,Hoshai H,Noda K

更新日期：2001-09-28 00:00:00

abstract：:We evaluated animal food intake and cooking methods in relation to endometrial cancer risk in a population-based case-control study in Shanghai, China. A validated food frequency questionnaire was used to collect the usual dietary habits of 1204 cases and 1212 controls aged 30-69 years between 1997 and 2003. Statistic...

journal_title：British journal of cancer

authors： Xu WH,Dai Q,Xiang YB,Zhao GM,Zheng W,Gao YT,Ruan ZX,Cheng JR,Shu XO

更新日期：2006-12-04 00:00:00

abstract：:The structural characteristics of mesoionic compounds, which contain distinct regions of positive and negative charges associated with a poly-heteroatomic system, enable them to cross cellular membranes and interact strongly with biomolecules. Potential biological applications have been described for mesoionic compoun...

journal_title：British journal of cancer

authors： Senff-Ribeiro A,Echevarria A,Silva EF,Franco CR,Veiga SS,Oliveira MB

更新日期：2004-07-19 00:00:00

abstract：:Hypomethylation has been reported to be responsible for the activation of several oncogenes. The possibility that hypomethylation is involved in the regulation of MET transcription was investigated through the analysis of the methylation status of one CpG island containing 43 CpGs in six cases of papillary carcinoma, ...

journal_title：British journal of cancer

authors： Scarpino S,Di Napoli A,Rapazzotti-Onelli M,Pilozzi E,Ruco L

更新日期：2004-08-16 00:00:00

abstract：:A prospective randomised study was carried out to compare the effect of mesna (2-mercaptoethane sulphonate sodium) with that of forced diuresis in preventing cyclophosphamide induced haemorrhagic cystitis in marrow transplant recipients. Sixty-one consecutive BMT recipients were randomised for treatment with forced di...

journal_title：British journal of cancer

authors： Hows JM,Mehta A,Ward L,Woods K,Perez R,Gordon MY,Gordon-Smith EC

更新日期：1984-12-01 00:00:00

abstract：:The relationship between hepatic arterial albumin microsphere distribution and hepatic arterial blood flow and the effects of regional angiotensin II were studied in a rat liver metastases model. Hooded-Lister rats were inoculated subcapsularly with 2 x 10(6) HSN sarcoma cells. At 20 days, hepatic arterial blood flow ...

journal_title：British journal of cancer

authors： Anderson JH,Angerson WJ,Willmott N,Kerr DJ,McArdle CS,Cooke TG

更新日期：1992-08-01 00:00:00

abstract：:Using a recently developed model for studying the biology of locally recurrent (LR) mammary tumours in the 13762NF rat mammary adenocarcinoma system, we examined the sensitivity to polymorphonuclear cell, macrophage and natural killer cell cytolysis. The parental MTF7(T20) cell line; the 'primary' tumours which arose ...

journal_title：British journal of cancer

authors： Aeed PA,Welch DR

更新日期：1988-12-01 00:00:00

abstract：:To evaluate the toxicity, pharmacological and biological properties of ATN-161, a five -amino-acid peptide derived from the synergy region of fibronectin, adult patients with advanced solid tumours were enrolled in eight sequential dose cohorts (0.1-16 mg kg(-1)), receiving ATN-161 administered as a 10-min infusion th...

journal_title：British journal of cancer

authors： Cianfrocca ME,Kimmel KA,Gallo J,Cardoso T,Brown MM,Hudes G,Lewis N,Weiner L,Lam GN,Brown SC,Shaw DE,Mazar AP,Cohen RB

更新日期：2006-06-05 00:00:00

abstract：:Early detection of relapse has been advocated to improve survival in children with recurrent medulloblastoma. However, the prognostic factors and the longer term outcome of these patients remains unclear. Pattern of recurrences were analysed in three consecutive protocols of the Société Française d'Oncologie Pédiatriq...

journal_title：British journal of cancer

authors： Bouffet E,Doz F,Demaille MC,Tron P,Roche H,Plantaz D,Thyss A,Stephan JL,Lejars O,Sariban E,Buclon M,Zücker JM,Brunat-Mentigny M,Bernard JL,Gentet JC

更新日期：1998-04-01 00:00:00

abstract：:In the present study organotypic multicellular spheroids (OMS) were used to study the effects of chemotherapeutic agents on malignant gliomas. Compared with the frequently used cell line models, OMS have several advantages with respect to the preservation of the cellular heterogeneity and the structure of the original...

journal_title：British journal of cancer

authors： Kaaijk P,Troost D,de Boer OJ,Van Amstel P,Bakker PJ,Leenstra S,Bosch DA

更新日期：1996-07-01 00:00:00

abstract：:Interferon-alpha (IFN-alpha) is a clinically useful cytokine for treatment of a variety of cancers, including chronic myelocytic leukaemia (CML). Most CML cells are sensitive to IFN-alpha; however, its biological effects on leukaemic cells are incompletely characterized. Here, we provide evidence that IFN-alpha induce...

journal_title：British journal of cancer

authors： Miyachi T,Adachi M,Hinoda Y,Imai K

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify prostate cancer (PC) oncogenic microRNAs (miRs) based on miR microarray and to investigate whether these oncogenic miRs may be useful as PC biomarkers. METHODS:Initially, we carried out miR microarray and real-time PCR using RWPE-1, PC-3, DU-145 and LNCaP cells. To ...

journal_title：British journal of cancer

authors： Ueno K,Hirata H,Shahryari V,Deng G,Tanaka Y,Tabatabai ZL,Hinoda Y,Dahiya R

更新日期：2013-04-30 00:00:00

abstract：:We identified 2384 patients in the Danish Cancer Register in whom cancer had been diagnosed in 1960-1996 before they reached the age of 20 and compared them with 53 143 sex- and age-matched controls identified from the Register of Population Statistics. Complete education records and demographic and socioeconomic info...

journal_title：British journal of cancer

authors： Koch SV,Kejs AM,Engholm G,Johansen C,Schmiegelow K

更新日期：2004-08-31 00:00:00

abstract：:Helix pomatia agglutinin (HPA)- and Concanavalin A (Con A)-binding carbohydrate expression were studied on 32 tumour samples from primary adenocarcinoma of the breast and 12 samples from lymph node metastases. Live cells were spilled from each of the fresh samples and the extent of fluorescent-labelled HPA and Con A-b...

journal_title：British journal of cancer

authors： Alam SM,Whitford P,Cushley W,George WD,Campbell AM

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%, next-generation sequencing (NGS)must be narrowed to target only clinically relevant genes. In this proof-of-concept study, we developed a panel to use ...

journal_title：British journal of cancer

authors： Malapelle U,Mayo de-Las-Casas C,Rocco D,Garzon M,Pisapia P,Jordana-Ariza N,Russo M,Sgariglia R,De Luca C,Pepe F,Martinez-Bueno A,Morales-Espinosa D,González-Cao M,Karachaliou N,Viteri Ramirez S,Bellevicine C,Molina-Vila M

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:A dose-dense strategy has been considered to improve results of adjuvant chemotherapy for breast cancer. This randomised phase II trial investigated the feasibility of this approach with sequential anthracyclines and taxanes-based chemotherapy. METHODS:Patients with high-risk node-positive breast cancer wer...

journal_title：British journal of cancer

authors： Brain E,Levy C,Serin D,Roché H,Spielmann M,Delva R,Veyret C,Mauriac L,Rios M,Martin AL,Jimenez M,Asselain B,Gauthier M,Bonnetain F,Fumoleau P

更新日期：2011-11-08 00:00:00

abstract：BACKGROUND:Rectal bleeding is a recognised early symptom of colorectal cancer. This study aimed to assess the diagnostic accuracy of symptoms, signs and diagnostic tests in patients with rectal bleeding in relation to risk of colorectal cancer in primary care. METHODS:Diagnostic accuracy systematic review. Medline (19...

journal_title：British journal of cancer

authors： Olde Bekkink M,McCowan C,Falk GA,Teljeur C,Van de Laar FA,Fahey T

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:Recent studies have indicated the prognostic value of tumour subtype and pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). However these results were reported after a short follow-up and using a standard Cox model which could be unsatisfactory for time-dependent factors. In the prese...

journal_title：British journal of cancer

authors： Baulies S,Belin L,Mallon P,Senechal C,Pierga JY,Cottu P,Sablin MP,Sastre X,Asselain B,Rouzier R,Reyal F

更新日期：2015-06-30 00:00:00

abstract：:Two subtypes of thrombospondin (TSP-1 and TSP-2) have inhibitory roles in angiogenesis in vitro, although the biological significance of these TSP isoforms has not been determined in vivo. We examined TSP-1 and TSP-2 gene expression by reverse transcription polymerase chain reaction (RT-PCR) analysis in 61 colon cance...

journal_title：British journal of cancer

authors： Tokunaga T,Nakamura M,Oshika Y,Abe Y,Ozeki Y,Fukushima Y,Hatanaka H,Sadahiro S,Kijima H,Tsuchida T,Yamazaki H,Tamaoki N,Ueyama Y

更新日期：1999-01-01 00:00:00

abstract：:In addition to the direct targeting effects on HER2-positive cells, trastuzumab may have a therapeutic role modulating the activity of the cellular immune system in patients with breast cancer. To investigate this further, the balance of T-regulatory (T(reg)), Th17, natural killer (NK) and NK T (NKT) cells before, dur...

journal_title：British journal of cancer

authors： Horlock C,Stott B,Dyson PJ,Morishita M,Coombes RC,Savage P,Stebbing J

更新日期：2009-04-07 00:00:00