当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > The relationship between tumour budding, the tumour microenvironment and survival in patients with primary operable colorectal cancer.

The relationship between tumour budding, the tumour microenvironment and survival in patients with primary operable colorectal cancer.

Abstract：

BACKGROUND:Tumour budding has been reported to reflect invasiveness, metastasis and unfavourable prognosis in colorectal cancer. The aim of the study was to examine the relationship between tumour budding and clinicopathological characteristics, tumour microenvironment and survival in patients with primary operable colorectal cancer. METHODS:A total of 303 patients from a prospective data set of patients with primary operable colorectal cancer were included in the study. The presence of budding was determined through assessment of all tumour-containing H&E slides and the number of tumour buds was counted using a 10 high-powered field method. Routine pathologic sections were used to assess: tumour necrosis, the tumour inflammatory cell infiltrate using Klintrup-Makinen (KM) grade and tumour stroma percentage (TSP) combined as the Glasgow Microenvironment Score (GMS). RESULTS:High-grade tumour budding was present in 39% of all tumours and in 28% of node-negative tumours respectively. High-grade budding was significantly associated with T stage (P<0.001), N stage (P<0.001), TNM stage (P<0.001), serosal involvement (P<0.001), venous invasion (P<0.005), KM grade (P=0.022), high tumour stroma (P<0.001) and GMS (P<0.001). Tumour budding was associated with reduced cancer-specific survival (CSS) (HR=4.03; 95% confidence interval (CI), 2.50-6.52; P<0.001), independent of age (HR=1.47; 95% CI, 1.13-1.90; P=0.004), TNM stage (HR=1.52; 95% CI, 1.02-2.25; P=0.040), venous invasion (HR=1.73; 95% CI, 1.13-2.64; P=0.012) and GMS (HR=1.54; 95% CI, 1.15-2.07; P=0.004). CONCLUSIONS:The presence of tumour budding was associated with elements of the tumour microenvironment and was an independent adverse prognostic factor in patients with primary operable colorectal cancer. Specifically high tumour budding stratifies effectively the prognostic value of tumour stage, venous invasion and GMS. Taken together, tumour budding should be assessed routinely in patients with primary operable colorectal cancer.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

van Wyk HC,Park JH,Edwards J,Horgan PG,McMillan DC,Going JJ

doi

10.1038/bjc.2016.173

subject

Has Abstract

pub_date

2016-07-12 00:00:00

pages

156-63

issue

eissn

0007-0920

issn

1532-1827

pii

bjc2016173

journal_volume

115

pub_type

杂志文章

在线工具

The relationship between tumour budding, the tumour microenvironment and survival in patients with primary operable colorectal cancer.