当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Effect of hormone manipulation on oxidation, reduction and sulphurylation of dehydroepiandrosterone and oestrone in DMBA-induced rat mammary tumours.

Effect of hormone manipulation on oxidation, reduction and sulphurylation of dehydroepiandrosterone and oestrone in DMBA-induced rat mammary tumours.

Abstract：

:Using the DMBA-induced mammary tumour as a model, the effect of hormone manipulation on steroid sulphurylation and on oxidative and reductive metabolism has been investigated. Oestradiol-17 beta, or oestradiol-17 beta + progesterone, administered to oophorectomized animals, had no effect on adenosine-3'-phosphate-5'-phosphosulphate formation in the tumours. Dehydroepiandrosterone sulphotransferase was also unaffected. A large increase in oestrogen sulphotransferase following administration of oestrogen + progesterone was observed in some but not all tumours, and the overall results were not statically significant. The major metabolities of dehydroepiandrosterone, by both human and carcinogen-induced rat mammary tumours in vitro, are 7-oxygenated derivatives. Oestrogen administration led to a significantly decreased production of total 7-oxygenated derivatives of dehydroepiandrosterone. Conversion to 5-androstene-3 beta, 17 beta-diol was unaffected by the hormones. The rate of formation of oestradiol-17 beta from oestrone was increased 5-fold in growing tumours from animals receiving oestrogen, or oestrogen + progesterone, compared to regressing tumours in oophorectomized control animals.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Li K,Chandra DP,Pewnim T,Foo T,Adams JB

doi

10.1038/bjc.1980.14

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

123-9

issue

1

eissn

0007-0920

issn

1532-1827

journal_volume

41

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • The prognostic impact of a combined carbonic anhydrase IX and Ki67 signature in oral squamous cell carcinoma.

    abstract：BACKGROUND:Tumour hypoxia is associated with impaired apoptosis, resistance to therapy and poor prognosis. We previously reported that high stromal expression of the endogenous marker of hypoxia, carbonic anhydrase IX (CAIX), is associated with significantly reduced survival in oral squamous cell carcinoma (OSCC). In a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.533

    authors： Klimowicz AC,Bose P,Petrillo SK,Magliocco AM,Dort JC,Brockton NT

    更新日期：2013-10-01 00:00:00

  • Electrophoretic mobility of mouse T-cell hybrids.

    abstract：:The hybrid cell line BH2 was derived by fusion between an AKR thymoma BW5147 (HGPRT-) and C57BL thymoma EL-4R (TK-). The hybrid cells showed a near-tetraploid modal number of chromosomes, in contrast to the near-diploid stem-lines of both parental cell populations; most of the BH2 hybrid cells acquired marker chromoso...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1981.255

    authors： Bubeník J,Perlmann P,Jónsdóttir I,Kypĕnová H,Bubeníková D,Símová J

    更新日期：1981-11-01 00:00:00

  • A phase II trial of induction chemotherapy and chemo-IMRT for head and neck squamous cell cancers at risk of bilateral nodal spread: the application of a bilateral superficial lobe parotid-sparing IMRT technique and treatment outcomes.

    abstract：PURPOSE:To determine the feasibility of induction chemotherapy and chemo-IMRT in head and neck squamous cell cancers at risk of bilateral nodal spread (midline tumours) and to evaluate whether bilateral superficial lobe parotid-sparing IMRT can reduce the incidence of ⩾G2 subjective xerostomia. METHODS:Patients with m...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.553

    authors： Miah AB,Schick U,Bhide SA,Guerrero-Urbano MT,Clark CH,Bidmead AM,Bodla S,Del Rosario L,Thway K,Wilson P,Newbold KL,Harrington KJ,Nutting CM

    更新日期：2015-01-06 00:00:00

  • A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants.

    abstract：BACKGROUND:defective DNA repair has a causal role in hereditary colorectal cancer (CRC). Defects in the base excision repair gene MUTYH are responsible for MUTYH-associated polyposis and CRC predisposition as an autosomal recessive trait. Numerous reports have suggested MUTYH mono-allelic variants to be low penetrance ...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析

    doi：10.1038/sj.bjc.6605966

    authors： Theodoratou E,Campbell H,Tenesa A,Houlston R,Webb E,Lubbe S,Broderick P,Gallinger S,Croitoru EM,Jenkins MA,Win AK,Cleary SP,Koessler T,Pharoah PD,Küry S,Bézieau S,Buecher B,Ellis NA,Peterlongo P,Offit K,Aaltonen L

    更新日期：2010-12-07 00:00:00

  • Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells.

    abstract：BACKGROUND:Current evidence indicates that a stem cell-like sub-population within malignant glioblastomas, that overexpress members of the adenosine triphosphate-binding cassette (ABC) family transporters, is responsible for multidrug resistance and tumour relapse. Eradication of the brain tumour stem cell (BTSC) compa...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.188

    authors： Martín V,Sanchez-Sanchez AM,Herrera F,Gomez-Manzano C,Fueyo J,Alvarez-Vega MA,Antolín I,Rodriguez C

    更新日期：2013-05-28 00:00:00

  • Phase I and pharmacokinetic study of the novel chemoprotector BNP7787 in combination with cisplatin and attempt to eliminate the hydration schedule.

    abstract：:BNP7787 (disodium 2,2'-dithio-bis-ethane sulphonate; Tavocept) is a novel agent developed to protect against cisplatin (cis-diammine-dichloroplatinum(II))-associated chronic toxicities. In this study, we determined the recommended dose of BNP7787 when preceding a fixed dose of cisplatin, the pharmacokinetics (PKs) and...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6602553

    authors： Boven E,Westerman M,van Groeningen CJ,Verschraagen M,Ruijter R,Zegers I,van der Vijgh WJ,Giaccone G

    更新日期：2005-05-09 00:00:00

  • A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours.

    abstract：:To assess tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and clinical activity of the dual epidermal growth factor receptor (EGFR) 1 and 2 (HER2) tyrosine kinase inhibitor BIBW 2992. An escalating schedule of once-daily (OD) BIBW 2992 for 14 days followed by 14 days off medication was explored. Thirty-eigh...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604108

    authors： Eskens FA,Mom CH,Planting AS,Gietema JA,Amelsberg A,Huisman H,van Doorn L,Burger H,Stopfer P,Verweij J,de Vries EG

    更新日期：2008-01-15 00:00:00

  • Androgen receptor expression in circulating tumour cells from castration-resistant prostate cancer patients treated with novel endocrine agents.

    abstract：BACKGROUND:Abiraterone and enzalutamide are novel endocrine treatments that abrogate androgen receptor (AR) signalling in castration-resistant prostate cancer (CRPC). Here, we developed a circulating tumour cells (CTCs)-based assay to evaluate AR expression in real-time in CRPC and investigated nuclear AR expression in...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2015.63

    authors： Crespo M,van Dalum G,Ferraldeschi R,Zafeiriou Z,Sideris S,Lorente D,Bianchini D,Rodrigues DN,Riisnaes R,Miranda S,Figueiredo I,Flohr P,Nowakowska K,de Bono JS,Terstappen LW,Attard G

    更新日期：2015-03-31 00:00:00

  • Artificial sweeteners and bladder cancer in Manchester, U.K., and Nagoya, Japan.

    abstract：:We have evaluated the relation between cancer of the lower urinary tract ("bladder cancer") and the use of artificial sweeteners, by means of case-control studies in Manchester, U.K., and Nagoya, Japan, areas where extensive use occurred 30-40 years ago. In each area, a broadly based series of cases (555 in Manchester...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1982.59

    authors： Morrison AS,Verhoek WG,Leck I,Aoki K,Ohno Y,Obata K

    更新日期：1982-03-01 00:00:00

  • Platelets enhance malignant behaviours of gastric cancer cells via direct contacts.

    abstract：:In this study, we aimed to analyse human cancer cell-platelet interactions in functional cell analyses and explore the molecular mechanisms behind tumour progression. Various functional analyses of gastric cancer (GC) cells were performed after direct/indirect co-incubation with platelets derived from GC patients. Fur...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-01134-7

    authors： Saito R,Shoda K,Maruyama S,Yamamoto A,Takiguchi K,Furuya S,Hosomura N,Akaike H,Kawaguchi Y,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Suzuki-Inoue K,Ichikawa D

    更新日期：2020-10-28 00:00:00

  • CD8+ T cell-mediated control of distant tumours following local photodynamic therapy is independent of CD4+ T cells and dependent on natural killer cells.

    abstract：:Cancer survival rates decrease in the presence of disseminated disease. However, there are few therapies that are effective at eliminating the primary tumour while providing control of distant stage disease. Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumours, resulting in cure...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603792

    authors： Kabingu E,Vaughan L,Owczarczak B,Ramsey KD,Gollnick SO

    更新日期：2007-06-18 00:00:00

  • Generation of metastatic variants by transfection of a rat non-metastatic epithelial cell line with genomic DNA from rat prostatic carcinoma cells.

    abstract：:Prostate cancer is the second leading cause of male death from malignant disease in Europe and in the USA. Failure to prevent or eliminate metastatic dissemination is a fundamental problem underlying the current inadequate treatment of prostate cancer, and novel therapeutic strategies are required if this disease is t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.45

    authors： Ke Y,Beesley C,Smith P,Barraclough R,Rudland P,Foster CS

    更新日期：1998-01-01 00:00:00

  • Targeting insulin-like growth factor pathways.

    abstract：:Some cancer cells depend on the function of specific molecules for their growth, survival, and metastatic potential. Targeting of these critical molecules has arguably been the best therapy for cancer as demonstrated by the success of tamoxifen and trastuzumab in breast cancer. This review will evaluate the type I IGF...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6602963

    authors： Yee D

    更新日期：2006-02-27 00:00:00

  • High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients.

    abstract：BACKGROUND:MiR-125b has critical role in non-small-cell lung cancer (NSCLC) cell migration, and its target genes have not been elucidated. Kinesin-1 light chain (KLC)-2 was predicted as one of miR-125b's targets by bioinformatics analysis. This study is to identify the function of KLC2 and its interaction with miR-125b...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2015.3

    authors： Wang M,Zhu X,Sha Z,Li N,Li D,Chen L

    更新日期：2015-03-03 00:00:00

  • DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?

    abstract：:DT-diaphorase (DTD) is an important enzyme for the bioreductive activation of the new alkylating indoloquinone EO9. In preclinical studies, EO9 has shown selective anti-tumour activity against solid tumours and under hypoxic conditions. The levels of three reductive enzymes have been determined in three types of human...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.433

    authors： Smitskamp-Wilms E,Giaccone G,Pinedo HM,van der Laan BF,Peters GJ

    更新日期：1995-10-01 00:00:00

  • First-line endocrine treatment of breast cancer: aromatase inhibitor or antioestrogen?

    abstract：:Until recently, endocrine therapy for breast cancer was relatively simple. If the tumour expressed hormone receptors, regardless of stage and age, tamoxifen was indicated. While this largely remains the case for premenopausal women, clinical trials in postmenopausal women have broadened our choice to include one of th...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6601508

    authors： Wong ZW,Ellis MJ

    更新日期：2004-01-12 00:00:00

  • Gene expression profiling identifies distinct molecular subgroups of leiomyosarcoma with clinical relevance.

    abstract：BACKGROUND:Soft tissue sarcomas are heterogeneous and a major complication in their management is that the existing classification scheme is not definitive and is still evolving. Leiomyosarcomas, a major histologic category of soft tissue sarcomas, are malignant tumours displaying smooth muscle differentiation. Althoug...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.280

    authors： Lee YF,Roe T,Mangham DC,Fisher C,Grimer RJ,Judson I

    更新日期：2016-10-11 00:00:00

  • Lung cancer and passive smoking: reconciling the biochemical and epidemiological approaches.

    abstract：:The accurate determination of exposure to environmental tobacco smoke is notoriously difficult. There have been to date two approaches to determining this exposure in the study of association of passive smoking and lung cancer: the biochemical approach, using cotinine in the main as a marker, and the epidemiological a...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析

    doi：10.1038/bjc.1992.341

    authors： Tweedie RL,Mengersen KL

    更新日期：1992-10-01 00:00:00

  • DNA content in high and intermediate grade non-Hodgkin's lymphoma-prognostic significance and clinicopathological correlations.

    abstract：:Flow cytometric (FCM) estimation of DNA content has been performed on tumour tissue from 197 patients with high and intermediate grade non-Hodgkin's lymphoma (NHL) to investigate the clinicopathological correlations and prognostic significance of DNA ploidy and proliferative activity. Fifty-one per cent of tumours wer...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1989.388

    authors： Cowan RA,Harris M,Jones M,Crowther D

    更新日期：1989-12-01 00:00:00

  • Combinatorial experimental protocols for Erbicin-derived immunoagents and Herceptin.

    abstract：:Erbicin is a human anti-ErbB2 single-chain antibody fragment with high affinity and selectivity for ErbB2-positive cancer cells. Two anti-ErbB2 immunoconjugates, called Erb-hRNase and Erb-hcAb, have been prepared and found to be selectively cytotoxic on ErbB2-positive cancer cells in vitro and vivo. In Erb-hRNase, Erb...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604022

    authors： De Lorenzo C,Troise F,Cafaro V,D'Alessio G

    更新日期：2007-11-19 00:00:00

  • Age as an independent prognostic factor for survival of localised synovial sarcoma patients.

    abstract：BACKGROUND:We performed a retrospective nationwide study to explore age as a prognostic factor in synovial sarcoma patients. METHODS:Data on 613 synovial sarcoma patients were obtained from the Netherlands Cancer Registry. The prognostic relevance of age groups (children, adolescent and young adults (AYAs), adults, an...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2015.375

    authors： Vlenterie M,Ho VK,Kaal SE,Vlenterie R,Haas R,van der Graaf WT

    更新日期：2015-12-01 00:00:00

  • Hypertension, obesity and their medications in relation to renal cell carcinoma.

    abstract：:A population-based, case-control study was conducted in Los Angeles County, California, to investigate the inter-relationships of obesity, hypertension and medications in relation to renal cell carcinoma (RCC) risk. A total of 1204 RCC patients and an equal number of neighbourhood controls were included. Obesity was a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.248

    authors： Yuan JM,Castelao JE,Gago-Dominguez M,Ross RK,Yu MC

    更新日期：1998-05-01 00:00:00

  • Case-control study: soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols.

    abstract：:In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenol...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1979.125

    authors： Hardell L,Sandström A

    更新日期：1979-06-01 00:00:00

  • Tumour growth rate and DNA flow cytometry parameters as prognostic factors in metastatic melanoma.

    abstract：:The prognostic value of flow cytometric parameters and tumour growth rate of melanoma metastases under the mouse renal capsule was investigated for tumours from 117 consecutive patients referred to the Helsinki University Central Hospital Melanoma Team. DNA flow cytometry (FCM) was interpretable for the tumours of 114...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.307

    authors： Muhonen T,Pyrhönen S,Laasonen A,Wasenius VM,Asko-Seljavaara S,Franssila K,Kangas L

    更新日期：1992-09-01 00:00:00

  • The tumour promoter 12-O-tetradecanoylphorbol-13-acetate increases the activities of some peroxisome-associated enzymes in in vitro cell culture.

    abstract：:A study was conducted on the effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on peroxisomal enzyme activities in mouse embryo fibroblasts C3H/10T1/2 C18 cells and chemically transformed C3H/10T1/2 MCA16 cells. TPA is a potent tumour promoter and treatment with this compound of the two cell lines induced peroxis...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1986.17

    authors： Lillehaug JR,Berge RK

    更新日期：1986-01-01 00:00:00

  • A multicenter phase II study of the combination of oxaliplatin, irinotecan and capecitabine in the first-line treatment of metastatic colorectal cancer.

    abstract：:The triple drug combination consisting of irinotecan, oxaliplatin and 5-fluorouracil (FOLFOXIRI) has demonstrated higher activity and efficacy compared to the doublet FOLFIRI. 5-Fluorouracil could be substituted in FOLFOXIRI regimen by capecitabine, an oral fluoropyrimidine with similar efficacy. Recently, a dose-find...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/sj.bjc.6605075

    authors： Vasile E,Masi G,Fornaro L,Cupini S,Loupakis F,Bursi S,Petrini I,Di Donato S,Brunetti IM,Ricci S,Antonuzzo A,Chiara S,Amoroso D,Andreuccetti M,Falcone A

    更新日期：2009-06-02 00:00:00

  • 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.

    abstract：:In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/bjc.1994.385

    authors： Jebb SA,Osborne RJ,Maughan TS,Mohideen N,Mack P,Mort D,Shelley MD,Elia M

    更新日期：1994-10-01 00:00:00

  • Early diagnosis of oesophageal cancer.

    abstract：:Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that develop from distinct epithelial sub-types; however, they are both related to chronic inflammation of differing aetiologies. Inflammation leads to somatically inherited genetic mutations altering control of the cell cycle, DNA replication an...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6605126

    authors： Bird-Lieberman EL,Fitzgerald RC

    更新日期：2009-07-07 00:00:00

  • Primary ovarian cancer chemotherapy: current standards of care.

    abstract：:Chemotherapy has been regarded as standard therapy for the majority of women with advanced epithelial ovarian cancer for several decades, with this role filled largely by the alkylating agents - used as monotherapy - until the mid-1980s. The activity of cisplatin in this disorder was established during the 1970s, and ...

    journal_title：British journal of cancer

    pub_type： 历史文章,杂志文章,评审

    doi：10.1038/sj.bjc.6601494

    authors： McGuire WP 3rd,Markman M

    更新日期：2003-12-01 00:00:00

  • Quantitative evaluation of metastases in axillary lymph nodes of breast cancer.

    abstract：:We have established a highly sensitive and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method to detect axillary lymph node metastases of breast cancer. Amplifying cytokeratin 19 (CK19) mRNA transcripts using real-time TaqMan PCR made it possible to quantify axillary metastatic burden. Metast...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601248

    authors： Inokuchi M,Ninomiya I,Tsugawa K,Terada I,Miwa K

    更新日期：2003-11-03 00:00:00