Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells.

abstract：:Increased fibre intake has been shown to reduce serum oestrogen concentrations. We hypothesized that fibre exerts this effect by decreasing the time available for reabsorption of oestrogens in the colon. We tested this in volunteers by measuring changes in serum oestrogen levels in response to manipulation of intestin...

journal_title：British journal of cancer

authors： Lewis SJ,Heaton KW,Oakey RE,McGarrigle HH

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumour and has poor prognosis. Currently, systematic chemotherapy is the only approach to prolong survival. Thus the development of new treatment regimens is urgently needed to improve the therapeutic efficacy. Our study intended to ...

journal_title：British journal of cancer

authors： Xu L,Zhu Y,Shao J,Chen M,Yan H,Li G,Zhu Y,Xu Z,Yang B,Luo P,He Q

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Current standards for assessment of tumour response to therapy (a) categorise therapeutic efficacy values, inappropriate for patient-specific and deterministic studies, (b) neglect the natural growth characteristics of tumours, (c) are based on tumour shrinkage, inappropriate for cytostatic therapies, and (d...

journal_title：British journal of cancer

authors： Mehrara E,Forssell-Aronsson E,Bernhardt P

更新日期：2011-08-23 00:00:00

abstract：BACKGROUND:Inter-individual differences in dihydropyrimidine dehydrogenase (DPYD encoding DPD) and thiopurine S-methyltransferase (TPMT) activity are important predictors for fluoropyrimidine and thiopurine toxicity. While several variants in these genes are known to decrease enzyme activities, many additional genetic ...

journal_title：British journal of cancer

authors： Zhou Y,Dagli Hernandez C,Lauschke VM

更新日期：2020-12-01 00:00:00

abstract：:We have purified epithelial cells from human colonic tumours by velocity sedimentation in an isokinetic density gradient of Ficoll in tissue culture medium. In frozen sections of colonic carcinoma, histochemically demonstrable N-acetyl-beta-D-glucosaminidase (HDAG) was observed primarily in epithelial cells. We used t...

journal_title：British journal of cancer

authors： Brattain MG,Kimball PM,Pretlow TG 2nd,Pitts AM

更新日期：1977-06-01 00:00:00

abstract：:High-level microsatellite instability (MSI-H) in colorectal cancer accounts for about 12% of colorectal cancers and is typically associated with a dense infiltration with cytotoxic CD8-positive lymphocytes. The role of regulatory T cells that may interfere with the host's antitumoural immune response in MSI-H colorect...

journal_title：British journal of cancer

authors： Michel S,Benner A,Tariverdian M,Wentzensen N,Hoefler P,Pommerencke T,Grabe N,von Knebel Doeberitz M,Kloor M

更新日期：2008-12-02 00:00:00

abstract：BACKGROUND:Cabazitaxel is approved for treatment of castration-resistant metastatic prostate cancer. The current dosing strategy of cabazitaxel is based on body surface area (BSA). Body surface area is known as a poor predictor for total systemic exposure to drugs, since it does not take into account variability in act...

journal_title：British journal of cancer

authors： Janssen A,Verkleij CPM,van der Vlist A,Mathijssen RHJ,Bloemendal HJ,Ter Heine R

更新日期：2017-05-09 00:00:00

abstract：BACKGROUND:Platinum-based doublet chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC), but earlier studies have suggested that non-platinum combinations are equally effective and better tolerated. We conducted a national, randomised study to compare a non-platinum with a pl...

journal_title：British journal of cancer

authors： Fløtten Ø,Grønberg BH,Bremnes R,Amundsen T,Sundstrøm S,Rolke H,Hornslien K,Wentzel-Larsen T,Aasebø U,von Plessen C

更新日期：2012-07-24 00:00:00

abstract：BACKGROUND:Tumour heterogeneity is documented for many characters, including the production of growth factors, one of the hallmarks of cancer. What maintains heterogeneity remains an open question that has implications for diagnosis and treatment, as drugs that target growth factors are susceptible to the evolution of ...

journal_title：British journal of cancer

authors： Archetti M

更新日期：2013-08-20 00:00:00

abstract：:Regionally administered vasopressors might increase tumour chemotherapy uptake by differentially constricting normal and tumour blood vessels, leading to a selective increase in blood flow to the tumour. In this study, we compared the effects of the vasopressors angiotensin II, vasopressin and endothelin I and the vas...

journal_title：British journal of cancer

authors： Dworkin MJ,Carnochan P,Allen-Mersh TG

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:There is no consensus agreement regarding optimal management of locally excised ductal carcinoma in situ (DCIS) or features of greatest assistance in predicting disease behaviour. Cases in the UKCCCR/ANZ DCIS trial have been histologically reviewed to determine the features of prognostic importance. METHOD:...

journal_title：British journal of cancer

authors： Pinder SE,Duggan C,Ellis IO,Cuzick J,Forbes JF,Bishop H,Fentiman IS,George WD,UK Coordinating Committee on Cancer Research (UKCCCR) Ductal Carcinoma In Situ (DCIS) Working Party.

更新日期：2010-06-29 00:00:00

abstract：:Currently, there are no effective biomarkers for ovarian cancer prognosis or prediction of therapeutic response. The objective of this study was to examine a panel of 10 serum biochemical parameters for their ability to predict response to chemotherapy, progression and survival of ovarian cancer patients. Sera from ov...

journal_title：British journal of cancer

authors： Oikonomopoulou K,Li L,Zheng Y,Simon I,Wolfert RL,Valik D,Nekulova M,Simickova M,Frgala T,Diamandis EP

更新日期：2008-10-07 00:00:00

abstract：:Palliative chemotherapy for inoperable/metastatic oesophageal cancer has limited activity. This study assesses the feasibility and activity of gemcitabine and cisplatin in this group of patients. In total, 42 patients with locally advanced/metastatic squamous or adenocarcinoma of the oesophagus were treated with gemci...

journal_title：British journal of cancer

authors： Millar J,Scullin P,Morrison A,McClory B,Wall L,Cameron D,Philips H,Price A,Dunlop D,Eatock M

更新日期：2005-11-14 00:00:00

abstract：:A partially purified fraction of the water soluble photosensitive dye sulphonated aluminium phthalocyanine (AlSPc) was encapsulated in liposomes which were then linked to a targeting monoclonal antibody 791T/36 using a heterobifunctional linking agent. The photocytotoxic effects of the liposomes were determined on two...

journal_title：British journal of cancer

authors： Morgan J,Gray AG,Huehns ER

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents. Patients who respond poorly to chemotherapy have a higher risk of metastatic disease and 5-year survival rates of only 10-20%. Therefore, identifying molecular targets that are specific for OS, or more specifically, metasta...

journal_title：British journal of cancer

authors： Endo-Munoz L,Cumming A,Sommerville S,Dickinson I,Saunders NA

更新日期：2010-06-29 00:00:00

abstract：BACKGROUND:Recent studies have indicated the prognostic value of tumour subtype and pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). However these results were reported after a short follow-up and using a standard Cox model which could be unsatisfactory for time-dependent factors. In the prese...

journal_title：British journal of cancer

authors： Baulies S,Belin L,Mallon P,Senechal C,Pierga JY,Cottu P,Sablin MP,Sastre X,Asselain B,Rouzier R,Reyal F

更新日期：2015-06-30 00:00:00

abstract：:In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity...

journal_title：British journal of cancer

authors： Jebb SA,Osborne RJ,Maughan TS,Mohideen N,Mack P,Mort D,Shelley MD,Elia M

更新日期：1994-10-01 00:00:00

abstract：:To investigate liver cancer-associated genes and to explore the molecular basis of liver cancer genesis, we have cloned a novel hepatocellular carcinoma (HCC)-related gene with a transcript of 2520 base pairs in length named HCCA2 by mRNA differential display polymerase chain reaction (DDPCR) and screening a placenta ...

journal_title：British journal of cancer

authors： Wang ZX,Wang HY,Wu MC

更新日期：2001-10-19 00:00:00

abstract：BACKGROUND:Patients whose colorectal cancer is treated after an emergency admission tend to have late-stage cancer and a poor prognosis. We identified risk factors for an emergency admission by linking data from the National Bowel Cancer Audit (NBCA) and the English Hospital Episode Statistics (HES), an administrative ...

journal_title：British journal of cancer

authors： Wallace D,Walker K,Kuryba A,Finan P,Scott N,van der Meulen J

更新日期：2014-07-29 00:00:00

abstract：:Insulin-like growth factors (IGFs) I and II are implicated in progression of various tumours including colorectal carcinomas. To interfere with the production of IGFs, we treated male nude mice bearing xenografts of HT-29 human colon cancer with various potent growth hormone-releasing hormone (GH-RH) antagonists. Twic...

journal_title：British journal of cancer

authors： Szepeshazi K,Schally AV,Groot K,Armatis P,Halmos G,Herbert F,Szende B,Varga JL,Zarandi M

更新日期：2000-05-01 00:00:00

abstract：:The widely held belief that 2-naphthylamine is not carcinogenic for the rat has been re-examined. Twenty female Wistar rats were dosed by gastric intubation weekly for 57 weeks with 2-naphthylamine, 300 mg/kg body wt, in arachis oil and 20 controls were given arachis oil alone. Animals which became moribund were kille...

journal_title：British journal of cancer

authors： Hicks RM,Wright R,Wakefield JS

更新日期：1982-10-01 00:00:00

abstract：:Studies in animal models of mouse mammary carcinoma have shown that ovine submaxillary mucin, which carries multiple sialyl-Tn (STn) epitopes, is effective in stimulating an immune response and inhibiting tumour growth. In similar studies using carbohydrate antigens, pretreatment with low-dose cyclophosphamide has bee...

journal_title：British journal of cancer

authors： Miles DW,Towlson KE,Graham R,Reddish M,Longenecker BM,Taylor-Papadimitriou J,Rubens RD

更新日期：1996-10-01 00:00:00

abstract：:Obesity has been associated with an increased risk of renal cell cancer among women, while the evidence for men is considered weaker. We conducted a quantitative summary analysis to evaluate the existing evidence that obesity increases the risk of renal cell cancer both among men and women. We identified all studies e...

journal_title：British journal of cancer

authors： Bergström A,Hsieh CC,Lindblad P,Lu CM,Cook NR,Wolk A

更新日期：2001-09-28 00:00:00

abstract：:Effects of c-Myc overexpression on the DNA damage-induced G2/M checkpoint were studied in finite lifespan, normal human mammary epithelial cells (HMECs). Previously, we showed that c-Myc attenuates G1/S arrest and leads to an inappropriate entry of cells with damaged DNA into the S phase, following treatment with ioni...

journal_title：British journal of cancer

authors： Sheen JH,Woo JK,Dickson RB

更新日期：2003-10-20 00:00:00

abstract：:Tumorigenic mouse lung-derived type 2 cell lines have large reductions in both beta-adrenergic-stimulated cAMP production and ligand binding to beta-adrenergic receptors. These tumorigenic cells are also relatively insensitive to glucocorticoids. Because glucocorticoids regulate both beta-adrenergic receptor expressio...

journal_title：British journal of cancer

authors： Droms KA

更新日期：1996-08-01 00:00:00

abstract：:Angiotensin II, a main effector peptide in the renin-angiotensin system, acts as a growth-promoting and angiogenic factor via type 1 angiotensin II receptors (AT(1)R). We have recently demonstrated that angiotensin II enhanced tumour cell invasion and vascular endothelial growth factor (VEGF) secretion via AT1R in ova...

journal_title：British journal of cancer

authors： Ino K,Shibata K,Kajiyama H,Yamamoto E,Nagasaka T,Nawa A,Nomura S,Kikkawa F

更新日期：2006-02-27 00:00:00

abstract：:The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor. In the present study, we investigated the role of met expression on the modulation of apoptosis in colorectal tumours. The gene expressions of c-met and the anti-apoptotic bcl-2 family, including bcl-2, bcl-x(L)and bcl-w...

journal_title：British journal of cancer

authors： Kitamura S,Kondo S,Shinomura Y,Kanayama S,Miyazaki Y,Kiyohara T,Hiraoka S,Matsuzawa Y

更新日期：2000-09-01 00:00:00

abstract：:In the BUPA study, a prospective study of 22,000 men attending a screening centre in London, the mean serum cholesterol level of the 267 men who developed cancer was 6.66 mmol l-1, not significantly different from the mean level of 6.72 mmol l-1 among the 525 unaffected controls matched for age, smoking history and th...

journal_title：British journal of cancer

authors： Wald NJ,Thompson SG,Law MR,Densem JW,Bailey A

更新日期：1989-06-01 00:00:00

abstract：:The haemodynamics of the uterine arteries and myometrium were assessed using Doppler ultrasound in forty consecutive patients requiring treatment for invasive mole and choriocarcinoma. The investigations were performed prior to the commencement of chemotherapy and the subjects followed prospectively. The Doppler wavef...

journal_title：British journal of cancer

authors： Long MG,Boultbee JE,Langley R,Newlands ES,Begent RH,Bagshawe KD

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Prescribing anti-programmed death-1 (PD-1) immunotherapy for advanced melanoma is currently not restricted by any biomarker assessment. Determination of programmed death-ligand-1 (PD-L1)-expression status is technically challenging and is not mandatory, because negative tumours also achieve therapeutic respo...

journal_title：British journal of cancer

authors： Dupuis F,Lamant L,Gerard E,Torossian N,Chaltiel L,Filleron T,Beylot-Barry M,Dutriaux C,Prey S,Gros A,Jullie ML,Meyer N,Vergier B

更新日期：2018-07-01 00:00:00