Clinical, histological and molecular predictors of metastatic melanoma responses to anti-PD-1 immunotherapy.

abstract：:Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA acts in vivo by binding to a membrane receptor known as uPAR. In this study, uPA and uPAR levels were semiquantitated by immunocytochemistry in 36 primary breast carcinomas. Using monoclonal antibody HD-UK 1, uPA...

journal_title：British journal of cancer

authors： Kennedy S,Duffy MJ,Duggan C,Barnes C,Rafferty R,Kramer MD

更新日期：1998-05-01 00:00:00

abstract：:To understand the role of p53 tumour suppressor gene in the carcinogenesis of arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan, we collected tumour samples from 23 patients with Bowen's disease, seven patients with basal cell carcinomas (BCC) and nine patients with squamous cell carcinoma...

journal_title：British journal of cancer

authors： Hsu CH,Yang SA,Wang JY,Yu HS,Lin SR

更新日期：1999-06-01 00:00:00

abstract：:Both host carbogen (95% oxygen/5% carbon dioxide) breathing and nicotinamide administration enhance tumour radiotherapeutic response and are being re-evaluated in the clinic. Non-invasive magnetic resonance imaging (MRI) and 31P magnetic resonance spectroscopy (MRS) methods have been used to give information on the ef...

journal_title：British journal of cancer

authors： Robinson SP,Howe FA,Stubbs M,Griffiths JR

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, using available large transcriptomic datasets, aims to identify genes assoc...

journal_title：British journal of cancer

authors： Kurozumi S,Joseph C,Sonbul S,Alsaeed S,Kariri Y,Aljohani A,Raafat S,Alsaleem M,Ogden A,Johnston SJ,Aleskandarany MA,Fujii T,Shirabe K,Caldas C,Ashankyty I,Dalton L,Ellis IO,Desmedt C,Green AR,Mongan NP,Rakha EA

更新日期：2019-06-01 00:00:00

abstract：:This study was undertaken to investigate the intracellular induction of reactive oxygen species (ROS) by cis-dichlorodiammineplatinum (CDDP) and the augmentation of their cytotoxicity in bladder cancer cells (KU7) by enhancement of ROS generation by the glutathione (GSH) depletors buthionine sulphoximine (BSO) and die...

journal_title：British journal of cancer

authors： Miyajima A,Nakashima J,Yoshioka K,Tachibana M,Tazaki H,Murai M

更新日期：1997-01-01 00:00:00

abstract：:A total of 152 non-small cell lung cancers (NSCLC) were studied retrospectively to determine the relationship between epidermal growth factor receptor (EGF-R) status and the histological type, tumour size, nodal status and prognosis. EGF-R status was assessed on routinely embedded paraffin sections with an antibody to...

journal_title：British journal of cancer

authors： Dazzi H,Hasleton PS,Thatcher N,Barnes DM,Wilkes S,Swindell R,Lawson RA

更新日期：1989-05-01 00:00:00

abstract：:Cytologic examination of peritoneal lavage fluid is a useful predictor of peritoneal recurrence in gastric cancer. However, this technique is not overly sensitive and requires special abilities in the cytologist. In this study, telomerase activity was used to detect free cancer cells in peritoneal lavage fluid from pa...

journal_title：British journal of cancer

authors： Mori N,Oka M,Hazama S,Iizuka N,Yamamoto K,Yoshino S,Tangoku A,Noma T,Hirose K

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:To describe the prescription patterns of analgesics during the last 3 months of life in lung cancer and to determine the associated factors. METHODS:Data on lung cancer patients (N=10,202) who died during 2000-2008 were extracted from the General Practice Research Database (GPRD). This database records pres...

journal_title：British journal of cancer

authors： Gao W,Gulliford M,Higginson IJ

更新日期：2011-05-24 00:00:00

abstract：:Data obtained from multiple sources indicate that no single mechanism can explain the resistance to chemotherapy exhibited by non-small cell lung carcinomas. The multi-factorial nature of drug resistance implies that the analysis of comprising expression profiles may predict drug resistance with higher accuracy than s...

journal_title：British journal of cancer

authors： Volm M,Koomägi R,Mattern J,Efferth T

更新日期：2002-07-29 00:00:00

abstract：:The continuous cell line UCRU BL 17CL was derived from a human invasive bladder cancer and expresses elements of transitional, squamous and glandular differentiation. Nine clones of this line were established by limit dilution and have been extensively characterised. Only six of these clones grew subcutaneously in nud...

journal_title：British journal of cancer

authors： Brown JL,Russell PJ,Philips J,Wotherspoon J,Raghavan D

更新日期：1990-03-01 00:00:00

abstract：:The 5-year relative survival rates of women diagnosed with breast cancer between 1992 and 1994 were compared among the 99 Health Authorities (1999 boundaries) of England. Substantial variation, with evidence of geographical clustering was observed. Part of this variation was explained by differences in deprivation bet...

journal_title：British journal of cancer

authors： Mullee MA,De Stavola B,Romanengo M,Coleman MP

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:The amplification of epidermal growth factor receptor (EGFR) in triple negative breast carcinomas (TNBC) suggests its potential therapeutic application, as for HER-2, using standardised methods of measurement. In this regard, we aimed to compare several methods for evaluating EGFR amplification along with po...

journal_title：British journal of cancer

authors： Secq V,Villeret J,Fina F,Carmassi M,Carcopino X,Garcia S,Metellus I,Boubli L,Iovanna J,Charpin C

更新日期：2014-02-18 00:00:00

abstract：:We identified 2384 patients in the Danish Cancer Register in whom cancer had been diagnosed in 1960-1996 before they reached the age of 20 and compared them with 53 143 sex- and age-matched controls identified from the Register of Population Statistics. Complete education records and demographic and socioeconomic info...

journal_title：British journal of cancer

authors： Koch SV,Kejs AM,Engholm G,Johansen C,Schmiegelow K

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients. METHODS:The study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model...

journal_title：British journal of cancer

authors： Staff S,Aaltonen M,Huhtala H,Pylvänäinen K,Mecklin JP,Mäenpää J

更新日期：2016-07-26 00:00:00

abstract：:The trimodality approach represented by concurrent chemoradiotherapy followed by surgical resection is a highly effective, but potentially toxic therapy for locally advanced non-small-cell lung cancer (NSCLC). In this review, we discuss the current status of this therapy in patients with mediastinal node-positive (N2)...

journal_title：British journal of cancer

authors： Kunitoh H,Suzuki K

更新日期：2007-05-21 00:00:00

abstract：:Interferon-alpha (IFN-alpha) is a clinically useful cytokine for treatment of a variety of cancers, including chronic myelocytic leukaemia (CML). Most CML cells are sensitive to IFN-alpha; however, its biological effects on leukaemic cells are incompletely characterized. Here, we provide evidence that IFN-alpha induce...

journal_title：British journal of cancer

authors： Miyachi T,Adachi M,Hinoda Y,Imai K

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Numerous markers have been evaluated to facilitate the non-invasive diagnostic work-up of mesothelioma. The purpose of this study was to conduct a structured review of the diagnostic performance of non-invasive marker tests for the detection of mesothelioma in patients with suspected mesothelioma. METHODS:S...

journal_title：British journal of cancer

authors： van der Bij S,Schaake E,Koffijberg H,Burgers JA,de Mol BA,Moons KG

更新日期：2011-04-12 00:00:00

abstract：:Nine hundred and eighty-four breast cancer patients were interviewed regarding exogenous hormonal use. This represents a random sample of breast cancer patients in Southern Sweden referred to the Department of Oncology at Lund for treatment between 1978 and 1997 (excluding 1980 and 1981) with a 100% follow-up. Ever-us...

journal_title：British journal of cancer

authors： Jernström H,Frenander J,Fernö M,Olsson H

更新日期：1999-07-01 00:00:00

abstract：:The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curativ...

journal_title：British journal of cancer

authors： Cooper R,Sarioğlu S,Sökmen S,Füzün M,Küpelioğlu A,Valentine H,Görken IB,Airley R,West C

更新日期：2003-09-01 00:00:00

abstract：:In this study, we aimed to analyse human cancer cell-platelet interactions in functional cell analyses and explore the molecular mechanisms behind tumour progression. Various functional analyses of gastric cancer (GC) cells were performed after direct/indirect co-incubation with platelets derived from GC patients. Fur...

journal_title：British journal of cancer

authors： Saito R,Shoda K,Maruyama S,Yamamoto A,Takiguchi K,Furuya S,Hosomura N,Akaike H,Kawaguchi Y,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Suzuki-Inoue K,Ichikawa D

更新日期：2020-10-28 00:00:00

abstract：:In addition to new tumour antigens, new prognostic and diagnostic markers are needed for common cancers. In this study, we report the expression of Dickkopf-1 (DKK1) in multiple common cancers. This constitutes a comprehensive analysis of the DKK1 expression profile. Dickkopf-1 expression was evaluated by classical an...

journal_title：British journal of cancer

authors： Forget MA,Turcotte S,Beauseigle D,Godin-Ethier J,Pelletier S,Martin J,Tanguay S,Lapointe R

更新日期：2007-02-26 00:00:00

abstract：:Gallium-67 is a radionuclide that accumulates in haematological malignancies and is used for diagnostic purposes. Uptake of 67Ga into the cell occurs via the transferrin receptor, which is differentially expressed during the various cell cycle phases. With the aim of selectively increasing 67Ga uptake, we studied whet...

journal_title：British journal of cancer

authors： van Leeuwen-Stok AE,Schuurhuis GJ,Dräger AM,Visser-Platier AW,Teule GJ,Huijgens PC

更新日期：1996-08-01 00:00:00

abstract：:The important role of the p53 gene in tumour progression and cellular response to DNA damage has prompted investigation of the clinical significance of alterations to this gene. We examined both p53 overexpression and mutation of the gene in endometrial carcinoma in order to evaluate the prognostic significance of the...

journal_title：British journal of cancer

authors： Soong R,Knowles S,Williams KE,Hammond IG,Wysocki SJ,Iacopetta BJ

更新日期：1996-08-01 00:00:00

abstract：:Recent evidence has demonstrated that endothelial-to-mesenchymal transition (EndMT) may have a significant role in a number of diseases. Although EndMT has been previously studied as a critical process in heart development, it is now clear that EndMT can also occur postnatally in various pathologic settings, including...

journal_title：British journal of cancer

authors： Potenta S,Zeisberg E,Kalluri R

更新日期：2008-11-04 00:00:00

abstract：:Nerve growth factor (NGF) administration to athymic mice with transplanted human bromocriptine-resistant prolactinoma, results in the expression of dopamine D-2 receptors in the tumour and restores sensitivity to subsequent treatment with bromocriptine, which then produces normalisation of plasma prolactin and tumour ...

journal_title：British journal of cancer

authors： Missale C,Losa M,Boroni F,Giovanelli M,Balsari A,Spano PF

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Elderly cancer patients form a heterogeneous population in which therapeutic decision-making is often difficult. The aim of this randomised phase II trial was to evaluate the feasibility and activity of weekly docetaxel/gemcitabine (DG) followed by erlotinib after progression (arm A) vs erlotinib followed by...

journal_title：British journal of cancer

authors： LeCaer H,Barlesi F,Corre R,Jullian H,Bota S,Falchero L,Vergnenegre A,Dujon C,Delhoume JY,Chouaid C,GFPC 0504 Team.

更新日期：2011-10-11 00:00:00

abstract：:BW12C (5-[2-formyl-3-hydroxypenoxyl] pentanoic acid) is an agent which stabilises oxyhaemoglobin and thus reduces oxygen delivery to tissues. It is of interest as a possible potentiator of bioreductive agents and/or hyperthermia. The increases in radiobiological hypoxic fraction of RIF-1 and KHT tumours 30 min after 7...

journal_title：British journal of cancer

authors： Honess DJ,Hu DE,Bleehen NM

更新日期：1991-10-01 00:00:00

abstract：:We studied 5555 seminoma patients and 3733 patients with nonseminomatous testicular cancers diagnosed in Southeast England between 1960 and 2004. For both groups survival improved over time: 10-year relative survival increased from 78% in 1960-1969 to 99% in 1990-2004 for seminomas, and from 55 to 95% for nonseminomas...

journal_title：British journal of cancer

authors： Robinson D,Møller H,Horwich A

更新日期：2007-02-12 00:00:00

abstract：BACKGROUND:Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence. METHODS:Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 ccRCC patients. Paired t-test was used for tumour-normal comp...

journal_title：British journal of cancer

authors： Shu X,Hildebrandt MA,Gu J,Tannir NM,Matin SF,Karam JA,Wood CG,Wu X

更新日期：2017-01-03 00:00:00

abstract：:The prognostic value of C-reactive protein, compared with ECOG performance status (ECOG-ps), in patients receiving alpha-interferon treatment for advanced renal cancer was assessed in 58 patients. In all, 55 patients died on follow-up. On multivariate analysis with ECOG-ps and C-reactive protein entered as covariates,...

journal_title：British journal of cancer

authors： Bromwich E,McMillan DC,Lamb GW,Vasey PA,Aitchison M

更新日期：2004-10-04 00:00:00