Abstract：
:BW12C (5-[2-formyl-3-hydroxypenoxyl] pentanoic acid) is an agent which stabilises oxyhaemoglobin and thus reduces oxygen delivery to tissues. It is of interest as a possible potentiator of bioreductive agents and/or hyperthermia. The increases in radiobiological hypoxic fraction of RIF-1 and KHT tumours 30 min after 70 mg kg-1 BW12C i.v. were measured and shown to be similar; factors (+/- 2 s.e.) ranged from 3.87 (2.84-5.29) to 5.92 (1.92-18.2) despite the large variation in initial hypoxic fraction, from 0.30 (0.18-0.50) % for RIF-1 intramuscularly in the leg to 16.3 (14.7-18.1) % for subcutaneous KHT flank tumours. Thermosensitivity of intramuscular KHT leg tumours was not enhanced by 70 mg kg-1 BW12C 30 min before heating at 43 degrees C, 43.5 degrees C or 44 degrees C, assayed by regrowth delay. The effect of 70 mg kg-1 BW12C on relative tissue perfusion (RTP), assayed by 86Rb extraction, was measured from 0.5 h to 6 h after treatment. After 1 h RTP (+/- 2 s.e.) in RIF-1 tumours was reduced to 84 +/- 5.7% and 68 +/- 9.6% of control in leg and flank tumours respectively, and to 86 +/- 6.4% in leg muscle while flank skin RTP was unaltered at 109 +/- 8.6%. There were substantial increases in kidney (149 +/- 10.7%) spleen (173 +/- 22.1%) and lung (128 +/- 10.4%) at 1 h but in liver there was a decrease at 2 h to 85 +/- 8.4%. Dose response studies showed that the threshold dose for reduction of tumour RTP is between 55 and 70 mg kg-1, but perturbations in normal tissue RTP occur at lower doses, e.g. 40 mg kg-1 for spleen. BW12C had minimal effects on renal function measured by 51CrEDTA clearance. The data as a whole indicate that reduction in tumour perfusion is likely to be an important determinant in the increase in tumour hypoxia induced by BW12C.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Honess DJ,Hu DE,Bleehen NMdoi
10.1038/bjc.1991.387subject
Has Abstractpub_date
1991-10-01 00:00:00pages
715-22issue
4eissn
0007-0920issn
1532-1827journal_volume
64pub_type
杂志文章abstract：:A bispecific monoclonal antibody recognising both carcinoembryonic antigen (CEA) and ricin toxin A chain (RTA) was tested for its ability to target recombinant RTA (r-RTA) to CEA-expressing tumour cells, alone and in combination with ricin B chain (RTB). The antibody, 636 (Robins et al., 1990), induced significant RTA...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.153
更新日期：1991-05-01 00:00:00
abstract：:The 5T4 oncofetal antigen is a 72 kDa glycoprotein defined by a monoclonal antibody raised against human placental trophoblast and is expressed in many different carcinomas but detected only at low levels in some normal epithelia. Immunohistochemical analysis of the patterns of expression in colorectal carcinomas has ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.173
更新日期：1994-05-01 00:00:00
abstract：:Survival and proliferation of cell cultures from human anaplastic astrocytomas were shown to be enhanced by glucocorticoids with an optimal concentration of approximately 2.5 x 10(-5)M (10 micrograms/ml). The stimulation of proliferation was only observed in a clonal growth assay and was reversed as the size of indivi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.161
更新日期：1980-06-01 00:00:00
abstract：:We assessed the association of postmenopausal serum levels of oestrogens and sex hormone-binding globulin (SHBG) with endometrial cancer risk in a case-control study nested within the NYU Women's Health Study cohort. Among 7054 women postmenopausal at enrolment, 57 cases of endometrial cancer were diagnosed a median o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1704
更新日期：2001-04-06 00:00:00
abstract：:Several substances mark the course of lung cancer and may reliably help the clinician in decision-making. This is the first clinical study specifically designed to compare tissue polypeptide antigen and CA 125 tumour associated antigen. Three hundred and eighty-four new lung cancer patients (309 males) were studied at...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600577
更新日期：2002-11-04 00:00:00
abstract：:Tamoxifen is the current therapy of choice for patients with oestrogen receptor positive breast cancer, and it is currently under evaluation as a prophylactic for women at high risk of developing the disease. However, tamoxifen is also known to induce proliferative changes in the endometrium increasing the risk of dev...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600157
更新日期：2002-03-04 00:00:00
abstract：BACKGROUND:The current analysis was performed to evaluate the impact of PIK3CA hotspot mutations on everolimus efficacy in BOLERO-2 participants, using cell-free DNA (cfDNA) from plasma samples collected at the time of patient randomisation. METHODS:PIK3CA H1047R, E545K, and E542K mutations in plasma-derived cfDNA wer...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2017.25
更新日期：2017-03-14 00:00:00
abstract：:Both host carbogen (95% oxygen/5% carbon dioxide) breathing and nicotinamide administration enhance tumour radiotherapeutic response and are being re-evaluated in the clinic. Non-invasive magnetic resonance imaging (MRI) and 31P magnetic resonance spectroscopy (MRS) methods have been used to give information on the ef...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1144
更新日期：2000-06-01 00:00:00
abstract：:Temozolomide is an oral alkylating agent that readily crosses the blood-brain barrier and has activity in patients with advanced melanoma. Carboplatin is a convenient outpatient treatment that also has activity in patients with melanoma. The purpose of this study was to assess the safety of a combination of temozolomi...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601414
更新日期：2003-11-17 00:00:00
abstract：:Many theories mention hypersensitive, promiscuous, outlaw or bypass signalling pathways to explain the acquisition of hormone independence in prostate cancer. Hormonal escape of prostate tumours is marked by many biological changes, including mucinous and neuroendocrine differentiation. Since expression of several muc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601570
更新日期：2004-02-09 00:00:00
abstract：:It has been postulated that paternal gonadal exposure would increase the sex ratio by inducing X-chromosomal dominant lethals but that maternal gonadal exposure would decrease the sex ratio by inducing recessive sex-linked lethals. We therefore evaluated the sex ratio (male-to-female ratio) of children born to survivo...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600748
更新日期：2003-02-10 00:00:00
abstract：:Metallothioneins are ubiquitous low molecular weight proteins characterised by high cysteine content and affinity for binding heavy metals. Abnormal metallothionein function and expression have been implicated in various disease states, including neoplasia. The aim of this study was to investigate metallothionein expr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.443
更新日期：1995-10-01 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is overexpressed in several epithelial tumours, including breast cancer. Cyclooxygenase-2-positive tumours tend to be larger, higher grade, node-positive and HER-2/neu-positive. High COX-2 expression is associated with poor prognosis. Cyclooxygenase-2 inhibition reduces the incidence of tumour...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6602690
更新日期：2005-08-01 00:00:00
abstract：:Tumour-associated cell-surface glycoprotein is associated with tumour progression in gastric cancer. We investigated the biological significance of tumour-associated cell-surface glycoprotein, determined by the binding of Helix pomatia agglutinin (HPA), with regard to survival time and to the malignant potential of ca...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.192
更新日期：1995-05-01 00:00:00
abstract：:Hepatocyte growth factor (HGF), through Met receptor binding, fulfils numerous functions in invasive tumour growth (survival/proliferation, motility, apoptosis), but epigenetic control of gene expression in this process is poorly understood. In HGF-treated breast cancer cells we studied (a) the chemoinvasion towards C...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604726
更新日期：2008-11-18 00:00:00
abstract：:This randomised trial compared platinum-based to anthracycline-based chemotherapy in patients with small-cell lung cancer (limited or extensive stage) and journal_title：British journal of cancer pub_type： 杂志文章,随机对照试验 doi：10.1038/sj.bjc.6604480 更新日期：2008-08-05 00:00:00
abstract：:Between 1980 and 1985, 914 patients with head and neck squamous cell carcinoma underwent lymph node dissection in our institution. The prognostic value of clinical factors has already been reported (Mamelle et al, 1994, Am J Surg 168: 494-498). We present here a comparison of biological characteristics of pharyngeal t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.320
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:Eukaryotic translation elongation factor 1A2 (eEF1A2) is a known proto-oncogene. We proposed that stimulation of the eEF1A2 expression in cancer tissues is caused by the loss of miRNA-mediated control. METHODS:Impact of miRNAs on eEF1A2 at the mRNA and protein levels was examined by qPCR and western blot, r...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.243
更新日期：2013-06-11 00:00:00
abstract：BACKGROUND:The target substrates of DNA mismatch recognising factors MutSalpha (MSH2+MSH6) and MutSbeta (MSH2+MSH3) have already been widely researched. However, the extent of their functional redundancy and clinical substance remains unclear. Mismatch repair (MMR)-deficient tumours are strongly associated with microsa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605531
更新日期：2010-03-16 00:00:00
abstract：:Carcinoembryonic antigen-like substances in the urine of patients with bladder carcinoma and of healthy male subjects occur in a wide range of average molecular sizes. Some of these substances are glycoproteins giving reactions of antigenic identity with carcinoembryonic antigen (CEA) derived from colorectal carcinoma...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.93
更新日期：1974-06-01 00:00:00
abstract：:In the UK, 10% of patients diagnosed with rectal cancer have inoperable disease at presentation. This study ascertained whether the resectability rate of inoperable locally advanced rectal cancer was improved by administration of intravenous irinotecan, 5-fluorouracil (5-FU) and pelvic radiotherapy. During phase I of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604292
更新日期：2008-04-08 00:00:00
abstract：:Prostate cancer is the second leading cause of male death from malignant disease in Europe and in the USA. Failure to prevent or eliminate metastatic dissemination is a fundamental problem underlying the current inadequate treatment of prostate cancer, and novel therapeutic strategies are required if this disease is t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.45
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Focal adhesion kinase (FAK) is overexpressed in a variety of cancers, such as breast, colon, prostate, ovary, and lung cancers. However, the mechanism by which extracellular matrix fibronectin stimulates lung cancer cell migration and invasion through FAK remains to be investigated. METHODS:The signalling p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605154
更新日期：2009-07-21 00:00:00
abstract：:Previous studies have reported the clinical usefulness of reverse transcription-polymerase chain reaction (RT-PCR) detection of thyroglobulin (TG) mRNA in the peripheral blood of patients with differentiated thyroid carcinoma. To evaluate this usefulness, we measured TG mRNA in the peripheral blood of patients diagnos...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1904
更新日期：2001-07-06 00:00:00
abstract：:Monocyte-macrophage series have an important role in host surveillance against cancer. The cytotoxic/cytostatic activity of macrophages is, to a great extent, attributed to the up-regulation of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO). Here, in 28 patients with primary lung cancer and...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.528
更新日期：1998-08-01 00:00:00
abstract：:A previous publication (Leith et al., 1992) showed that administration of basic fibroblast growth factor (FGF-2, 0.25 mg kg-1, q.i.d. x 7) to mice bearing xenografted DLD-2 human colon cancers would increase treated tumour growth rates as compared to control neoplasms. Additionally, at the end of the 7 day treatment p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.418
更新日期：1993-10-01 00:00:00
abstract：:Raised risks of several cancers have been found in patients with type II diabetes, but there are few data on cancer risk in type I diabetes. We conducted a cohort study of 28 900 UK patients with insulin-treated diabetes followed for 520 517 person-years, and compared their cancer incidence and mortality with national...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602611
更新日期：2005-06-06 00:00:00
abstract：BACKGROUND:The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy. METHODS:A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chron...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0288-2
更新日期：2018-10-01 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) gene mutations and increased copy numbers are considered as predictors of response to EGFR tyrosine kinase inhibitors (EGFR-TKI) in non-small-cell lung cancer (NSCLC). Lung cancer diagnosis is often based on cytology alone. However, almost all published data on EGFR gene analyse...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604142
更新日期：2008-01-15 00:00:00
abstract：:Recent studies indicate that cancer antigen 125 (CA125) response criteria tend to overestimate a tumour reduction measured by standard WHO response criteria in recurrent epithelial ovarian carcinoma. The aim of the study was to validate the recently introduced GCIG (The Gynaecological Cancer Intergroup) CA125 response...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601501
更新日期：2004-01-26 00:00:00
