Abstract：
BACKGROUND:Cancer survival statistics are typically reported by using measures discounting the impact of other-cause mortality, such as net survival. This is a hypothetical measure and is interpreted as excluding the possibility of cancer patients dying from other causes. Crude probability of death partitions the all-cause probability of death into deaths from cancer and other causes. METHODS:The National Cancer Registration and Analysis Service is the single cancer registry for England. In 2006-2015, 1,590,477 malignant tumours were diagnosed for breast, colorectal, lung, melanoma and prostate cancer in adults. We used a relative survival framework, with a period approach, providing estimates for up to 10-year survival. Mortality was partitioned into deaths due to cancer or other causes. Unconditional and conditional (on surviving 1-years and 5-years) crude probability of death were estimated for the five cancers. RESULTS:Elderly patients who survived for a longer period before dying were more likely to die from other causes of death (except for lung cancer). For younger patients, deaths were almost entirely due to the cancer. CONCLUSION:There are different measures of survival, each with their own strengths and limitations. Careful choices of survival measures are needed for specific scenarios to maximise the understanding of the data.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Wong KF,Lambert PC,Mozumder SI,Broggio J,Rutherford MJdoi
10.1038/s41416-019-0597-0subject
Has Abstractpub_date
2019-11-01 00:00:00pages
883-889issue
10eissn
0007-0920issn
1532-1827pii
10.1038/s41416-019-0597-0journal_volume
121pub_type
杂志文章abstract：:Mechanisms of resistance to Tomudex include increased thymidylate synthase activity, as well as reduced intracellular drug uptake and polyglutamation. However, little is known about other mechanisms of resistance, such as a possible protection against Tomudex-induced apoptosis mediated by bcl-2. We transfected the MDA...
journal_title：British journal of cancer
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journal_title：British journal of cancer
pub_type： 杂志文章
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doi：10.1038/bjc.1992.269
更新日期：1992-08-01 00:00:00
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journal_title：British journal of cancer
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doi：10.1038/bjc.1997.242
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journal_title：British journal of cancer
pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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journal_title：British journal of cancer
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1038/bjc.2013.585
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.151
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pub_type： 杂志文章
doi：10.1038/s41416-018-0030-0
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doi：10.1038/bjc.2012.525
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doi：10.1038/sj.bjc.6602460
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.549
更新日期：1998-09-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.216
更新日期：1974-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6605731
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pub_type： 临床试验,杂志文章
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doi：10.1038/bjc.1995.478
更新日期：1995-11-01 00:00:00
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更新日期：2009-12-15 00:00:00
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更新日期：2011-01-18 00:00:00
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pub_type： 杂志文章
doi：10.1054/bjoc.2001.1813
更新日期：2001-06-15 00:00:00
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更新日期：2015-09-29 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2012-02-14 00:00:00
abstract：:The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor. In the present study, we investigated the role of met expression on the modulation of apoptosis in colorectal tumours. The gene expressions of c-met and the anti-apoptotic bcl-2 family, including bcl-2, bcl-x(L)and bcl-w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1301
更新日期：2000-09-01 00:00:00
