当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).

Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).

Abstract：

:P450 reductase (NADPH:cytochrome P450 reductase, EC 1.6.2.4) is known to be important in the reductive activation of the benzotriazene-di-N-oxide tirapazamine (SR 4233). Using a panel of six human breast adenocarcinoma cell lines we have examined the relationship between P450 reductase activity and sensitivity to tirapazamine. The toxicity of tirapazamine was found to correlate strongly with P450 reductase activity following an acute (3 h) exposure under hypoxic conditions, the drug being most toxic in the cell lines with the highest P450 reductase activity. A similar correlation was also observed following a chronic (96 h) exposure to the drug in air but not following acute (3 h) exposure in air. We have also determined the ability of lysates prepared from the cell lines to metabolise tirapazamine to its two-electron reduced product, SR 4317, under hypoxic conditions using NADPH as an electron donor. The rate of SR 4317 formation was found to correlate both with P450 reductase activity and with sensitivity to tirapazamine, the highest rates of SR 4317 formation being associated with the highest levels of P450 reductase activity and the greatest sensitivity to the drug. These findings indicate a major role for P450 reductase in determining the hypoxic toxicity of tirapazamine in breast tumour cell lines.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Patterson AV,Barham HM,Chinje EC,Adams GE,Harris AL,Stratford IJ

doi

10.1038/bjc.1995.478

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

1144-50

issue

5

eissn

0007-0920

issn

1532-1827

journal_volume

72

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Prospective surveillance of women with a family history of breast cancer: auditing the risk threshold.

    abstract：:To evaluate current guidelines criteria for inclusion of women in special 'breast cancer family history' surveillance programmes, records were reviewed of women referred to Scottish breast cancer family clinics between January 1994 and December 2003 but discharged as at 'less than 'moderate' familial risk'. The Scotti...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/sj.bjc.6604155

    authors： Anderson E,Berg J,Black R,Bradshaw N,Campbell J,Carnaghan H,Cetnarkyj R,Drummond S,Davidson R,Dunlop J,Fordyce A,Gibbons B,Goudie D,Gregory H,Holloway S,Longmuir M,McLeish L,Murday V,Miedzybrodska Z,Nicholson D,Pe

    更新日期：2008-02-26 00:00:00

  • Familial aggregation of lung cancer in a high incidence area in China.

    abstract：:To investigate whether lung cancer clusters in families in a high incidence county of China, an analysis was conducted using data on domestic fuel history and tobacco use for family members of 740 deceased lung cancer probands and 740 controls (probands' spouses). Lung cancer prevalence was compared among first-degree...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602465

    authors： Jin YT,Xu YC,Yang RD,Huang CF,Xu CW,He XZ

    更新日期：2005-04-11 00:00:00

  • Inhibition of cell-cycle progression by acute treatment with various degrees of hypoxia: modifications induced by low concentrations of misonidazole present during hypoxia.

    abstract：:The effect on cell-cycle progression in various phases of the cell cycle caused by an acute exposure to hypoxia in absence and presence of misonidazole (MISO) was investigated. Exponentially growing and synchronized cells of the human line NHIK 3025 were exposed to different degrees of hypoxia for a short period (1.5 ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1983.271

    authors： Pettersen EO,Lindmo T

    更新日期：1983-12-01 00:00:00

  • Relationships between CYP2D6 phenotype, breast cancer and hot flushes in women at high risk of breast cancer receiving prophylactic tamoxifen: results from the IBIS-I trial.

    abstract：BACKGROUND:Several studies have reported discordant results regarding the impact of the CYP2D6 phenotype on both the effectiveness and the degree of endocrine symptoms associated with tamoxifen. Other studies have suggested that menopausal symptoms may be a predictive factor to tamoxifen response. METHODS:We investiga...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2012.278

    authors： Sestak I,Kealy R,Nikoloff M,Fontecha M,Forbes JF,Howell A,Cuzick J

    更新日期：2012-07-10 00:00:00

  • Selecting first-line bevacizumab-containing therapy for advanced breast cancer: TURANDOT risk factor analyses.

    abstract：BACKGROUND:The randomised phase III TURANDOT trial compared first-line bevacizumab-paclitaxel (BEV-PAC) vs bevacizumab-capecitabine (BEV-CAP) in HER2-negative locally recurrent/metastatic breast cancer (LR/mBC). The interim analysis revealed no difference in overall survival (OS; primary end point) between treatment ar...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2014.504

    authors： Brodowicz T,Lang I,Kahan Z,Greil R,Beslija S,Stemmer SM,Kaufman B,Petruzelka L,Eniu A,Anghel R,Koynov K,Vrbanec D,Pienkowski T,Melichar B,Spanik S,Ahlers S,Messinger D,Inbar MJ,Zielinski C

    更新日期：2014-11-25 00:00:00

  • Photochemical internalisation of chemotherapy potentiates killing of multidrug-resistant breast and bladder cancer cells.

    abstract：:Multidrug resistance (MDR) is the major confounding factor in adjuvant solid tumour chemotherapy. Increasing intracellular amounts of chemotherapeutics to circumvent MDR may be achieved by a novel delivery method, photochemical internalisation (PCI). PCI consists of the co-administration of drug and photosensitiser; u...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603895

    authors： Adigbli DK,Wilson DG,Farooqui N,Sousi E,Risley P,Taylor I,Macrobert AJ,Loizidou M

    更新日期：2007-08-20 00:00:00

  • The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types.

    abstract：:In addition to new tumour antigens, new prognostic and diagnostic markers are needed for common cancers. In this study, we report the expression of Dickkopf-1 (DKK1) in multiple common cancers. This constitutes a comprehensive analysis of the DKK1 expression profile. Dickkopf-1 expression was evaluated by classical an...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603579

    authors： Forget MA,Turcotte S,Beauseigle D,Godin-Ethier J,Pelletier S,Martin J,Tanguay S,Lapointe R

    更新日期：2007-02-26 00:00:00

  • The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium and endothelium.

    abstract：:Tumour angiogenesis is a complex multistep process regulated by a number of angiogenic factors. One such factor, platelet-derived endothelial cell growth factor has recently been shown to be thymidine phosphorylase (TP). TP catalyses the reversible phosphorylation of thymidine to deoxyribose-1-phosphate and thymine. A...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.49

    authors： Fox SB,Westwood M,Moghaddam A,Comley M,Turley H,Whitehouse RM,Bicknell R,Gatter KC,Harris AL

    更新日期：1996-02-01 00:00:00

  • Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer.

    abstract：BACKGROUND:Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in earlier stages of CR...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.489

    authors： Snoeren N,Emmink BL,Koerkamp MJ,van Hooff SR,Goos JA,van Houdt WJ,de Wit M,Prins AM,Piersma SR,Pham TV,Belt EJ,Bril H,Stockmann HB,Meijer GA,van Hillegersberg R,Holstege FC,Jimenez CR,Fijneman RJ,Kranenburg OW,Rinke

    更新日期：2013-09-17 00:00:00

  • Galectin-3 immunodetection in follicular thyroid neoplasms: a prospective study on fine-needle aspiration samples.

    abstract：:Fine-needle aspiration cytology, which is well established to be accurate for the diagnosis of thyroid cancer, may be inconclusive for the follicular thyroid neoplasms. As galectin-3 was suggested to be a marker of malignant thyrocytes, we investigated whether this protein might be helpful in the diagnosis of aspirate...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6602822

    authors： Collet JF,Hurbain I,Prengel C,Utzmann O,Scetbon F,Bernaudin JF,Fajac A

    更新日期：2005-11-14 00:00:00

  • Multiple gene expression analysis reveals distinct differences between G2 and G3 stage breast cancers, and correlations of PKC eta with MDR1, MRP and LRP gene expression.

    abstract：:A possible link between protein kinase C (PKC) and P-glycoprotein (P-gp)-mediated-multidrug resistance (MDR) was assumed from studies on MDR cell lines selected in vitro. The functional relevance of PKC for the MDR phenotype remains unclear, and the involvement of a particular PKC isozyme in clinically occurring drug ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.13

    authors： Beck J,Bohnet B,Brügger D,Bader P,Dietl J,Scheper RJ,Kandolf R,Liu C,Niethammer D,Gekeler V

    更新日期：1998-01-01 00:00:00

  • Enhancement of drug sensitivity of human malignancies by epidermal growth factor.

    abstract：:We have previously shown that epidermal growth factor (EGF) enhances the in vitro and in vivo sensitivity of human ovarian carcinoma 2008 cells to cisplatin. EGF was found to enhance selectively the in vivo toxicity of cisplatin to 2008 cell xenografts without altering the toxicity of cisplatin to non-malignant target...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.382

    authors： Kröning R,Jones JA,Hom DK,Chuang CC,Sanga R,Los G,Howell SB,Christen RD

    更新日期：1995-09-01 00:00:00

  • N-methylformamide induces changes on adhesive properties and lung-colonizing potential of M14 melanoma cells.

    abstract：:We have studied whether N-methylformamide can affect the expression pattern of adhesion molecules and the attachment behaviour of M14 human melanoma cells. The role of N-methylformamide on experimental and spontaneous pulmonary metastases from M14 cells in nude mice was also investigated. We demonstrate that N-methylf...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.35

    authors： Del Bufalo D,Leonetti C,Bucci B,Amedeo C,Falcioni R,Biroccio A,Zupi G

    更新日期：1998-01-01 00:00:00

  • Identification of two contiguous minimally deleted regions on chromosome 1p36.31-p36.32 in oligodendroglial tumours.

    abstract：:Loss of the short arm of chromosome 1 is a hallmark of oligodendroglial tumours (OTs). Deletion mapping studies in OTs have revealed multiple commonly deleted regions on chromosome 1p, suggesting that there are more than one tumour suppressor gene. To map critical deletion regions on 1p, a series of 25 OTs were examin...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602093

    authors： Dong Z,Pang JS,Ng MH,Poon WS,Zhou L,Ng HK

    更新日期：2004-09-13 00:00:00

  • Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies.

    abstract：:There is increasing evidence of a systemic inflammatory response associated with malignancy, which may have an impact on both drug disposition and resistance to cytotoxic therapy. The impact of inflammation on drug disposition was studied in mice bearing a number of common tumour xenografts. C57BL/6 mice were inoculat...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604101

    authors： Sharma R,Kacevska M,London R,Clarke SJ,Liddle C,Robertson G

    更新日期：2008-01-15 00:00:00

  • A quantitative morphological analysis of the response of a transplantable rat fibrosarcoma to cyclophosphamide.

    abstract：:The response of a transplantable rat fibrosarcoma, RIB(5), to a single injection of 100 mg/kg body weight of cyclophosphamide, 0·5, 1, 2 and 3 days after treatment, has been studied by means of a morphometric analysis of tumour sections and has been compared to the changes occurring in untreated tumours. The results s...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1973.9

    authors： Peel S,Cowen DM

    更新日期：1973-01-01 00:00:00

  • Chemoradiotherapy with extended nodal irradiation and/or erlotinib in locally advanced oesophageal squamous cell cancer: long-term update of a randomised phase 3 trial.

    abstract：BACKGROUND:To report the long-term outcomes of a phase III trial designed to test two hypotheses: (1) elective nodal irradiation (ENI) is superior to conventional field irradiation (CFI), and (2) chemoradiotherapy plus erlotinib is superior to chemoradiotherapy in locally advanced oesophageal squamous cell cancer (ESCC...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-01054-6

    authors： Xie C,Jing Z,Luo H,Jiang W,Ma L,Hu W,Zheng A,Li D,Ding L,Zhang H,Xie C,Lian X,Du D,Chen M,Bian X,Tan B,Xia B,Xie R,Liu Q,Wang L,Wu S

    更新日期：2020-11-01 00:00:00

  • Long-term results of screening with magnetic resonance imaging in women with BRCA mutations.

    abstract：BACKGROUND:The addition of breast magnetic resonance imaging (MRI) to screening mammography for women with BRCA mutations significantly increases sensitivity, but there is little data on clinical outcomes. We report screening performance, cancer stage, distant recurrence rate, and breast cancer-specific mortality in ou...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.204

    authors： Passaperuma K,Warner E,Causer PA,Hill KA,Messner S,Wong JW,Jong RA,Wright FC,Yaffe MJ,Ramsay EA,Balasingham S,Verity L,Eisen A,Curpen B,Shumak R,Plewes DB,Narod SA

    更新日期：2012-06-26 00:00:00

  • Periodate-treated, non-anticoagulant heparin-carrying polystyrene (NAC-HCPS) affects angiogenesis and inhibits subcutaneous induced tumour growth and metastasis to the lung.

    abstract：:Periodate-treated, non-anticoagulant heparin-carrying polystyrene consists of about ten periodate-oxidized, alkaline-degraded low molecular weight-heparin chains linked to a polystyrene core and has a markedly lower anti-coagulant activity than heparin. In this study, we evaluated the effect of non-anticoagulant hepar...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600307

    authors： Ono K,Ishihara M,Ishikawa K,Ozeki Y,Deguchi H,Sato M,Hashimoto H,Saito Y,Yura H,Kurita A,Maehara T

    更新日期：2002-06-05 00:00:00

  • The detectability of breast cancer by screening mammography.

    abstract：:We reviewed 134 patients with breast cancer (screen detected = 85, interval = 49) who had been reported as negative at previous mammographic screening in the Florence District Programme. At prior mammograms review, 12% of the cases were classified as 'screening error' (suspicious signs missed owing to misperception or...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.67

    authors： Ciatto S,Rosselli Del Turco M,Zappa M

    更新日期：1995-02-01 00:00:00

  • Stimulation of the apoptotic response as a basis for the therapeutic synergism of lonidamine and cisplatin in combination in human tumour xenografts.

    abstract：:The pharmacological interest in lonidamine is related to its ability to enhance the cytotoxic effects of several DNA-damaging anti-tumour agents. This study was undertaken to better understand the in vivo interaction between lonidamine and cisplatin in the treatment of human tumour xenografts, including three carcinom...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.69

    authors： De Cesare M,Pratesi G,Giusti A,Polizzi D,Zunino F

    更新日期：1998-01-01 00:00:00

  • The mechanisms of action of the carcinogenic nitroso and related compounds.

    abstract：:It is suggested that the proximate carcinogenic forms of dialkylnitrosamines are their oxidation products, which retain the alkylnitrosamino moiety, but have acquired a carbonyl function as a result of omega or beta oxidation of an alkyl group. Such metabolites resemble the locally acting carcinogenic "nitrosamides" a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1973.169

    authors： Schoental R

    更新日期：1973-11-01 00:00:00

  • The antileukaemic activity of 5-Aza-2 deoxycytidine (Aza-dC) in patients with relapsed and resistant leukaemia.

    abstract：:In the present study we demonstrate that Aza-dC in combination with Amsacrine has major antileukaemic properties in patients who have not already received extensive Ara-C therapy. Eight out of 11 patients in their first relapse of acute leukaemia achieved complete remission. Cross resistance between Ara-C and Aza-dC w...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1991.258

    authors： Richel DJ,Colly LP,Kluin-Nelemans JC,Willemze R

    更新日期：1991-07-01 00:00:00

  • Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells.

    abstract：:Cimetidine has been shown to have beneficial effects in colorectal cancer patients. In this study, a total of 64 colorectal cancer patients who received curative operation were examined for the effects of cimetidine treatment on survival and recurrence. The cimetidine group was given 800 mg day(-1) of cimetidine orall...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1038/sj.bjc.6600048

    authors： Matsumoto S,Imaeda Y,Umemoto S,Kobayashi K,Suzuki H,Okamoto T

    更新日期：2002-01-21 00:00:00

  • Updated investigations of cancer excesses in individuals born or resident in the vicinity of Sellafield and Dounreay.

    abstract：BACKGROUND:Earlier studies have shown raised risks of leukaemia and non-Hodgkin lymphoma in children, teenagers and young adults resident either at birth or diagnosis in Seascale. Some increases in cancer risk in these age groups have also been noted among those living around Dounreay. We aimed to update previous analy...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.357

    authors： Bunch KJ,Vincent TJ,Black RJ,Pearce MS,McNally RJ,McKinney PA,Parker L,Craft AW,Murphy MF

    更新日期：2014-10-28 00:00:00

  • A new monoclonal antibody (A46-B/B10) highly specific for the blood group H type 2 epitope: generation, epitope analysis, serological and histological evaluation.

    abstract：:A monoclonal antibody recognizing the blood group H type 2 antigen has been obtained from a BALB/c mouse immunized with MCF-7 (human mammary carcinoma) cells. The specificity of this antibody (A46-B/B10, IgM, kappa) has been identified by haemagglutination tests, immunohistochemistry, binding inhibition studies, and a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1988.187

    authors： Karsten U,Pilgrim G,Hanisch FG,Uhlenbruck G,Kasper M,Stosiek P,Papsdorf G,Pasternak G

    更新日期：1988-08-01 00:00:00

  • Independent prognostic significance of cell cycle regulator proteins p16(INK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: a translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaek

    abstract：:The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas. We performed immunohistochemical analysis of p16(INK4a) and pRb expression and correlated with survival in a series of 300 patients w...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/sj.bjc.6603531

    authors： Kommoss S,du Bois A,Ridder R,Trunk MJ,Schmidt D,Pfisterer J,Kommoss F,AGO-OVAR.

    更新日期：2007-01-29 00:00:00

  • HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer.

    abstract：:Interactions between immune and malignant cells have been known to have clinical relevance for decades. The potential for immune control is now being therapeutically enhanced with checkpoint inhibitors and other novel agents to improve outcomes in cancer. The importance of the immune infiltrate as a prognostic marker ...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2017.220

    authors： Barnes TA,Amir E

    更新日期：2017-08-08 00:00:00

  • Suppression of proline-directed protein kinase F(A) expression inhibits the growth of human chronic myeloid leukaemia cells.

    abstract：:Initial studies revealed that proline-directed protein kinase F(A) (PDPK F(A)) was overexpressed in various cancerous tissues relative to normal controls. However, the functional role of overexpressed PDPK F(A) in cancer remains to be established. In this report, we explore the potential role of PDPK F(A) in leukaemia...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.1133

    authors： Hsu CP,Hsueh SF,Yang CC,Yang SD

    更新日期：2000-04-01 00:00:00

  • Co-detection of members of the urokinase plasminogen activator system in tumour tissue and serum correlates with a poor prognosis for soft-tissue sarcoma patients.

    abstract：BACKGROUND:The urokinase plasminogen activator (uPA) system is one of the best-investigated protease systems, both under physiological and pathological conditions, including various types of cancer. However, effects of co-expression of members of the uPA system in soft-tissue sarcoma (STS) patients at the protein level...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605520

    authors： Taubert H,Würl P,Greither T,Kappler M,Bache M,Lautenschläger C,Füssel S,Meye A,Eckert AW,Holzhausen HJ,Magdolen V,Kotzsch M

    更新日期：2010-02-16 00:00:00