Abstract：
:Trends in long-term relative survival from breast cancer are examined for women diagnosed in England and Wales up to 2001, using both period and hybrid approaches. Large improvements in long-term survival are predicted. Women with breast cancer still experience persistent excess mortality up to at least 20 years after diagnosis.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Woods LM,Rachet B,Cooper N,Coleman MPdoi
10.1038/sj.bjc.6603668subject
Has Abstractpub_date
2007-04-10 00:00:00pages
1135-8issue
7eissn
0007-0920issn
1532-1827pii
6603668journal_volume
96pub_type
杂志文章abstract：:Leukaemia L 1210 cells preincubated in vitro with neuraminidase preparations derived either from Vibrio cholerae (VCN) or Clostridium perfringens (CPN) lost their i.p. transplantability for normal DBA/2 mice. This loss of transplantability could not be observed when the enzyme treated cells were implanted in mice whos...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.14
更新日期：1973-02-01 00:00:00
abstract：BACKGROUND:LGR5 is an important marker of intestinal stem cells and performs its vital functions at the cell membrane. Despite the importance of LGR5 to both normal and cancer stem cell biology, it is not known how microenvironmental stress affects the expression and subcellular distribution of the protein. METHODS:Nu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.4
更新日期：2015-02-17 00:00:00
abstract：:Somatostatin analogues may be useful novel agents in the systemic treatment of advanced colorectal cancer, as somatostatin inhibits proliferation in a wide variety of cell types. Here, we report the expression profiles of somatostatin receptor mRNAs in 32 pairs of malignant and normal colonic epithelia. Receptor subty...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.59
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:In 2006, the National Health Service Bowel Cancer Screening Programme in England (NHSBCSP) began offering routine population-based biennial faecal occult blood testing (FOBt) at ages 60-69. There is, however, limited information on how characteristics of individuals affect participation and outcomes of scree...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.69
更新日期：2015-04-28 00:00:00
abstract：:Flow cytometric (FCM) estimation of DNA content has been performed on tumour tissue from 197 patients with high and intermediate grade non-Hodgkin's lymphoma (NHL) to investigate the clinicopathological correlations and prognostic significance of DNA ploidy and proliferative activity. Fifty-one per cent of tumours wer...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.388
更新日期：1989-12-01 00:00:00
abstract：:One hundred and seven untreated patients with acute myelogenous leukaemia (AML) were admitted to St Bartholomew's Hospital between 10 October 1970 and 31 January 1973. Before receiving drugs to induce remission they were allocated alternatively into 2 groups to decide their remission treatment-a group to receive chemo...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1973.162
更新日期：1973-11-01 00:00:00
abstract：:Two aspects of the aerobic metabolism of nitroimidazole markers for hypoxia were investigated. Several normal murine tissues which are likely to be well oxygenated bind misonidazole at rates comparable to those of hypoxic regions in tumours. The possibility that this aerobic activation occurs via an oxygen independent...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.418
更新日期：1992-12-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) regulate colon cancer growth and metastasis. Previous studies utilizing antibodies against the VEGF receptor (DC101) or EGF receptor (C225) have demonstrated independently that these agents can inhibit tumour growth and induce apoptosis in col...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1936
更新日期：2001-08-17 00:00:00
abstract：:In vitro cloned lines derived from a primary nickel-induced rat rhabdomyosarcoma exhibited diverse levels of susceptibility to spontaneous NK activity. The presence of NK target structures was revealed by competition assays on all cloned cell lines, and the NK susceptibility of the tumour lines varied according to the...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1983.159
更新日期：1983-07-01 00:00:00
abstract：:Capecitabine is an oral prodrug of 5-fluorouracil (FU). Since FU concentrations achieved in malignant lesions are an important determinant of efficacy, we investigated the intratumoral transcapillary transfer of capecitabine and its metabolites in vivo. A total of 10 patients with skin metastases from breast cancer re...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600809
更新日期：2003-03-10 00:00:00
abstract：:To investigate the efficacy and safety of combining weekly oxaliplatin with weekly 24-h infusion of high-dose 5-fluorouracil (5-FU) and folinic acid (FA) in treatment of patients with advanced gastric cancer. Patients with histologically confirmed, locally advanced or recurrent/metastatic gastric cancer were studied. ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/sj.bjc.6601985
更新日期：2004-08-02 00:00:00
abstract：BACKGROUND:The purpose of this study was to evaluate the number of ovarian cancer and primary peritoneal cancer (PPC) progressive disease cases identified via routine follow-up procedures and the corresponding cost throughout a 16-year period at a single medical institution. METHODS:Previously undiagnosed epithelial o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605963
更新日期：2010-11-23 00:00:00
abstract：BACKGROUND:Abiraterone and enzalutamide are novel endocrine treatments that abrogate androgen receptor (AR) signalling in castration-resistant prostate cancer (CRPC). Here, we developed a circulating tumour cells (CTCs)-based assay to evaluate AR expression in real-time in CRPC and investigated nuclear AR expression in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.63
更新日期：2015-03-31 00:00:00
abstract：:Limb-sparing surgeries have been performed more frequently than amputation based on the belief that limb-sparing surgeries provide improved function and quality-of-life (QOL). However, this has not been extensively studied in the paediatric population, which has unique characteristics that have implications for functi...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6602220
更新日期：2004-11-29 00:00:00
abstract：BACKGROUND:We investigated whether pazopanib maintenance following first-line chemotherapy would improve survival in patients with extensive disease small-cell lung cancer (ED-SCLC). METHODS:This study is a randomised, placebo-controlled, phase II study that enroled ED-SCLC patients who had not progressed after four c...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2017.465
更新日期：2018-03-06 00:00:00
abstract：:Histochemical studies on the cell surface and intercellular matrix of normal cervical epithelium, and squamous cell carcinomata have shown the mucosubstances present may be symbolized by the descriptive formula:C(G) mucosubstance; B 3.5; A 2.5 (0.6m MgCl(2)); T; S.This indicates that sulphate groups are absent and tha...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1970.88
更新日期：1970-12-01 00:00:00
abstract：:Forty-two patients with small cell lung cancer were treated with a combination of carboplatin, ifosfamide and etoposide. Vincristine was given on day 14 of each course, the courses being repeated every 28 days for a maximum of six. Thoracic radiotherapy was given 4 weeks after the last course of chemotherapy but no pr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.228
更新日期：1989-07-01 00:00:00
abstract：:We report the use of tumour antigen (TA-4) polyclonal antiserum to assess the level and pattern of TA-4 antigen expression in formalin-fixed paraffin-embedded tissue sections from 110 patients with a range of normal, dysplastic and malignant squamous epithelia from various sites in the upper aerodigestive tract. There...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.140
更新日期：1990-04-01 00:00:00
abstract：:The cytocidal properties of metronidazole against hypoxic mammalian cells are described. This chemotherapeutic action has been shown to be dependent on drug concentration and duration of exposure. The x-ray TCD50 for a murine anaplastic carcinoma was reduced from 6081 rad to 4643 rad when animals were given metronidaz...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.78
更新日期：1976-05-01 00:00:00
abstract：OBJECTIVE:Detection of lymph node involvement in women with IB2-IIB cervical cancer could have a positive effect on survival. We set out to evaluate the incidence of pelvic and/or para-aortic lymph node involvement using the sentinel node (SN) biopsy and its impact on survival. METHODS:From 2002 to 2010, 66 women with...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.541
更新日期：2012-01-03 00:00:00
abstract：BACKGROUND:The role of chemotherapy for neuroendocrine tumours remains controversial and there is no standard regimen. METHOD:We report the outcome for a consecutive series of chemonaive patients with metastatic or locally advanced neuroendocrine tumours treated with a combination of 5-fluorouracil (500 mg m(-2)), cis...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6605618
更新日期：2010-03-30 00:00:00
abstract：:To investigate the association between medullary carcinoma of the thyroid (MCT) and carcinoembryonic antigen (CEA), we assayed 78 sera from patients with thyroid diseases for CEA, employing the radioimmunoassay of double antibody technique. All 13 sera from patients with MCT had high levels of CEA, ranging from 14 to ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.133
更新日期：1976-08-01 00:00:00
abstract：:The prognostic value of C-reactive protein, compared with ECOG performance status (ECOG-ps), in patients receiving alpha-interferon treatment for advanced renal cancer was assessed in 58 patients. In all, 55 patients died on follow-up. On multivariate analysis with ECOG-ps and C-reactive protein entered as covariates,...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6602152
更新日期：2004-10-04 00:00:00
abstract：:In this paper, we develop a Markov chain model to estimate parameters pertaining to the natural history of nasopharyngeal carcinoma (NPC). The model is of progression from no disease to Epstein-Barr virus (EBV) infection, preclinical screen-detectable tumour and clinical tumour. We derive tentative estimates of the pa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690301
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Focal adhesion kinase (FAK) is overexpressed in a variety of cancers, such as breast, colon, prostate, ovary, and lung cancers. However, the mechanism by which extracellular matrix fibronectin stimulates lung cancer cell migration and invasion through FAK remains to be investigated. METHODS:The signalling p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605154
更新日期：2009-07-21 00:00:00
abstract：:We evaluated the interaction between hepatitis C virus (HCV) and cigarette smoking on death from hepatocellular cancer in The Japan Collaborative Cohort Study. The odds ratio of death from HCC for smoking was 9.60 (1.50-61.35) and 1.71(0.58-5.08) among anti-HCV positive and negative individuals, respectively. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602981
更新日期：2006-03-13 00:00:00
abstract：:The aim of this study was to evaluate the expression of CC chemokine receptor 7 (CCR7) in squamous cell cancer of the tonsil with respect to patterns of spread, relapse-free, overall and disease-specific survival. Eighty-four patients with squamous cell cancer of the tonsil were identified. There was a male predominan...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603907
更新日期：2007-09-03 00:00:00
abstract：:A series of three dose escalating studies were conducted to investigate the ability of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate, to cause maximum suppression of testosterone synthesis when delivered to castrate and noncastrate males with prostate cancer. Study A was a single dose study in c...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/sj.bjc.6601879
更新日期：2004-06-14 00:00:00
abstract：:We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for b...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1252
更新日期：2000-08-01 00:00:00
abstract：:Major advances in cancer immunotherapy have dramatically expanded the potential to manipulate immune cells in cancer patients with metastatic disease to counteract cancer spread and extend patient lifespan. One of the most successful types of immunotherapy is the immune checkpoint inhibitors, such as anti-CTLA-4 and a...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/s41416-020-01160-5
更新日期：2021-01-01 00:00:00
