Prognostic role of topoisomerase-IIalpha in advanced ovarian cancer patients.

abstract：BACKGROUND:Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients. METHODS:The study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model...

journal_title：British journal of cancer

authors： Staff S,Aaltonen M,Huhtala H,Pylvänäinen K,Mecklin JP,Mäenpää J

更新日期：2016-07-26 00:00:00

abstract：:In this study, the role of parity in conferring protection of the mammary gland against chemical carcinogenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA) was investigated. Experiments were also carried out to determine if an 'interrupted' pregnancy was capable of reducing the incidence of mammary tumour inducti...

journal_title：British journal of cancer

authors： Sinha DK,Pazik JE,Dao TL

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:This study aims to investigate the association between statin use and all-cancer survival in a prospective cohort of postmenopausal women, using data from the Women's Health Initiative Observational Study (WHI-OS) and Clinical Trial (WHI-CT). METHODS:The WHI study enrolled women aged 50-79 years from 1993 t...

journal_title：British journal of cancer

authors： Wang A,Aragaki AK,Tang JY,Kurian AW,Manson JE,Chlebowski RT,Simon M,Desai P,Wassertheil-Smoller S,Liu S,Kritchevsky S,Wakelee HA,Stefanick ML

更新日期：2016-06-28 00:00:00

abstract：:The prognostic value of tissue-type plasminogen activator (tPA) measured in samples derived from 865 patients with primary breast cancer using a recently developed enzyme-linked immunosorbent assay (ELISA) was evaluated. Since the assay could easily be adapted to the assessment of the complex of tPA with its type-1 in...

journal_title：British journal of cancer

authors： de Witte JH,Sweep CG,Klijn JG,Grebenschikov N,Peters HA,Look MP,van Tienoven TH,Heuvel JJ,Bolt-De Vries J,Benraad TJ,Foekens JA

更新日期：1999-04-01 00:00:00

abstract：:A number of polyunsaturated fatty acids have been shown to inhibit the growth of malignant cells in vitro. To investigate whether fatty acids modify the growth of human pancreatic cancer, lauric, stearic, palmitic, oleic, linoleic, alpha-linolenic, gamma-linolenic, arachidonic, docosahexaenoic and eicosapentaenoic (EP...

journal_title：British journal of cancer

authors： Falconer JS,Ross JA,Fearon KC,Hawkins RA,O'Riordain MG,Carter DC

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Heterogeneity and low incidence comprise the biggest challenge in sarcoma diagnosis and treatment. Chemotherapy, although efficient for some sarcoma subtypes, generally results in poor clinical responses and is mostly recommended for advanced disease. Specific genomic aberrations have been identified in some...

journal_title：British journal of cancer

authors： Brodin BA,Wennerberg K,Lidbrink E,Brosjö O,Potdar S,Wilson JN,Ma L,Moens LN,Hesla A,Porovic E,Bernhardsson E,Papakonstantinou A,Bauer H,Tsagkozis P,von Sivers K,Wejde J,Östling P,Kallioniemi O,Stragliotto CL

更新日期：2019-02-01 00:00:00

abstract：:Secretary component (SC) is expressed basolaterally as a transmembrane protein (pIg receptor) on secretory epithelial cells. As pIg receptor it plays a central role in humoral immunity by mediating the external translocation of dimeric IgA and pentameric IgM. A few case reports have suggested that reduced or absent SC...

journal_title：British journal of cancer

authors： Krajci P,Meling GI,Andersen SN,Hofstad B,Vatn MH,Rognum TO,Brandtzaeg P

更新日期：1996-06-01 00:00:00

abstract：:A human prostate tumour cell line, LNCaP C4-2, when injected into athymic male nude mice, produced tumours containing: (1) only human cancer cells similar to those injected; (2) only murine stromal cells containing abnormal chromosome constitutions; or (3) both human prostate cancer cells similar to those injected and...

journal_title：British journal of cancer

authors： Pathak S,Nemeth MA,Multani AS,Thalmann GN,von Eschenbach AC,Chung LW

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Systemic failure remains a challenge in rectal cancer. We investigated the possible systemic anti-tumour immune activity invoked within oxaliplatin-based neoadjuvant therapy. METHODS:In two high-risk patient cohorts, we assessed the circulating levels of the fms-like tyrosine kinase 3 ligand (Flt3L), a fact...

journal_title：British journal of cancer

authors： Kalanxhi E,Meltzer S,Schou JV,Larsen FO,Dueland S,Flatmark K,Jensen BV,Hole KH,Seierstad T,Redalen KR,Nielsen DL,Ree AH

更新日期：2018-05-01 00:00:00

abstract：:The aim of this study was to ascertain whether assessing the growth fraction of cervical carcinoma of 28 patients, using antibody Ki-67, would be of value in clinical practice. The results showed no relationship between growth fraction and age, clinical stage, lymph node involvement or short term (3-5 years) survival....

journal_title：British journal of cancer

authors： Cole DJ,Brown DC,Crossley E,Alcock CJ,Gatter KC

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:The urokinase plasminogen activator (uPA) system is one of the best-investigated protease systems, both under physiological and pathological conditions, including various types of cancer. However, effects of co-expression of members of the uPA system in soft-tissue sarcoma (STS) patients at the protein level...

journal_title：British journal of cancer

authors： Taubert H,Würl P,Greither T,Kappler M,Bache M,Lautenschläger C,Füssel S,Meye A,Eckert AW,Holzhausen HJ,Magdolen V,Kotzsch M

更新日期：2010-02-16 00:00:00

abstract：:We have investigated dihydropyrimidine dehydrogenase expression as a prognostic marker in breast cancer. A total of 119 women with breast cancer undergoing surgery between 1985 and 1996 were included in this study. Eighty-seven patients were treated with postoperative chemotherapy including 5-fluorouracil or 5-fluorou...

journal_title：British journal of cancer

authors： Horiguchi J,Takei H,Koibuchi Y,Iijima K,Ninomiya J,Uchida K,Ochiai R,Yoshida M,Yokoe T,Iino Y,Morishita Y

更新日期：2002-01-21 00:00:00

abstract：:gamma-Irradiated rat hepatoma cells are immunogenic in syngeneic WAB/Not rats, so that immunized animals are protected against tumour-cell challenge and circulating tumour-specific antibody is produced. Treatment of the immunizing cells with glutaraldehyde at concentrations of 0.001% or greater for 30 min rendered the...

journal_title：British journal of cancer

authors： Price MR,Dennick RG,Robins RA,Baldwin RW

更新日期：1979-06-01 00:00:00

abstract：:The cytochrome P450 CYP1B1 is consistently overexpressed in tumour cells as compared to their normal counterparts, but its precise role in drug resistance is yet to be defined. It has been reported that transfection of CYP1B1 results in increased resistance to docetaxel in V79 cells (McFadyen et al, 2001). In this stu...

journal_title：British journal of cancer

authors： Martinez VG,O'Connor R,Liang Y,Clynes M

更新日期：2008-02-12 00:00:00

abstract：BACKGROUND:Circulating total cytokeratin 18 (tCK18) and/or caspase cleaved cytokeratin 18 (cCK18) (measured by M65 and M30 enzyme-linked immunosorbent assays (ELISAs), respectively) are used as pharmacodynamic (PD) biomarkers of epithelial cell death in clinical trials. Having validated these ELISAs, we assessed their ...

journal_title：British journal of cancer

authors： Greystoke A,Dean E,Saunders MP,Cummings J,Hughes A,Ranson M,Dive C,Renehan AG

更新日期：2012-10-23 00:00:00

abstract：:Soluble and nuclear oestrogen receptor status was determined in both the central and peripheral portions of tumour for 37 cases of adenocarcinoma of the endometrium. Of these, 29 had functional receptor in the peripheral biopsy, but only 19 retained functional receptor in the centre. Six of the 10 patients whose tumou...

journal_title：British journal of cancer

authors： Castagnetta L,Lo Casto M,Mercadante T,Polito L,Cowan S,Leake RE

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) is highly expressed in adenoid cystic carcinoma (ACC). The efficacy and toxicity of cetuximab with concomitant platinum-based chemoradio- or chemotherapy in patients with locally advanced or metastatic ACC, respectively, was evaluated. METHODS:Eligible patients (9 wit...

journal_title：British journal of cancer

authors： Hitre E,Budai B,Takácsi-Nagy Z,Rubovszky G,Tóth E,Remenár É,Polgár C,Láng I

更新日期：2013-09-03 00:00:00

abstract：:Administration of 5-aminolaevulinic acid (ALA) leads to porphyrin accumulation in malignant and premalignant tissues, and ALA is used as a prodrug in photodynamic therapy (PDT). To understand the mechanism of porphyrin accumulation after the administration of ALA and to investigate whether ALA-induced protoporphyrin I...

journal_title：British journal of cancer

authors： Hinnen P,de Rooij FW,van Velthuysen ML,Edixhoven A,van Hillegersberg R,Tilanus HW,Wilson JH,Siersema PD

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Prognosis of localised gastrointestinal stromal tumour (GIST) is heterogeneous, notably for patients with AFIP intermediate or high risk of relapse, who are candidates to adjuvant imatinib. We hypothesised that gene expression profiles might improve the prognostication and help to refine the indications for ...

journal_title：British journal of cancer

authors： Bertucci F,Finetti P,Ostrowski J,Kim WK,Kim H,Pantaleo MA,Astolfi A,Polkowski M,Birnbaum D

更新日期：2012-10-09 00:00:00

abstract：:KRN 8602 (MX2) is a novel morpholino anthracycline derivative having the chemical structure 3'-deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin hydrochloride. To investigate the mechanisms of resistance to MX2, we established an MX2-resistant phenotype (K562/MX2) of the human myelogeneous leukaemia cell line (K56...

journal_title：British journal of cancer

authors： Asano T,Nakamura K,Fujii H,Horichi N,Ohmori T,Hasegawa K,Isoe T,Adachi M,Otake N,Fukunaga Y

更新日期：2005-04-25 00:00:00

abstract：BACKGROUND:Laboratory studies suggest a possible role of magnesium intake in colorectal carcinogenesis but epidemiological evidence is inconclusive. METHOD:We tested magnesium-colorectal cancer hypothesis in the Nurses' Health Study, in which 85 924 women free of cancer in 1980 were followed until June 2008. Cox propo...

journal_title：British journal of cancer

authors： Zhang X,Giovannucci EL,Wu K,Smith-Warner SA,Fuchs CS,Pollak M,Willett WC,Ma J

更新日期：2012-03-27 00:00:00

abstract：:Transformation of primary hamster embryo cells was investigated using 3-methylcholanthrene (MCA), a combination of MCA and 12-O-tetradecanoylphorbol-13-acetate (TPA), and initiation with MCA or dibenz(a,h)anthracene (DBA) followed by promotion with TPA. Evidence for transformation was (a) abnormal cellular morphology,...

journal_title：British journal of cancer

authors： Poiley JA,Raineri R,Pienta RJ

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify prostate cancer (PC) oncogenic microRNAs (miRs) based on miR microarray and to investigate whether these oncogenic miRs may be useful as PC biomarkers. METHODS:Initially, we carried out miR microarray and real-time PCR using RWPE-1, PC-3, DU-145 and LNCaP cells. To ...

journal_title：British journal of cancer

authors： Ueno K,Hirata H,Shahryari V,Deng G,Tanaka Y,Tabatabai ZL,Hinoda Y,Dahiya R

更新日期：2013-04-30 00:00:00

abstract：:MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our results indicate that MBD3 is not a major target of genetic and epigenetic alteration in these cance...

journal_title：British journal of cancer

authors： Zhu Y,Harrison DJ,Bader SA

更新日期：2004-05-17 00:00:00

abstract：:Apoptosis is a physiological form of cell death important in normal processes such as morphogenesis and the functioning of the immune system. In addition, defects in the apoptotic process play a major role in a number of important areas of disease, such as autoimmune diseases and cancer. DNA-damage-induced apoptosis p...

journal_title：British journal of cancer

authors： Camplejohn RS,Hodgson S,Carter N,Kato BS,Spector TD

更新日期：2006-08-21 00:00:00

abstract：:Hypoxic cells in KHT sarcomas were characterized using fluorescence activated cell sorting based on the diffusion properties of the fluorochrome Hoechst 33342. Tumour-bearing female C3H/HeJ mice were injected i.v. with 10 micrograms g-1 Hoechst 33342 and the cells derived from the tumours sorted on the basis of their ...

journal_title：British journal of cancer

authors： Siemann DW,Keng PC

更新日期：1988-09-01 00:00:00

abstract：:Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 recepto...

journal_title：British journal of cancer

authors： Rivera E,Arrieta O,Guevara P,Duarte-Rojo A,Sotelo J

更新日期：2001-11-02 00:00:00

abstract：BACKGROUND:SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. METHODS:Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks o...

journal_title：British journal of cancer

authors： Hurt CN,Falk S,Crosby T,McDonald A,Ray R,Joseph G,Staffurth J,Abrams RA,Griffiths G,Maughan T,Mukherjee S

更新日期：2017-05-09 00:00:00

abstract：:There is a need to evaluate cancer services and provide a baseline on current treatment success and organization. This study shows that this process may be severely hindered by case note destruction or inaccessibility and incomplete information. This is an ongoing problem that needs to be addressed now. ...

journal_title：British journal of cancer

authors： Smith SJ,Muir KR,Wolstenholme JL,Thornhill KG,Zamorski A,Tolley K,Logan RF,Chilvers CE

更新日期：1997-01-01 00:00:00

abstract：:A multicentre phase 2 trial (single-stage design) was undertaken to test the efficacy and toxicity of carboplatin (AUC 6 according to Calvert) plus paclitaxel (175 mg/m(2)3-h infusion) every 4 weeks in the first line treatment of patients affected by extensive small cell lung cancer. The primary end-point of the trial...

journal_title：British journal of cancer

authors： Gridelli C,Manzione L,Perrone F,Veltri E,Cioffi R,Caprio MG,Frontini L,Rossi A,Barletta E,Barzelloni ML,Bilancia D,Gallo C

更新日期：2001-01-05 00:00:00