Two-stage malignant transformation in hamster embryo cells.

abstract：BACKGROUND:The role of processed meat in the aetiology of several cancers was explored in detail. METHODS:In the time period 1996-2004, a multisite case-control study was conducted in Montevideo, Uruguay. The study included 6 060 participants (3 528 cases and 2 532 controls) corresponding to cancers of the oral cavity...

journal_title：British journal of cancer

authors： De Stefani E,Boffetta P,Ronco AL,Deneo-Pellegrini H,Correa P,Acosta G,Mendilaharsu M,Luaces ME,Silva C

更新日期：2012-10-23 00:00:00

abstract：:Angiogenesis is an essential requirement for tumour growth and metastasis and is regulated by a complex network of factors produced by both stromal cells and neoplastic cells within solid tumours. The cytokine tumour necrosis factor alpha (TNF-alpha) and the enzyme thymidine phosphorylase (TP) are two factors known to...

journal_title：British journal of cancer

authors： Leek RD,Landers R,Fox SB,Ng F,Harris AL,Lewis CE

更新日期：1998-06-01 00:00:00

abstract：:We have recently established a cancer-reactive human monoclonal antibody, GAH, with a positive ratio of over 90% against stomach cancer. GAH was formulated as polyethyleneglycol (PEG)-modified immunoliposomal doxorubicin (DXR) (ILD) and its efficacy was examined against gastrointestinal human cancers. In in vitro stud...

journal_title：British journal of cancer

authors： Hosokawa S,Tagawa T,Niki H,Hirakawa Y,Nohga K,Nagaike K

更新日期：2003-10-20 00:00:00

abstract：:This paper describes the results of a study set up to investigate factors associated with the high proportions of 'death certificate only' registrations (DCOs) for all cancers registered in south-east England between 1987 and 1989 and to identify those which might be subject to registry intervention. DCOs as a proport...

journal_title：British journal of cancer

authors： Pollock AM,Vickers N

更新日期：1995-03-01 00:00:00

abstract：:One hundred and eighteen doctors who treat pulmonary neoplasms in Ontario were asked how they would wish to be treated if they had non-small cell lung cancer. Four different scenarios were given. The physicians were then asked if they would consent to take part as subjects in one or more clinical trials for which they...

journal_title：British journal of cancer

authors： Mackillop WJ,Ward GK,O'Sullivan B

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:The immune system has a central role in controlling cancer, and factors that influence protective antitumour immunity could therefore have a significant impact on the course of malignant disease. Opioids are essential for the management of cancer pain, and preclinical studies indicate that opioids have the p...

journal_title：British journal of cancer

authors： Boland JW,McWilliams K,Ahmedzai SH,Pockley AG

更新日期：2014-08-26 00:00:00

abstract：:Magnetic resonance spectroscopy was used to study intracellular pH and compounds which contain phosphorus in normal human brain and primary brain tumours non-invasively. In normal subjects (n = 7) intracellular pH (pHi) of the brain was 7.03 +/- 0.02 (mean +/- s.e.m.). The pHi did not vary between superficial (2 cm, m...

journal_title：British journal of cancer

authors： Cadoux-Hudson TA,Blackledge MJ,Rajagopalan B,Taylor DJ,Radda GK

更新日期：1989-09-01 00:00:00

abstract：:The relationship between mammalian facilitative glucose transport proteins (GLUT) and multidrug resistance was examined in two vincristine (VCR)-selected murine erythroleukaemia (MEL) PC4 cell lines. GLUT proteins, GLUT1 and GLUT3, were constitutively coexpressed in the parental cell line and also in the VCR-selected ...

journal_title：British journal of cancer

authors： Martell RL,Slapak CA,Levy SB

更新日期：1997-01-01 00:00:00

abstract：:In vivo models of acquired resistance to the platinum-based agents cisplatin (CDDP), carboplatin (CBDCA), iproplatin (CHIP) and tetraplatin have been established using a panel of six parent human ovarian carcinoma lines, two (HX/110 and PXN/87) being derived from previously untreated patients. Resistance has been gene...

journal_title：British journal of cancer

authors： Jones M,Siracky J,Kelland LR,Harrap KR

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:To compare the imaging and clinical features of temporal lobe necrosis (TLN) in nasopharyngeal carcinoma (NPC) patients treated with two-dimensional radiotherapy (2D-RT) or those with intensity-modulated radiotherapy (IMRT). METHODS:We retrospectively analysed NPC patients who underwent 2D-RT (72 patients, ...

journal_title：British journal of cancer

authors： Mao YP,Zhou GQ,Liu LZ,Guo R,Sun Y,Li L,Lin AH,Zeng MS,Kang TB,Jia WH,Shao JY,Mai HQ,Ma J

更新日期：2014-05-27 00:00:00

abstract：:Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associ...

journal_title：British journal of cancer

authors： Lecot P,Alimirah F,Desprez PY,Campisi J,Wiley C

更新日期：2016-05-24 00:00:00

abstract：:Small-cell lung cancers (SCLCs) initially respond to chemotherapy, but are often resistant at recurrence. The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1 (MRP1) function. The doxorubicin-resistant MRP1-overexpressing human SCLC cell line GLC(4)-Adr was highly sen...

journal_title：British journal of cancer

authors： de Groot DJ,van der Deen M,Le TK,Regeling A,de Jong S,de Vries EG

更新日期：2007-10-22 00:00:00

abstract：BACKGROUND:This study is to investigate the effects of geserelin+tamoxifen (TAM) on estradiol level, breast density (BD), endometrial thickness (ET), and blood lipids in premenopausal and perimenopausal women with hormone receptor-positive early-stage breast cancer. METHODS:This study recruited 110 premenopausal and p...

journal_title：British journal of cancer

authors： Yang H,Zong X,Yu Y,Shao G,Zhang L,Qian C,Bian Y,Xu X,Sun W,Meng X,Ding X,Chen D,Zou D,Xie S,Zheng Y,Zhang J,He X,Sun C,Yu X,Ni J

更新日期：2013-08-06 00:00:00

abstract：:During the COVID-19 era, Chinese hospitals have developed a system that enables vulnerable cancer patients to continue to receive high-quality medical care, optimising their survival whilst protecting them. This includes use of digital quick codes, fever clinics and optimal scheduling. We wish to share our experiences...

journal_title：British journal of cancer

authors： Peng L,Yang JS,Stebbing J

更新日期：2020-07-01 00:00:00

abstract：:The objective of this study was to examine the relationship between educational level and mortality from cancer in the city of Barcelona. The data were derived from a record linkage between the Barcelona Mortality Registry and the Municipal Census. The relative risks (RR) of death and 95% confidence intervals (CIs) ac...

journal_title：British journal of cancer

authors： Fernandez E,Borrell C

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:The Sloane audit compares screen-detected ductal carcinoma in situ (DCIS) pathology with subsequent management and outcomes. METHODS:This was a national, prospective cohort study of DCIS diagnosed during 2003-2012. RESULTS:Among 11,337 patients, 7204 (64%) had high-grade DCIS. Over time, the proportion of ...

journal_title：British journal of cancer

authors： Shaaban AM,Hilton B,Clements K,Provenzano E,Cheung S,Wallis MG,Sawyer E,Thomas JS,Hanby AM,Pinder SE,Thompson AM,Sloane Project Steering Committee.

更新日期：2020-11-17 00:00:00

abstract：:BALB/c mice born to and nursed by females immunized against MSV-M showed a reduced tumour incidence and a high tumour regression rate following MSV-M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not...

journal_title：British journal of cancer

authors： Chieco-Bianchi L,Collavo D,Biasi G,Colombatti A

更新日期：1973-09-01 00:00:00

abstract：BACKGROUND:Preoperative radiotherapy (RT) is commonly used to treat localised soft-tissue sarcomas (STS). Hypoxia is an important determinant of radioresistance. Whether antiangiogenic therapy can 'normalise' tumour vasculature, thereby improving oxygenation, remains unknown. METHODS:Two cohorts were prospectively enr...

journal_title：British journal of cancer

authors： Lewin J,Khamly KK,Young RJ,Mitchell C,Hicks RJ,Toner GC,Ngan SY,Chander S,Powell GJ,Herschtal A,Te Marvelde L,Desai J,Choong PF,Stacker SA,Achen MG,Ferris N,Fox S,Slavin J,Thomas DM

更新日期：2014-12-09 00:00:00

abstract：:The effect of 10(-6) M tamoxifen on MCF-7 cells adapted to growth in 0.5% foetal calf serum has been studied. The growth inhibitory effect of this tamoxifen concentration was abolished by simultaneous addition of 10(-8) M oestradiol, indicating that tamoxifen may exert its effect via binding to the oestrogen receptor....

journal_title：British journal of cancer

authors： Lykkesfeldt AE,Larsen JK,Christensen IJ,Briand P

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:There remains uncertainty on the need for bone staging in men with intermediate-risk prostate cancer. Current guidelines do not use mpMRI-staging information and rely on historic pathology grading. METHODS:We investigated the ability of mpMRI and the new Grade Group system to better predict bone metastasis ...

journal_title：British journal of cancer

authors： Thurtle D,Hsu RC,Chetan M,Lophatananon A,Hubbard R,Gnanapragasam VJ,Barrett T

更新日期：2016-11-22 00:00:00

abstract：BACKGROUND:Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in earlier stages of CR...

journal_title：British journal of cancer

authors： Snoeren N,Emmink BL,Koerkamp MJ,van Hooff SR,Goos JA,van Houdt WJ,de Wit M,Prins AM,Piersma SR,Pham TV,Belt EJ,Bril H,Stockmann HB,Meijer GA,van Hillegersberg R,Holstege FC,Jimenez CR,Fijneman RJ,Kranenburg OW,Rinke

更新日期：2013-09-17 00:00:00

abstract：:The tissue-specific translation elongation factor eEF1A2 is a potential oncogene that is overexpressed in human ovarian cancer. eEF1A2 is highly similar (98%) to the near-ubiquitously expressed eEF1A1 (formerly known as EF1-alpha) making analysis with commercial antibodies difficult. We wanted to establish the express...

journal_title：British journal of cancer

authors： Tomlinson VA,Newbery HJ,Bergmann JH,Boyd J,Scott D,Wray NR,Sellar GC,Gabra H,Graham A,Williams AR,Abbott CM

更新日期：2007-05-21 00:00:00

abstract：:We investigated whether cholecystectomy is associated with subsequent cancer and, if so, whether the association is likely to be causal, by undertaking a retrospective cohort study using linked medical statistics, comprising a cholecystectomy group (n=39 254) and a reference cohort admitted for a range of other medica...

journal_title：British journal of cancer

authors： Goldacre MJ,Abisgold JD,Seagroatt V,Yeates D

更新日期：2005-04-11 00:00:00

abstract：:In 1985 a second randomisation was initiated for women in the treatment arm of the Scottish Tamoxifen Trial either to stop tamoxifen at 5 years or to continue indefinitely. A preliminary analysis of outcome in 342 patients at a median follow-up of 6 years suggests that a worthwhile gain in disease control from continu...

journal_title：British journal of cancer

authors： Stewart HJ,Forrest AP,Everington D,McDonald CC,Dewar JA,Hawkins RA,Prescott RJ,George WD

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The characterisation of desmoplastic reaction (DR) has emerged as a new, independent prognostic determinant in colorectal cancer. Herein, we report the validation of its prognostic value in a randomised controlled study (SACURA trial). METHODS:The study included 991 stage II colon cancer patients. DR was cl...

journal_title：British journal of cancer

authors： Ueno H,Ishiguro M,Nakatani E,Ishikawa T,Uetake H,Murotani K,Matsui S,Teramukai S,Sugai T,Ajioka Y,Maruo H,Kotaka M,Tsujie M,Munemoto Y,Yamaguchi T,Kuroda H,Fukunaga M,Tomita N,Sugihara K

更新日期：2021-01-07 00:00:00

abstract：:Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours, including 47 epitheli...

journal_title：British journal of cancer

authors： Gabra H,Taylor L,Cohen BB,Lessels A,Eccles DM,Leonard RC,Smyth JF,Steel CM

更新日期：1995-08-01 00:00:00

abstract：:We present the cytogenetic investigations of five histiocytic tumour lesions from children. In four cases there was a confirmed diagnosis of Langerhans cell histiocytosis (LCH) and one case of histiocytosis that did not fulfil all the criteria for true LCH. All five cases showed cytogenetic abnormalities, including th...

journal_title：British journal of cancer

authors： Betts DR,Leibundgut KE,Feldges A,Plüss HJ,Niggli FK

更新日期：1998-02-01 00:00:00

abstract：:This study was designed to evaluate the activity, safety and tolerance of docetaxel (D) in a selected population with metastatic squamous cell carcinoma of the head and neck (SCCHN). Twenty-four patients with no prior palliative therapy were enrolled and received D 100 mg m(-2) by 1 h of infusion, every 3 weeks. All b...

journal_title：British journal of cancer

authors： Couteau C,Chouaki N,Leyvraz S,Oulid-Aissa D,Lebecq A,Domenge C,Groult V,Bordessoule S,Janot F,De Forni M,Armand JP

更新日期：1999-10-01 00:00:00

abstract：:The radiation response of Epstein-Barr virus (EBV)-immortalised lymphoblastoid cell lines derive from Li-Fraumeni syndrome (LFS) and LFS-like individuals was investigated. Cells from all LFS and LFS-like cases showed an accumulation of p53 protein following 137Cs gamma-irradiation, which was associated with cell cycle...

journal_title：British journal of cancer

authors： Williams KJ,Heighway J,Birch JM,Norton JD,Scott D

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Though p53 mutations are rare in ES, there is a strong indication that p53 mutant tumours form a particularly bad prognostic group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumour cells containing mutant p53 in this subset of ES patients. METHODS:PRIMA-1...

journal_title：British journal of cancer

authors： Aryee DN,Niedan S,Ban J,Schwentner R,Muehlbacher K,Kauer M,Kofler R,Kovar H

更新日期：2013-11-12 00:00:00