Incorporating multiparametric MRI staging and the new histological Grade Group system improves risk-stratified detection of bone metastasis in prostate cancer.

abstract：:During the period from 1950 to 1952, three patients were studied by electrophoresis according to Tiselius on account of anticomplementary activity at WR; the presence of an M-component was demonstrated. On several later occasions it was observed that this component at first seemed to remain unchanged, later it was sli...

journal_title：British journal of cancer

authors： Norgaard O

更新日期：1971-09-01 00:00:00

abstract：:Smoke condensate from two types of cigarette, dissolved in two solvents, has been applied regularly to the backs of mice at each of seven different dose levels. Treatment was continued 3 times weekly for up to 110 weeks, by which time 509 of the 1428 treated mice had developed skin tumours. The dependence of tumour in...

journal_title：British journal of cancer

authors： Davies RF,Lee PN,Rothwell K

更新日期：1974-08-01 00:00:00

abstract：:The 5T4 oncofetal antigen is a 72 kDa glycoprotein defined by a monoclonal antibody raised against human placental trophoblast and is expressed in many different carcinomas but detected only at low levels in some normal epithelia. Immunohistochemical analysis of the patterns of expression in colorectal carcinomas has ...

journal_title：British journal of cancer

authors： Starzynska T,Marsh PJ,Schofield PF,Roberts SA,Myers KA,Stern PL

更新日期：1994-05-01 00:00:00

abstract：:Kaposi's sarcoma (KS) is a highly vascular tumour and is the most common neoplasm associated with human immunodeficiency virus (HIV-1) infection. Growth factors, in particular vascular endothelial growth factor (VEGF), have been shown to play an important role in its development. The role of insulin-like growth factor...

journal_title：British journal of cancer

authors： Catrina SB,Lewitt M,Massambu C,Dricu A,Grünler J,Axelson M,Biberfeld P,Brismar K

更新日期：2005-04-25 00:00:00

abstract：BACKGROUND:The National Comprehensive Cancer Network (NCCN) guidelines provide recommendations for staging of prostate cancer patients in the objective regarding presence of locoregional lymph node metastases (LNM) and bone metastases. We tested the performance characteristics of these recommendations in a community se...

journal_title：British journal of cancer

authors： Preisser F,Mazzone E,Nazzani S,Marchioni M,Bandini M,Tian Z,Saad F,Soulières D,Shariat SF,Montorsi F,Huland H,Graefen M,Tilki D,Karakiewicz PI

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:CYFRA 21-1 serves as biomarker in several epithelial malignancies. However, its role in pancreatic cancer (PC) has not yet been investigated. METHODS:Within a prospective single-centre study serial blood samples were collected from patients with confirmed advanced PC. Pre-treatment values and weekly measure...

journal_title：British journal of cancer

authors： Boeck S,Wittwer C,Heinemann V,Haas M,Kern C,Stieber P,Nagel D,Holdenrieder S

更新日期：2013-04-30 00:00:00

abstract：:We conducted a national, retrospective population-based cohort study of 705 patients hospitalized with a first diagnosis of dermatomyositis (DM) or polymyositis (PM) during 1982-1996 based on linkage of hospital discharge, cancer registration, and death records in Scotland. Risks of cancer were assessed by calculating...

journal_title：British journal of cancer

authors： Stockton D,Doherty VR,Brewster DH

更新日期：2001-07-06 00:00:00

abstract：:Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with inflammation and inflammatory cytokines such as interleukin-1alpha (IL-1alpha) have recently been shown to induce both inflammatory and anti-infla...

journal_title：British journal of cancer

authors： Gubbay O,Guo W,Rae MT,Niven D,Langdon SP,Hillier SG

更新日期：2005-05-23 00:00:00

abstract：BACKGROUND:The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities. METHODS:Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates...

journal_title：British journal of cancer

authors： Genus TSE,Bouvier C,Wong KF,Srirajaskanthan R,Rous BA,Talbot DC,Valle JW,Khan M,Pearce N,Elshafie M,Reed NS,Morgan E,Deas A,White C,Huws D,Ramage J

更新日期：2019-11-01 00:00:00

abstract：:Two aspects of the aerobic metabolism of nitroimidazole markers for hypoxia were investigated. Several normal murine tissues which are likely to be well oxygenated bind misonidazole at rates comparable to those of hypoxic regions in tumours. The possibility that this aerobic activation occurs via an oxygen independent...

journal_title：British journal of cancer

authors： Parliament MB,Wiebe LI,Franko AJ

更新日期：1992-12-01 00:00:00

abstract：:Initial studies revealed that proline-directed protein kinase F(A) (PDPK F(A)) was overexpressed in various cancerous tissues relative to normal controls. However, the functional role of overexpressed PDPK F(A) in cancer remains to be established. In this report, we explore the potential role of PDPK F(A) in leukaemia...

journal_title：British journal of cancer

authors： Hsu CP,Hsueh SF,Yang CC,Yang SD

更新日期：2000-04-01 00:00:00

abstract：:In the early period following radical hepatectomy for hepatoma, recurrences in the remaining liver are frequently found. In regenerating liver, implantation and growth of tumour cells released into the portal system during surgical treatment might be promoted. We examined the relationship between liver regeneration an...

journal_title：British journal of cancer

authors： Mizutani J,Hiraoka T,Yamashita R,Miyauchi Y

更新日期：1992-06-01 00:00:00

abstract：:When purified fibre and hexon proteins of adenovirus 12 were given intramuscularly to 4-week-old BALB/c mice (250-300 mug/mouse) 2 h prior to inoculation with mouse sarcoma virus (0.05 ml of 10(4) FFU/ml) at the same site, significant suppression of tumour growth (P less than 0.001), and rapid regression in tumour siz...

journal_title：British journal of cancer

authors： Abid SH,Khoobyarian N

更新日期：1976-04-01 00:00:00

abstract：:Clonal subpopulations of different ploidy values and metastatic capacities, isolated from the RIF-1 mouse sarcoma, have been tested for in vitro X-radiation sensitivity, for in vitro sensitivity to adriamycin and for in vitro and in vivo sensitivity to melphalan and CCNU. Following X-radiation, no consistent differenc...

journal_title：British journal of cancer

authors： Reeve JG,Wright KA,Twentyman PR

更新日期：1983-06-01 00:00:00

abstract：:Epidemiological evidence indicates that non-steroidal anti-inflammatory drugs (NSAIDs) protect against colorectal cancer (CRC) to a greater degree than other non-gastrointestinal cancers, but the molecular basis for this difference is unknown. We previously reported that aspirin induces signal-specific I kappa B alpha...

journal_title：British journal of cancer

authors： Din FV,Dunlop MG,Stark LA

更新日期：2004-07-19 00:00:00

abstract：:6-Mercaptopurine (MP)-sensitive and -resistant cell culture lines were used to further characterize the apparent ability of MP nucleotide derivatives to overcome resistance to the parent drug. 6-Mercaptopurine-9-beta-D-ribofuranoside 5'-monophosphate [MPRP], bis(6-mercaptopurine-9-beta-D-ribofuranoside)-5', 5"'-monoph...

journal_title：British journal of cancer

authors： Johnston HP,Hawley P,White SE,Gibson I,Tidd DM

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF)-mediated angiogenesis mediates tumour growth and metastasis. Meningiomas are primarily benign, slow-growing, highly vascularised tumours. Aside from VEGF, there is little data on the function of major angiogenic proteins in meningiomas. METHODS:The VEGFA, platelet-d...

journal_title：British journal of cancer

authors： Pfister C,Pfrommer H,Tatagiba MS,Roser F

更新日期：2012-11-06 00:00:00

abstract：:1,25(OH)2D3 promotes differentiation and has an antiproliferative effect in a variety of cell lines derived from the immunohaematopoetic system. alpha-Calcidol which is metabolised to 1,25(OH)2D3 has been shown to produce tumour regression in follicular low grade non-Hodgkin's lymphoma (NHL) and the dose limiting toxi...

journal_title：British journal of cancer

authors： Hickish T,Cunningham D,Colston K,Millar BC,Sandle J,Mackay AG,Soukop M,Sloane J

更新日期：1993-10-01 00:00:00

abstract：:We analysed the molecular genetic profiles of breast cancer samples before and after neoadjuvant chemotherapy with combination doxorubicin and cyclophosphamide (AC). DNA was obtained from microdissected frozen breast core biopsies from 44 patients before chemotherapy. Additional samples were obtained before the second...

journal_title：British journal of cancer

authors： Pierga JY,Reis-Filho JS,Cleator SJ,Dexter T,Mackay A,Simpson P,Fenwick K,Iravani M,Salter J,Hills M,Jones C,Ashworth A,Smith IE,Powles T,Dowsett M

更新日期：2007-01-29 00:00:00

abstract：:To evaluate whether green tea consumption provides protection against stomach cancer death, relative risks were calculated using Cox proportional hazards regression analysis in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based...

journal_title：British journal of cancer

authors： Hoshiyama Y,Kawaguchi T,Miura Y,Mizoue T,Tokui N,Yatsuya H,Sakata K,Kondo T,Kikuchi S,Toyoshima H,Hayakawa N,Tamakoshi A,Ohno Y,Yoshimura T,Japan Collaborative Cohort Study Group.

更新日期：2002-07-29 00:00:00

abstract：BACKGROUND:The risk and prognosis of ovarian cancer have not been well established in women with endometriosis. Thus, we investigated the impact of endometriosis on the risk and prognosis for ovarian cancer, and evaluated clinicopathologic characteristics of endometriosis-associated ovarian cancer (EAOC) in comparison ...

journal_title：British journal of cancer

authors： Kim HS,Kim TH,Chung HH,Song YS

更新日期：2014-04-02 00:00:00

abstract：:The sera from patients with advanced cancer were tested for their specific inhibitory effects on the cytotoxicity of autologous lymphocytes on tumour cells in a microculture assay. By adding a standard volume of the sera to suspensions of well-washed lymphocytes the inhibitory effect was quantitated by comparison with...

journal_title：British journal of cancer

authors： Currie GA

更新日期：1973-07-01 00:00:00

abstract：:Dendritic cells (DC) are professional antigen-presenting cells (APC) of the immune system, uniquely able to prime naive T-cell responses. They are the focus of a range of novel strategies for the immunotherapy of cancer, a proportion of which include treating DC with ionising radiation to high dose. The effects of rad...

journal_title：British journal of cancer

authors： Merrick A,Errington F,Milward K,O'Donnell D,Harrington K,Bateman A,Pandha H,Vile R,Morrison E,Selby P,Melcher A

更新日期：2005-04-25 00:00:00

abstract：BACKGROUND:Focal adhesion kinase (FAK) is overexpressed in a variety of cancers, such as breast, colon, prostate, ovary, and lung cancers. However, the mechanism by which extracellular matrix fibronectin stimulates lung cancer cell migration and invasion through FAK remains to be investigated. METHODS:The signalling p...

journal_title：British journal of cancer

authors： Meng XN,Jin Y,Yu Y,Bai J,Liu GY,Zhu J,Zhao YZ,Wang Z,Chen F,Lee KY,Fu SB

更新日期：2009-07-21 00:00:00

abstract：:Serum concentrations of oestradiol-17β were measured by radio-immunoassay during 40 menstrual cycles from 38 normal premenopausal women. Repeated samples were studied from 25 normal postmenopausal women. The method was highly specific and extremely sensitive. In premenopausal women the pattern of serum oestradiol-17β ...

journal_title：British journal of cancer

authors： England PC,Skinner LG,Cottrell KM,Sellwood RA

更新日期：1974-06-01 00:00:00

abstract：:There is disagreement concerning the expression of thyroid peroxidase (TPO) in thyroid cancer, some studies finding qualitative as well as quantitative differences compared to normal tissue. To investigate TPO protein expression and its antigenic properties, TPO was captured from a solubilizate of thyroid microsomes b...

journal_title：British journal of cancer

authors： Czarnocka B,Pastuszko D,Janota-Bzowski M,Weetman AP,Watson PF,Kemp EH,McIntosh RS,Asghar MS,Jarzab B,Gubala E,Wloch J,Lange D

更新日期：2001-09-14 00:00:00

abstract：:Human chorionic gonadotrophin (hCG) and alphafetoprotein (AFP) were measured in culture media from a panel of 29 cell lines including 9 bladder carcinomas, 5 'normal' bladder epithelia, 10 germ cell tumours, and 5 miscellaneous tumours and 'normal' cell lines. In 7 of the 9 bladder carcinomas and 4 of the 5 'normal' b...

journal_title：British journal of cancer

authors： Iles RK,Oliver RT,Kitau M,Walker C,Chard T

更新日期：1987-06-01 00:00:00

abstract：:Between 1946 and 1976 over 9,000 women with breast cancer were seen within one year of diagnosis at the A. Maxwell Evans Clinic (AMEC) in Vancouver, British Columbia. By 1978, 275 had a subsequent diagnosis of a second primary in the contralateral breast: 100 were diagnosed within 1 year, and 175 after 1 year of the f...

journal_title：British journal of cancer

authors： Hislop TG,Elwood JM,Coldman AJ,Spinelli JJ,Worth AJ,Ellison LG

更新日期：1984-01-01 00:00:00

abstract：:The effect of 6 putative prognostic factors on survival was studied in patients with Stages III and IV malignant teratoma of the testis. Differences between survival curves were tested for statistical significance. A diameter greater than 5 cm in the largest tumour mass, and greater than 8 pulmonary metastases were ad...

journal_title：British journal of cancer

authors： Germa-Lluch JR,Begent RH,Bagshawe KD

更新日期：1980-12-01 00:00:00

abstract：:Rats were given a single dose of dimethylnitrosamine (DMN, 20 mg/kg body weight) alone or 42 or 60 hours after a non-lethal hepatotoxic dose of carbon tetrachloride (CC1(4)) and killed 12 months later. DMN alone produced no tumours in the kidney and a few in the liver, but when given 42 hours after CC1(4), tumours for...

journal_title：British journal of cancer

authors： Pound AW,Lawson TA,Horn L

更新日期：1973-06-01 00:00:00