Tumour rejection in rats sensitized to embryonic tissue. I. Rejection of tumour cells implanted s.c. and detection of cytotoxic lymphoid cells.

abstract：:Photodynamic therapy (PDT) for cancer in the oesophagus and bronchi with red (630 nm) light may occasionally lead to wall perforation and fistula. Therefore, we investigated the clinical use of a less penetrating wavelength (514 nm) for the curative treatment of nine superficial carcinomas in the oesophagus and bronch...

journal_title：British journal of cancer

authors： Grosjean P,Wagnieres G,Fontolliet C,van den Bergh H,Monnier P

更新日期：1998-06-01 00:00:00

abstract：:Women with a family history of breast cancer generally self-refer because they have a feeling that their risk is high. However, they have, in general, only a hazy notion of the population risk of breast cancer and their own risk in relation to this. It is probable that they are helped by genetic counselling and, if at...

journal_title：British journal of cancer

authors： Evans DG,Blair V,Greenhalgh R,Hopwood P,Howell A

更新日期：1994-11-01 00:00:00

abstract：:Accumulating evidence suggests that the p53 gene is a good target for molecular epidemiological studies. We previously reported an association between the presence of p53 mutations and lifetime cigarette consumption. Although over 675 p53 mutations have been reported in lung cancers in the literature thus far, very li...

journal_title：British journal of cancer

authors： Takagi Y,Osada H,Kuroishi T,Mitsudomi T,Kondo M,Niimi T,Saji S,Gazdar AF,Takahashi T,Minna JD,Takahashi T

更新日期：1998-05-01 00:00:00

abstract：:The lability of cell surface histocompatibility antigens of 2 murine lymphomata was examined. These 2 tumours differ greatly in their capacity to metastasize in syngeneic hosts. Cells of the metastatic lymphoma released histocompatibility antigens in vivo and in vitro at a greater rate than cells of the non-metastasiz...

journal_title：British journal of cancer

authors： Davey GC,Currie GA,Alexander P

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Gender-associated epigenetic alterations are poorly investigated in male and female familial breast cancer (fBC). MicroRNAs may contribute to the different biology in men and women particularly related to RASSF1A pathways. METHODS:Microarray technology was used to evaluate miRNA profile in 24 male and 43 fe...

journal_title：British journal of cancer

authors： Pinto R,De Summa S,Danza K,Popescu O,Paradiso A,Micale L,Merla G,Palumbo O,Carella M,Tommasi S

更新日期：2014-12-09 00:00:00

abstract：:Proton pump inhibitor (PPI) use leads to hypergastrinaemia, which has been associated with gastrointestinal neoplasia. We evaluated the association between PPI use and risk of gastric cancer using population-based health-care registers in North Jutland, Denmark, during 1990-2003. We compared incidence rates among new ...

journal_title：British journal of cancer

authors： Poulsen AH,Christensen S,McLaughlin JK,Thomsen RW,Sørensen HT,Olsen JH,Friis S

更新日期：2009-05-05 00:00:00

abstract：:We investigated trends in first-time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population-based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991-2006. We identified new cases of HCC through record...

journal_title：British journal of cancer

authors： McDonald SA,Hutchinson SJ,Bird SM,Robertson C,Mills PR,Dillon JF,Goldberg DJ

更新日期：2008-09-02 00:00:00

abstract：BACKGROUND:Primary high-risk human papillomavirus (hrHPV) testing in cervical cancer screening shows relatively low specificity, which makes triage testing necessary. In this study, DNA methylation analysis was compared with cytology for triage testing in hrHPV-positive women. Moreover, feasibility of DNA methylation a...

journal_title：British journal of cancer

authors： Boers A,Bosgraaf RP,van Leeuwen RW,Schuuring E,Heideman DA,Massuger LF,Verhoef VM,Bulten J,Melchers WJ,van der Zee AG,Bekkers RL,Wisman GB

更新日期：2014-09-09 00:00:00

abstract：:The patterns of early and late relapses (those occurring later than 3 years after diagnosis) in 432 patients achieving complete remission after treatment for stage I and II Hodgkin's disease at the Royal Marsden Hospital between 1964 and 1983 were studied to identify factors predicting for late relapse. The incidence ...

journal_title：British journal of cancer

authors： Duchesne G,Crow J,Ashley S,Brada M,Horwich A

更新日期：1989-08-01 00:00:00

abstract：:Exposure to the fibrous mineral erionite is known to induce mesothelioma in man and laboratory animals. Previous studies demonstrated the presence of a trypsin-like protease associated with tumour cells. This protease could be demonstrated by the use of fluorescent probes which located cells possessing this enzyme. We...

journal_title：British journal of cancer

authors： Steven FS,Hill RJ

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:The United Kingdom performs poorly in international comparisons of colorectal cancer survival with much of the deficit owing to high numbers of deaths close to the time of diagnosis. This retrospective cohort study investigates the patient, tumour and treatment characteristics of those who die in the first y...

journal_title：British journal of cancer

authors： Downing A,Aravani A,Macleod U,Oliver S,Finan PJ,Thomas JD,Quirke P,Wilkinson JR,Morris EJ

更新日期：2013-02-19 00:00:00

abstract：:Immunoreactive and bioassayable plasma fibronectin (opsonic α(2) surface-binding (SB) glycoprotein) was measured during experimental Sarcoma-180 tumour growth in mice. Male C57BL/6 mice were challenged s.c. with 2 × 10(6) viable Sarcoma-180 tumour cells and evaluated sequentially in parallel with saline-injected contr...

journal_title：British journal of cancer

authors： Saba TM,Gregory TJ,Blumenstock FA

更新日期：1980-06-01 00:00:00

abstract：:Chromosomal translocation t(11;22)(q24:q12) is detected in approximately 90% of tumours of the Ewing family (ET). This translocation results in EWS-Fli1 gene fusion which produces a EWS-Fli1 fusion protein acting as an aberrant transcriptional activator. We previously reported that the inhibition of EWS-Fli1 expressio...

journal_title：British journal of cancer

authors： Matsumoto Y,Tanaka K,Nakatani F,Matsunobu T,Matsuda S,Iwamoto Y

更新日期：2001-03-23 00:00:00

abstract：:We assayed methyl-p-hydroxyphenyllactate esterase (MeHPLAase) activity in 63 cases of primary laryngeal squamous cell carcinoma. MeHPLAase activity did not show any correlation with oestrogen, progesterone and epidermal growth factor (EGF) receptor levels. No significant relationship was found between MeHPLAase activi...

journal_title：British journal of cancer

authors： Maurizi M,Ferrandina G,Almadori G,Scambia G,Cadoni G,D'Agostino G,Serra FG,Piantelli M,Mancuso S,Ranelletti FO

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:New prognostic markers are needed to identify patients with Ewing sarcoma (EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the incidence and association with outcome of circulating tumour DNA (ctDNA) using next-generation sequencing (NGS) assays. METHODS:A NGS hybrid capture ass...

journal_title：British journal of cancer

authors： Shulman DS,Klega K,Imamovic-Tuco A,Clapp A,Nag A,Thorner AR,Van Allen E,Ha G,Lessnick SL,Gorlick R,Janeway KA,Leavey PJ,Mascarenhas L,London WB,Vo KT,Stegmaier K,Hall D,Krailo MD,Barkauskas DA,DuBois SG,Crompton B

更新日期：2018-08-01 00:00:00

abstract：:High experienced continuity of care in patients with cancer is associated with lower needs for care, better quality of life and better psychological outcomes. We developed and evaluated an intervention to improve experienced continuity. The intervention, consisted of (1) a 17-item patient-completed continuity assessme...

journal_title：British journal of cancer

authors： King M,Jones L,McCarthy O,Rogers M,Richardson A,Williams R,Tookman A,Nazareth I

更新日期：2009-01-27 00:00:00

abstract：:The predictive value of KRAS mutation in metastatic colorectal cancer (MCRC) patients treated with cetuximab plus chemotherapy has recently been suggested. In our study, 59 patients with a chemotherapy-refractory MCRC treated with cetuximab plus chemotherapy were included and clinical response was evaluated according ...

journal_title：British journal of cancer

authors： Di Fiore F,Blanchard F,Charbonnier F,Le Pessot F,Lamy A,Galais MP,Bastit L,Killian A,Sesboüé R,Tuech JJ,Queuniet AM,Paillot B,Sabourin JC,Michot F,Michel P,Frebourg T

更新日期：2007-04-23 00:00:00

abstract：:The chick embryo was used to study the relationship between the onset of tumour neovascularization and tumour growth. Walker 256 carcinosarcoma was implanted on the chrioallantoic membrane (CAM) of about 600 embryos aged 5-16 days. Tumour diameter and changes in the CAM vasculature in response to the implants were rec...

journal_title：British journal of cancer

authors： Knighton D,Ausprunk D,Tapper D,Folkman J

更新日期：1977-03-01 00:00:00

abstract：:Endosialin is a transmembrane glycoprotein selectively expressed in blood vessels and stromal fibroblasts of various human tumours. It has been functionally implicated in angiogenesis, but the factors that control its expression have remained unclear. As insufficient delivery of oxygen is a driving force of angiogenes...

journal_title：British journal of cancer

authors： Ohradanova A,Gradin K,Barathova M,Zatovicova M,Holotnakova T,Kopacek J,Parkkila S,Poellinger L,Pastorekova S,Pastorek J

更新日期：2008-10-21 00:00:00

abstract：:We have examined a series of human colorectal adenomas, carcinomas and cell lines derived from human colorectal cancer for loss of heterozygosity (LOH) on chromosome 11q22-23 by polymerase chain reaction (PCR) amplification of a microsatellite polymorphism of the dopamine D2 receptor (DRD2) locus. LOH was demonstrated...

journal_title：British journal of cancer

authors： Gustafson CE,Young J,Leggett B,Searle J,Chenevix-Trench G

更新日期：1994-09-01 00:00:00

abstract：:The therapeutic efficacy of gemcitabine, a new nucleoside analogue, was assessed in a variety of well-established human soft tissue sarcoma and ovarian cancer xenografts grown s.c. in nude mice. Tumour lines selected had different histological subtypes, growth rates and sensitivities to conventional cytostatic agents....

journal_title：British journal of cancer

authors： Boven E,Schipper H,Erkelens CA,Hatty SA,Pinedo HM

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:The PI3K/Akt signalling pathway, induced by epidermal growth factor receptor (EGFR) and Her-2, is involved in the constitutive activation of NF-kappaB in prostate cancer cell lines. In this study, we extended the in vitro observation using an ex vivo model of prostate cancer tissues and assessed the prognost...

journal_title：British journal of cancer

authors： Koumakpayi IH,Le Page C,Mes-Masson AM,Saad F

更新日期：2010-03-30 00:00:00

abstract：BACKGROUND:This study explored the association between smoking and colorectal malignant carcinoma (CRC) in the Chinese population at the national level for the first time. METHODS:In the China Nationwide Retrospective Mortality Survey conducted during 1989-1991, 12,942 CRC cases among 1,136,336 all-cause deaths aged ≥...

journal_title：British journal of cancer

authors： Hou L,Jiang J,Liu B,Nasca PC,Wu Y,Zou X,Han W,Chen Y,Zhang B,Xue F,Pang H,Li J

更新日期：2014-03-04 00:00:00

abstract：:Phyto-oestrogens are plant compounds structurally similar to oestradiol, which have been proposed to have protective effects against breast cancer. The main class of phyto-oestrogens in the Western diet is lignans. Literature reports on the effect of lignans in breast cancer risk have been conflicting. We performed th...

journal_title：British journal of cancer

authors： Velentzis LS,Cantwell MM,Cardwell C,Keshtgar MR,Leathem AJ,Woodside JV

更新日期：2009-05-05 00:00:00

abstract：:Protracted venous infusion 5-fluorouracil (5FU) combined with mitomycin C (MMC) has demonstrated significant activity against metastatic colorectal cancer. Owing to potential synergy based upon upregulation of thymidine phosphorylase by MMC, the combination of capecitabine and MMC may improve outcomes in irinotecan-re...

journal_title：British journal of cancer

authors： Chong G,Dickson JL,Cunningham D,Norman AR,Rao S,Hill ME,Price TJ,Oates J,Tebbutt N

更新日期：2005-09-05 00:00:00

abstract：BACKGROUND:SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. METHODS:Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks o...

journal_title：British journal of cancer

authors： Hurt CN,Falk S,Crosby T,McDonald A,Ray R,Joseph G,Staffurth J,Abrams RA,Griffiths G,Maughan T,Mukherjee S

更新日期：2017-05-09 00:00:00

abstract：:Hyper-activation of mitogen-activated protein kinase (MAPK) has recently been reported in several human cancers and activation of MAPK in those cancers may be associated with carcinogenesis through aberrant cell proliferation. To understand the roles of the MAPK pathway in colorectal tumorigenesis, we examined the sta...

journal_title：British journal of cancer

authors： Park KS,Kim NG,Kim JJ,Kim H,Ahn YH,Choi KY

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and recurrence. However, the mechanism of CSC formation, maintenance and expansion in colorectal cancer (CRC) remains poorly characterised. METHODS:The role of COP9 signalosome subunit 6 (CSN6) in regulating cancer stemness was evalu...

journal_title：British journal of cancer

authors： Qin B,Zou S,Li K,Wang H,Wei W,Zhang B,Xiao L,Choi HH,Tang Q,Huang D,Liu Q,Pan Q,Meng M,Fang L,Lee MH

更新日期：2020-05-01 00:00:00

abstract：:The present study investigates the role of nitric oxide and the involvement of nitric oxide synthase II isoform on the invasion of human colorectal adenocarcinoma cell lines HRT-18 and HT-29. HRT-18 cells, which constitutively express nitric oxide synthase II mRNA were three-fold more invasive in a Matrigel invasion a...

journal_title：British journal of cancer

authors： Siegert A,Rosenberg C,Schmitt WD,Denkert C,Hauptmann S

更新日期：2002-04-22 00:00:00

abstract：:Recombinant single-chain fragments (scFv) of the murine anti-MUC1 monoclonal antibody C595 have been produced using the original hybridoma cells as a source of variable heavy (V(H))- and variable light (V(L))-chain-encoding antibody genes. The use of the polymerase chain reaction (PCR), bacteriophage (phage) display t...

journal_title：British journal of cancer

authors： Denton G,Sekowski M,Spencer DI,Hughes OD,Murray A,Denley H,Tendler SJ,Price MR

更新日期：1997-01-01 00:00:00