Abstract：
:Differences were seen in the ability of 2 strains of C. parvum to augment cytotoxicity attributable to NK cells towards a rat lymphoma. Furthermore, 2 batches of the same strain of C. parvum prepared by different methods also differed in their ability to augment cytotoxicity. Other factors influencing cytotoxicity were dose, route of inoculation and time after injection at which the assay was performed. Although all preparations of C. parvum augmented the cytotoxicity of peritoneal-exudate cells when injected i.p., only the most stimulatory preparation consistently augmented splenic cytotoxicity when given by this route. I.v. administration of 1 mg of C. parvum produced peak levels of splenic cytotoxicity 2-3 days later, but this response was strictly dose-dependent, since 1 microgram depressed splenic cytotoxicity. This dose-dependent effect also extended to ADCC, since 1 mg stimulated cytotoxicity towards antibody-coated P815 cells, whilst 1 microgram depressed it in a manner similar to its effect on natural cytotoxicity. Whilst the cytotoxic cells of stimulated rats closely resembled the NK cells of normal rats, BN rats responded differently to C. parvum from W/Fu or WAG rats, in that marked lysis of P815 or RBL-5 cells was observed, though these targets are usually resistant to lysis by rat NK cells in short-term assays.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Flexman JP,Shellam GRdoi
10.1038/bjc.1980.201subject
Has Abstractpub_date
1980-07-01 00:00:00pages
41-51issue
1eissn
0007-0920issn
1532-1827journal_volume
42pub_type
杂志文章abstract：BACKGROUND:Cabazitaxel is approved for treatment of castration-resistant metastatic prostate cancer. The current dosing strategy of cabazitaxel is based on body surface area (BSA). Body surface area is known as a poor predictor for total systemic exposure to drugs, since it does not take into account variability in act...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.91
更新日期：2017-05-09 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is one of the most malignant human tumours because of its high incidence of metastasis. The mechanisms underlying the metastasis of HCC, however, remain poorly understood. In this study, we performed cDNA microarray analysis to profile gene expression patterns in two subtypes of HCC, sol...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601749
更新日期：2004-06-14 00:00:00
abstract：:Two meta-analyses were conducted to quantify the benefit of combining alpha-IFN to 5FU in advanced colorectal cancer in terms of tumour response and survival. Analyses were based on a total of 3254 individual patient data provided by principal investigators of each trial. The meta-analysis of 5FU +/- LV vs. 5FU +/- LV...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1054/bjoc.2000.1669
更新日期：2001-03-02 00:00:00
abstract：:Counter-irritation (CI) triggered by different non-specific irritant stimuli delayed the growth of a murine tumour of non-detected immunogenicity. The syngeneic LB tumour transplant by itself also induced CI and decreased the number of leukocytes migrating to a secondary s.c. irritant stimulus, e.g. sponge or carragee...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.349
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. METHODS:A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0910-y
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Breast cancer 1, early onset (BRCA1) is a tumour-suppressor gene associated with familial epithelial ovarian cancer (EOC). Reduced BRCA1 expression is associated with enhanced sensitivity to platinum-based chemotherapy. We sought to examine the prognostic relevance of BRCA1 expression in EOC patients treated...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2013.70
更新日期：2013-04-02 00:00:00
abstract：BACKGROUND:Topoisomerase I (Topo I) poisons (e.g., camptothecin (CPT)), used to treat cancer, cause DNA breaks that are most cytotoxic during S phase. PARP-1 promotes DNA repair and PARP inhibitors (PARPi) sensitise cells to Topo I poisons. We aimed to determine whether chemosensitisation is also S phase specific using...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.378
更新日期：2014-09-23 00:00:00
abstract：:The objective of this study was to prospectively measure peri-diagnostic and surgical time intervals for patients with suspected colorectal, lung, or prostate cancer. Prospective eligible patients were referred to a regional hospital in Ottawa, Canada between February 2004 and February 2005 for diagnostic assessment o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604819
更新日期：2009-01-13 00:00:00
abstract：:A late-gestation neonatal antigen (gamma foetal antigen; gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-FA from both foetus ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.173
更新日期：1979-08-01 00:00:00
abstract：BACKGROUND:The lipogenic transcription factor carbohydrate response element-binding protein (ChREBP) may play a key role in malignant progression of breast cancer by allowing metabolic adaptations to take place in response to changes in oxygenation. METHODS:Immunohistochemical analysis of ChREBP was carried out in hum...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.765
更新日期：2014-02-04 00:00:00
abstract：:Mutations of the p53 tumour suppressor gene are infrequent at presentation of both acute myeloblastic leukaemia (AML) and acute lymphoblastic leukaemia (ALL), being found in between 5-10% of AML and 2-3% of ALL. Here we have studied the frequency of detection of p53 mutations at relapse of both AML and B-precursor ALL...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690183
更新日期：1999-03-01 00:00:00
abstract：:Antibody drug conjugates (ADCs) employ the exquisite specificity of tumour-specific monoclonal antibodies (mAb) for the targeted delivery of highly potent cytotoxic drugs to the tumour site. The chemistry of the linker, which connects the drug to the mAb, determines how and when the drug is released from the mAb. This...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2017.367
更新日期：2017-12-05 00:00:00
abstract：:Erbicin is a human anti-ErbB2 single-chain antibody fragment with high affinity and selectivity for ErbB2-positive cancer cells. Two anti-ErbB2 immunoconjugates, called Erb-hRNase and Erb-hcAb, have been prepared and found to be selectively cytotoxic on ErbB2-positive cancer cells in vitro and vivo. In Erb-hRNase, Erb...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604022
更新日期：2007-11-19 00:00:00
abstract：:In a clinical investigation of observed postoperative survival, 563 patients have been registered for primary surgical treatment of colorectal cancer since 1974. The potential prognostic factors examined within the first days of hospitalization for primary resection included age of the patients, operability, location ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.250
更新日期：1981-11-01 00:00:00
abstract：:In vivo growth characteristics of myeloid leukaemia induced by whole-body irradiation of CBA/H male mice were examined in the strain of origin by procedures expected to enhance or depress immunological responses. Syngeneic growth in vivo (survival time and frequency of takes) was not modified by attempted active immun...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.68
更新日期：1982-03-01 00:00:00
abstract：:Loss of cell cycle control through the structural or functional aberration of checkpoint genes and their products is a potentially important process in carcinogenesis. In this study, a panel of well-characterised established human bladder cancer cell lines was screened by the polymerase chain reaction for homozygous l...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.488
更新日期：1995-11-01 00:00:00
abstract：:The prostate cancer cell lines PC3 and LNCaP have been shown to lack expression of the tumour suppressor gene MMAC1/PTEN, in contrast to the immortalized non-tumorigenic epithelial lines PNT1a and PNT2. We have measured the effects of reintroduction of wild type (wt) and mutant MMAC1 genes on to these genetic backgrou...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1400
更新日期：2000-10-01 00:00:00
abstract：:Gallium-67 is a radionuclide that accumulates in haematological malignancies and is used for diagnostic purposes. Uptake of 67Ga into the cell occurs via the transferrin receptor, which is differentially expressed during the various cell cycle phases. With the aim of selectively increasing 67Ga uptake, we studied whet...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.411
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:The target substrates of DNA mismatch recognising factors MutSalpha (MSH2+MSH6) and MutSbeta (MSH2+MSH3) have already been widely researched. However, the extent of their functional redundancy and clinical substance remains unclear. Mismatch repair (MMR)-deficient tumours are strongly associated with microsa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605531
更新日期：2010-03-16 00:00:00
abstract：BACKGROUND:The germline BRCA2 mutation is associated with increased prostate cancer (PrCa) risk. We have assessed survival in young PrCa cases with a germline mutation in BRCA2 and investigated loss of heterozygosity at BRCA2 in their tumours. METHODS:Two cohorts were compared: one was a group with young-onset PrCa, t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605822
更新日期：2010-09-07 00:00:00
abstract：:Aminoglutethimide has been used in combination with hydrocortisone in patients with advanced prostatic cancer with the rationale that it causes a 'medical adrenalectomy'. Both objective and subjective responses have been recorded. We have examined the effect of AG and HC alone and in combination on plasma androgen lev...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.40
更新日期：1988-02-01 00:00:00
abstract：:A cell-free plasmid reactivation assay was used to determine the fidelity of DNA double-strand break (DSB) repair in a panel of eight DSB repair-proficient human tumour cell lines. Nuclear protein extracts derived from radiosensitive tumour cells were less capable of correctly rejoining EcoRI-induced DSBs than were si...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.576
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and recurrence. However, the mechanism of CSC formation, maintenance and expansion in colorectal cancer (CRC) remains poorly characterised. METHODS:The role of COP9 signalosome subunit 6 (CSN6) in regulating cancer stemness was evalu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0779-9
更新日期：2020-05-01 00:00:00
abstract：:The author Sara Lonardi was incorrectly listed as Sara Leonardi. The correct name is listed above. ...
journal_title：British journal of cancer
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41416-018-0067-0
更新日期：2018-06-01 00:00:00
abstract：:The cardiotoxicity of 5-fluorouracil (FU) was attributed to impurities present in the injected vials. One of these impurities was identified as fluoroacetaldehyde which is metabolised by isolated perfused rabbit hearts into fluoroacetate (FAC), a highly cardiotoxic compound. FAC was also detected in the urine of patie...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.227
更新日期：1992-07-01 00:00:00
abstract：:The effect of 6 putative prognostic factors on survival was studied in patients with Stages III and IV malignant teratoma of the testis. Differences between survival curves were tested for statistical significance. A diameter greater than 5 cm in the largest tumour mass, and greater than 8 pulmonary metastases were ad...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.332
更新日期：1980-12-01 00:00:00
abstract：:Darbepoetin alfa (Aranesp), Amgen) is a novel erythropoiesis-stimulating protein with a serum half-life longer than recombinant human erythropoietin (Epo), used in the treatment of cancer-associated anaemia. Anaemia is known to adversely affect prognosis and response to treatment in cancer patients. Solid tumours cont...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602685
更新日期：2005-07-25 00:00:00
abstract：:Studies of underground miners occupationally exposed to radon have consistently demonstrated an increased risk of lung cancer in both smokers and non-smokers. Radon exposure also occurs elsewhere, especially in houses, and estimates based on the findings for miners suggest that residential radon is responsible for abo...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.506
更新日期：1998-08-01 00:00:00
abstract：:Besides its cardiotoxic effect, doxorubicin also elicits inflammatory effects in vivo. 7-Monohydroxyethylrutoside (monoHER) has recently been used as a protector against doxorubicin-induced cardiotoxicity in vivo. It is not known yet whether monoHER can also protect against doxorubicin-induced inflammatory effects. Th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601022
更新日期：2003-07-21 00:00:00
abstract：:Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that develop from distinct epithelial sub-types; however, they are both related to chronic inflammation of differing aetiologies. Inflammation leads to somatically inherited genetic mutations altering control of the cell cycle, DNA replication an...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605126
更新日期：2009-07-07 00:00:00
