Abstract:
:Studies of underground miners occupationally exposed to radon have consistently demonstrated an increased risk of lung cancer in both smokers and non-smokers. Radon exposure also occurs elsewhere, especially in houses, and estimates based on the findings for miners suggest that residential radon is responsible for about one in 20 lung cancers in the UK, most being caused in combination with smoking. These calculations depend, however, on several assumptions and more direct evidence on the magnitude of the risk is needed. To obtain such evidence, a case-control study was carried out in south-west England in which 982 subjects with lung cancer and 3185 control subjects were interviewed. In addition, radon concentrations were measured at the addresses at which subjects had lived during the 30-year period ending 5 years before the interview. Lung cancer risk was examined in relation to residential radon concentration after taking into account the length of time that subjects had lived at each address and adjusting for age, sex, smoking status, county of residence and social class. The relative risk of lung cancer increased by 0.08 (95% CI -0.03, 0.20) per 100 Bq m(-3) increase in the observed time-weighted residential radon concentration. When the analysis was restricted to the 484 subjects with lung cancer and the 1637 control subjects with radon measurements available for the entire 30-year period of interest, the corresponding increase was somewhat higher at 0.14 per 100 Bq m(-3) (95% CI 0.01, 0.29), although the difference between this group and the remaining subjects was not statistically significant. When the analysis was repeated taking into account uncertainties in the assessment of radon exposure, the estimated increases in relative risk per 100 Bq m(-3) were larger, at 0.12 (95% CI -0.05, 0.33) when all subjects were included and 0.24 (95% CI -0.01, 0.56) when limited to subjects with radon measurements available for all 30 years. These results are consistent with those from studies of residential radon carried out in other countries in which data on individual subjects have been collected. The combined evidence suggests that the risk of lung cancer associated with residential radon exposure is about the size that has been postulated on the basis of the studies of miners exposed to radon.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Darby S,Whitley E,Silcocks P,Thakrar B,Green M,Lomas P,Miles J,Reeves G,Fearn T,Doll Rdoi
10.1038/bjc.1998.506subject
Has Abstractpub_date
1998-08-01 00:00:00pages
394-408issue
3eissn
0007-0920issn
1532-1827journal_volume
78pub_type
杂志文章abstract::The behaviour in vivo of tight and loose variants of murine melanoma cells is further characterized. In vitro clonal morphology is reproduced on a variety of substrates. Results suggest that repeated selection of loose cells can co-select for cells with high metastatic and colonization potentials. Measurement of cell ...
journal_title:British journal of cancer
pub_type: 杂志文章
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abstract:BACKGROUND:The overexpression of oestrogen-related receptor-β (ERRβ) in breast cancer patients is correlated with improved prognosis and longer relapse-free survival, and the level of ERRβ mRNA is inversely correlated with the S-phase fraction of cells from breast cancer patients. METHODS:Chromatin immunoprecipitation...
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abstract::This cross-sectional survey aimed to evaluate the prevalence of burnout and estimated psychiatric disorders among haemato-oncology healthcare professionals in Italy. The aspects of work that respondents perceive as stressful and satisfying have also been examined. The assessments were made using the Maslach Burnout In...
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journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-10-21 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.512
更新日期:1996-10-01 00:00:00
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更新日期:1989-09-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.675
更新日期:1998-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1054/bjoc.2001.1875
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journal_title:British journal of cancer
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更新日期:2016-06-14 00:00:00
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pub_type: 杂志文章
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journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-10-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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