Abstract:
BACKGROUND:Determining the rate of breast cancer (BC) growth in vivo, which can predict prognosis, has remained elusive despite its relevance for treatment, screening recommendations and medicolegal practice. We developed a model that predicts the rate of in vivo tumour growth using a unique study cohort of BC patients who had two serial mammograms wherein the tumour, visible in the diagnostic mammogram, was missed in the first screen. METHODS:A serial mammography-derived in vivo growth rate (SM-INVIGOR) index was developed using tumour volumes from two serial mammograms and time interval between measurements. We then developed a machine learning-based surrogate model called Surr-INVIGOR using routinely assessed biomarkers to predict in vivo rate of tumour growth and extend the utility of this approach to a larger patient population. Surr-INVIGOR was validated using an independent cohort. RESULTS:SM-INVIGOR stratified discovery cohort patients into fast-growing versus slow-growing tumour subgroups, wherein patients with fast-growing tumours experienced poorer BC-specific survival. Our clinically relevant Surr-INVIGOR stratified tumours in the discovery cohort and was concordant with SM-INVIGOR. In the validation cohort, Surr-INVIGOR uncovered significant survival differences between patients with fast-growing and slow-growing tumours. CONCLUSION:Our Surr-INVIGOR model predicts in vivo BC growth rate during the pre-diagnostic stage and offers several useful applications.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Bhattarai S,Klimov S,Aleskandarany MA,Burrell H,Wormall A,Green AR,Rida P,Ellis IO,Osan RM,Rakha EA,Aneja Rdoi
10.1038/s41416-019-0539-xsubject
Has Abstractpub_date
2019-09-01 00:00:00pages
497-504issue
6eissn
0007-0920issn
1532-1827pii
10.1038/s41416-019-0539-xjournal_volume
121pub_type
临床试验,杂志文章abstract::NK911 is a novel supramolecular nanocarrier designed for the enhanced delivery of doxorubicin (DXR) and is one of the successful polymer micelle systems to exhibit an efficient accumulation in solid tumours in mice. The purpose of this study was to define the maximum-tolerated dose (MTD) and dose-limiting toxicities (...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
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abstract::In this study, we have investigated the expression of inhibin subunits and activin receptors (ActRs) in normal and malignant ovarian cells. Each product of the inhibin subunits (alpha, betaa, betab) and activin receptors (ActRs) amplified by reverse transcription polymerase chain reaction were detected as a single ban...
journal_title:British journal of cancer
pub_type: 杂志文章
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journal_title:British journal of cancer
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abstract::The S-phase fraction (SPF) in flow cytometric DNA histograms in soft tissue sarcoma (STS) can be calculated in various ways. The traditional planimetric method of Baisch has been shown to be prognostic, but is hampered by a failure rate of around 40%. We therefore tested other models to see if this rate could be decre...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690193
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abstract::The zinc finger protein glioma-associated oncogene homologue 1 (Gli-1) is a critical component of the Hedgehog (Hh) signalling pathway, which is essential for morphogenesis and stem-cell renewal, and is dysregulated in many cancer types. As data were not available on the role of Gli-1 expression in oesophageal cancer ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604361
更新日期:2008-05-20 00:00:00
abstract::The effect of acute carbon monoxide (CO) breathing on blood oxygenation and tumour hypoxia was related to the radiation response of the C3H/Tif mammary carcinoma. Blood gas analysis showed that CO breathing caused a time- and dose-dependent formation of carboxyhaemoglobin (HbCO), a significant left shift of the oxygen...
journal_title:British journal of cancer
pub_type: 杂志文章
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abstract:BACKGROUND:New therapeutic options for metastatic pancreatic cancer are urgently needed. In pancreatic cancer, overexpression of the epidermal growth factor receptor 2 (HER2) has been reported in up to 45%. This multicentre phase II study investigated the efficacy and toxicity of the HER2 antibody trastuzumab combined ...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,评审
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600913
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abstract::To clarify the prognostic factors in patients with submucosal carcinoma of the oesophagus, we examined the results of surgical treatment for 78 cases over the last decade. The clinicopathological factors including age, sex, location of the tumour, length of the tumour, histological differentiation, subclassification o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1288
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abstract::The present study was designed to examine whether different p53 haplotypes of exon 4-intron 3-intron 6 affect the frequency of mutations and loss of heterozygosity (LOH) of the p53 gene in male oral squamous cell carcinomas (OSCCs) in Taiwan. We found that individuals without two Pro-W-G alleles had significantly high...
journal_title:British journal of cancer
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abstract::Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respirato...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603140
更新日期:2006-05-22 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.284
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journal_title:British journal of cancer
pub_type: 杂志文章
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1982.45
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.170
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1980.332
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journal_title:British journal of cancer
pub_type: 杂志文章
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abstract::The prodrug N-[4-(daunorubicin-N-carbonyl-oxymethyl)phenyl] O-beta-glucuronyl carbamate (DNR-GA3) was synthesized for specific activation by human beta-glucuronidase, released in necrotic areas of tumour lesions. In vitro, DNR-GA3 was 18 times less toxic than daunorubicin (DNR) and the prodrug was completely activated...
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pub_type: 杂志文章
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journal_title:British journal of cancer
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.402
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abstract::Insulin-like growth factor-1 (IGF-1) has been described as an important factor in proliferation, cell survival and migration of multiple myeloma (MM) cells. Angiogenesis correlates with development and prognosis of the MM disease. Vascular endothelial growth factor (VEGF) is one of the prominent factors involved in th...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601613
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.80
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journal_title:British journal of cancer
pub_type: 杂志文章
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