Zinc induction of testicular teratomas in Japanese quail (Coturnix coturnix Japonica) after photoperiodic stimulation of testis.

abstract：BACKGROUND:The aim of this study was to investigate the safety of neoadjuvant chemoradiation using radiotherapy (RT) combined with concurrent capecitabine and irinotecan for locally advanced rectal cancer before surgery. METHODS:Forty-six patients were recruited and treated on the basis that MRI scanning had shown poo...

journal_title：British journal of cancer

authors： Gollins SW,Myint S,Susnerwala S,Haylock B,Wise M,Topham C,Samuel L,Swindell R,Morris J,Mason L,Levine E

更新日期：2009-09-15 00:00:00

abstract：:The effect on cell-cycle progression in various phases of the cell cycle caused by an acute exposure to hypoxia in absence and presence of misonidazole (MISO) was investigated. Exponentially growing and synchronized cells of the human line NHIK 3025 were exposed to different degrees of hypoxia for a short period (1.5 ...

journal_title：British journal of cancer

authors： Pettersen EO,Lindmo T

更新日期：1983-12-01 00:00:00

abstract：:We have investigated the effects of 50 min whole-body hyperthermia (WBH; 15 min equilibration followed by 41 degrees C for 35 min) on the toxicity and pharmacokinetics of the radiosensitizer Ro 03-8799 in mice. WBH markedly reduced Ro 03-8799 LD50/7d from 779 to 259 micrograms g-1 (P less than 0.001). Pharmacokinetics...

journal_title：British journal of cancer

authors： Walton MI,Bleehen NM,Workman P

更新日期：1987-05-01 00:00:00

abstract：:In the past decade, an increasing number of frequently positive randomised clinical trials have been completed, allowing new consideration of the present therapeutic armamentarium for advanced renal cell carcinoma. These studies were predominantly designed to compare the experimental drugs with 1 of 2 active control a...

journal_title：British journal of cancer

authors： Bracarda S,Porta C,Sisani M,Marrocolo F,Paglino C,Hamzaj A,D Buono S,Sternberg CN

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:Clear cell renal cancer frequently harbours von Hippel-Lindau (VHL) gene mutations, leading to stabilisation of the hypoxia-inducible factors (HIFs) and expression of their target genes. We investigated HIF-1 and HIF-2 in the regulation of microRNA-210 (miR-210), and its clinical relevance in renal tumours. ...

journal_title：British journal of cancer

authors： McCormick RI,Blick C,Ragoussis J,Schoedel J,Mole DR,Young AC,Selby PJ,Banks RE,Harris AL

更新日期：2013-03-19 00:00:00

abstract：:The sera from patients with advanced cancer were tested for their specific inhibitory effects on the cytotoxicity of autologous lymphocytes on tumour cells in a microculture assay. By adding a standard volume of the sera to suspensions of well-washed lymphocytes the inhibitory effect was quantitated by comparison with...

journal_title：British journal of cancer

authors： Currie GA

更新日期：1973-07-01 00:00:00

abstract：:The aim of our analysis was to assess retrospectively the effect on local relapse, overall survival (OS) and disease-free survival (DFS) of a limited or an extended lymphadenectomy in radically resected gastric cancer patients. This study was performed in order to identify a subgroup of patients possibly not benefitin...

journal_title：British journal of cancer

authors： Scartozzi M,Galizia E,Graziano F,Catalano V,Berardi R,Baldelli AM,Testa E,Mari D,Silva RR,Cascinu S

更新日期：2005-03-28 00:00:00

abstract：BACKGROUND:MSMB, a gene coding for beta-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant....

journal_title：British journal of cancer

authors： Kote-Jarai Z,Leongamornlert D,Tymrakiewicz M,Field H,Guy M,Al Olama AA,Morrison J,O'Brien L,Wilkinson R,Hall A,Sawyer E,Muir K,Hamdy F,Donovan J,Neal D,Easton D,Eeles R

更新日期：2010-01-19 00:00:00

abstract：BACKGROUND:A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is currently the best predictor of responsiveness towards immune checkpoint blockade. Data about the prevalence of high-level microsatellite instability in cholangiocarc...

journal_title：British journal of cancer

authors： Goeppert B,Roessler S,Renner M,Singer S,Mehrabi A,Vogel MN,Pathil A,Czink E,Köhler B,Springfeld C,Pfeiffenberger J,Rupp C,Weiss KH,Schirmacher P,von Knebel Doeberitz M,Kloor M

更新日期：2019-01-01 00:00:00

abstract：:The metabolism of serotonin was studied in cancer patients of their first day of their first course of chemotherapeutic drugs either with strongly or moderately emetogenic regimens. It was observed that strongly emetogenic treatments induce greater increases in serotonin release than moderately emetogenic regimens. Hi...

journal_title：British journal of cancer

authors： Cubeddu LX,Hoffmann IS,Fuenmayor NT,Malave JJ

更新日期：1992-07-01 00:00:00

abstract：:Histological sections of the primary tumour and of homolateral axillary lymph nodes from 500 women with operable invasive breast cancer have been examined. The tumours have been graded and the degree of round cell infiltration assessed. These features, together with clinical palpability and pathological involvement of...

journal_title：British journal of cancer

authors： Champion HR,Wallace IW,Prescott RJ

更新日期：1972-04-01 00:00:00

abstract：BACKGROUND:Faecal immunochemical tests (FITs) have replaced guaiac-based faecal occult blood test (gFOBTs) in several colorectal cancer (CRC) screening programmes. We aimed to evaluate the benefits of this transition based on the Wallonia-Brussels-organised CRC screening programme. METHODS:A total of 1,569,868 individ...

journal_title：British journal of cancer

authors： Guo F,De Brabander I,Francart J,Candeur M,Polus M,Van Eycken L,Brenner H

更新日期：2020-03-01 00:00:00

abstract：:The topical carcinogenicity to mouse skin of smoke condensates obtained from a tobacco substitute (NSM), alone or in combination with tobacco, has been compared with condensate from tobacco and with acetone, the solvent used. Sixteen different types of cigarette were used to make the condensates, and the age-standardi...

journal_title：British journal of cancer

authors： Clapp MJ,Conning DM,Wilson J

更新日期：1977-03-01 00:00:00

abstract：:We analysed 26 metastases from 25 patients with sporadic cutaneous malignant melanoma for alterations in the CDKN2 gene by a combined polymerase chain reaction/single-strand conformation polymorphism (PCR/SSCP)/nucleotide sequencing approach. Eleven alterations (one in exon 1, five in exon 2 and five in the 3' non-cod...

journal_title：British journal of cancer

authors： Platz A,Ringborg U,Lagerlöf B,Lundqvist E,Sevigny P,Inganäs M

更新日期：1996-02-01 00:00:00

abstract：:Dendritic cells (DC) are professional antigen-presenting cells that play a pivotal role in the induction of immunity. Ex vivo-generated, tumour antigen-loaded mature DC are currently exploited as cancer vaccines in clinical studies. However, antigen loading and maturation of DC directly in vivo would greatly facilitat...

journal_title：British journal of cancer

authors： den Brok MH,Sutmuller RP,Nierkens S,Bennink EJ,Frielink C,Toonen LW,Boerman OC,Figdor CG,Ruers TJ,Adema GJ

更新日期：2006-10-09 00:00:00

abstract：:The discoidin domain receptors, (DDR)1 and DDR2, have been linked to numerous human cancers. We sought to determine expression levels of DDRs in human lung cancer, investigate prognostic determinates, and determine the prevalence of recently reported mutations in these receptor tyrosine kinases. Tumour samples from 14...

journal_title：British journal of cancer

authors： Ford CE,Lau SK,Zhu CQ,Andersson T,Tsao MS,Vogel WF

更新日期：2007-03-12 00:00:00

abstract：BACKGROUND:Random error in the numbers of avoidable deaths among cancer patients has not been considered in earlier studies. METHODS:Methods to obtain valid confidence intervals (CIs) for numbers of avoidable deaths were developed. The excess mortality rates were estimated for patients diagnosed with colon cancer in f...

journal_title：British journal of cancer

authors： Seppä K,Hakulinen T,Läärä E

更新日期：2012-05-22 00:00:00

abstract：:Expression of CDX2, a caudal-related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to Cdx2 develop multiple intestinal adenomatous polyps. To clarify the role of CDX2 in colorectal carcinogenesis, we determined its genomic structure, and searched for mutations of C...

journal_title：British journal of cancer

authors： Yagi OK,Akiyama Y,Yuasa Y

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Glomerular filtration rate (GFR) is used in the calculation of carboplatin dose. Glomerular filtration rate is measured using a radioisotope method (radionuclide GFR (rGFR)), however, estimation equations are available (estimated GFR (eGFR)). Our aim was to assess the accuracy of three eGFR equations and the...

journal_title：British journal of cancer

authors： Craig AJ,Samol J,Heenan SD,Irwin AG,Britten A

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:This phase 1 study examined the safety, tolerability, pharmacokinetics and preliminary efficacy of eribulin-liposomal formulation (eribulin-LF) in patients with advanced solid tumours. METHODS:Eligible patients with ECOG PS 0-1 were treated with eribulin-LF either on day 1 every 21 days (Schedule 1), or on ...

journal_title：British journal of cancer

authors： Evans TRJ,Dean E,Molife LR,Lopez J,Ranson M,El-Khouly F,Zubairi I,Savulsky C,Reyderman L,Jia Y,Sweeting L,Greystoke A,Barriuso J,Kristeleit R

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Placental-site trophoblastic (PSTT) and epithelioid trophoblastic tumours (ETT) are the rarest malignant forms of gestational trophoblastic disease (GTD). Our prior work demonstrated that an interval of ≥48 months from the antecedent pregnancy was associated with 100% death rate, independent of the stage. He...

journal_title：British journal of cancer

authors： Froeling FEM,Ramaswami R,Papanastasopoulos P,Kaur B,Sebire NJ,Short D,Fisher RA,Sarwar N,Wells M,Singh K,Ellis L,Horsman JM,Winter MC,Tidy J,Hancock BW,Seckl MJ

更新日期：2019-03-01 00:00:00

abstract：:6-Mercaptopurine (MP)-sensitive and -resistant cell culture lines were used to further characterize the apparent ability of MP nucleotide derivatives to overcome resistance to the parent drug. 6-Mercaptopurine-9-beta-D-ribofuranoside 5'-monophosphate [MPRP], bis(6-mercaptopurine-9-beta-D-ribofuranoside)-5', 5"'-monoph...

journal_title：British journal of cancer

authors： Johnston HP,Hawley P,White SE,Gibson I,Tidd DM

更新日期：1985-04-01 00:00:00

abstract：:Plasma concentrations of certain hormones linked to breast cancer risk were measured in age-pooled samples from 3,250 rural Chinese women in 65 counties, and 300 British women, all aged 35-64. In age-groups 35-44, 45-54 and 55-64 respectively, mean oestradiol concentrations were 36% (P = 0.043), 90% (P less than 0.001...

journal_title：British journal of cancer

authors： Key TJ,Chen J,Wang DY,Pike MC,Boreham J

更新日期：1990-10-01 00:00:00

abstract：:An initial report suggested that patients homozygous for the arginine allele at codon 72 of P53 were at increased risk for human papillomavirus (HPV)-related cervical cancer, but other groups have not confirmed this finding. Since approximately 18-36% of head and neck cancers are HPV-related, we examined the genotypic...

journal_title：British journal of cancer

authors： Hamel N,Black MJ,Ghadirian P,Foulkes WD

更新日期：2000-02-01 00:00:00

abstract：:We report observations on the spread by metastasis and infiltration of a transplantable tumour in rats treated by 60Co gamma-irradiation of the primary, irradiation plus parenteral cyclophosphamide, or parenteral cyclophosphamide alone. The proportion of animals with overt disseminated disease and the extent of spread...

journal_title：British journal of cancer

authors： Moore JV,Dixon B

更新日期：1977-08-01 00:00:00

abstract：:The triple drug combination consisting of irinotecan, oxaliplatin and 5-fluorouracil (FOLFOXIRI) has demonstrated higher activity and efficacy compared to the doublet FOLFIRI. 5-Fluorouracil could be substituted in FOLFOXIRI regimen by capecitabine, an oral fluoropyrimidine with similar efficacy. Recently, a dose-find...

journal_title：British journal of cancer

authors： Vasile E,Masi G,Fornaro L,Cupini S,Loupakis F,Bursi S,Petrini I,Di Donato S,Brunetti IM,Ricci S,Antonuzzo A,Chiara S,Amoroso D,Andreuccetti M,Falcone A

更新日期：2009-06-02 00:00:00

abstract：:Somatostatin receptor (sstr)-mediated radiation therapy is a new therapeutic modality for neuroendocrine (NE) tumours. High expression of sstr in NE tumours leads to tumour-specific uptake of radiolabelled somatostatin analogues and high absorbed doses. In this study, we present the first optimised radiation therapy v...

journal_title：British journal of cancer

authors： Kölby L,Bernhardt P,Johanson V,Schmitt A,Ahlman H,Forssell-Aronsson E,Mäcke H,Nilsson O

更新日期：2005-11-14 00:00:00

abstract：:We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA ...

journal_title：British journal of cancer

authors： Szybka M,Zawlik I,Kulczycka D,Golanska E,Jesien E,Kupnicka D,Stawski R,Piaskowski S,Bieniek E,Zakrzewska M,Kordek R,Liberski PP,Rieske P

更新日期：2008-04-22 00:00:00

abstract：:Magnetic resonance spectroscopy is increasingly used as a non-invasive method to investigate apoptosis. Apoptosis was induced in Jurkat T-cells by Fas mAb. (1)H magnetic resonance spectra of live cells showed an increase in methylene signal as well as methylene/methyl ratio of fatty acid side chains at 5 and 24 h foll...

journal_title：British journal of cancer

authors： Al-Saffar NM,Titley JC,Robertson D,Clarke PA,Jackson LE,Leach MO,Ronen SM

更新日期：2002-03-18 00:00:00

abstract：:Since hyperinsulinaemia may promote obesity-linked cancers, we compared type 2 diabetes prevalence among oesophageal adenocarcinoma (OAC) patients and population controls. Diabetes increased the risk of OAC (adjusted odds ratio 1.59, 95% confidence interval (CI) 1.04-2.43), although the risk was attenuated after furth...

journal_title：British journal of cancer

authors： Neale RE,Doecke JD,Pandeya N,Sadeghi S,Green AC,Webb PM,Whiteman DC,Australian Cancer Study.

更新日期：2009-03-10 00:00:00