Two types of soft tissue sarcoma of uncertain histogenesis.

abstract：BACKGROUND:Myelosuppression has been observed with several multikinase angiogenesis inhibitors in clinical studies, although the frequency and severity varies among the different agents. Inhibitors targeting vascular endothelial growth factor receptor (VEGFR) often inhibit other kinases, which may contribute to their a...

journal_title：British journal of cancer

authors： Kumar R,Crouthamel MC,Rominger DH,Gontarek RR,Tummino PJ,Levin RA,King AG

更新日期：2009-11-17 00:00:00

abstract：:Using a panel of ten polymorphic markers, we examined the frequency of loss of heterozygosity (LOH) on chromosome 17 in 55 sporadic ovarian tumours. LOH on 17p and 17q was observed to be 50% and 62% respectively. LOH at D17S5 was detected in 24/36 (67%) of malignant cases and in 19/43 (44%) at TP53; the marker D17S855...

journal_title：British journal of cancer

authors： Papp J,Csokay B,Bosze P,Zalay Z,Toth J,Ponder B,Olah E

更新日期：1996-11-01 00:00:00

abstract：:The aims of this study were to identify prognostic variables for toxicity and survival in patients with cancer participating in phase I clinical trials and compare characteristics of those treated with cytotoxic chemotherapy (CT) and non-cytotoxic drugs (non-CT). Data were collected from 420 (114 CT, 306 non-CT) patie...

journal_title：British journal of cancer

authors： Han C,Braybrooke JP,Deplanque G,Taylor M,Mackintosh D,Kaur K,Samouri K,Ganesan TS,Harris AL,Talbot DC

更新日期：2003-10-06 00:00:00

abstract：:The aim of this study is to evaluate different options for introducing liquid-based cytology (LBC) and human papillomavirus (HPV) testing into the UK cervical cancer screening programme. These include options that incorporate HPV testing either as a triage for mild and borderline smear abnormalities or as a primary sc...

journal_title：British journal of cancer

authors： Sherlaw-Johnson C,Philips Z

更新日期：2004-07-05 00:00:00

abstract：:In the present study organotypic multicellular spheroids (OMS) were used to study the effects of chemotherapeutic agents on malignant gliomas. Compared with the frequently used cell line models, OMS have several advantages with respect to the preservation of the cellular heterogeneity and the structure of the original...

journal_title：British journal of cancer

authors： Kaaijk P,Troost D,de Boer OJ,Van Amstel P,Bakker PJ,Leenstra S,Bosch DA

更新日期：1996-07-01 00:00:00

abstract：:Patients with refractory metastatic renal cell carcinoma (RCC) were enrolled in a phase II study with teniposide (VM26) and cyclosporin A (CSA) to investigate (1) the effect of CSA on the response rate to VM26; and (2) the effect of CSA on the pharmacokinetics and pharmacodynamics of VM26. Sixteen patients initially r...

journal_title：British journal of cancer

authors： Toffoli G,Sorio R,Gigante M,Corona G,Galligioni E,Boiocchi M

更新日期：1997-01-01 00:00:00

abstract：:Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques-including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The optimal use of imagin...

journal_title：British journal of cancer

authors： Beaton L,Bandula S,Gaze MN,Sharma RA

更新日期：2019-04-01 00:00:00

abstract：:Four human melanoma xenograft lines (A-07, D-12, R-18, U-25) grown orthotopically in Balb/c nu/nu mice were characterized with respect to the fraction of radiobiologically hypoxic cells. The purpose of the study was to establish a firm radiobiological basis for future use of the lines in the development and evaluation...

journal_title：British journal of cancer

authors： Rofstad EK,Måseide K

更新日期：1998-10-01 00:00:00

abstract：:In a study of 157 patients with lymphoid malignancy, the phenotype of the tumour cells was correlated with the histological classification of the tumour using the Rappaport and the Kiel classifications. The markers used included E, Fc gamma, Fc micron (IgM) and C3d rosetting, estimation of SIg and CyIg, and tests for ...

journal_title：British journal of cancer

authors： Habeshaw JA,Catley PF,Stansfeld AG,Brearley RL

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:Gold(III) porphyrin 1a is a new class of anticancer drug, which inhibits cell proliferation of wide range of human cancer cell lines and induces apoptosis in human nasopharyngeal carcinoma cells. However, the underlying signalling mechanism by which gold(III) porphyrin 1a modifies the intracellular apoptosis...

journal_title：British journal of cancer

authors： Li W,Xie Y,Sun RW,Liu Q,Young J,Yu WY,Che CM,Tam PK,Ren Y

更新日期：2009-07-21 00:00:00

abstract：:A case-control study from Uganda found that the risk of Kaposi's sarcoma increased with increasing titre of antibodies against Kaposi's sarcoma-associated herpesvirus (KSHV) latent nuclear antigens, independently of HIV infection. Clinically, widespread Kaposi's sarcoma was more frequent among patients with HIV infect...

journal_title：British journal of cancer

authors： Newton R,Ziegler J,Bourboulia D,Casabonne D,Beral V,Mbidde E,Carpenter L,Parkin DM,Wabinga H,Mbulaiteye S,Jaffe H,Weiss R,Boshoff C

更新日期：2003-08-04 00:00:00

abstract：:Combinations of dacarbazine (DTIC) and other cytotoxic agents or alpha-interferon were given to 136 patients in five different regimens. The total response rate was 32% (95% confidence interval 24-40%); 13% had a complete remission. Female patients had a significantly higher chance of response than male patients: 46% ...

journal_title：British journal of cancer

authors： Mulder NH,van der Graaf WT,Willemse PH,Koops HS,de Vries EG,Sleijfer DT

更新日期：1994-10-01 00:00:00

abstract：:Decreased accumulation of the fluorescent dye BCECF [2', 7'-bis-(2-carboxyethyl)-5-(6)- carboxyfluorescein] characterized murine and human multidrug-resistant cell lines overexpressing the multidrug resistance protein (MRP). Indomethacin (10 microM), a known cyclo-oxygenase and glutathione-S-transferase inhibitor as w...

journal_title：British journal of cancer

authors： Draper MP,Martell RL,Levy SB

更新日期：1997-01-01 00:00:00

abstract：:Tissue from 54 histologically-identified basal cell carcinomas of the skin was obtained at surgery and assayed using a combination of functional and immunochemical procedures for matrix metalloproteinases (MMPs) with collagenolytic activity and for MMPs with gelatinolytic activity. Collagenolytic enzymes included MMP-...

journal_title：British journal of cancer

authors： Varani J,Hattori Y,Chi Y,Schmidt T,Perone P,Zeigler ME,Fader DJ,Johnson TM

更新日期：2000-02-01 00:00:00

abstract：:I.p. or i.v. administration of Corynebacterium parvum (CP) to MF1 mice induces a generalized inflammatory response, associated with marked hepatosplenomegaly and accompanied by a pronounced granulomatous response in the liver. Injection of the Landschütz ascites carcinoma (LAC) 24 h after CP substantially reduced the ...

journal_title：British journal of cancer

authors： McIntosh LC,Pugh-Humphreys RG,Fraser RA,Thomson AW

更新日期：1982-04-01 00:00:00

abstract：:The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas. We performed immunohistochemical analysis of p16(INK4a) and pRb expression and correlated with survival in a series of 300 patients w...

journal_title：British journal of cancer

authors： Kommoss S,du Bois A,Ridder R,Trunk MJ,Schmidt D,Pfisterer J,Kommoss F,AGO-OVAR.

更新日期：2007-01-29 00:00:00

abstract：:The trimodality approach represented by concurrent chemoradiotherapy followed by surgical resection is a highly effective, but potentially toxic therapy for locally advanced non-small-cell lung cancer (NSCLC). In this review, we discuss the current status of this therapy in patients with mediastinal node-positive (N2)...

journal_title：British journal of cancer

authors： Kunitoh H,Suzuki K

更新日期：2007-05-21 00:00:00

abstract：BACKGROUND:Cancer survival statistics are typically reported by using measures discounting the impact of other-cause mortality, such as net survival. This is a hypothetical measure and is interpreted as excluding the possibility of cancer patients dying from other causes. Crude probability of death partitions the all-c...

journal_title：British journal of cancer

authors： Wong KF,Lambert PC,Mozumder SI,Broggio J,Rutherford MJ

更新日期：2019-11-01 00:00:00

abstract：:The assessment of a tumour's angiogenic potential, by measuring the microvessel density in histological sections, assumes that a 4-microm section is representative of whole tumour vascularity. This study has examined this assumption by comparing the vessel density found radiologically, after injecting specimens with c...

journal_title：British journal of cancer

authors： Martin L,Holcombe C,Green B,Leinster SJ,Winstanley J

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Consumption of wholegrain (WG) products may protect against colon and rectal cancer. METHODS:The associations between total and individual WG product consumption and colon and rectal cancer risk were prospectively examined using data on 461 incident cases of colon cancer and 283 incident cases of rectal can...

journal_title：British journal of cancer

authors： Egeberg R,Olsen A,Loft S,Christensen J,Johnsen NF,Overvad K,Tjønneland A

更新日期：2010-08-24 00:00:00

abstract：:Both biodegradable emboli and pharmacological agents can enhance regional therapy for hepatic targeting. Using a rat model with similar haemodynamic characteristics to human colorectal liver tumour and a radio-labelled marker of similar molecular weight to Adriamycin, we have combined the two approaches to see if the ...

journal_title：British journal of cancer

authors： Carter R,Cooke TG,Hemingway D,McArdle CS,Angerson W

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Here, we explore the therapeutic potential of dasatinib, a small-molecule inhibitor that targets multiple cytosolic and membrane-bound tyrosine kinases, including members of the Src kinase family, EphA2, and focal adhesion kinase for the treatment of ovarian cancer. METHODS:We examined the effects of dasati...

journal_title：British journal of cancer

authors： Konecny GE,Glas R,Dering J,Manivong K,Qi J,Finn RS,Yang GR,Hong KL,Ginther C,Winterhoff B,Gao G,Brugge J,Slamon DJ

更新日期：2009-11-17 00:00:00

abstract：:At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05),...

journal_title：British journal of cancer

authors： Barber MD,McMillan DC,Wallace AM,Ross JA,Preston T,Fearon KC

更新日期：2004-03-22 00:00:00

abstract：:Acute myeloid leukaemia (AML) is a molecularly and clinically heterogeneous disease, and its incidence is increasing as the populations in Western countries age. Despite major advances in understanding the genetic landscape of AML and its impact on the biology of the disease, standard therapy has not changed significa...

journal_title：British journal of cancer

authors： Cassier PA,Castets M,Belhabri A,Vey N

更新日期：2017-10-10 00:00:00

abstract：:Measurements of methotrexate have been made in the liver and plasma of 4 patients and in the bile and plasma of 1 patient receiving [(3)H]methotrexate. Projections from a theoretical model of concentration of methotrexate in liver are confirmed but projections of biliary excretion are not. ...

journal_title：British journal of cancer

authors： Creaven PJ,Hansen HH,Alford DA,Allen LM

更新日期：1973-12-01 00:00:00

abstract：:Two hundred and thirty five patients with osteosarcoma, aged less than 40 years, and treated by amputation or radiotherapy, were entered in a randomised trial of two forms of adjuvant chemotherapy. A two drug regimen, namely vincristine 2 mg m-2 (maximum 2mg) followed by methotrexate 200 mgm-2, given every three weeks...

journal_title：British journal of cancer

authors：

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans. METHODS:We performed a nested cas...

journal_title：British journal of cancer

authors： Yang B,Hagberg KW,Chen J,Sahasrabuddhe VV,Graubard BI,Jick S,McGlynn KA

更新日期：2016-06-28 00:00:00

abstract：BACKGROUND:MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development. METHODS:We evaluated the effects of selumetinib in vitro and in vivo in CRC and NSCLC cell lines to identify cancer cell...

journal_title：British journal of cancer

authors： Troiani T,Vecchione L,Martinelli E,Capasso A,Costantino S,Ciuffreda LP,Morgillo F,Vitagliano D,D'Aiuto E,De Palma R,Tejpar S,Van Cutsem E,De Lorenzi M,Caraglia M,Berrino L,Ciardiello F

更新日期：2012-05-08 00:00:00

abstract：:Three hundred and nineteen patients with primary adenocarcinoma of the ovary were studied to define those factors, many of them histopathological, which influence survival. The paper considers the stage of spread at the time of operation, the histological type of the tumour, its grade and in particular its mitotic act...

journal_title：British journal of cancer

authors： Dyson JL,Beilby JO,Steele SJ

更新日期：1971-06-01 00:00:00

abstract：:The largest single underlying cause of hepatocellular carcinoma (HCC) worldwide is hepatitis B virus (HBV) infection. Hepatitis B virus increases cellular oxidative stress and the development of HCC occurs after a long latency period. The study was carried out to determine whether mitochondrial DNA abnormalities were ...

journal_title：British journal of cancer

authors： Wheelhouse NM,Lai PB,Wigmore SJ,Ross JA,Harrison DJ

更新日期：2005-04-11 00:00:00