Does type 2 diabetes influence the risk of oesophageal adenocarcinoma?

abstract：BACKGROUND:Uterine serous papillary carcinoma (USPC) is a biologically aggressive variant of endometrial cancer. We investigated the expression of Serum Amyloid A (SAA) and evaluated its potential as a serum biomarker in USPC patients. METHODS:SAA gene and protein expression levels were evaluated in USPC and normal en...

journal_title：British journal of cancer

authors： Cocco E,Bellone S,El-Sahwi K,Cargnelutti M,Casagrande F,Buza N,Tavassoli FA,Siegel ER,Visintin I,Ratner E,Silasi DA,Azodi M,Schwartz PE,Rutherford TJ,Pecorelli S,Santin AD

更新日期：2009-07-21 00:00:00

abstract：:Human pancreatic exocrine adenocarcinoma cells established in tissue culture expressed both HLA and beta 2-microglobulin (beta 2M). Plasma-membrane components of this pancreatic cancer cell line were purified from plasma membrane fractions enriched by sucrose density-gradient centrifugation, using immunoaffinity chrom...

journal_title：British journal of cancer

authors： Påhlman S,Ljungstedt-Poahlman I,Sanderson A,Ward PJ,Grant A,Hermon-Taylor J

更新日期：1979-11-01 00:00:00

abstract：BACKGROUND:Multiple myeloma is a plasma cell disorder that is characterised by clonal proliferation of malignant plasma cells in the bone marrow, monoclonal paraprotein in the blood or urine and associated organ dysfunction. It accounts for approximately 1% of cancers and 13% of haematological cancers. Myeloma arises f...

journal_title：British journal of cancer

authors： Jones CI,Zabolotskaya MV,King AJ,Stewart HJ,Horne GA,Chevassut TJ,Newbury SF

更新日期：2012-12-04 00:00:00

abstract：:In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies (mAb) recognizing the Fc region of surface IgM (anti-Fc mu). Experiments using anti-Fc mu mAb (single or non-c...

journal_title：British journal of cancer

authors： Cragg MS,Zhang L,French RR,Glennie MJ

更新日期：1999-02-01 00:00:00

abstract：:In a study involving 50 breast cancer tumours, we compared two oestrogen receptor (ER) detection methods developed by us--a microplate immunoenzymometric assay (EIA96) and an immunohistochemistry kit (HistoCIS-ER)--with the radioligand assay (RLA), the Abbott immunoenzymometric assay ER-EIA and the reverse transcripta...

journal_title：British journal of cancer

authors： Delage V,Deytieux S,Le Doussal V,Degorce F,Bellanger L,Hacene K,Seguin P,Descotes F,Saez S,Spyratos F

更新日期：1997-01-01 00:00:00

abstract：:Primary liver cancer (PLC) incidence trends from Africa are unknown. Using Kampala Cancer Registry data from 1960 to 1980 and 1991 to 2005, we identified 771 PLCs. Although rates were stable among men, PLC incidence among women increased >50%. Investigations of viral hepatitis, aflatoxin, obesity, and human immunodefi...

journal_title：British journal of cancer

authors： Ocama P,Nambooze S,Opio CK,Shiels MS,Wabinga HR,Kirk GD

更新日期：2009-03-10 00:00:00

abstract：:The present study set out to evaluate perceptions of risk, psychological morbidity and health behaviours in women with a family history of breast cancer who have attended genetic counselling and determine how these differ from general population risk women. Data were collected from 62 genetic counselees (cases) attend...

journal_title：British journal of cancer

authors： Lloyd S,Watson M,Waites B,Meyer L,Eeles R,Ebbs S,Tylee A

更新日期：1996-08-01 00:00:00

abstract：:Ninety-nine patients with advanced breast cancer were randomized to receive either cyclophosphamide continuously or a combination of cyclophosphamide, methotrexate, 5-fluorouracil and vinblastine given intermittently. The number and duration of objective responses were greater in patients receiving the combination but...

journal_title：British journal of cancer

authors： Rubens RD,Knight RK,Hayward JL

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Risk factors for the development of myelodysplastic syndromes (MDS) include age, exposure to ionising radiation, and cytotoxic drug treatment. Recently, asthma also has been suggested as a risk factor for MDS. METHODS:We undertook this nationwide population-based cohort study on patients with a first-time h...

journal_title：British journal of cancer

authors： Frederiksen H,Farkas DK,Horváth-Puhó E,Nørgaard JM,Nørgaard M,Sørensen HT

更新日期：2017-01-03 00:00:00

abstract：:The cellular pharmacology of a series of C8-linked pyrrolobenzodiazepine dimers with polymethylene linkers of n = 3-6 (compounds 1-4) has been studied in a range of human tumour cell lines. The four compounds showed the same pattern of relative activity in five ovarian carcinoma cell lines and one cervical carcinoma c...

journal_title：British journal of cancer

authors： Smellie M,Kelland LR,Thurston DE,Souhami RL,Hartley JA

更新日期：1994-07-01 00:00:00

abstract：:The relationship between oestrogen receptor (RE) content of primary breast cancer and subsequent prognosis was examined with regard to nodal status. It was found that, within a particular nodal group, patients with tumours containing fully functional RE experienced a longer disease-free interval than those with RE- di...

journal_title：British journal of cancer

authors： Leake RE,Laing L,McArdle C,Smith DC

更新日期：1981-01-01 00:00:00

abstract：:The distribution of labelled cells through 5 different mouse tumours was measured after a single injection of [3H]-thymidine [( 3H]-TdR) or [3H]-deoxyuridine [( 3H]-UdR). All the tumours had areas where the percentage of labelled cells (the labelling index, LI) was high and areas where the LI was very low. The total a...

journal_title：British journal of cancer

authors： Hamilton E,Dobbin J

更新日期：1985-01-01 00:00:00

abstract：:Chlamydia pneumoniae, Chlamydia trachomatis and Chlamydia psittaci were detected at low frequencies (<20%) among 69 pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas, 30 other lymphoproliferative disorders (LPD) and 44 non-LPD. The incidence of individual Chlamydiae was generally higher in MALT lymphoma tha...

journal_title：British journal of cancer

authors： Chanudet E,Adam P,Nicholson AG,Wotherspoon AC,Ranaldi R,Goteri G,Pileri SA,Ye H,Müller-Hermelink HK,Du MQ

更新日期：2007-10-08 00:00:00

abstract：:Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and...

journal_title：British journal of cancer

authors： Scott HR,McMillan DC,Crilly A,McArdle CS,Milroy R

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Therapies targeting ERBB2 have shown success in the clinic. However, response is not determined solely by expression of ERBB2. Levels of ERBB3, its preferred heterodimerisation partner and ERBB ligands may also have a role. METHODS:We measured NRG1 expression by real-time quantitative RT-PCR and ERBB recept...

journal_title：British journal of cancer

authors： Forster JA,Paul AB,Harnden P,Knowles MA

更新日期：2011-03-29 00:00:00

abstract：:The ten most frequently reported pretreatment symptoms on the Rotterdam Symptom Checklist, which was completed by more than 650 patients entering two MRC Lung Cancer Working Party multicentre randomised trials, included general symptoms (tiredness, lack of appetite) and psychological distress (worry, anxiety) in addit...

journal_title：British journal of cancer

authors： Hopwood P,Stephens RJ

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Tumours consist of heterogeneous cancer cells and are likely to contain drug-tolerant cell subpopulations, causing early relapse. However, treatment strategies to eliminate these cells have not been established. METHODS:We established gastric cancer patient-derived cells (PDCs) to examine the contribution o...

journal_title：British journal of cancer

authors： Mashima T,Iwasaki R,Kawata N,Kawakami R,Kumagai K,Migita T,Sano T,Yamaguchi K,Seimiya H

更新日期：2019-11-01 00:00:00

abstract：:Although most colorectal cancer develops based on the adenoma-adenocarcinoma sequence, morphologically, colorectal cancer is not a homogeneous disease entity. Generally, there are two distinct morphological types: polypoid and ulcerative colorectal tumours. Previous studies have demonstrated that K-ras codon 12 mutati...

journal_title：British journal of cancer

authors： Chiang JM,Chou YH,Chen TC,Ng KF,Lin JL

更新日期：2002-04-08 00:00:00

abstract：:In an Italian case-control study of oral cancer, number of missing teeth and other aspects of dental care were similar, but the general condition of the mouth, as indicated by gum bleeding, tartar deposits and mucosal irritation, was worse among oral cancer cases than controls. No differences were detected in sexual p...

journal_title：British journal of cancer

authors： Talamini R,Vaccarella S,Barbone F,Tavani A,La Vecchia C,Herrero R,Muñoz N,Franceschi S

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) testing in oropharyngeal squamous cell carcinoma (OPSCC) is now advocated. Demonstration of transcriptionally active high-risk HPV (HR-HPV) in fresh tumour tissue is considered to be the analytical 'gold standard'. Clinical testing has focused on formalin-fixed paraffin-embedded (F...

journal_title：British journal of cancer

authors： Schache AG,Liloglou T,Risk JM,Jones TM,Ma XJ,Wang H,Bui S,Luo Y,Sloan P,Shaw RJ,Robinson M

更新日期：2013-04-02 00:00:00

abstract：:Epidemiological evidence indicates that non-steroidal anti-inflammatory drugs (NSAIDs) protect against colorectal cancer (CRC) to a greater degree than other non-gastrointestinal cancers, but the molecular basis for this difference is unknown. We previously reported that aspirin induces signal-specific I kappa B alpha...

journal_title：British journal of cancer

authors： Din FV,Dunlop MG,Stark LA

更新日期：2004-07-19 00:00:00

abstract：:Overexpression of the c-erbB-2 proto-oncogene in mammary carcinoma is frequently associated with amplification of the c-erbB-2 gene, but it also occurs from single-copy gene. Studies in mammary-derived cell lines have shown that, whether or not the gene is amplified, there is a 6- to 8-fold increase in the accumulatio...

journal_title：British journal of cancer

authors： Hollywood DP,Hurst HC

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:This open-label, phase 1 trial (NCT02316197) aimed to determine the maximum-tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of peposertib (formerly M3814), a DNA-dependent protein kinase (DNA-PK) inhibitor in patients with advanced solid tumours. Secondary/exploratory objectives included safety/t...

journal_title：British journal of cancer

authors： van Bussel MTJ,Awada A,de Jonge MJA,Mau-Sørensen M,Nielsen D,Schöffski P,Verheul HMW,Sarholz B,Berghoff K,El Bawab S,Kuipers M,Damstrup L,Diaz-Padilla I,Schellens JHM

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:The clinical utility of machine-learning (ML) algorithms for breast cancer risk prediction and screening practices is unknown. We compared classification of lifetime breast cancer risk based on ML and the BOADICEA model. We explored the differences in risk classification and their clinical impact on screenin...

journal_title：British journal of cancer

authors： Ming C,Viassolo V,Probst-Hensch N,Dinov ID,Chappuis PO,Katapodi MC

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT's different functional aspects in non-small cell lung cancer (NSCLC). Thymidylate synthase (TS) has been previously correlated with EMT t...

journal_title：British journal of cancer

authors： Siddiqui MA,Gollavilli PN,Ramesh V,Parma B,Schwab A,Vazakidou ME,Natesan R,Saatci O,Rapa I,Bironzo P,Schuhwerk H,Asangani IA,Sahin O,Volante M,Ceppi P

更新日期：2021-01-01 00:00:00

abstract：:The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...

journal_title：British journal of cancer

authors： Campbell FC,Blamey RW,Elston CW,Nicholson RI,Griffiths K,Haybittle JL

更新日期：1981-09-01 00:00:00

abstract：:Stathmin is an intracellular phosphoprotein that is overexpressed in a number of human malignancies. Our previous study using proteomic profiling showed that significant upregulation of stathmin occurs in oral squamous-cell carcinoma (OSCC)-derived cell lines. In the current study, to determine the potential involveme...

journal_title：British journal of cancer

authors： Kouzu Y,Uzawa K,Koike H,Saito K,Nakashima D,Higo M,Endo Y,Kasamatsu A,Shiiba M,Bukawa H,Yokoe H,Tanzawa H

更新日期：2006-03-13 00:00:00

abstract：BACKGROUND:Stathmin mediates cell migration and invasion in vitro, and metastasis in vivo. To investigate stathmin's role on the metastatic process, we performed integrated mRNA-miRNA expression analysis to identify pathways regulated by stathmin. METHODS:MiRNA and gene arrays followed by miRNA-target-gene integration...

journal_title：British journal of cancer

authors： Po'uha ST,Le Grand M,Brandl MB,Gifford AJ,Goodall GJ,Khew-Goodall Y,Kavallaris M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Anoctamin (ANO)/transmembrane member 16 (TMEM16) proteins mediate diverse physiological and pathophysiological functions including cancer cell proliferation. The present study aimed to identify the role of ANOs in pancreatic cancer. METHODS:In an initial screen of ANOs, ANO9/TMEM16J was overexpressed in pan...

journal_title：British journal of cancer

authors： Jun I,Park HS,Piao H,Han JW,An MJ,Yun BG,Zhang X,Cha YH,Shin YK,Yook JI,Jung J,Gee HY,Park JS,Yoon DS,Jeung HC,Lee MG

更新日期：2017-12-05 00:00:00

abstract：:Ductal carcinoma in situ (DCIS) now represents 20-25% of all 'breast cancers' consequent upon detection by population-based breast cancer screening programmes. Currently, all DCIS lesions are treated, and treatment comprises either mastectomy or breast-conserving surgery supplemented with radiotherapy. However, most D...

journal_title：British journal of cancer

authors： van Seijen M,Lips EH,Thompson AM,Nik-Zainal S,Futreal A,Hwang ES,Verschuur E,Lane J,Jonkers J,Rea DW,Wesseling J,PRECISION team.

更新日期：2019-08-01 00:00:00