Thymidine labelling studies in a transmissible venereal tumour of the dog.

abstract：BACKGROUND:Successful introduction of new anticancer agents into the clinic is often hampered by a lack of qualified biomarkers. Studies have been conducted of 17 ELISAs representing a potential panel of pharmacodynamic/predictive biomarkers for drugs targeted to tumour vasculature. METHODS:The fit-for-purpose approac...

journal_title：British journal of cancer

authors： Brookes K,Cummings J,Backen A,Greystoke A,Ward T,Jayson GC,Dive C

更新日期：2010-05-11 00:00:00

abstract：:The relationship between mammalian facilitative glucose transport proteins (GLUT) and multidrug resistance was examined in two vincristine (VCR)-selected murine erythroleukaemia (MEL) PC4 cell lines. GLUT proteins, GLUT1 and GLUT3, were constitutively coexpressed in the parental cell line and also in the VCR-selected ...

journal_title：British journal of cancer

authors： Martell RL,Slapak CA,Levy SB

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:After radical prostatectomy (RP) for prostate cancer (PC), p53 alterations predict biochemical relapse (BCR), however, recent evidence suggests that metastatic relapse (MR) not BCR is a surrogate for PC specific mortality (PCSM). This updated analysis of a previously published study investigated the associat...

journal_title：British journal of cancer

authors： Quinn DI,Stricker PD,Kench JG,Grogan J,Haynes AM,Henshall SM,Grygiel JJ,Delprado W,Turner JJ,Horvath LG,Mahon KL

更新日期：2019-10-01 00:00:00

abstract：:The assessment of a tumour's angiogenic potential, by measuring the microvessel density in histological sections, assumes that a 4-microm section is representative of whole tumour vascularity. This study has examined this assumption by comparing the vessel density found radiologically, after injecting specimens with c...

journal_title：British journal of cancer

authors： Martin L,Holcombe C,Green B,Leinster SJ,Winstanley J

更新日期：1997-01-01 00:00:00

abstract：:The matrix metalloprotease MMP-9 localizes to tumour-associated macrophages in human ovarian cancer but little is known of its regulation. Co-culture of human ovarian cancer cells (PEO-1) and a monocytic cell line (THP-1) led to production of 92-kDa proMMP-9. PEO-1-conditioned medium (CM) also stimulated THP-1 cells o...

journal_title：British journal of cancer

authors： Leber TM,Balkwill FR

更新日期：1998-09-01 00:00:00

abstract：:Kaposi's sarcoma (KS) is a highly vascular tumour and is the most common neoplasm associated with human immunodeficiency virus (HIV-1) infection. Growth factors, in particular vascular endothelial growth factor (VEGF), have been shown to play an important role in its development. The role of insulin-like growth factor...

journal_title：British journal of cancer

authors： Catrina SB,Lewitt M,Massambu C,Dricu A,Grünler J,Axelson M,Biberfeld P,Brismar K

更新日期：2005-04-25 00:00:00

abstract：BACKGROUND:While current chemotherapy has increased cure rates for children with acute lymphoblastic leukaemia (ALL), the largest number of relapsing patients are still stratified as medium risk (MR) at diagnosis (50-60%). This highlights an opportunity to develop improved relapse-prediction models for MR patients. We ...

journal_title：British journal of cancer

authors： Alruwetei AM,Bendak K,Yadav BD,Carol H,Evans K,Mayoh C,Sutton R,Marshall GM,Lock RB

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Efficacy and safety are the two considerations when characterising the effects of a new therapy. We sought to apply an innovative method of assessing the benefit-risk balance using data from a completed randomised controlled trial that compared erlotinib vs placebo added to gemcitabine in patients with advan...

journal_title：British journal of cancer

authors： Péron J,Roy P,Ding K,Parulekar WR,Roche L,Buyse M

更新日期：2015-03-17 00:00:00

abstract：BACKGROUND:Uterine serous papillary carcinoma (USPC) is a biologically aggressive variant of endometrial cancer. We investigated the expression of Serum Amyloid A (SAA) and evaluated its potential as a serum biomarker in USPC patients. METHODS:SAA gene and protein expression levels were evaluated in USPC and normal en...

journal_title：British journal of cancer

authors： Cocco E,Bellone S,El-Sahwi K,Cargnelutti M,Casagrande F,Buza N,Tavassoli FA,Siegel ER,Visintin I,Ratner E,Silasi DA,Azodi M,Schwartz PE,Rutherford TJ,Pecorelli S,Santin AD

更新日期：2009-07-21 00:00:00

abstract：BACKGROUND:On the base of the microRNA (miRNA) expression signature of bladder cancer (BC), we found that miR-1 and miR-133a were significantly downregulated in BC. In this study, we focussed on the functional significance of miR-1 and miR-133a in BC cell lines and identified a molecular network of these miRNAs. METHO...

journal_title：British journal of cancer

authors： Yoshino H,Chiyomaru T,Enokida H,Kawakami K,Tatarano S,Nishiyama K,Nohata N,Seki N,Nakagawa M

更新日期：2011-03-01 00:00:00

abstract：:A novel sterically hindered platinum complex, AMD473 [cis-aminedichloro(2-methylpyridine) platinum (II)], has been selected for phase I clinical trials due to commence in 1997. AMD473 was rationally designed to react preferentially with nucleic acids over sulphur ligands such as glutathione. This report documents the ...

journal_title：British journal of cancer

authors： Holford J,Sharp SY,Murrer BA,Abrams M,Kelland LR

更新日期：1998-01-01 00:00:00

abstract：:Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antige...

journal_title：British journal of cancer

authors： Løvig T,Andersen SN,Thorstensen L,Diep CB,Meling GI,Lothe RA,Rognum TO

更新日期：2002-09-23 00:00:00

abstract：:Antibody drug conjugates (ADCs) employ the exquisite specificity of tumour-specific monoclonal antibodies (mAb) for the targeted delivery of highly potent cytotoxic drugs to the tumour site. The chemistry of the linker, which connects the drug to the mAb, determines how and when the drug is released from the mAb. This...

journal_title：British journal of cancer

authors： Staudacher AH,Brown MP

更新日期：2017-12-05 00:00:00

abstract：BACKGROUND:Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients. METHODS:The study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model...

journal_title：British journal of cancer

authors： Staff S,Aaltonen M,Huhtala H,Pylvänäinen K,Mecklin JP,Mäenpää J

更新日期：2016-07-26 00:00:00

abstract：:In contrast to cutaneous melanoma, there is no evidence that BRAF mutations are involved in the activation of the mitogen-activated protein kinase (MAPK) pathway in uveal melanoma, although there is increasing evidence that this pathway is activated frequently in the latter tumours. In this study, we performed mutatio...

journal_title：British journal of cancer

authors： Zuidervaart W,van Nieuwpoort F,Stark M,Dijkman R,Packer L,Borgstein AM,Pavey S,van der Velden P,Out C,Jager MJ,Hayward NK,Gruis NA

更新日期：2005-06-06 00:00:00

abstract：:SGN-40 is a therapeutic antibody targeting CD40, which induces potent anti-lymphoma activities via direct apoptotic signalling cells and by cell-mediated cytotoxicity. Here we show antibody-dependent cellular phagocytosis (ADCP) by macrophages to contribute significantly to the therapeutic activities and that the anti...

journal_title：British journal of cancer

authors： Oflazoglu E,Stone IJ,Brown L,Gordon KA,van Rooijen N,Jonas M,Law CL,Grewal IS,Gerber HP

更新日期：2009-01-13 00:00:00

abstract：:The relationship of cytogenetic changes with the acquisition of an indefinite life span in vitro, the ability of cells to grow in soft agar and their tumourigenicity in syngeneic animals has been studied in control, trans-7,8-dihydrodiolbenzo(a)pyrene and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrah...

journal_title：British journal of cancer

authors： Connell JR

更新日期：1984-08-01 00:00:00

abstract：:The ability of human tumour cells to form colonies in soft agar is enhanced by the presence of autologous phagocytic/adherent cells. We investigated the effect of irradiation on the ability of the adherent cells to support human tumour colony formation. Relatively low doses of irradiation significantly increased the g...

journal_title：British journal of cancer

authors： Hamburger AW,White CP,Dunn FE

更新日期：1983-11-01 00:00:00

abstract：:Four-hundred-forty-five husbands of women with invasive cervical carcinoma, 165 of women with in situ cervical cancer, and 717 of control women (age range 19-82 years) were interviewed and a sample of exfoliated cells from the penis obtained in seven case-control studies conducted by the International Agency for Resea...

journal_title：British journal of cancer

authors： Franceschi S,Castellsagué X,Dal Maso L,Smith JS,Plummer M,Ngelangel C,Chichareon S,Eluf-Neto J,Shah KV,Snijders PJ,Meijer CJ,Bosch FX,Muñoz N

更新日期：2002-03-04 00:00:00

abstract：:Three hundred and ninety women participated in the quality of life (QL) study of ACCOG1, a high-dose vs conventional adjuvant chemotherapy breast cancer trial, for patients with a high risk of relapse. Patients completed the European Organisation for Research and Treatment of Cancer QLQ-C30, questions on menopausal sy...

journal_title：British journal of cancer

authors： Malinovszky KM,Gould A,Foster E,Cameron D,Humphreys A,Crown J,Leonard RC,Anglo Celtic Co-operative Oncology Group.

更新日期：2006-12-18 00:00:00

abstract：:The mechanisms underlying sperm protein 17 (Sp17) gene expression in myeloma cells remained unclear. Using reverse transcription-polymerase chain reaction (RT-PCR), Sp17 transcripts were detected in ARK-B, ARP-1, RPMI-8226 and KMS-11 but not in H929, IM-9, MM1-R and U266 cells. Using a panel of primer pairs in methyla...

journal_title：British journal of cancer

authors： Wang Z,Zhang Y,Ramsahoye B,Bowen D,Lim SH

更新日期：2004-10-18 00:00:00

abstract：:A risk model for febrile neutropenia (FN) after conventional cytotoxic chemotherapy, based on early (day 5) lymphopenia and the dose of chemotherapy, has been described. A risk index based on parameters available at day 1 would be easier in daily practice. The objectives of this work were (1) to investigate a risk mod...

journal_title：British journal of cancer

authors： Ray-Coquard I,Borg C,Bachelot T,Sebban C,Philip I,Clapisson G,Le Cesne A,Biron P,Chauvin F,Blay JY,ELYPSE study group.

更新日期：2003-01-27 00:00:00

abstract：BACKGROUND:This study is to investigate the effects of geserelin+tamoxifen (TAM) on estradiol level, breast density (BD), endometrial thickness (ET), and blood lipids in premenopausal and perimenopausal women with hormone receptor-positive early-stage breast cancer. METHODS:This study recruited 110 premenopausal and p...

journal_title：British journal of cancer

authors： Yang H,Zong X,Yu Y,Shao G,Zhang L,Qian C,Bian Y,Xu X,Sun W,Meng X,Ding X,Chen D,Zou D,Xie S,Zheng Y,Zhang J,He X,Sun C,Yu X,Ni J

更新日期：2013-08-06 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumour and has poor prognosis. Currently, systematic chemotherapy is the only approach to prolong survival. Thus the development of new treatment regimens is urgently needed to improve the therapeutic efficacy. Our study intended to ...

journal_title：British journal of cancer

authors： Xu L,Zhu Y,Shao J,Chen M,Yan H,Li G,Zhu Y,Xu Z,Yang B,Luo P,He Q

更新日期：2017-04-11 00:00:00

abstract：:Mechanisms of resistance to Tomudex include increased thymidylate synthase activity, as well as reduced intracellular drug uptake and polyglutamation. However, little is known about other mechanisms of resistance, such as a possible protection against Tomudex-induced apoptosis mediated by bcl-2. We transfected the MDA...

journal_title：British journal of cancer

authors： Orlandi L,Bearzatto A,Abolafio G,De Marco C,Daidone MG,Zaffaroni N

更新日期：1999-09-01 00:00:00

abstract：:We evaluated whether social deprivation affected decision-making for breast cancer surgery. Of 3419 patients, 53.6% had mastectomy and this was predicted by deprivation, age, tumour size and hospital, all of which retained significance on multivariate analysis, except deprivation. Pathological characteristics and surg...

journal_title：British journal of cancer

authors： Henley NC,Hole DJ,Kesson E,Burns HJ,George WD,Cooke TG

更新日期：2005-02-28 00:00:00

abstract：:Measurements of methotrexate have been made in the liver and plasma of 4 patients and in the bile and plasma of 1 patient receiving [(3)H]methotrexate. Projections from a theoretical model of concentration of methotrexate in liver are confirmed but projections of biliary excretion are not. ...

journal_title：British journal of cancer

authors： Creaven PJ,Hansen HH,Alford DA,Allen LM

更新日期：1973-12-01 00:00:00

abstract：:In a prospective study we determined the frequency and causes of delay in the diagnosis of breast cancer after suspicious screening mammography. We included all women aged 50-75 years who underwent biennial screening mammography in the southern breast cancer screening region of the Netherlands between 1 January 1996 a...

journal_title：British journal of cancer

authors： Duijm LE,Groenewoud JH,Jansen FH,Fracheboud J,van Beek M,de Koning HJ

更新日期：2004-11-15 00:00:00

abstract：:Bcl-2 expression in colorectal carcinomas was studied in a series of 224 patients and the relation to p53 expression, stage and survival assessed. Bcl-2 expression was down-regulated compared with normal mucosa in 67% (151) of the cases. In 144 cases staining was positive for p53 (MAB DO7), and 41 of these 144 p53-pos...

journal_title：British journal of cancer

authors： Kaklamanis L,Savage A,Whitehouse R,Doussis-Anagnostopoulou I,Biddolph S,Tsiotos P,Mortensen N,Gatter KC,Harris AL

更新日期：1998-06-01 00:00:00

abstract：:Until recently, endocrine therapy for breast cancer was relatively simple. If the tumour expressed hormone receptors, regardless of stage and age, tamoxifen was indicated. While this largely remains the case for premenopausal women, clinical trials in postmenopausal women have broadened our choice to include one of th...

journal_title：British journal of cancer

authors： Wong ZW,Ellis MJ

更新日期：2004-01-12 00:00:00