Abstract:
BACKGROUND:After radical prostatectomy (RP) for prostate cancer (PC), p53 alterations predict biochemical relapse (BCR), however, recent evidence suggests that metastatic relapse (MR) not BCR is a surrogate for PC specific mortality (PCSM). This updated analysis of a previously published study investigated the association between p53 aberrations, MR and PCSM in men with localised PC. METHODS:Two hundred and seventy-one men with localised PC treated with RP were included. RP specimens stained for p53 by immunohistochemistry were scored as (a) percentage of p53-positive tumour nuclei; and (b) clustering, where ≥12 p53-positive cells within a ×200 power field was deemed 'cluster positive'. Associations between p53 status and clinical outcomes (BCR, MR and PCSM) were evaluated. RESULTS:Increasing percentage of p53-positive nuclei was significantly associated with shorter time to BCR, MR and PCSM (All p < 0.001). Half of the patients were p53 cluster positive. p53 cluster positivity was significantly associated with poorer outcomes at all clinical endpoints (BCR: HR 2.0, 95% CI 1.51-2.65, p < 0.001; MR: HR 4.1, 95% CI 2.02-8.14, p < 0.001; PCSM: HR 12.2, 95% CI 1.6-93; p = 0.016). These associations were independent of other established prognostic variables. CONCLUSIONS:p53 aberrations in radical prostatectomy tissue predict clinically relevant endpoints of MR and PCSM.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Quinn DI,Stricker PD,Kench JG,Grogan J,Haynes AM,Henshall SM,Grygiel JJ,Delprado W,Turner JJ,Horvath LG,Mahon KLdoi
10.1038/s41416-019-0549-8subject
Has Abstractpub_date
2019-10-01 00:00:00pages
578-583issue
7eissn
0007-0920issn
1532-1827pii
10.1038/s41416-019-0549-8journal_volume
121pub_type
杂志文章abstract::Oesophageal adenocarcinoma is believed to arise from metaplastic mucosa in the distal oesophagus, a condition also known as Barrett's oesophagus (BE). BE develops as a result of injury caused by refluxing gastric and duodenal contents and is associated with increased risk of malignant transformation. Matrix metallopro...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.1929
更新日期:2001-08-03 00:00:00
abstract::In a previous study we found that aromatic amines, particularly 4-aminobiphenyl, formed haemoglobin adducts at higher concentrations in the blood of smokers compared to non-smokers. We re-analyse here data on haemoglobin adducts of 14 aromatic amines in order to ascertain if the inter-individual variability left unexp...
journal_title:British journal of cancer
pub_type: 杂志文章
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abstract::Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies u...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.402
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abstract:BACKGROUND:Bladder cancer (BC) predominantly affects the elderly and is often the cause of death among patients with muscle-invasive disease. Clinicians lack quantitative estimates of competing mortality risks when considering treatments for BC. Our aim was to determine the bladder cancer-specific mortality (CSM) rate ...
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更新日期:2013-04-16 00:00:00
abstract::We have recently established a cancer-reactive human monoclonal antibody, GAH, with a positive ratio of over 90% against stomach cancer. GAH was formulated as polyethyleneglycol (PEG)-modified immunoliposomal doxorubicin (DXR) (ILD) and its efficacy was examined against gastrointestinal human cancers. In in vitro stud...
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abstract::Monocyte-macrophage series have an important role in host surveillance against cancer. The cytotoxic/cytostatic activity of macrophages is, to a great extent, attributed to the up-regulation of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO). Here, in 28 patients with primary lung cancer and...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.528
更新日期:1998-08-01 00:00:00
abstract::Nuclear polyploidization in the livers of CF-1 mice, exposed to dieldrin (0, 1, 5 and 10 ppm in the diet), was studied up to the median time of liver tumour development (ranging from 15 to 27 months) in the respective treatment groups. In untreated controls nuclear polyploidization is characterized by a linear increas...
journal_title:British journal of cancer
pub_type: 杂志文章
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doi:10.1038/sj.bjc.6600067
更新日期:2002-02-01 00:00:00
abstract::The aim of the present study was to evaluate the occult lymph node carcinomatous diffusion in head and neck squamous cell carcinoma (HNSCC). A total of 1328 lymph nodes from 31 patients treated between 2004 and 2005 were prospectively evaluated by routine haematoxylin-eosin-safran (HES) staining, immunohistochemistry ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603073
更新日期:2006-04-24 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6605883
更新日期:2010-09-28 00:00:00
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pub_type: 杂志文章
doi:10.1038/bjc.1992.252
更新日期:1992-08-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.363
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Uterine serous papillary carcinoma (USPC) is a biologically aggressive variant of endometrial cancer. We investigated the expression of Serum Amyloid A (SAA) and evaluated its potential as a serum biomarker in USPC patients. METHODS:SAA gene and protein expression levels were evaluated in USPC and normal en...
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doi:10.1038/sj.bjc.6605129
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pub_type: 杂志文章
doi:10.1038/bjc.1992.167
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Determining the rate of breast cancer (BC) growth in vivo, which can predict prognosis, has remained elusive despite its relevance for treatment, screening recommendations and medicolegal practice. We developed a model that predicts the rate of in vivo tumour growth using a unique study cohort of BC patients...
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pub_type: 临床试验,杂志文章
doi:10.1038/s41416-019-0539-x
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journal_title:British journal of cancer
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doi:10.1038/sj.bjc.6690494
更新日期:1999-06-01 00:00:00
abstract::The establishment and characterisation (morphology, ultrastructure, tumourigenicity) of six cell lines from primary human colorectal adenocarcinomas is described. These lines were established from surgical specimens, from 49 unselected patients, without the use of 'feeder' cells, 'conditioned' medium or passage of cel...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.132
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doi:10.1038/sj.bjc.6604568
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doi:10.1038/sj.bjc.6602981
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doi:10.1038/sj.bjc.6605875
更新日期:2010-10-26 00:00:00
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abstract::One hundred and one consecutive patients with newly diagnosed stage I Hodgkin's disease (HD) received treatment at St Bartholomew's Hospital, between 1968 and 1987, with a median follow-up of 12 years. Eleven patients have been excluded from detailed analysis because they either received involved field radiotherapy (R...
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abstract::The effect of 6 putative prognostic factors on survival was studied in patients with Stages III and IV malignant teratoma of the testis. Differences between survival curves were tested for statistical significance. A diameter greater than 5 cm in the largest tumour mass, and greater than 8 pulmonary metastases were ad...
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pub_type: 杂志文章
doi:10.1038/bjc.1980.332
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:Uncertainty remains about the associations of adiposity with intestinal cancer in China and by its anatomical subtype. METHODS:The prospective China Kadoorie Biobank recorded 3024 incident cases of colorectal (CRC) and 143 cases of small intestine (SIC) cancer during a 10-year follow-up among 509 568 partic...
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更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Neutropenia is a common adverse reaction of chemotherapy. We assessed whether chemotherapy-induced neutropenia could be a predictor of survival for patients with non-small-cell lung cancer (NSCLC). METHODS:A total of 387 chemotherapy-naïve patients who received chemotherapy (vinorelbine and gemcitabine foll...
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doi:10.1038/sj.bjc.6605348
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.190
更新日期:1973-12-01 00:00:00
abstract::Extramammary Paget's disease is a particular form of skin cancer of unknown histogenesis. To look for the genetic defects underlying the pathogenesis of this tumour, we have examined loss of heterozygosity (LOH), p53 and human papillomavirus (HPV) status, and the expression of c-erbB-2 and bcl-2 proteins in 14 cases. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.482
更新日期:1997-01-01 00:00:00
abstract::For the first time in a clinical study oral Ifosfamide was used: 65 elderly or unfit patients with small cell lung cancer (SCLC) were treated as outpatients with fractionated oral Ifosfamide and Etoposide. Forty patients (62%) had extensive stage (ED) disease. The median age of the patients was 66 years. In the 60 pat...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.265
更新日期:1989-08-01 00:00:00