Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion.


BACKGROUND:Lymph node metastasis is one of the most important adverse prognostic factors for pancreatic cancer. The aim of this study was to identify novel lymphatic metastasis-associated markers and therapeutic targets for pancreatic cancer. METHODS:DNA microarray study was carried out to identify genes differentially expressed between 17 pancreatic cancer tissues with lymph node metastasis and 17 pancreatic cancer tissues without lymph node metastasis. The microarray results were validated by real-time PCR. Immunohistochemistry and western blotting were used to examine the expression of farnesoid X receptor (FXR). The function of FXR was studied by small interfering RNA and treatment with FXR antagonist guggulsterone and FXR agonist GW4064. RESULTS:Farnesoid X receptor overexpression in pancreatic cancer tissues with lymph node metastasis is associated with poor patient survival. Small interfering RNA-mediated downregulation of FXR and guggulsterone-mediated FXR inhibition resulted in a marked reduction in cell migration and invasion. In addition, downregulation of FXR reduced NF-κB activation and conditioned medium from FXR siRNA-transfected cells showed reduced VEGF levels. Moreover, GW4064-mediated FXR activation increased cell migration and invasion. CONCLUSIONS:These findings indicated that FXR overexpression plays an important role in lymphatic metastasis of pancreatic cancer and that downregulation of FXR is an effective approach for inhibition of pancreatic tumour progression.


Br J Cancer


Lee JY,Lee KT,Lee JK,Lee KH,Jang KT,Heo JS,Choi SH,Kim Y,Rhee JC




Has Abstract


2011-03-15 00:00:00














  • A method for detecting carcinogenic organic chemicals using mammalian cells in culture.

    abstract::A method for testing organic chemicals for their carcinogenic potential is described. Baby hamster kidney cells (BHK-21/C1 13) were exposed to different doses of test compound in liquid tissue culture medium containing rat liver post-mitochondrial supernatant and cofactors (S-9 mix) to aid metabolism, but without seru...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Styles JA

    更新日期:1977-11-01 00:00:00

  • Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases.

    abstract:BACKGROUND:Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer. METHO...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Starzer AM,Steindl A,Mair MJ,Deischinger C,Simonovska A,Widhalm G,Gatterbauer B,Dieckmann K,Heller G,Preusser M,Berghoff AS

    更新日期:2021-01-21 00:00:00

  • The COVID-19 pandemic and impact on breast cancer diagnoses: what happened in England in the first half of 2020.

    abstract::Delays in cancer diagnosis and treatment due to the COVID-19 pandemic is a widespread source of concern, but the scale of the challenge for different tumour sites is not known. Routinely collected NHS England Cancer Waiting Time data were analysed to compare activity for breast cancer in the first 6 months of 2020 com...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Gathani T,Clayton G,MacInnes E,Horgan K

    更新日期:2020-11-30 00:00:00

  • Inhibition by the Landschütz ascites carcinoma of the granulomatous inflammatory response to C. parvum.

    abstract::I.p. or i.v. administration of Corynebacterium parvum (CP) to MF1 mice induces a generalized inflammatory response, associated with marked hepatosplenomegaly and accompanied by a pronounced granulomatous response in the liver. Injection of the Landschütz ascites carcinoma (LAC) 24 h after CP substantially reduced the ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: McIntosh LC,Pugh-Humphreys RG,Fraser RA,Thomson AW

    更新日期:1982-04-01 00:00:00

  • Evidence for metal inhibition of tumour membrane-bound neutral protease and the control of tumour-induced target cell cytolysis.

    abstract::Previous studies have characterized the enzymatic properties and inhibition of a trypsin-like neutral protease on the surface of Ehrlich ascites cells by means of kinetic analysis. The present study links these kinetic studies with the recently reported role of a tumour-cell membrane-bound serine protease in tumour-in...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Steven FS,Hulley TP,Griffin MM,Itzhaki S

    更新日期:1982-12-01 00:00:00

  • Examining the common aetiology of serous ovarian cancers and basal-like breast cancers using double primaries.

    abstract:BACKGROUND:The somatic molecular profiles of basal-like breast cancers and high-grade serous ovarian cancers share many similarities, leading to the hypothesis that they have similar aetiologies, in which case they should occur together in the same patient more often than expected. METHODS:We identified 545 women with...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Begg CB,Rice MS,Zabor EC,Tworoger SS

    更新日期:2017-04-11 00:00:00

  • Lignans and breast cancer risk in pre- and post-menopausal women: meta-analyses of observational studies.

    abstract::Phyto-oestrogens are plant compounds structurally similar to oestradiol, which have been proposed to have protective effects against breast cancer. The main class of phyto-oestrogens in the Western diet is lignans. Literature reports on the effect of lignans in breast cancer risk have been conflicting. We performed th...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Velentzis LS,Cantwell MM,Cardwell C,Keshtgar MR,Leathem AJ,Woodside JV

    更新日期:2009-05-05 00:00:00

  • First-line chemotherapy for advanced ovarian cancer: paclitaxel, cisplatin and the evidence.

    abstract::As of June 1998, four randomized trials have been completed comparing the combination of paclitaxel and cisplatin with a cisplatin-based control arm. The results of three of these trials are available; one has been published as a full paper, the other two in abstract form only. Two of the reported trials (GOG-111 and ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sandercock J,Parmar MK,Torri V

    更新日期:1998-12-01 00:00:00

  • Binding of TGF-beta1 latency-associated peptide (LAP) to alpha(v)beta6 integrin modulates behaviour of squamous carcinoma cells.

    abstract::The integrin alpha(v)beta6 is not detectable on normal keratinocytes in vivo but expression is increased significantly in oral squamous cell carcinoma where this heterodimer has been shown to play a role in cell migration, invasion and protease expression. Although regarded initially as a fibronectin receptor, alpha(v...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Thomas GJ,Hart IR,Speight PM,Marshall JF

    更新日期:2002-10-07 00:00:00

  • Meta-analysis of agreement between MRI and pathologic breast tumour size after neoadjuvant chemotherapy.

    abstract:BACKGROUND:Magnetic resonance imaging (MRI) has been proposed to guide breast cancer surgery by measuring residual tumour after neoadjuvant chemotherapy. This study-level meta-analysis examines MRI's agreement with pathology, compares MRI with alternative tests and investigates consistency between different measures of...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Marinovich ML,Macaskill P,Irwig L,Sardanelli F,von Minckwitz G,Mamounas E,Brennan M,Ciatto S,Houssami N

    更新日期:2013-09-17 00:00:00

  • A retrospective study of the cancer patterns among hospital in-patients in Botswana 1960-72.

    abstract::Records of approximately 310,000 patients admitted to the 10 hospitals in Botswana between 1960 and 1972 have been studied and details of 1445 patients with malignant tumours abstracted. For the 894 tumours for which there was some supporting evidence--at best histological proof and minimally a clinical description of...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Macrae SM,Cook BV

    更新日期:1975-07-01 00:00:00

  • Seropositivity for Helicobacter pylori and hepatobiliary cancers in the PLCO study.

    abstract::Helicobacter has been suggested to play a possible role in hepatitis, gallstones, and hepatobiliary tumours. We assessed whether seropositivity to 15 H. pylori proteins was associated with subsequent incidence of 74 biliary tract and 105 liver cancer cases vs. 357 matched controls in the Prostate, Lung, Colorectal, an...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Makkar R,Butt J,Huang WY,McGlynn KA,Koshiol J,Pawlita M,Waterboer T,Freedman ND,Murphy G

    更新日期:2020-09-01 00:00:00

  • Diagnostic accuracy for different strategies of image-guided breast intervention in cases of nonpalpable breast lesions.

    abstract::To find out whether ultrasound-guided fine-needle aspiration (FNA) and ultrasound and stereotactic-guided large core needle biopsy (LCNB) are reliable alternatives to needle-localised open breast biopsy (NLBB) in daily practice, we performed a retrospective study and evaluated the validity of these methods. In all, 71...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Pijnappel RM,van den Donk M,Holland R,Mali WP,Peterse JL,Hendriks JH,Peeters PH

    更新日期:2004-02-09 00:00:00

  • Prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice.

    abstract::BALB/c mice born to and nursed by females immunized against MSV-M showed a reduced tumour incidence and a high tumour regression rate following MSV-M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Chieco-Bianchi L,Collavo D,Biasi G,Colombatti A

    更新日期:1973-09-01 00:00:00

  • Photodynamic destruction of human bladder carcinoma.

    abstract::Eleven human bladder carcinomata of different degrees of differentiation were implanted in mice immunosuppressed by thymectomy, anti-thymocyte serum and x-rays. Seven carcinomata grew well and one poorly and 3 produced mainly fibrous nodules in the mice. Normal human bladder tissues were grown from 4 other patients. T...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kelly JF,Snell ME,Berenbaum MC

    更新日期:1975-02-01 00:00:00

  • Cyclosporin A as a multidrug-resistant modulator in patients with renal cell carcinoma treated with teniposide.

    abstract::Patients with refractory metastatic renal cell carcinoma (RCC) were enrolled in a phase II study with teniposide (VM26) and cyclosporin A (CSA) to investigate (1) the effect of CSA on the response rate to VM26; and (2) the effect of CSA on the pharmacokinetics and pharmacodynamics of VM26. Sixteen patients initially r...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Toffoli G,Sorio R,Gigante M,Corona G,Galligioni E,Boiocchi M

    更新日期:1997-01-01 00:00:00

  • An integrative bioinformatics approach reveals coding and non-coding gene variants associated with gene expression profiles and outcome in breast cancer molecular subtypes.

    abstract:BACKGROUND:Sequence variations in coding and non-coding regions of the genome can affect gene expression and signalling pathways, which in turn may influence disease outcome. METHODS:In this study, we integrated somatic mutations, gene expression and clinical data from 930 breast cancer patients included in the TCGA d...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Győrffy B,Pongor L,Bottai G,Li X,Budczies J,Szabó A,Hatzis C,Pusztai L,Santarpia L

    更新日期:2018-04-01 00:00:00

  • Microsomal epoxide hydrolase gene polymorphism and susceptibility to colon cancer.

    abstract::We examined polymorphisms in exons 3 and 4 of microsomal epoxide hydrolase in 101 patients with colon cancer and compared the results with 203 control samples. The frequency of the exon 3 T to C mutation was higher in cancer patients than in controls (odds ratio 3.8; 95% confidence intervals 1.8-8.0). This sequence al...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Harrison DJ,Hubbard AL,MacMillan J,Wyllie AH,Smith CA

    更新日期:1999-01-01 00:00:00

  • Expression of two WFDC1/ps20 isoforms in prostate stromal cells induces paracrine apoptosis through regulation of PTGS2/COX-2.

    abstract:BACKGROUND:WFDC1/Prostate stromal 20 (ps20) is a small secreted protein highly expressed within the prostate stroma. WFDC1/ps20 expression is frequently downregulated or lost in prostate cancer (PCa) and ps20 has demonstrated growth-suppressive functions in numerous tumour model systems, although the mechanisms of this...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hickman OJ,Smith RA,Dasgupta P,Rao SN,Nayak S,Sreenivasan S,Vyakarnam A,Galustian C

    更新日期:2016-05-24 00:00:00

  • Antitumour activity of the recombination polypeptide GST-NT21MP is mediated by inhibition of CXCR4 pathway in breast cancer.

    abstract:BACKGROUND:CXC chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1α (SDF-1α, also known as CXCL12) have important roles in promoting tumour growth and metastasis. Therefore, targeting CXCR4 could be a promising strategy for treatment of human cancer. METHODS:To achieve this goal, we developed a h...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Yang Q,Zhang F,Ding Y,Huang J,Chen S,Wu Q,Wang Z,Wang Z,Chen C

    更新日期:2014-03-04 00:00:00

  • The association between population-based treatment guidelines and adjuvant therapy for node-negative breast cancer. British Columbia/Ontario Working Group.

    abstract::This study evaluated the impact of province-wide treatment guidelines on consistency of adjuvant therapy for node-negative breast cancer. A retrospective population-based cohort study was conducted in the Canadian provinces of British Columbia, which has province-wide guidelines, and Ontario, which does not. All eligi...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sawka C,Olivotto I,Coldman A,Goel V,Holowaty E,Hislop TG

    更新日期:1997-01-01 00:00:00

  • Increasingly strong reduction in breast cancer mortality due to screening.

    abstract:BACKGROUND:Favourable outcomes of breast cancer screening trials in the 1970s and 1980s resulted in the launch of population-based service screening programmes in many Western countries. We investigated whether improvements in mammography and treatment modalities have had an influence on the effectiveness of breast can...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: van Schoor G,Moss SM,Otten JD,Donders R,Paap E,den Heeten GJ,Holland R,Broeders MJ,Verbeek AL

    更新日期:2011-03-15 00:00:00

  • The prognostic significance of transforming growth factors in human breast cancer.

    abstract::Transforming growth factor alpha (TGF alpha) and Transforming growth factor beta-1 (TGF-beta 1) are growth regulatory for breast cancer cell lines in vitro and several studies have suggested that levels of the receptor for TGF alpha, the epidermal growth factor (EGFR) in tumour biopsies predict relapse and survival. W...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Murray PA,Barrett-Lee P,Travers M,Luqmani Y,Powles T,Coombes RC

    更新日期:1993-06-01 00:00:00

  • Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer.

    abstract::Individuals with a deficiency in the enzyme dihydropyrimidine dehydrogenase (DPD) may experience severe life-threatening toxicity when treated with 5-fluorouracil (5-FU). As routine measurement of enzyme activity is not practical in many clinical centres, we have investigated the use of DNA mutation analysis to identi...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Ridge SA,Sludden J,Wei X,Sapone A,Brown O,Hardy S,Canney P,Fernandez-Salguero P,Gonzalez FJ,Cassidy J,McLeod HL

    更新日期:1998-01-01 00:00:00

  • p53 immunohistochemistry as an independent prognostic factor for superficial transitional cell carcinoma of the bladder.

    abstract::Although patients with superficial bladder cancer (Ta, T1) have a generally good prognosis, those patients who develop muscle-invasive tumours or metastatic disease at recurrence do poorly clinically. In the current study 69 patients undergoing complete transurethral resection for superficial transitional cell cancer ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Serth J,Kuczyk MA,Bokemeyer C,Hervatin C,Nafe R,Tan HK,Jonas U

    更新日期:1995-01-01 00:00:00

  • A phase I/IIa study of adjuvant immunotherapy with tumour antigen-pulsed dendritic cells in patients with hepatocellular carcinoma.

    abstract:BACKGROUND:To date, no adjuvant treatment has been shown to have a clear benefit in patients with hepatocellular carcinoma (HCC). In this prospective phase I/IIa study, we evaluated the safety and efficacy of adjuvant dendritic cell (DC) therapy in HCC patients who received primary treatment for HCC. METHODS:Twelve HC...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Lee JH,Lee Y,Lee M,Heo MK,Song JS,Kim KH,Lee H,Yi NJ,Lee KW,Suh KS,Bae YS,Kim YJ

    更新日期:2015-12-22 00:00:00

  • Geographical variation in breast cancer survival rates for women diagnosed in England between 1992 and 1994.

    abstract::The 5-year relative survival rates of women diagnosed with breast cancer between 1992 and 1994 were compared among the 99 Health Authorities (1999 boundaries) of England. Substantial variation, with evidence of geographical clustering was observed. Part of this variation was explained by differences in deprivation bet...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Mullee MA,De Stavola B,Romanengo M,Coleman MP

    更新日期:2004-06-01 00:00:00

  • Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose-response meta-analysis.

    abstract:BACKGROUND:Epidemiological studies evaluating the association of vitamin B6, vitamin B12 and methionine with breast cancer risk have produced inconsistent results. METHODS:Pertinent studies were identified by a search in PubMed and Web of Knowledge. Random-effect model was used. Dose-response relationship was assessed...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Wu W,Kang S,Zhang D

    更新日期:2013-10-01 00:00:00

  • Effect of hormone manipulation on oxidation, reduction and sulphurylation of dehydroepiandrosterone and oestrone in DMBA-induced rat mammary tumours.

    abstract::Using the DMBA-induced mammary tumour as a model, the effect of hormone manipulation on steroid sulphurylation and on oxidative and reductive metabolism has been investigated. Oestradiol-17 beta, or oestradiol-17 beta + progesterone, administered to oophorectomized animals, had no effect on adenosine-3'-phosphate-5'-p...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Li K,Chandra DP,Pewnim T,Foo T,Adams JB

    更新日期:1980-01-01 00:00:00

  • The impact of genetic counselling about breast cancer risk on women's risk perceptions and levels of distress.

    abstract::Women referred to a familial breast cancer clinic completed questionnaires before and after counselling and at annual follow-up to assess their risk estimate and psychological characteristics. The aims were to determine whether those who attended the clinic overestimated their risk or were highly anxious and whether c...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Cull A,Anderson ED,Campbell S,Mackay J,Smyth E,Steel M

    更新日期:1999-02-01 00:00:00