当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Ras oncogene expression and DNA content in plasma cell dyscrasias: a flow cytofluorimetric study.

Ras oncogene expression and DNA content in plasma cell dyscrasias: a flow cytofluorimetric study.

Abstract：

:Using bivariate flow cytofluorometry, we have determined the nuclear DNA distribution and the expression of the p21 protein (coded by the Ha-ras oncogene) in the bone marrow (BM) cells of five solid tumour patients having histologically normal BM and in those of 57 patients with plasma cell dyscrasia (28 with monoclonal gammopathies of undertermined significance, MGUS, and 29 with multiple myeloma, MM). All normal and MGUS and 21/29 (72.4%) MM BM had diploid modal DNA content and 8/29 (27.6%) MM BM had both diploid and hyperdiploid cell populations. In normal and MGUS BM, the level of the p21 oncoprotein was low and uniform in all G0/G1, S and G2 cells (median fluorescence values in arbitrary units were 6.1 and 7.5, respectively). The level of p21 was increased both in different aliquots of G0/G1 cells and in the S and G2 cells in diploid MM (median value for G0/G1 cells was 20), and especially in MM with hyperdiploid clones (median value for hyperdiploid cells was 40.5, P less than 0.005 with respect to normal and MGUS BM and less than 0.005 with respect to diploid MM BM). The p21 expression was greater in patients with advanced (stage III) than in earlier MM (stages I + II) (P less than 0.005), and it was directly related to the BMPC infiltration (r = 0.7; P less than 0.005). Since p21 expression is greater in MM than in both normal and MGUS BM, Ha-ras could be involved in the malignant plasma cell transformation that distinguishes MM from MGUS.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Danova M,Riccardi A,Ucci G,Luoni R,Giordano M,Mazzini G

doi

10.1038/bjc.1990.379

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

781-5

issue

5

eissn

0007-0920

issn

1532-1827

journal_volume

62

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • TRAIL-beta and TRAIL-gamma: two novel splice variants of the human TNF-related apoptosis-inducing ligand (TRAIL) without apoptotic potential.

    abstract：:Tumour necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL/APO2L) is a recently identified member of the TNF family, which induces programmed cell death in a variety of neoplastic cell types, but not in most nonneoplastic cells. In this study, we report on the identification of two novel alternative splice ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600772

    authors： Krieg A,Krieg T,Wenzel M,Schmitt M,Ramp U,Fang B,Gabbert HE,Gerharz CD,Mahotka C

    更新日期：2003-03-24 00:00:00

  • Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer.

    abstract：:A series of three dose escalating studies were conducted to investigate the ability of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate, to cause maximum suppression of testosterone synthesis when delivered to castrate and noncastrate males with prostate cancer. Study A was a single dose study in c...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1038/sj.bjc.6601879

    authors： O'Donnell A,Judson I,Dowsett M,Raynaud F,Dearnaley D,Mason M,Harland S,Robbins A,Halbert G,Nutley B,Jarman M

    更新日期：2004-06-14 00:00:00

  • Changes in serotonin metabolism in cancer patients: its relationship to nausea and vomiting induced by chemotherapeutic drugs.

    abstract：:The metabolism of serotonin was studied in cancer patients of their first day of their first course of chemotherapeutic drugs either with strongly or moderately emetogenic regimens. It was observed that strongly emetogenic treatments induce greater increases in serotonin release than moderately emetogenic regimens. Hi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.242

    authors： Cubeddu LX,Hoffmann IS,Fuenmayor NT,Malave JJ

    更新日期：1992-07-01 00:00:00

  • Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues.

    abstract：:Extracellular proteases of the matrix metalloproteinase (MMP) and serine protease families participate in many aspects of tumour growth and metastasis. Using quantitative real-time RT-PCR analysis, we have undertaken a comprehensive survey of the expression of these enzymes and of their natural inhibitors in 44 cases ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602630

    authors： Riddick AC,Shukla CJ,Pennington CJ,Bass R,Nuttall RK,Hogan A,Sethia KK,Ellis V,Collins AT,Maitland NJ,Ball RY,Edwards DR

    更新日期：2005-06-20 00:00:00

  • A rodent model for testicular involvement in acute lymphoblastic leukaemia.

    abstract：:The testis is the third common site of relapse after primary treatment of childhood acute lymphoblastic leukaemia, but in adults relatively few testicular relapses of acute lymphoblastic leukaemia have been reported. In the present investigation the differences in the behaviour of leukaemia in immature and mature rat ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1993.166

    authors： Jahnukainen K,Morris I,Roe S,Salmi TT,Mäkipernaa A,Pöllänen P

    更新日期：1993-05-01 00:00:00

  • Prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice.

    abstract：:BALB/c mice born to and nursed by females immunized against MSV-M showed a reduced tumour incidence and a high tumour regression rate following MSV-M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1973.143

    authors： Chieco-Bianchi L,Collavo D,Biasi G,Colombatti A

    更新日期：1973-09-01 00:00:00

  • Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy.

    abstract：:The predictive value of KRAS mutation in metastatic colorectal cancer (MCRC) patients treated with cetuximab plus chemotherapy has recently been suggested. In our study, 59 patients with a chemotherapy-refractory MCRC treated with cetuximab plus chemotherapy were included and clinical response was evaluated according ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603685

    authors： Di Fiore F,Blanchard F,Charbonnier F,Le Pessot F,Lamy A,Galais MP,Bastit L,Killian A,Sesboüé R,Tuech JJ,Queuniet AM,Paillot B,Sabourin JC,Michot F,Michel P,Frebourg T

    更新日期：2007-04-23 00:00:00

  • Cell-cell contact and specific cytokines inhibit apoptosis of colonic epithelial cells: growth factors protect against c-myc-independent apoptosis.

    abstract：:In this study we sought factors that determine the survival of human colonic epithelial cells. Normal colonic epithelial cells are dependent on cell-cell contacts and survival factors for the inhibition of apoptosis whereas, during colorectal tumorigenesis, cells develop mechanisms to evade these controls. The ability...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.167

    authors： Hague A,Hicks DJ,Bracey TS,Paraskeva C

    更新日期：1997-01-01 00:00:00

  • Prevalence and determinants of human papillomavirus genital infection in men.

    abstract：:Four-hundred-forty-five husbands of women with invasive cervical carcinoma, 165 of women with in situ cervical cancer, and 717 of control women (age range 19-82 years) were interviewed and a sample of exfoliated cells from the penis obtained in seven case-control studies conducted by the International Agency for Resea...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600194

    authors： Franceschi S,Castellsagué X,Dal Maso L,Smith JS,Plummer M,Ngelangel C,Chichareon S,Eluf-Neto J,Shah KV,Snijders PJ,Meijer CJ,Bosch FX,Muñoz N

    更新日期：2002-03-04 00:00:00

  • Underexpression of peroxisome proliferator-activated receptor (PPAR)gamma in PAX8/PPARgamma-negative thyroid tumours.

    abstract：:The expression of peroxisome proliferator-activated receptor (PPAR)gamma in thyroid neoplasias and in normal thyroid (NT) tissues has not been fully investigated. The objectives of the present work were: to study and compare the relative expression of PPARgamma in normal, benign and malignant thyroid tissues and to co...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601989

    authors： Marques AR,Espadinha C,Frias MJ,Roque L,Catarino AL,Sobrinho LG,Leite V

    更新日期：2004-08-16 00:00:00

  • Improving survival in recurrent medulloblastoma: earlier detection, better treatment or still an impasse?

    abstract：:Early detection of relapse has been advocated to improve survival in children with recurrent medulloblastoma. However, the prognostic factors and the longer term outcome of these patients remains unclear. Pattern of recurrences were analysed in three consecutive protocols of the Société Française d'Oncologie Pédiatriq...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1038/bjc.1998.220

    authors： Bouffet E,Doz F,Demaille MC,Tron P,Roche H,Plantaz D,Thyss A,Stephan JL,Lejars O,Sariban E,Buclon M,Zücker JM,Brunat-Mentigny M,Bernard JL,Gentet JC

    更新日期：1998-04-01 00:00:00

  • Induction chemotherapy followed by alternating chemo-radiotherapy in stage IV undifferentiated nasopharyngeal carcinoma.

    abstract：:In locally advanced undifferentiated nasopharyngeal carcinoma (UNPC), concomitant chemo-radiotherapy is the only strategy that gave better results over radiation alone in a phase III trial. Adding effective chemotherapy to a concomitant chemo-radiotherapy programme may be a way to improve the results further. 30 patie...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1054/bjoc.2000.1485

    authors： Benasso M,Sanguineti G,D'Amico M,Corvò R,Ricci I,Numico G,Guarneri D,Vitale V,Pallestrini E,Santelli A,Rosso R

    更新日期：2000-12-01 00:00:00

  • The effect of Corynebacterium parvum therapy on immunoglobulin class and IgG subclass levels in cancer patients.

    abstract：:Detailed serological studies have been undertaken in a small group of cancer patients receiving nonspecific immunotherapy with Corynebacterium parvum (C. parvum). These patients included 4 cases of recurrent malignant melanoma, 2 of stomach cancer and 2 of recurrent breast cancer. They all received an initial i.v. inf...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1975.229

    authors： James K,Clunie GJ,Woodruff MF,McBride WH,Stimson WH,Drew R,Catty D

    更新日期：1975-09-01 00:00:00

  • Cell killing and DNA damage by etoposide in Chinese hamster V79 monolayers and spheroids: influence of growth kinetics, growth environment and DNA packaging.

    abstract：:Cells from V79 multicell spheroids must be exposed to approximately 50 times more etoposide than exponentially growing monolayers in order to produce the same amount of cell killing. A part of this difference in sensitivity is readily explained by the decrease in growth fraction of large spheroids, and by the protecti...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1993.97

    authors： Olive PL,Banáth JP,Evans HH

    更新日期：1993-03-01 00:00:00

  • Clinical and microarray analysis of breast cancers of all subtypes from two prospective preoperative chemotherapy studies.

    abstract：BACKGROUND:We aimed to analyse clinical and gene expression profiles to predict pathologic complete response and disease-free survival using two consecutive, prospective, preoperative chemotherapy trial cohorts. METHODS:Clinicopathological and gene expression data were evaluated in a cohort from two consecutive phase ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.184

    authors： Okuma HS,Koizumi F,Hirakawa A,Nakatochi M,Komori O,Hashimoto J,Kodaira M,Yunokawa M,Yamamoto H,Yonemori K,Shimizu C,Fujiwara Y,Tamura K

    更新日期：2016-08-09 00:00:00

  • Comparing comparators: a look at control arms in kidney cancer studies over the years.

    abstract：:In the past decade, an increasing number of frequently positive randomised clinical trials have been completed, allowing new consideration of the present therapeutic armamentarium for advanced renal cell carcinoma. These studies were predominantly designed to compare the experimental drugs with 1 of 2 active control a...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2014.240

    authors： Bracarda S,Porta C,Sisani M,Marrocolo F,Paglino C,Hamzaj A,D Buono S,Sternberg CN

    更新日期：2015-01-06 00:00:00

  • Long-term results and recurrence patterns from SCALOP: a phase II randomised trial of gemcitabine- or capecitabine-based chemoradiation for locally advanced pancreatic cancer.

    abstract：BACKGROUND:SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. METHODS:Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks o...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2017.95

    authors： Hurt CN,Falk S,Crosby T,McDonald A,Ray R,Joseph G,Staffurth J,Abrams RA,Griffiths G,Maughan T,Mukherjee S

    更新日期：2017-05-09 00:00:00

  • Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

    abstract：BACKGROUND:Chromosomal instability (CIN) is a common trait of cancer characterised by the continuous gain and loss of chromosomes during mitosis. Excessive levels of CIN can suppress tumour growth, providing a possible therapeutic strategy. The Mps1/TTK kinase has been one of the prime targets to explore this concept, ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-018-0081-2

    authors： Maia ARR,Linder S,Song JY,Vaarting C,Boon U,Pritchard CEJ,Velds A,Huijbers IJ,van Tellingen O,Jonkers J,Medema RH

    更新日期：2018-06-01 00:00:00

  • Galectin-1 has potential prognostic significance and is implicated in clear cell renal cell carcinoma progression through the HIF/mTOR signaling axis.

    abstract：BACKGROUND:Metastatic clear cell renal cell carcinoma (ccRCC) patients have <9% 5-year survival rate, do not respond well to targeted therapy and eventually develop resistance. A better understanding of molecular pathways of RCC metastasis is the basis for the discovery of novel prognostic markers and targeted therapie...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.828

    authors： White NM,Masui O,Newsted D,Scorilas A,Romaschin AD,Bjarnason GA,Siu KW,Yousef GM

    更新日期：2014-03-04 00:00:00

  • Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer.

    abstract：BACKGROUND:Ovarian cancer is frequently advanced at presentation when treatment is rarely curative. Response to first-line platinum-based chemotherapy significantly influences survival, but clinical response is unpredictable and is frequently limited by the development of drug-resistant disease. METHODS:We used qRT-PC...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.410

    authors： Smith G,Ng MT,Shepherd L,Herrington CS,Gourley C,Ferguson MJ,Wolf CR

    更新日期：2012-10-09 00:00:00

  • Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.

    abstract：BACKGROUND:Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS:We pooled data from 39 Ovarian Cancer Association Con...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41416-018-0011-3

    authors： Dixon-Suen SC,Nagle CM,Thrift AP,Pharoah PDP,Ewing A,Pearce CL,Zheng W,Australian Ovarian Cancer Study Group.,Chenevix-Trench G,Fasching PA,Beckmann MW,Lambrechts D,Vergote I,Lambrechts S,Van Nieuwenhuysen E,Rossing MA,Do

    更新日期：2018-04-01 00:00:00

  • A case-control study of head and neck cancer in the Republic of Ireland.

    abstract：:A retrospective case-control study of 200 patients with head and neck cancer, and 200 controls matched for age and sex, confirmed the importance of tobacco and alcohol consumption in the aetiology of malignant tumours of the upper gastrointestinal and upper respiratory tracts. A male-female ratio of 3:1 was found, and...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1981.26

    authors： Herity B,Moriarty M,Bourke GJ,Daly L

    更新日期：1981-02-01 00:00:00

  • Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer.

    abstract：BACKGROUND:Four-and-a-half LIM domains protein 2 (FHL2) is a component of the focal adhesion structures and has been suggested to have a role in cancer progression. It has been shown to be overexpressed in the colorectal cancer (CRC). METHODS:Here, we examined a possible prognostic value of FHL2 in CRC. Immunohistoche...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.290

    authors： Verset L,Tommelein J,Moles Lopez X,Decaestecker C,Mareel M,Bracke M,Salmon I,De Wever O,Demetter P

    更新日期：2013-07-09 00:00:00

  • CD8+ T cell-mediated control of distant tumours following local photodynamic therapy is independent of CD4+ T cells and dependent on natural killer cells.

    abstract：:Cancer survival rates decrease in the presence of disseminated disease. However, there are few therapies that are effective at eliminating the primary tumour while providing control of distant stage disease. Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumours, resulting in cure...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603792

    authors： Kabingu E,Vaughan L,Owczarczak B,Ramsey KD,Gollnick SO

    更新日期：2007-06-18 00:00:00

  • Survival of mice with NC carcinoma is unchanged by drugs that are thought to inhibit thromboxane synthesis or increase prostacyclin formation.

    abstract：:Mice transplanted with NC carcinoma were treated with the thromboxane synthetase inhibitor dazmegrel (UK38485) or with nafazatrom (BAY G 6575), a compound that is reported to increase prostacyclin formation. Some experiments included the cytotoxic drugs methotrexate and melphalan. The tumours were excised under anaest...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1986.171

    authors： Stamford IF,Melhuish PB,Carroll MA,Corrigan CJ,Patel S,Bennett A

    更新日期：1986-08-01 00:00:00

  • Expression of tissue inhibitor of metalloproteinases TIMP-2 in human colorectal cancer--a predictor of tumour stage.

    abstract：:The aim of this study was to investigate whether immunohistochemical staining patterns of tissue inhibitor of metalloproteinases TIMP-2 and matrix metalloproteinases MMP-2 and MMP-9 can be predictors of tumour stage and survival time in colorectal cancer. Frozen tumour sections from 212 patients operated on between Ja...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.466

    authors： Ring P,Johansson K,Höyhtyä M,Rubin K,Lindmark G

    更新日期：1997-01-01 00:00:00

  • Tumour-marker levels and prognosis in malignant teratoma of the testis.

    abstract：:The effect of 6 putative prognostic factors on survival was studied in patients with Stages III and IV malignant teratoma of the testis. Differences between survival curves were tested for statistical significance. A diameter greater than 5 cm in the largest tumour mass, and greater than 8 pulmonary metastases were ad...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1980.332

    authors： Germa-Lluch JR,Begent RH,Bagshawe KD

    更新日期：1980-12-01 00:00:00

  • Phase II study of nedaplatin and irinotecan with concurrent thoracic radiotherapy in patients with locally advanced non-small-cell lung cancer.

    abstract：BACKGROUND:Current international guidelines recommend the use of platinum-based chemotherapy with thoracic radiotherapy (TRT) for patients with locally advanced non-small-cell lung cancer (NSCLC). METHODS:Patients with unresectable stage IIIA or IIIB NSCLC were treated with nedaplatin (NP) at 50 mg m(-2) and irinoteca...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605875

    authors： Oshita F,Ohe M,Honda T,Murakami S,Kondo T,Saito H,Noda K,Yamashita K,Nakayama Y,Yamada K

    更新日期：2010-10-26 00:00:00

  • Isolation and partial characterization of macromolecular urinary aggregates containing carcinoembryonic antigen-like activity.

    abstract：:Carcinoembryonic antigen-like substances in the urine of patients with bladder carcinoma and of healthy male subjects occur in a wide range of average molecular sizes. Some of these substances are glycoproteins giving reactions of antigenic identity with carcinoembryonic antigen (CEA) derived from colorectal carcinoma...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1974.93

    authors： Nery R,James R,Barsoum AL,Bullman H

    更新日期：1974-06-01 00:00:00

  • microRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer.

    abstract：BACKGROUND:The purpose of this study was to identify prostate cancer (PC) oncogenic microRNAs (miRs) based on miR microarray and to investigate whether these oncogenic miRs may be useful as PC biomarkers. METHODS:Initially, we carried out miR microarray and real-time PCR using RWPE-1, PC-3, DU-145 and LNCaP cells. To ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.125

    authors： Ueno K,Hirata H,Shahryari V,Deng G,Tanaka Y,Tabatabai ZL,Hinoda Y,Dahiya R

    更新日期：2013-04-30 00:00:00