Osteoid osteoma and osteoblastoma with clonal chromosome changes.

abstract：:Hepatic arterial floxuridine (HAI) in 35 patients with systemic fluorouracil/folinic acid-resistant colorectal liver metastases achieved a 14% partial response and 26% disease stabilization rate, with a median response duration of 7 months from onset of HAI. ...

journal_title：British journal of cancer

authors： Fordy C,Glover C,Davies MM,Allen-Mersh TG

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Random error in the numbers of avoidable deaths among cancer patients has not been considered in earlier studies. METHODS:Methods to obtain valid confidence intervals (CIs) for numbers of avoidable deaths were developed. The excess mortality rates were estimated for patients diagnosed with colon cancer in f...

journal_title：British journal of cancer

authors： Seppä K,Hakulinen T,Läärä E

更新日期：2012-05-22 00:00:00

abstract：:An analysis of the occurrence of breast cancer in this long-term prospective cohort study shows a significant relative risk (RR) in women who have ever used oral contraceptives (OC) of 3.33 in women age 30 to 34 years at diagnosis and an RR of 5.88 (P = 0.0011) in women who were parity 1 at the time of diagnosis. In w...

journal_title：British journal of cancer

authors： Kay CR,Hannaford PC

更新日期：1988-11-01 00:00:00

abstract：:Karyotyping and marker analysis of G- and C-banded metaphases from a metastatic bronchial carcinoma revealed a dominant stemline with five markers and four sidelines with additional markers. One to three minute bodies were noted in the majority of cells and these were classified as markers. On the basis of this analys...

journal_title：British journal of cancer

authors： Pickthall VJ

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:Emerging studies have shown the potential benefit of arming oncolytic viruses with therapeutic genes. However, most of these therapeutic genes are placed under the regulation of ubiquitous viral promoters. Our goal is to generate a safer yet potent oncolytic herpes simplex virus type-1 (HSV-1) for cancer the...

journal_title：British journal of cancer

authors： Miao L,Fraefel C,Sia KC,Newman JP,Mohamed-Bashir SA,Ng WH,Lam PY

更新日期：2014-01-07 00:00:00

abstract：:The origin of metastatic adenocarcinoma lesions can sometimes be difficult to diagnose. The objectives of our study were to establish the cytokeratin staining pattern of primary and metastatic lung and colorectal adenocarcinomas, and to determine if this helps to identify the site of origin of metastatic lesions. We r...

journal_title：British journal of cancer

authors： Kummar S,Fogarasi M,Canova A,Mota A,Ciesielski T

更新日期：2002-06-17 00:00:00

abstract：:We assessed the external validity of a prediction rule for nonseminomatous testicular cancer patients. The rule was developed to predict the probability of retroperitoneal metastases being benign (only necrosis/fibrosis) after chemotherapy treatment. Patients with a high probability of benign residual masses might be ...

journal_title：British journal of cancer

authors： Vergouwe Y,Steyerberg EW,de Wit R,Roberts JT,Keizer HJ,Collette L,Stenning SP,Habbema JD

更新日期：2003-03-24 00:00:00

abstract：BACKGROUND:Although the anti-tumour effect of cyclooxygenase-2 (Cox-2) inhibitors in invasive bladder cancer has been confirmed, its mechanisms of action are unclear. Recently, the concept of an epithelial-to-mesenchymal transition (EMT) promoting carcinoma progression has been suggested, and a key feature of the EMT i...

journal_title：British journal of cancer

authors： Adhim Z,Matsuoka T,Bito T,Shigemura K,Lee KM,Kawabata M,Fujisawa M,Nibu K,Shirakawa T

更新日期：2011-07-26 00:00:00

abstract：:The feasibility of combination irinotecan, carboplatin and docetaxel chemotherapy as first-line treatment for advanced epithelial ovarian carcinoma was assessed. One hundred patients were randomised to receive four 3-weekly cycles of carboplatin (area under the curve (AUC) 7) followed by four 3-weekly cycles of doceta...

journal_title：British journal of cancer

authors： Clamp AR,Mäenpää J,Cruickshank D,Ledermann J,Wilkinson PM,Welch R,Chan S,Vasey P,Sorbe B,Hindley A,Jayson GC,Scottish Gynaecological Cancer Trials Group.

更新日期：2006-01-16 00:00:00

abstract：:Two-tumour-cell-aggregation factors derived from rat ascites hepatoma cells had different antigenicity; one, with a strong potency, was not absorbed by immunoadsorbent chromatography with anti-rat serum antibody and the other, with a weak potency, was. The unabsorbed factor possessed mitogenic activity on lymphocytes ...

journal_title：British journal of cancer

authors： Kuratsu J,Yoshinaga M,Hayashi H

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:The mitogen-activated protein kinase (MAPK) pathway has been implicated in the molecular pathogenesis of human cancers, including metastatic colorectal cancer (mCRC). This provides a rationale for the development of MAPK-targeted agents such as pimasertib. METHODS:Patients with KRAS mutant mCRC were treated...

journal_title：British journal of cancer

authors： Macarulla T,Cervantes A,Tabernero J,Roselló S,Van Cutsem E,Tejpar S,Prenen H,Martinelli E,Troiani T,Laffranchi B,Jego V,von Richter O,Ciardiello F

更新日期：2015-06-09 00:00:00

abstract：:The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...

journal_title：British journal of cancer

authors： Campbell FC,Blamey RW,Elston CW,Nicholson RI,Griffiths K,Haybittle JL

更新日期：1981-09-01 00:00:00

abstract：:Reductions in cell-cell adhesion and stromal and vascular invasion are essential steps in the progression from localized malignancy to metastatic disease. In this study, changes in the expression of the components of the E-cadherin-catenin cell adhesion complex have been investigated using immunohistochemical techniqu...

journal_title：British journal of cancer

authors： Andrews NA,Jones AS,Helliwell TR,Kinsella AR

更新日期：1997-01-01 00:00:00

abstract：:Chromosome 17 alterations are found in more cancers than those of any other chromosome, and frequently involve the p53 gene on 17p13. The aim of this study was to identify the correlations between the presence of loss of heterozygosity (LOH) and microsatellite instability (MI) on chromosome 17p13 in patients with cerv...

journal_title：British journal of cancer

authors： Harima Y,Shirahama S,Harima K,Aoki S,Ohnishi T,Tanaka Y

更新日期：1999-09-01 00:00:00

abstract：:Perforin (PFP) is a cytotoxic protein released from killer cells. PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody. PFP was detected in the cytoplasm of 10% of PBL. We perform...

journal_title：British journal of cancer

authors： Nakanishi H,Monden T,Morimoto H,Kobayashi T,Shimano T,Mori T

更新日期：1991-08-01 00:00:00

abstract：:Metallothioneins are ubiquitous low molecular weight proteins characterised by high cysteine content and affinity for binding heavy metals. Abnormal metallothionein function and expression have been implicated in various disease states, including neoplasia. The aim of this study was to investigate metallothionein expr...

journal_title：British journal of cancer

authors： Goulding H,Jasani B,Pereira H,Reid A,Galea M,Bell JA,Elston CW,Robertson JF,Blamey RW,Nicholson RA

更新日期：1995-10-01 00:00:00

abstract：:To test the anti-tumour activity of rhizoxin in recurrent and/or metastatic squamous cell head and neck cancer, we performed a phase II study. Eligibility required histologically proven squamous cell head and neck cancer. Patients could only have received one prior chemotherapy. Patients were entered if WHO PS was < o...

journal_title：British journal of cancer

authors： Verweij J,Wanders J,Gil T,Schöffski P,Catimel G,te Velde A,de Mulder PH

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Tumour carbonic anhydrase IX (CAIX), a hypoxia-inducible tumour-associated cell surface enzyme, is thought to acidify the tumour microenvironment by hydrating CO2 to form protons and bicarbonate, but there is no definitive evidence for this in solid tumours in vivo. METHODS:We used 1H magnetic resonance spe...

journal_title：British journal of cancer

authors： Lee SH,McIntyre D,Honess D,Hulikova A,Pacheco-Torres J,Cerdán S,Swietach P,Harris AL,Griffiths JR

更新日期：2018-08-01 00:00:00

abstract：:Benzo[b]thiophenesulphonamide 1,1-dioxide (BTS) derivatives are strong cytotoxic agents that induce reactive oxygen species (ROS) overproduction and apoptosis in tumour cells. Although the precise origin of BTS-induced ROS is not known, a clear correlation between their cytotoxic effect and ability to inhibit a tumour...

journal_title：British journal of cancer

authors： Encío I,Morré DJ,Villar R,Gil MJ,Martínez-Merino V

更新日期：2005-02-28 00:00:00

abstract：:In contrast to cutaneous melanoma, there is no evidence that BRAF mutations are involved in the activation of the mitogen-activated protein kinase (MAPK) pathway in uveal melanoma, although there is increasing evidence that this pathway is activated frequently in the latter tumours. In this study, we performed mutatio...

journal_title：British journal of cancer

authors： Zuidervaart W,van Nieuwpoort F,Stark M,Dijkman R,Packer L,Borgstein AM,Pavey S,van der Velden P,Out C,Jager MJ,Hayward NK,Gruis NA

更新日期：2005-06-06 00:00:00

abstract：BACKGROUND:There have been controversies in prognostic impact of mucinous histology on colorectal cancer, and its implication in patients treated with adjuvant 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) is unclear. METHODS:Stage II and III colorectal cancer patients who underwent curative resection followed ...

journal_title：British journal of cancer

authors： Lee DW,Han SW,Lee HJ,Rhee YY,Bae JM,Cho NY,Lee KH,Kim TY,Oh DY,Im SA,Bang YJ,Jeong SY,Park KJ,Park JG,Kang GH,Kim TY

更新日期：2013-05-28 00:00:00

abstract：:Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined th...

journal_title：British journal of cancer

authors： Weinlich G,Eisendle K,Hassler E,Baltaci M,Fritsch PO,Zelger B

更新日期：2006-03-27 00:00:00

abstract：:In clinically organ-confined prostate cancer patients, bloodstream tumour cell dissemination generally occurs, and may be enhanced by surgical prostate manipulation. To evaluate cancer-cell seeding impact upon patient recurrence-free survival, 155 patients were prospectively enrolled then followed. Here, 57 patients p...

journal_title：British journal of cancer

authors： Eschwège P,Moutereau S,Droupy S,Douard R,Gala JL,Benoit G,Conti M,Manivet P,Loric S

更新日期：2009-02-24 00:00:00

abstract：:To determine the maximum-tolerated dose (MTD), dose-limiting toxicities and pharmacokinetic of semisynthetic homoharringtonine (ssHHT), given as a twice daily subcutaneous (s.c.) injections for 9 days, in patients with advanced acute leukaemia, 18 patients with advanced acute myeloid leukaemia were included in this se...

journal_title：British journal of cancer

authors： Lévy V,Zohar S,Bardin C,Vekhoff A,Chaoui D,Rio B,Legrand O,Sentenac S,Rousselot P,Raffoux E,Chast F,Chevret S,Marie JP

更新日期：2006-08-07 00:00:00

abstract：BACKGROUND:Previous studies on the effects of different prostate cancer treatments on quality of life, were confounded because patients were not comparable. This study examined treatment effects in more comparable groups. METHODS:From 2008-2011, 240 patients with localised prostate cancer were selected to be eligible ...

journal_title：British journal of cancer

authors： van Tol-Geerdink JJ,Leer JW,van Oort IM,van Lin EJ,Weijerman PC,Vergunst H,Witjes JA,Stalmeier PF

更新日期：2013-05-14 00:00:00

abstract：:The hybrid cell line BH2 was derived by fusion between an AKR thymoma BW5147 (HGPRT-) and C57BL thymoma EL-4R (TK-). The hybrid cells showed a near-tetraploid modal number of chromosomes, in contrast to the near-diploid stem-lines of both parental cell populations; most of the BH2 hybrid cells acquired marker chromoso...

journal_title：British journal of cancer

authors： Bubeník J,Perlmann P,Jónsdóttir I,Kypĕnová H,Bubeníková D,Símová J

更新日期：1981-11-01 00:00:00

abstract：:Using flow cytometry and immunocytochemistry, we investigated the reactivities of two different murine monoclonal antibodies (MAbs), MRK 16 and MRK 20, specific to adriamycin-resistant K562 cells (K562/ADM) with peripheral human mononuclear cells (MNC) (mainly blastic cells and lymphocytes) from 31 patients with leuka...

journal_title：British journal of cancer

authors： Sugawara I,Kodo H,Ohkochi E,Hamada H,Tsuruo T,Mori S

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Multiple early gastric cancers (EGCs) may develop in 6-14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional c...

journal_title：British journal of cancer

authors： Hirata K,Suzuki H,Imaeda H,Matsuzaki J,Tsugawa H,Nagano O,Asakura K,Saya H,Hibi T

更新日期：2013-07-23 00:00:00

abstract：:NIH3T3 cells transfected with c-H-ras and/or c-myc genes were examined for differences in drug sensitivity. The five transfectants used were N8, NIH3T3-nm-1, pT22-3-nm-2, pP1-4 and pT22-3. They were transfected with pKOneo alone, pKOneo and c-myc, pKOneo and c-myc plus activated c-H-ras, normal c-H-ras and activated c...

journal_title：British journal of cancer

authors： Niimi S,Nakagawa K,Yokota J,Tsunokawa Y,Nishio K,Terashima Y,Shibuya M,Terada M,Saijo N

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Metastasis is associated with poor prognosis for melanoma. The formation of metastases is a multi-step process, in which cancer cells can subsequently acquire the potential to intravasate into the blood or lymph vessels, disseminate through the circulation, extravasate through the endothelium and invade the ...

journal_title：British journal of cancer

authors： Amatschek S,Lucas R,Eger A,Pflueger M,Hundsberger H,Knoll C,Grosse-Kracht S,Schuett W,Koszik F,Maurer D,Wiesner C

更新日期：2011-02-01 00:00:00