Multiple primary tumours in women following breast cancer, 1973-2000.


:We investigated the predictors of the risk of developing a second primary cancer after breast cancer, this occurring in about 12% of affected women. The analysis included 335 191 females, registered in the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) database, who had been diagnosed with breast cancer. Observed numbers of subsequent cancers in the SEER database with a first breast cancer diagnosed from 1973 to 2000 were compared with the expected numbers based on age-adjusted incidence rates to calculate standardised incidence ratios. Kaplan-Meier curves were conducted to determine the median time until the second primary cancer diagnosis. Average number of years until diagnosis varied by site and by age as well as median years until second cancer diagnosis. Most cancer risks decreased with age, but there was an increase in aging-related cancers such as lung cancer. The median years of follow-up were well beyond the 5-year mark. Breast cancer survivors should be advised of their increased risk for developing certain cancers in their lifetime.


Br J Cancer


Raymond JS,Hogue CJ




Has Abstract


2006-06-05 00:00:00














  • Quantitative studies of the kinetics of 5-aminolaevulinic acid-induced fluorescence in bladder transitional cell carcinoma.

    abstract::Photodynamic therapy is a potential treatment for superficial bladder cancer that utilizes photosensitizer drugs, which are activated by light to cause tissue destruction. However, first-generation photosensitizers cause prolonged phototoxicity, have poor tumour specificity and can accumulate within detrusor muscle, r...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Datta SN,Loh CS,MacRobert AJ,Whatley SD,Matthews PN

    更新日期:1998-10-01 00:00:00

  • A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer.

    abstract:BACKGROUND:Our previous laboratory and clinical data suggested that one mechanism underlying the development of platinum resistance in ovarian cancer is the acquisition of DNA methylation. We therefore tested the hypothesis that the DNA hypomethylating agent 5-aza-2'-deoxycytodine (decitabine) can reverse resistance to...

    journal_title:British journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Glasspool RM,Brown R,Gore ME,Rustin GJ,McNeish IA,Wilson RH,Pledge S,Paul J,Mackean M,Hall GD,Gabra H,Halford SE,Walker J,Appleton K,Ullah R,Kaye S,Scottish Gynaecological Trials Group.

    更新日期:2014-04-15 00:00:00

  • The influence of timing of radiation therapy following breast-conserving surgery on 10-year disease-free survival.

    abstract:BACKGROUND:The Dutch guidelines advise to start radiation therapy (RT) within 5 weeks following breast-conserving surgery (BCS). However, much controversy exists regarding timing of RT. This study investigated its effect on 10-year disease-free survival (DFS) in a Dutch population-based cohort. METHODS:All women diagn...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: van Maaren MC,Bretveld RW,Jobsen JJ,Veenstra RK,Groothuis-Oudshoorn CG,Struikmans H,Maduro JH,Strobbe LJ,Poortmans PM,Siesling S

    更新日期:2017-07-11 00:00:00

  • Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer.

    abstract::The aim of the study is to assess the value of carbonic anhydrase isozyme IX (CA IX) expression as a predictor of disease-free survival (DFS) and disease-specific survival (DSS) in rectal cancer treated by preoperative radio- or chemoradiotherapy or surgery only. Archival tumour samples from 166 patients were analysed...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Korkeila E,Talvinen K,Jaakkola PM,Minn H,Syrjänen K,Sundström J,Pyrhönen S

    更新日期:2009-03-24 00:00:00

  • Alpha-interferon does not increase the efficacy of 5-fluorouracil in advanced colorectal cancer.

    abstract::Two meta-analyses were conducted to quantify the benefit of combining alpha-IFN to 5FU in advanced colorectal cancer in terms of tumour response and survival. Analyses were based on a total of 3254 individual patient data provided by principal investigators of each trial. The meta-analysis of 5FU +/- LV vs. 5FU +/- LV...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Thirion P,Piedbois P,Buyse M,O'Dwyer PJ,Cunningham D,Man A,Greco FA,Colucci G,Köhne CH,Di Constanzo F,Piga A,Palmeri S,Dufour P,Cassano A,Pajkos G,Pensel RA,Aykan NF,Marsh J,Seymour MT,Meta-Analysis Group in Cancer.

    更新日期:2001-03-02 00:00:00

  • CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer.

    abstract::Although CD133 has been shown to be a marker for cancer stem cells in various tumours, its expression in pancreatic cancer has not yet been clinically reported. In this study, we investigated the relationship between CD133 expression and clinicopathological factors in pancreatic cancer. Pancreatic head carcinoma speci...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Maeda S,Shinchi H,Kurahara H,Mataki Y,Maemura K,Sato M,Natsugoe S,Aikou T,Takao S

    更新日期:2008-04-22 00:00:00

  • GOLPH3 is a novel marker of poor prognosis and a potential therapeutic target in human renal cell carcinoma.

    abstract:BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Xue Y,Wu G,Liao Y,Xiao G,Ma X,Zou X,Zhang G,Xiao R,Wang X,Liu Q,Long D,Yang J,Xu H,Liu F,Liu M,Xie K,Huang R

    更新日期:2014-04-29 00:00:00

  • Treatment with interleukin-2 in malignant pleural mesothelioma: immunological and angiogenetic assessment and prognostic impact.

    abstract:BACKGROUND:Administration of interleukin-2 (IL-2) has shown some effects on malignant pleural mesothelioma (MPM) tumour regression. The purpose of this study was to investigate the ability of IL-2 to modify immunological effector cells and angiogenesis in MPM patients and their prognostic value. METHODS:Tumour-infiltr...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Alì G,Boldrini L,Lucchi M,Picchi A,Dell'Omodarme M,Prati MC,Mussi A,Corsi V,Fontanini G

    更新日期:2009-12-01 00:00:00

  • Cytogenetic study in therapy-related myelodysplastic syndromes (t-MDS) and acute non-lymphocytic leukaemia (t-ANLL).

    abstract::A cytogenetic study was performed in 27 patients suspected of t-MDS or t-ANLL. In 12 patients the diagnosis of t-MDS or t-ANLL was confirmed by morphological, cytochemical and immunophenotypical analysis. The cases were classified as RA (one), RAEB (four), CMML (two), ANLL (five). They had received chemotherapy and/or...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sozzi G,Miozzo M,Orazi A,Calderone C,Castellano M,Viviani S,Santoro A,Pierotti MA,Della Porta G

    更新日期:1990-03-01 00:00:00

  • Protein kinase C in human renal cell carcinomas: role in invasion and differential isoenzyme expression.

    abstract::The role of protein kinase C (PKC) in in vitro invasiveness of four different human renal cell carcinoma (RCC) cell lines of the clear cell type was investigated. Different PKC-inhibitors markedly inhibited invasiveness of the highly invasive cell lines, suggesting an invasion-promoting role of PKC in human RCC. Analy...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Engers R,Mrzyk S,Springer E,Fabbro D,Weissgerber G,Gernharz CD,Gabbert HE

    更新日期:2000-03-01 00:00:00

  • The anti-proliferative effect of lithium chloride on melanoma cells and its reversion by myo-inositol.

    abstract::The effect of LiCl on melanoma cell growth and differentiation was studied in mouse and human melanoma cell lines. LiCl markedly inhibited B16 and HT-144 melanoma cell growth in vitro. Clonogenicity in soft agar of the melanoma cells was also markedly inhibited by LiCl. Pretreatment of B16 mouse melanoma cells with Li...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Nordenberg J,Panet C,Wasserman L,Malik Z,Fuchs A,Stenzel KH,Novogrodsky A

    更新日期:1987-01-01 00:00:00

  • Analysis of acute vascular damage after photodynamic therapy using benzoporphyrin derivative (BPD).

    abstract::Benzoporphyrin derivative monoacid ring A (BPD-MA, verteporfin) is currently under investigation as a photosensitizer for photodynamic therapy (PDT). Since BPD exhibits rapid pharmacokinetics in plasma and tissues, we assessed damage to tumour and muscle microvasculature when light treatment for PDT was given at short...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Fingar VH,Kik PK,Haydon PS,Cerrito PB,Tseng M,Abang E,Wieman TJ

    更新日期:1999-04-01 00:00:00

  • Detection of telomerase activity in peritoneal lavage fluid from patients with gastric cancer using immunomagnetic beads.

    abstract::Cytologic examination of peritoneal lavage fluid is a useful predictor of peritoneal recurrence in gastric cancer. However, this technique is not overly sensitive and requires special abilities in the cytologist. In this study, telomerase activity was used to detect free cancer cells in peritoneal lavage fluid from pa...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Mori N,Oka M,Hazama S,Iizuka N,Yamamoto K,Yoshino S,Tangoku A,Noma T,Hirose K

    更新日期:2000-10-01 00:00:00

  • Methylation status of oestrogen receptor-alpha gene promoter sequences in human ovarian epithelial cell lines.

    abstract::We have determined the methylation status of the CpG island of the oestrogen receptor alpha gene in seven human ovarian cell lines. Cell lines expressing oestrogen receptor alpha showed no evidence of hypermethylation. In three of four cell lines that produced no detectable oestrogen receptor alpha protein, hypermethy...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: O'Doherty AM,Church SW,Russell SE,Nelson J,Hickey I

    更新日期:2002-01-21 00:00:00

  • Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2).

    abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) has poor survival and treatment options. PDAC cells shift their metabolism towards glycolysis, which fuels the plasma membrane calcium pump (PMCA), thereby preventing Ca2+-dependent cell death. The ATP-generating pyruvate kinase-M2 (PKM2) is oncogenic and overexpressed...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: James AD,Richardson DA,Oh IW,Sritangos P,Attard T,Barrett L,Bruce JIE

    更新日期:2020-01-01 00:00:00

  • Cells bearing Fc receptors in human malignant solid tumours.

    abstract::Fc-receptor-bearing cells forming EA rosettes with antibody-coated human erythrocytes (Ripley) were studied in cell suspensions and in purified preparations of mononuclear cells (MC) from 20 human malignant tumours. The EA rosettes were studied in preparations made by cytocentrifugation and the rosette-forming cells i...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Svennevig JL,Andersson TR

    更新日期:1982-02-01 00:00:00

  • Anti-Her-2/neu antibody induces apoptosis in Her-2/neu overexpressing breast cancer cells independently from p53 status.

    abstract::Anti-Her-2/neu antibody is known to induce apoptosis in HER-2/neu overexpressing breast cancer cells. However, exact regulatory mechanisms mediating and controlling this phenomenon are still unknown. In the present study, we have investigated the effect of anti-Her-2/neu antibody on apoptosis of HER-2/neu overexpressi...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Brodowicz T,Kandioler D,Tomek S,Ludwig C,Rudas M,Kunstfeld R,Koestler W,Hejna M,Budinsky A,Wiltschke C,Zielinski CC

    更新日期:2001-11-30 00:00:00

  • Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies.

    abstract::Temozolomide, an oral cytotoxic agent with approximately 100% bioavailability after one administration, has demonstrated schedule-dependent clinical activity against highly resistant cancers. Thirty patients with minimal prior chemotherapy were enrolled in this phase I trial to characterize the drug's safety, pharmaco...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Brada M,Judson I,Beale P,Moore S,Reidenberg P,Statkevich P,Dugan M,Batra V,Cutler D

    更新日期:1999-11-01 00:00:00

  • Smoking, diet, pregnancy and oral contraceptive use as risk factors for cervical intra-epithelial neoplasia in relation to human papillomavirus infection.

    abstract::Smoking, nutrition, parity and oral contraceptive use have been reported as major environmental risk factors for cervical cancer. After the discovery of the very strong link between human papillomavirus (HPV) infection and cervical cancer, it is unclear whether the association of these environmental factors with cervi...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kjellberg L,Hallmans G,Ahren AM,Johansson R,Bergman F,Wadell G,Angström T,Dillner J

    更新日期:2000-04-01 00:00:00

  • A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants.

    abstract:BACKGROUND:defective DNA repair has a causal role in hereditary colorectal cancer (CRC). Defects in the base excision repair gene MUTYH are responsible for MUTYH-associated polyposis and CRC predisposition as an autosomal recessive trait. Numerous reports have suggested MUTYH mono-allelic variants to be low penetrance ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Theodoratou E,Campbell H,Tenesa A,Houlston R,Webb E,Lubbe S,Broderick P,Gallinger S,Croitoru EM,Jenkins MA,Win AK,Cleary SP,Koessler T,Pharoah PD,Küry S,Bézieau S,Buecher B,Ellis NA,Peterlongo P,Offit K,Aaltonen L

    更新日期:2010-12-07 00:00:00

  • Ki-ras point mutations and proliferation activity in biliary tract carcinomas.

    abstract::The association between Ki-ras mutations and proliferation activity was investigated in a comprehensive series of biliary tract carcinomas (BTCs). We precisely microdissected samples of tissue from paraffin-embedded sections of 77 BTCs including 22 intrahepatic cholangiocarcinomas (ICCs), 36 extrahepatic cholangiocarc...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Ohashi K,Tstsumi M,Nakajima Y,Nakano H,Konishi Y

    更新日期:1996-09-01 00:00:00

  • Familial risk in testicular cancer as a clue to a heritable and environmental aetiology.

    abstract::We used the nation-wide Swedish Family-Cancer Database to examine the risk for testicular cancer in offspring through parental and sibling probands. Among 0-68-year-old offspring, 4082 patients had testicular cancer in years 1961-2000, among whom 68 (1.67%) had an affected father/brother. Standardized incidence ratios...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hemminki K,Li X

    更新日期:2004-05-04 00:00:00

  • Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma.

    abstract:BACKGROUND:A frequent mechanism of acquired multidrug resistance in human cancers is overexpression of ATP-binding cassette transporters such as the Multi-Drug Resistance Protein 1 (MDR-1). Nutlin-3, an MDM2-p53 antagonist, has previously been reported to be a competitive MDR-1 inhibitor. METHODS:This study assessed w...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Chen L,Zhao Y,Halliday GC,Berry P,Rousseau RF,Middleton SA,Nichols GL,Del Bello F,Piergentili A,Newell DR,Lunec J,Tweddle DA

    更新日期:2014-08-12 00:00:00

  • Identification of a cell-surface glycoprotein associated with normal mammary and extramammary epithelial cells.

    abstract::The goal of the study was to identify any normal genes that may become inactivated in malignant cells, with associated modifications or loss of gene products. Consequently, attempts were made to identify such products by generating monoclonal antibodies using an immune tolerisation-immunisation procedure. Using such a...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Imam SA,Stampfer MR,Yilmaz A,Taylor CR

    更新日期:1994-03-01 00:00:00

  • c-Myc alters the DNA damage-induced G2/M arrest in human mammary epithelial cells.

    abstract::Effects of c-Myc overexpression on the DNA damage-induced G2/M checkpoint were studied in finite lifespan, normal human mammary epithelial cells (HMECs). Previously, we showed that c-Myc attenuates G1/S arrest and leads to an inappropriate entry of cells with damaged DNA into the S phase, following treatment with ioni...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sheen JH,Woo JK,Dickson RB

    更新日期:2003-10-20 00:00:00

  • Intensified therapies improve survival and identification of novel prognostic factors for placental-site and epithelioid trophoblastic tumours.

    abstract:BACKGROUND:Placental-site trophoblastic (PSTT) and epithelioid trophoblastic tumours (ETT) are the rarest malignant forms of gestational trophoblastic disease (GTD). Our prior work demonstrated that an interval of ≥48 months from the antecedent pregnancy was associated with 100% death rate, independent of the stage. He...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Froeling FEM,Ramaswami R,Papanastasopoulos P,Kaur B,Sebire NJ,Short D,Fisher RA,Sarwar N,Wells M,Singh K,Ellis L,Horsman JM,Winter MC,Tidy J,Hancock BW,Seckl MJ

    更新日期:2019-03-01 00:00:00

  • Therapy of human ovarian cancer xenografts with intraperitoneal liposome encapsulated muramyl-tripeptide phosphoethanolamine (MTP-PE) and recombinant GM-CSF.

    abstract::Three intraperitoneal human ovarian cancer xenografts (OS, HU, and LA) were used to assess the antitumour activity of intraperitoneal therapy with liposome encapsulated MTP-PE. MTP-PE led to significant prolongation of survival in all three xenograft models, but with varying efficacy. In one tumour model (OS), 80% of ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Malik ST,Martin D,Hart I,Balkwill F

    更新日期:1991-03-01 00:00:00

  • Combination chemotherapy in advanced gastrointestinal cancers: ex vivo sensitivity to gemcitabine and mitomycin C.

    abstract::Advanced or metastatic disease is common in both oesophagogastric and colorectal cancers, with poor 5-year survival despite palliative chemotherapy. We have investigated the sensitivity of gastrointestinal tumours to gemcitabine in combination with mitomycin C (GeM), using a modified ex vivo ATP-based tumour chemosens...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Whitehouse PA,Mercer SJ,Knight LA,Di Nicolantonio F,O'Callaghan A,Cree IA,Portsmouth Upper GI and Colorectal Cancer Multidisciplinary Teams.

    更新日期:2003-12-15 00:00:00

  • Effect of modulation of the transferrin receptor on gallium-67 uptake and cytotoxicity in lymphoma cell lines.

    abstract::Gallium-67 is a radionuclide that accumulates in haematological malignancies and is used for diagnostic purposes. Uptake of 67Ga into the cell occurs via the transferrin receptor, which is differentially expressed during the various cell cycle phases. With the aim of selectively increasing 67Ga uptake, we studied whet...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: van Leeuwen-Stok AE,Schuurhuis GJ,Dräger AM,Visser-Platier AW,Teule GJ,Huijgens PC

    更新日期:1996-08-01 00:00:00

  • Enzymic retrodifferentiation during hepatocarcinogenesis and liver regeneration in rats in vivo.

    abstract::The work presented here has concerned the study of early, as well as late, enzymic changes occurring during diethylnitrosamine-induced hepatocarcinogenesis and liver regeneration after partial hepatectomy in comparison with normal liver differentiation. Rank correlation analysis of the enzyme data suggested a step-wis...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Curtin NJ,Snell K

    更新日期:1983-10-01 00:00:00