Abstract:
:Clonogenic survival of HeLa, Chinese hamster and HaK cells after treatment with a range of cisplatin concentrations and exposure times was determined and cellular platinum concentrations were measured by PIXE. It was demonstrated that cisplatin cytotoxicity of the three cell lines varied considerably as a function of drug exposure dose. These differences are related to differential cellular drug uptake.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Eichholtz-Wirth H,Hietel Bdoi
10.1038/bjc.1986.168subject
Has Abstractpub_date
1986-08-01 00:00:00pages
239-43issue
2eissn
0007-0920issn
1532-1827journal_volume
54pub_type
杂志文章abstract::Alveolar macrophage (AM) phagocytic activity and glucose metabolism were evaluated during lung tumour growth in adult rats challenged i.v. with 10(5) viable Walker 256 tumour cells. Phagocytosis was estimated by the in vitro uptake of (14)C-labelled Pseudomonas aeruginosa and glucose oxidation was evaluated by (14)CO(...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.249
更新日期:1977-12-01 00:00:00
abstract::Recent studies indicate that cancer antigen 125 (CA125) response criteria tend to overestimate a tumour reduction measured by standard WHO response criteria in recurrent epithelial ovarian carcinoma. The aim of the study was to validate the recently introduced GCIG (The Gynaecological Cancer Intergroup) CA125 response...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6601501
更新日期:2004-01-26 00:00:00
abstract::KRN 8602 (MX2) is a novel morpholino anthracycline derivative having the chemical structure 3'-deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin hydrochloride. To investigate the mechanisms of resistance to MX2, we established an MX2-resistant phenotype (K562/MX2) of the human myelogeneous leukaemia cell line (K56...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602498
更新日期:2005-04-25 00:00:00
abstract::Both biodegradable emboli and pharmacological agents can enhance regional therapy for hepatic targeting. Using a rat model with similar haemodynamic characteristics to human colorectal liver tumour and a radio-labelled marker of similar molecular weight to Adriamycin, we have combined the two approaches to see if the ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.7
更新日期:1992-01-01 00:00:00
abstract::Connective tissue growth factor (CTGF) is a major chemotactic and mitogenic factor for connective tissue cells. The amino acid sequence shares an overall 28-38% identity to IGFBPs and contains critical conserved sequences in the amino terminus. It has been demonstrated that human CTGF specifically binds IGFs with low ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1364
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the prognostic value of pre-treatment NLR in patients with oropharyngeal cancer. METHODS:Patients who completed definitive radiotherapy (RT) for oropharyngeal cancer and had blood counts taken pre-RT from 2002 to 2013 were included. NLR was calculated as total neutrophil/lymphoc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01106-x
更新日期:2020-10-14 00:00:00
abstract:BACKGROUND:Metastasis is associated with poor prognosis for melanoma. The formation of metastases is a multi-step process, in which cancer cells can subsequently acquire the potential to intravasate into the blood or lymph vessels, disseminate through the circulation, extravasate through the endothelium and invade the ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6606056
更新日期:2011-02-01 00:00:00
abstract::Several diseases are known or suspected to be associated with altered levels of hormones and growth factors that may influence breast cancer risk. To elucidate this possibility, we studied the relationship between 23 medical conditions or procedures and breast cancer risk by means of data from a multicentric case-cont...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.289
更新日期:1997-01-01 00:00:00
abstract::The antitumour activities of N-methylformamide, N-ethylformamide and formamide against a number of murine tumours in vivo (Sarcoma 180, M5076 ovarian sarcoma and TLX5 lymphoma) have been estimated. In all cases N-methyl-formamide had significant activity, formamide had marginal or no activity and N-ethylformamide had ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1982.136
更新日期:1982-06-01 00:00:00
abstract::The aim of the study was to investigate the association of physician communication behaviours as perceived by the patient with patient reported satisfaction, distress, cancer-related self-efficacy, and perceived control over the disease in cancer patients. Questionnaires measuring distress, self-efficacy, and perceive...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600798
更新日期:2003-03-10 00:00:00
abstract::Pancreatic cancer is a highly lethal malignancy with a dismal 5-year survival of less than 5%. The scarcity of early biomarkers has considerably hindered our ability to launch preventive measures for this malignancy in a timely manner. Neutrophil gelatinase-associated lipocalin (NGAL), a 24-kDa glycoprotein, was repor...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604329
更新日期:2008-05-06 00:00:00
abstract::HuR, a ubiquitously expressed member of the Hu protein family that binds and stabilizes an AU-rich element (ARE)-containing mRNAs, is known to shuttle between the nucleus and the cytoplasm via several export pathways. When normal cells were treated with heat shock, HuR was exported to the cytoplasm in a chromosome mai...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605084
更新日期:2009-06-16 00:00:00
abstract:BACKGROUND:Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse. METHOD:The aim of this study was to compare tumour stage and survival of IBD patients...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605359
更新日期:2009-11-17 00:00:00
abstract::The aim of this study was to assess the cost-effectiveness of combination chemotherapy with paclitaxel/cisplatin, compared with standard etoposide/cisplatin in patients with advanced non-small cell lung cancer (NSCLC). We obtained the primary survival and resource utilization data from a large three-arm randomized tri...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.bjc.6690426
更新日期:1999-05-01 00:00:00
abstract::Fc-receptor-bearing cells forming EA rosettes with antibody-coated human erythrocytes (Ripley) were studied in cell suspensions and in purified preparations of mononuclear cells (MC) from 20 human malignant tumours. The EA rosettes were studied in preparations made by cytocentrifugation and the rosette-forming cells i...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1982.34
更新日期:1982-02-01 00:00:00
abstract::The tissue-specific translation elongation factor eEF1A2 is a potential oncogene that is overexpressed in human ovarian cancer. eEF1A2 is highly similar (98%) to the near-ubiquitously expressed eEF1A1 (formerly known as EF1-alpha) making analysis with commercial antibodies difficult. We wanted to establish the express...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603748
更新日期:2007-05-21 00:00:00
abstract:BACKGROUND:Cetuximab plus FOLFIRI improved overall survival compared with bevacizumab plus FOLFIRI in KRAS wild-type metastatic colorectal cancer (mCRC) in FIRE-3, but no corresponding benefit was found for progression-free survival. This analysis aimed to determine whether cetuximab improves response and survival vers...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01140-9
更新日期:2020-11-06 00:00:00
abstract::Serum protein induced by vitamin K absence or antagonist II (PIVKAII), hepatoma-specific band of serum gamma-glutamyl transferase (GGTII), and alpha-fetoprotein (AFP) levels were determined in 120 patients with hepatocellular carcinoma (HCC) and 90 patients with cirrhosis. The mean serum concentration of PIVKAII in HC...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601018
更新日期:2003-06-16 00:00:00
abstract::The relationship between breast self examination (BSE) and breast cancer stage at diagnosis was examined in 616 women aged 15-59 years. Differences in tumour characteristics between those not practising BSE and those practising but not taught were small and inconstant. However, women who had both practised and had bee...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.39
更新日期:1987-02-01 00:00:00
abstract::A total of 164 consecutive adults with newly confirmed stage IIIB, IVA or IVB Hodgkin's disease (HD) commenced cyclical combination chemotherapy comprising mustine, vinblastine, prednisolone and procarbazine (MVPP) every 6 weeks (145 patients) or minor variants (19) at St Bartholomew's Hospital between 1968 and 1984. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.88
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:Although salt intake is considered a probable risk factor for gastric cancer, relevant studies have provided heterogeneous results, and the magnitude of the association has not been accurately quantified. METHODS:To quantify gastric cancer risk in relation to dietary salt exposure according to Helicobacter ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605993
更新日期:2011-01-04 00:00:00
abstract:BACKGROUND:We previously showed that activation of the nuclear factor of activated T cells (NFAT)1/Fas ligand (FasL) pathway induces glioma cell death. Lithium (Li) is an inhibitor of glycogen synthase kinase (GSK)-3 that activates NFAT1/FasL signalling. Temozolomide (TMZ) inhibits GSK-3 and activates Fas in tumour pro...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.89
更新日期:2017-05-09 00:00:00
abstract::The effect of acute carbon monoxide (CO) breathing on blood oxygenation and tumour hypoxia was related to the radiation response of the C3H/Tif mammary carcinoma. Blood gas analysis showed that CO breathing caused a time- and dose-dependent formation of carboxyhaemoglobin (HbCO), a significant left shift of the oxygen...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.8
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Evasion of apoptosis contributes to the pathogenesis of solid tumours including non-small cell lung cancer (NSCLC). Malignant cells resist apoptosis through over-expression of inhibitor of apoptosis proteins (IAPs), such as X-linked IAP (XIAP). METHODS:A phenylurea-based small molecule inhibitor of XIAP, XI...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605418
更新日期:2010-01-05 00:00:00
abstract::Differentiation-inducing ability of gamma-radiation, N,N-dimethylformamide and their combination has been tested on human rhabdomyosarcoma RMZ-RC2 clone cells. Ionising radiation at 2-5 Gy doses induced a more differentiated morphology, with the appearance of an increased proportion of multinuclear myotube-like cells,...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.107
更新日期:1992-04-01 00:00:00
abstract::The WWOX (WW-domain containing oxidoreductase) is a candidate tumour suppressor gene spanning the same chromosome region, 16q23, as the second most common fragile site (FS), FRA16D. Deletions detected by comparative genomic hybridisation (CGH) and loss of heterozygosity at microsatellite markers on chromosome 16q are ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602023
更新日期:2004-08-16 00:00:00
abstract:BACKGROUND:High amplification of epiregulin (EREG) and amphireglin (AREG) in tumour tissues has been previously reported to be associated with better outcome in metastatic colorectal cancer (mCRC) patients who were treated with anti-EGFR antibodies. Here we investigated associations between the expression of other cand...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.74
更新日期:2016-04-26 00:00:00
abstract::Adriamycin and cyclophosphamide are active agents in human and experimental tumours. Using the L1210 murine leukaemia, their effectiveness alone and in combination was studied. The combination is highly synergistic in this tumour, resulting in a greater than 50% survival rate when the agents used alone at optimal dose...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1975.150
更新日期:1975-08-01 00:00:00
abstract::High-level microsatellite instability (MSI-H) in colorectal cancer accounts for about 12% of colorectal cancers and is typically associated with a dense infiltration with cytotoxic CD8-positive lymphocytes. The role of regulatory T cells that may interfere with the host's antitumoural immune response in MSI-H colorect...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604756
更新日期:2008-12-02 00:00:00
abstract:BACKGROUND:In two clinical trials of the vascular endothelial growth factor (VEGF) receptor inhibitor pazopanib in advanced renal cell carcinoma (mRCC), we found interleukin-6 as predictive of pazopanib benefit. We evaluated the prognostic significance of candidate cytokines and angiogenic factors (CAFs) identified in ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.206
更新日期:2017-08-08 00:00:00