Abstract:
:We empirically evaluated the performance of a new method for age adjustment of cancer survival compared to traditional age adjustment using data from the Finnish Cancer Registry. We find that both methods provide almost identical results for absolute survival but the new method generally provides more meaningful estimates of relative survival with often a smaller standard error.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Brenner H,Hakulinen Tdoi
10.1038/sj.bjc.6602704subject
Has Abstractpub_date
2005-08-08 00:00:00pages
372-5issue
3eissn
0007-0920issn
1532-1827pii
6602704journal_volume
93pub_type
杂志文章abstract:BACKGROUND:This study aimed to evaluate the safety and efficacy of dose-dense weekly chemotherapy, followed by resection and/or thoracic radiotherapy. METHODS:Patients with histologically documented thymoma with unresectable stage III disease received 9 weeks of chemotherapy: cisplatin 25 mg m(-2) on weeks 1-9; vincri...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605731
更新日期:2010-06-29 00:00:00
abstract:BACKGROUND:Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS:Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nucle...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.414
更新日期:2016-01-12 00:00:00
abstract::The aim of the study is to assess the value of carbonic anhydrase isozyme IX (CA IX) expression as a predictor of disease-free survival (DFS) and disease-specific survival (DSS) in rectal cancer treated by preoperative radio- or chemoradiotherapy or surgery only. Archival tumour samples from 166 patients were analysed...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604949
更新日期:2009-03-24 00:00:00
abstract::In a cohort of 29,584 residents of Linxian, China, followed from 1985 to 2001, we conducted a case-cohort study of the magnitude of the association of Helicobacter pylori seropositivity with cancer risk in a random sample of 300 oesophageal squamous cell carcinomas, 600 gastric cardia adenocarcinomas, all 363 diagnose...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603517
更新日期:2007-01-15 00:00:00
abstract::There are two main histological groups of testicular germ cell tumours, which may have different risk factors. Some authors have analysed potential risk factors by histological group but few consistent differences have been identified. In this paper we examine risk factors for pure seminoma and other tumours using dat...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690611
更新日期:1999-08-01 00:00:00
abstract::The antiapoptotic Livin/ML-IAP gene has recently gained much attention as a potential new target for cancer therapy. Reports indicating that livin is expressed almost exclusively in tumours, but not in the corresponding normal tissue, suggested that the targeted inhibition of livin may present a novel tumour-specific ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604028
更新日期:2007-11-05 00:00:00
abstract::Forty-three children with malignant soft tissue sarcomas (IRS Groups II-IV) were treated with rapid dose delivery chemotherapy protocol comprising six courses of vincristine, adriamycin and cyclophosphamide, given in most cases within 8 weeks (Rapid VAC). This was followed in 36 patients by high dose melphalan with au...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1991.313
更新日期:1991-08-01 00:00:00
abstract::Human chorionic gonadotrophin (hCG) and alphafetoprotein (AFP) were measured in culture media from a panel of 29 cell lines including 9 bladder carcinomas, 5 'normal' bladder epithelia, 10 germ cell tumours, and 5 miscellaneous tumours and 'normal' cell lines. In 7 of the 9 bladder carcinomas and 4 of the 5 'normal' b...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.126
更新日期:1987-06-01 00:00:00
abstract::The toxicity produced by two courses of methotrexate separated by different intervals has been studied in matched groups of rats. The maximum degree of neutropenia reached when courses were separated by 8 days or more was no greater than that seen after a single course of methotrexate. However, when courses of neutrop...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.2
更新日期:1977-01-01 00:00:00
abstract::We have established a novel ascites tumour model (MDA435/LCC6) from the oestrogen receptor-negative, invasive and metastatic MDA-MB-435 human breast cancer cell line. MDA435/LCC6 cells grow as both malignant ascites and solid tumours in vivo in nude mice and nude rats, with a tumour incidence of approximately 100%. Un...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.29
更新日期:1996-01-01 00:00:00
abstract::A retrospective case-control study of 200 patients with head and neck cancer, and 200 controls matched for age and sex, confirmed the importance of tobacco and alcohol consumption in the aetiology of malignant tumours of the upper gastrointestinal and upper respiratory tracts. A male-female ratio of 3:1 was found, and...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.26
更新日期:1981-02-01 00:00:00
abstract::E-cadherin function is thought to be impaired in epithelial cancer. To investigate the alterations in E-cadherin associated with cytoplasmic molecules including alpha-catenin, beta-catenin, gamma-catenin, p120CAS, and IQGAP1 in various endometrial cancers with different degree of differentiation, we examined the local...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1386
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Emergence of drug-resistant cancer phenotypes is a challenge for anti-cancer therapy. Cancer stem cells are identified as one of the ways by which chemoresistance develops. METHOD:We investigated the anti-inflammatory combinatorial treatment (DA) of doxorubicin and aspirin using a preclinical microfluidic m...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0301-9
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:The current analysis was performed to evaluate the impact of PIK3CA hotspot mutations on everolimus efficacy in BOLERO-2 participants, using cell-free DNA (cfDNA) from plasma samples collected at the time of patient randomisation. METHODS:PIK3CA H1047R, E545K, and E542K mutations in plasma-derived cfDNA wer...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2017.25
更新日期:2017-03-14 00:00:00
abstract:BACKGROUND:Docetaxel is widely used as a chemotherapeutic agent for gastric cancer treatment. A combined regimen with sunitinib demonstrated a synergistic antitumour effect in a preclinical model. The aim of this study was to evaluate the efficacy and safety of this combination in patients with unresectable or metastat...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2012.100
更新日期:2012-04-24 00:00:00
abstract::Human pancreatic exocrine adenocarcinoma cells established in tissue culture expressed both HLA and beta 2-microglobulin (beta 2M). Plasma-membrane components of this pancreatic cancer cell line were purified from plasma membrane fractions enriched by sucrose density-gradient centrifugation, using immunoaffinity chrom...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1979.250
更新日期:1979-11-01 00:00:00
abstract::To assess tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and clinical activity of the dual epidermal growth factor receptor (EGFR) 1 and 2 (HER2) tyrosine kinase inhibitor BIBW 2992. An escalating schedule of once-daily (OD) BIBW 2992 for 14 days followed by 14 days off medication was explored. Thirty-eigh...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604108
更新日期:2008-01-15 00:00:00
abstract:BACKGROUND:To evaluate safety, pharmacokinetics, and maximum tolerated dose of roniciclib in patients with advanced malignancies, with dose expansion to evaluate clinical benefit at the recommended phase II dose (RP2D). METHODS:Two phase I dose-escalation studies evaluated two roniciclib dosing schedules: 3 days on/4 ...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.2017.92
更新日期:2017-06-06 00:00:00
abstract::Epidemiological evidence indicates that non-steroidal anti-inflammatory drugs (NSAIDs) protect against colorectal cancer (CRC) to a greater degree than other non-gastrointestinal cancers, but the molecular basis for this difference is unknown. We previously reported that aspirin induces signal-specific I kappa B alpha...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601913
更新日期:2004-07-19 00:00:00
abstract::We have studied the cytotoxic effects of recombinant tumour necrosis factor and recombinant gamma interferon on primary cultures of leukaemia cells. The agents were added alone or in a combination to cells from 17 patients. Eleven had acute myeloblastic leukaemia (6 at presentation, 5 at relapse), 4 had acute lymphobl...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.55
更新日期:1987-03-01 00:00:00
abstract::The potential antitumoral effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) led us to evaluate GM-CSF alone or with dacarbazine (DTIC) in metastatic melanoma in first line randomized phase II. Treatment was arm A: GM-CSF: 5 microg kg(-1), bid, 14 consecutive days every 21 days and arm B: GM-CSF: 5 mi...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1054/bjoc.2001.2120
更新日期:2001-11-16 00:00:00
abstract::The multivariate lognormal survival model can be used to determine the relationship of prognostic covariates to two important parameters of malignancy. Cured fraction and median survival time among uncured patients. Analysis with this model revealed that cured fraction is primarily a function of histologic type and no...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.196
更新日期:1993-05-01 00:00:00
abstract::The family history of cancer in children treated for a solid malignant tumour in the Paediatric Oncology Department at Institute Gustave-Roussy, has been investigated. In order to determine the role of germline p53 mutations in genetic predisposition to childhood cancer, germline p53 mutations were sought in individua...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1167
更新日期:2000-06-01 00:00:00
abstract::Throughout the world there are problems recruiting ethnic minority patients into cancer clinical trials. A major barrier to trial entry may be distrust of research and the medical system. This may be compounded by the regulatory framework governing research with an emphasis on written consent, closed questions and con...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2012.240
更新日期:2012-09-25 00:00:00
abstract::The possible use of liposomes (phospholipid vesicles) to direct cytotoxic drugs to tumours has led us to investigate the tissue localization of i.v. injected 99m-Tc-labelled liposomes in cancer patients. Twenty mg or 300 mg doses of liposomal lipid (7:2:1 molar ratio of phosphatidylcholine : cholesterol : phosphatidic...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1979.138
更新日期:1979-07-01 00:00:00
abstract::Cellular adhesion molecules have been implicated in tumour progression and metastasis. This study examines for the first time the serum concentrations of circulating VCAM-1 and E-selectin in a consecutive series of 110 cancer patients seen in a general medical oncology clinic, and confirms and extends previous studies...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.298
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. METHODS:We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 200...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0500-z
更新日期:2019-07-01 00:00:00
abstract::It has recently been reported that a series of testis cancers shows a temporal cycle in birth dates with a peak in certain months. This observation has been tested by an examination of a larger series covering all testis cancers diagnosed in the years 1971-84 in England and Wales, in men born in 1940 or later. Limited...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.117
更新日期:1987-05-01 00:00:00
abstract::In compiling official mortality statistics, rules for selecting the underlying cause of death have changed twice in the last 20 years in England. Mortality statistics for most types of cancer were not greatly affected, but there were significant effects on coding for cancers of colon, liver, breast, prostate, testis a...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601633
更新日期:2004-03-08 00:00:00
abstract::Telomerase is a specialized ribonucleoprotein polymerase that directs the synthesis of telomerase repeats at chromosome ends. Accumulating evidence has indicated that telomerase is stringently repressed in normal human somatic tissues but reactivated in cancers and immortal cells, suggesting that activation of telomer...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.363
更新日期:1998-06-01 00:00:00