当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells.

Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells.

Abstract：

BACKGROUND:Human polypyrimidine tract binding protein 3 (PTBP3) was first discovered in 1999 and has been well characterised as a differentiation regulator. However, its role in human cancer has rarely been reported. Our previous study revealed increased PTBP3 protein level in gastric cancer tissues. Downregulation of PTBP3 suppressed the proliferation and differentiation of gastric cancer cells in vivo. METHODS:PTBP3 mRNA levels in human gastric cancer and adjuvant non-tumour tissues were detected. Apoptosis and 5-FU effect were determined in PTBP3-silenced gastric cancer cells. Underlying molecular mechanisms were investigated. RESULTS:MRNA expression of PTBP3 was upregulated in gastric cancer tissues, especially in those at an advanced stage. PTBP3 silencing led to apoptosis, under which modulation of PTB and thereby switch of Bcl-x pre-mRNA splicing pattern might be an important mechanism. Further research found that inhibition of PTBP3 expression enhanced the chemosensitivity of gastric cancer cells towards 5-FU treatment. This was mediated by reduced expression of histone deacetylase 6 (HDAC6), which further inhibited the phosphorylation of Akt and the expression of thymidylate synthase (TYMS), the critical determinant of 5-FU cytotoxicity. CONCLUSIONS:PTBP3 might serve as a biomarker of gastric cancer or potential target for anti-cancer therapy.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Liang X,Shi H,Yang L,Qiu C,Lin S,Qi Y,Li J,Zhao A,Liu J

doi

10.1038/bjc.2017.32

subject

Has Abstract

pub_date

2017-03-28 00:00:00

pages

903-911

issue

7

eissn

0007-0920

issn

1532-1827

pii

bjc201732

journal_volume

116

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • The impact of genetic counselling on risk perception in women with a family history of breast cancer.

    abstract：:Women with a family history of breast cancer generally self-refer because they have a feeling that their risk is high. However, they have, in general, only a hazy notion of the population risk of breast cancer and their own risk in relation to this. It is probable that they are helped by genetic counselling and, if at...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.423

    authors： Evans DG,Blair V,Greenhalgh R,Hopwood P,Howell A

    更新日期：1994-11-01 00:00:00

  • Birth weight and melanoma risk: a population-based case-control study.

    abstract：:We investigated whether lower birth weight was associated with lower risk of melanoma later in life. This population-based case-control study included all incident cases of histologically verified invasive melanoma diagnosed until 31 December 2003 in the Norwegian population born between 1967 and 1986 (n=709). The con...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/sj.bjc.6604159

    authors： Franco-Lie I,Iversen T,Robsahm TE,Abdelnoor M

    更新日期：2008-01-15 00:00:00

  • Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease.

    abstract：BACKGROUND:The precise timing of the angiogenic switch and the role of angiogenesis in the development of breast malignancy is currently unknown. METHODS:Therefore, the expression of CD31 (pan endothelial cells (ECs)), endoglin (actively proliferating ECs), hypoxia-inducible factor-1 (HIF-1alpha), vascular endothelial...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605196

    authors： Bluff JE,Menakuru SR,Cross SS,Higham SE,Balasubramanian SP,Brown NJ,Reed MW,Staton CA

    更新日期：2009-08-18 00:00:00

  • The level of haemoglobin in anaemic cancer patients correlates positively with quality of life.

    abstract：:The aim of this study was to assess the relationship between haemoglobin level and quality-of-life in anaemic cancer patients. Patients, diagnosed with one of four cancers, were recruited if their haemoglobin level was <12 g dl(-1) (female) or <13 g dl(-1) (male). The condition-specific Functional Assessment of Cancer...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/sj.bjc.6600247

    authors： Lind M,Vernon C,Cruickshank D,Wilkinson P,Littlewood T,Stuart N,Jenkinson C,Grey-Amante P,Doll H,Wild D

    更新日期：2002-04-22 00:00:00

  • Human tumour cell lines established in vitro from tumours after long-term passage as nude mouse xenografts. Comparative fingerprinting of their concanavalin-A acceptor glycoproteins.

    abstract：:Two human colon cancer xenografts (EC and AC) were established in tissue culture only after long-term passage in nude mice. Earlier attempts to establish cell lines were unsuccessful. The epithelioid cells retain their tumourigenicity after in vitro growth, giving rise to tumours with a take rate of 60-80%. After reim...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1985.102

    authors： Walton J,Winterbourne D,Fiennes A,Harris P,Hermon-Taylor J,Grant A

    更新日期：1985-05-01 00:00:00

  • Tumour necrosis factor gene polymorphism: a predictive factor for the development of post-transplant lymphoproliferative disease.

    abstract：BACKGROUND:Epstein-Barr virus-positive post-transplant lymphoproliferative disease (PTLD) is a potentially lethal complication of iatrogenic immunosupression after transplantation. Predicting the development of PTLD allowing early and effective intervention is therefore of importance. Polymorphisms within cytokine gene...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605278

    authors： McAulay KA,Haque T,Crawford DH

    更新日期：2009-09-15 00:00:00

  • Increased constitutive activity of mitogen-activated protein kinase and renaturable 85 kDa kinase in human-colorectal cancer.

    abstract：:Protein kinases play a key role in intracellular signalling, participating at multiple levels along the transduction cascades that trigger mitogenic response. Because protein kinases are involved in mitogenic pathways, they are likely to play a role in the abnormal proliferation of malignant cells. In this study we co...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.675

    authors： Ostrowski J,Trzeciak L,Kołodziejski J,Bomsztyk K

    更新日期：1998-11-01 00:00:00

  • Prognostic role of ERBB2, MET and VEGFA expression in metastatic colorectal cancer patients treated with anti-EGFR antibodies.

    abstract：BACKGROUND:High amplification of epiregulin (EREG) and amphireglin (AREG) in tumour tissues has been previously reported to be associated with better outcome in metastatic colorectal cancer (mCRC) patients who were treated with anti-EGFR antibodies. Here we investigated associations between the expression of other cand...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.74

    authors： Takahashi N,Iwasa S,Taniguchi H,Sasaki Y,Shoji H,Honma Y,Takashima A,Okita N,Kato K,Hamaguchi T,Shimada Y,Yamada Y

    更新日期：2016-04-26 00:00:00

  • State-of-the-art management of nasopharyngeal carcinoma: current and future directions.

    abstract：:Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer. Approximately 70% of patients with newly diagnosed NPC present with locally advanced disease. Phase III clinical trials support the addition of chemotherapy to radiotherapy for the initial treatment of these patients. Once metastatic disease de...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6602449

    authors： Agulnik M,Siu LL

    更新日期：2005-03-14 00:00:00

  • Selecting first-line bevacizumab-containing therapy for advanced breast cancer: TURANDOT risk factor analyses.

    abstract：BACKGROUND:The randomised phase III TURANDOT trial compared first-line bevacizumab-paclitaxel (BEV-PAC) vs bevacizumab-capecitabine (BEV-CAP) in HER2-negative locally recurrent/metastatic breast cancer (LR/mBC). The interim analysis revealed no difference in overall survival (OS; primary end point) between treatment ar...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2014.504

    authors： Brodowicz T,Lang I,Kahan Z,Greil R,Beslija S,Stemmer SM,Kaufman B,Petruzelka L,Eniu A,Anghel R,Koynov K,Vrbanec D,Pienkowski T,Melichar B,Spanik S,Ahlers S,Messinger D,Inbar MJ,Zielinski C

    更新日期：2014-11-25 00:00:00

  • A new superinvasive in vitro phenotype induced by selection of human breast carcinoma cells with the chemotherapeutic drugs paclitaxel and doxorubicin.

    abstract：:Doxorubicin- and paclitaxel-selected variants of an in vitro invasive clonal population of the human breast cancer cell line, MDA-MB-435S, were established by pulse selection, and exhibited a novel 'superinvasive' phenotype. This phenotype is characterised by an ability to relocate to another surface following invasio...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602221

    authors： Glynn SA,Gammell P,Heenan M,O'Connor R,Liang Y,Keenan J,Clynes M

    更新日期：2004-11-15 00:00:00

  • The role of Mediterranean diet on the risk of pancreatic cancer.

    abstract：BACKGROUND:The Mediterranean diet has been shown to have a beneficial role on various neoplasms, but data are scanty on pancreatic cancer. METHODS:We analysed data from two case-control studies conducted in Italy between 1983 and 2008, including 362 and 326 pancreatic cancer cases and 1552 and 652 hospital-controls, r...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.345

    authors： Bosetti C,Turati F,Dal Pont A,Ferraroni M,Polesel J,Negri E,Serraino D,Talamini R,La Vecchia C,Zeegers MP

    更新日期：2013-09-03 00:00:00

  • Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations.

    abstract：:High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing's sarcoma and medulloblastoma. However, the anti-tumour activity of busulfan as a single agent remains to be defined, and this was evaluated in athymic mice bearing advanced ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690126

    authors： Boland I,Vassal G,Morizet J,Terrier-Lacombe MJ,Valteau-Couanet D,Kalifa C,Hartmann O,Gouyette A

    更新日期：1999-02-01 00:00:00

  • Sequential alteration of peanut agglutinin binding-glycoprotein expression during progression of murine mammary neoplasia.

    abstract：:A sequential, quantitative loss of Peanut agglutinin (PNA) binding with progression of mouse mammary cells from normal to preneoplastic to neoplastic phenotypes was observed. Normal mammary epithelium, preneoplastic mammary lesions designated D2HAN (D2-type hyperplastic alveolar nodules) and a series of nine spontaneo...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.138

    authors： Rak JW,McEachern D,Miller FR

    更新日期：1992-05-01 00:00:00

  • Photodynamic destruction of human bladder carcinoma.

    abstract：:Eleven human bladder carcinomata of different degrees of differentiation were implanted in mice immunosuppressed by thymectomy, anti-thymocyte serum and x-rays. Seven carcinomata grew well and one poorly and 3 produced mainly fibrous nodules in the mice. Normal human bladder tissues were grown from 4 other patients. T...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1975.30

    authors： Kelly JF,Snell ME,Berenbaum MC

    更新日期：1975-02-01 00:00:00

  • Lymphocyte sensitization in advanced malignant disease: a study of serum lymphocyte depressive factor.

    abstract：:Patients with advanced malignant disease show an apparent lesser degree of lymphocyte sensitization to cancer antigen when tested under standard conditions than do early cases. In the serum of cancer patients there is a lymphocyte response depressing factor whose titre rises as the neoplasm becomes more extensive. The...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1972.23

    authors： Field EJ,Caspary EA

    更新日期：1972-06-01 00:00:00

  • Antitumour efficacy of VEGFR2 tyrosine kinase inhibitor correlates with expression of VEGF and its receptor VEGFR2 in tumour models.

    abstract：:During the development of indazolylpyrimidines as novel and potent inhibitors of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR2) tyrosine kinase, we observed that some human tumour xenografts are more sensitive to VEGFR2 kinase inhibitors than others. A better understanding of the basis for this differen...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602109

    authors： Dev IK,Dornsife RE,Hopper TM,Onori JA,Miller CG,Harrington LE,Dold KM,Mullin RJ,Johnson JH,Crosby RM,Truesdale AT,Epperly AH,Hinkle KW,Cheung M,Stafford JA,Luttrell DK,Kumar R

    更新日期：2004-10-04 00:00:00

  • Rationale for extensive lymphadenectomy in early gastric carcinoma.

    abstract：:The incidence of nodal metastasis in early gastric carcinoma (EGC) is 10-20%. However, the optimal nodal dissection for early gastric carcinoma has not been established. A retrospective study was conducted in 392 consecutive patients who underwent potentially curative distal gastrectomy for EGC between 1962 and 1990. ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.540

    authors： Miwa K,Miyazaki I,Sahara H,Fujimura T,Yonemura Y,Noguchi M,Falla R

    更新日期：1995-12-01 00:00:00

  • Type I and type III collagen metabolites in adult osteosarcoma patients.

    abstract：:Three biochemical markers of collagen metabolism were measured in 39 osteosarcoma patients. The pretreatment values did not predict outcome, and the markers showed no consistent change upon development of metastases. Both the age of the patients and the multimodality therapy affected the collagen metabolites. These fi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.19

    authors： Wiklund T,Blomqvist C,Risteli L,Risteli J,Karaharju E,Elomaa I

    更新日期：1996-01-01 00:00:00

  • Non-autocrine, constitutive activation of Met in human anaplastic thyroid carcinoma cells in culture.

    abstract：:Activation of Met by its ligand HGF has been shown to elicit both mitogenic and motogenic responses in thyrocytes in vitro. In the present study we have investigated the expression of Met in human anaplastic thyroid carcinoma cells in culture. There was a variation in expression level and size of Met in the different ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690406

    authors： Bergström JD,Hermansson A,Diaz de Ståhl T,Heldin NE

    更新日期：1999-05-01 00:00:00

  • Collaborative study of bronchial tumour-associated antigens.

    abstract：:Eleven groups of workers submitted a total of 21 bronchial tumour-associated antigen preparations and 19 antisera for comparative studies. Many of the antisera proved to be polyspecific despite absorption procedures. Most of the antigen preparations contained some material reactive towards a reference antiserum to nor...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1981.216

    authors： Gennings JN,Bagshawe KD,Axelsen NH,Sizaret P

    更新日期：1981-10-01 00:00:00

  • Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.

    abstract：:It has been reported that the rho genes, which consist of a ras-related small GTPase protein family, regulate cytoskeletal structures and have the potential to transform cultured cells. To investigate the biological relevance of the rho genes in pancreatic carcinogenesis, we examined expressions of the rhoA, B and C g...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.23

    authors： Suwa H,Ohshio G,Imamura T,Watanabe G,Arii S,Imamura M,Narumiya S,Hiai H,Fukumoto M

    更新日期：1998-01-01 00:00:00

  • Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression.

    abstract：:Tumour-associated angiogenesis is partly regulated by the hypoxia-inducible factor (HIF) pathway. Endocrine tumours are highly vascularised and the molecular mechanisms of their angiogenesis are not fully delineated. The aim of this study is to evaluate angiogenesis and expression of HIF-related molecules in a series ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602245

    authors： Couvelard A,O'Toole D,Turley H,Leek R,Sauvanet A,Degott C,Ruszniewski P,Belghiti J,Harris AL,Gatter K,Pezzella F

    更新日期：2005-01-17 00:00:00

  • c-erbB-4 protein expression in human breast cancer.

    abstract：:The Type 1 family of growth factor receptors includes epidermal growth factor receptor (EGFR), c-erbB-2, c-erbB-3 and c-erbB-4. Overexpression of the first two members is associated with poorer prognosis in patients with breast carcinoma. In this study we examined the expression of c-erbB-4 protein using the monoclona...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.1057

    authors： Kew TY,Bell JA,Pinder SE,Denley H,Srinivasan R,Gullick WJ,Nicholson RI,Blamey RW,Ellis IO

    更新日期：2000-03-01 00:00:00

  • Phase II study of the oxygen saturation curve left shifting agent BW12C in combination with the hypoxia activated drug mitomycin C in advanced colorectal cancer.

    abstract：:BW12C (5-[2-formyl-3-hydroxypenoxyl] pentanoic acid) stabilizes oxyhaemoglobin, causing a reversible left-shift of the oxygen saturation curve (OSC) and tissue hypoxia. The activity of mitomycin C (MMC) is enhanced by hypoxia. In this phase II study, 17 patients with metastatic colorectal cancer resistant to 5-fluorou...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1054/bjoc.2000.1138

    authors： Propper DJ,Levitt NC,O'Byrne K,Braybrooke JP,Talbot DC,Ganesan TS,Thompson CH,Rajagopalan B,Littlewood TJ,Dixon RM,Harris AL

    更新日期：2000-06-01 00:00:00

  • Intermittent chemotherapy in metastatic androgen-independent prostate cancer.

    abstract：:Intermittent use of chemotherapy for androgen-independent prostate cancer (AIPC) instead of treatment until disease progression may reduce toxicity. We prospectively tested this approach in eight AIPC patients responding to calcitriol plus docetaxel who reached a serum prostate-specific antigen (PSA) <4 ng ml(-1). Che...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6601232

    authors： Beer TM,Garzotto M,Henner WD,Eilers KM,Wersinger EM

    更新日期：2003-09-15 00:00:00

  • Regulation of cell proliferation under extreme and moderate hypoxia: the role of pyrimidine (deoxy)nucleotides.

    abstract：:In the present study we have used flow cytometric DNA measurements on synchronised human NHIK 3025 cells to measure cell cycle progression under various conditions of reduced oxygenation. Our data indicate that addition of 0.1 mM deoxycytidine or uridine has no effect on the oxygen-dependent arrest in late G1 or on th...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.411

    authors： Amellem O,Löffler M,Pettersen EO

    更新日期：1994-11-01 00:00:00

  • Pharmacokinetics and cytotoxicity of RSU-1069 in subcutaneous 9L tumours under oxic and hypoxic conditions.

    abstract：:The acute toxicity, pharmacokinetics and hypoxic cytotoxicity of RSU-1069 were investigated using the subcutaneous (sc) rat 9L tumour model. The pharmacokinetics were studied after i.p. injection of RSU-1069 (20 mg kg-1 or 100 mg kg-1). For both doses, the elimination of RSU-1069 followed first-order kinetics in both ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1991.116

    authors： Wong KH,Koch CJ,Wallen CA,Wheeler KT

    更新日期：1991-04-01 00:00:00

  • Characterization of human sarcoma antigen S3.

    abstract：:An antigen common to human sarcomas, S3, has been further characterized. It is antigenically distinct from human blood-group substances A and B and from heterophile antigens such as Forssman, infectious mononucleosis and serum sickness antigens. Whilst S3 antigen preparations may contain small amounts of CEA and AFP t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1981.43

    authors： Sethi JK,Hirshaut Y

    更新日期：1981-03-01 00:00:00

  • Clinical-guide risk prediction of hepatocellular carcinoma development in chronic hepatitis C patients after interferon-based therapy.

    abstract：BACKGROUND:Interferon (IFN)-based therapies could eradicate hepatitis C (HCV) and reduce the risk of hepatocellular carcinoma (HCC). However, HCC could still happen after sustained virological response (SVR). We aimed to develop a simple scoring system to predict the risk of HCC development among HCV patients after ant...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.564

    authors： Chang KC,Wu YY,Hung CH,Lu SN,Lee CM,Chiu KW,Tsai MC,Tseng PL,Huang CM,Cho CL,Chen HH,Hu TH

    更新日期：2013-10-29 00:00:00