NF-kappaB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase.

abstract：:Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and...

journal_title：British journal of cancer

authors： Scott HR,McMillan DC,Crilly A,McArdle CS,Milroy R

更新日期：1996-06-01 00:00:00

abstract：:We have established a highly sensitive and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method to detect axillary lymph node metastases of breast cancer. Amplifying cytokeratin 19 (CK19) mRNA transcripts using real-time TaqMan PCR made it possible to quantify axillary metastatic burden. Metast...

journal_title：British journal of cancer

authors： Inokuchi M,Ninomiya I,Tsugawa K,Terada I,Miwa K

更新日期：2003-11-03 00:00:00

abstract：:Survival and proliferation of cell cultures from human anaplastic astrocytomas were shown to be enhanced by glucocorticoids with an optimal concentration of approximately 2.5 x 10(-5)M (10 micrograms/ml). The stimulation of proliferation was only observed in a clonal growth assay and was reversed as the size of indivi...

journal_title：British journal of cancer

authors： Freshney RI,Sherry A,Hassanzadah M,Freshney M,Crilly P,Morgan D

更新日期：1980-06-01 00:00:00

abstract：:Staging and surgical as well as post-operative treatment of primary Fallopian tube carcinoma (FTC) followed the lines established for primary ovarian cancer (OC). In a nationwide retrospective analysis we were able to find a distinct difference between these two tumours. A total of 262 patients, 68 with FTC and 194 wi...

journal_title：British journal of cancer

authors： Rosen AC,Sevelda P,Klein M,Graf AH,Lahousen M,Reiner A,Auerbach L,Vavra N,Rosen HR

更新日期：1994-03-01 00:00:00

abstract：:New therapeutic strategies are now being developed against adenocarcinoma associated with erbB-2 amplification, particularly by inhibiting p185erbB-2 expression. Antisense oligodeoxynucleotides seem promising for this purpose as long as they are efficiently protected against degradation and targeted into the cells. We...

journal_title：British journal of cancer

authors： Allal C,Sixou S,Kravtzoff R,Soulet N,Soula G,Favre G

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Although mortality rates are elevated in psychiatric patients relative to their healthy counterparts, little is known about the impact of mental health on survival in people with cancer. METHODS AND RESULTS:Among 16 498 Swedish men with cancer, survival was worse in those with a history of psychiatric hospi...

journal_title：British journal of cancer

authors： Batty GD,Whitley E,Gale CR,Osborn D,Tynelius P,Rasmussen F

更新日期：2012-05-22 00:00:00

abstract：:Teratomas have been induced in Japanese quail (Coturnix coturnix Japonica) by intra-testicular injections of 3% zinc chloride solution during a period of testicular growth artificially stimulated by increased photoperiod. These tumours resemble those previously induced by similar methods in domestic fow1 and have hist...

journal_title：British journal of cancer

authors： Guthrie J

更新日期：1971-06-01 00:00:00

abstract：:We investigated the effects of individual fatty acids on breast cancer in a prospective study of 35,298 Singapore Chinese women aged 45-74 years, who were enrolled during April 1993 to December 1998 (The Singapore Chinese Health Study). At recruitment, each study subject was administered, in-person, a validated, semiq...

journal_title：British journal of cancer

authors： Gago-Dominguez M,Yuan JM,Sun CL,Lee HP,Yu MC

更新日期：2003-11-03 00:00:00

abstract：:The response of a transplantable rat fibrosarcoma, RIB(5), to a single injection of 100 mg/kg body weight of cyclophosphamide, 0·5, 1, 2 and 3 days after treatment, has been studied by means of a morphometric analysis of tumour sections and has been compared to the changes occurring in untreated tumours. The results s...

journal_title：British journal of cancer

authors： Peel S,Cowen DM

更新日期：1973-01-01 00:00:00

abstract：:The cytotoxicity of methotrexate (MTX) on representative human tumour cell lines (two cell lines from head and neck carcinomas, two from breast carcinomas, two from osteosarcomas and one lymphoblastoid cell line) was evaluated to: (1) examine the optimal time interval between MTX and folinic acid (FA) administration; ...

journal_title：British journal of cancer

authors： Bernard S,Etienne MC,Fischel JL,Formento P,Milano G

更新日期：1991-02-01 00:00:00

abstract：:We investigated the effects of interleukin-2 (IL-2) exposure on T-cell signal transduction molecules and apoptosis markers in tumour-infiltrating lymphocytes (TIL) isolated from 20 melanoma and 16 colorectal carcinoma metastases and expanded in vitro for therapeutic reinfusion. Before IL-2 culture, TIL showed undetect...

journal_title：British journal of cancer

authors： De Paola F,Ridolfi R,Riccobon A,Flamini E,Barzanti F,Granato AM,Mordenti GL,Medri L,Vitali P,Amadori D

更新日期：2003-01-27 00:00:00

abstract：:Steroid receptor was assessed immunohistochemically in 158 samples of normal breast for variation through the menstrual cycle. Patterns and intensity of reaction were used in a semi-quantitative scoring system to examine the influence of cycle phase, cycle type, parity and age. The changes in oestrogen receptor for na...

journal_title：British journal of cancer

authors： Battersby S,Robertson BJ,Anderson TJ,King RJ,McPherson K

更新日期：1992-04-01 00:00:00

abstract：:Cell viability following short (1 h) contact with paclitaxel or docetaxel was assayed using synchronised HeLa cells. Docetaxel proved almost totally lethal against S-phase cells. Its toxicity was only partial against cells in mitosis, and declined to a minimum with progression to G1. For paclitaxel, cytotoxicity incre...

journal_title：British journal of cancer

authors： Hennequin C,Giocanti N,Favaudon V

更新日期：1995-06-01 00:00:00

abstract：:Prolactin (PRL) has been reported to inhibit apoptosis in various cell types and to serve as a cofactor in the upregulation of CD25 on T cells during activation. We investigated a possible relation between prolactin receptor (PRL-R) or IL-2 receptor alpha (IL-2Ralpha, CD25) expression on circulating T lymphocytes and ...

journal_title：British journal of cancer

authors： Bauernhofer T,Kuss I,Friebe-Hoffmann U,Baum AS,Dworacki G,Vonderhaar BK,Whiteside TL

更新日期：2003-04-22 00:00:00

abstract：:In the district of Srikakulam in Andhra Pradesh in South India the habit of reverse smoking is widespread. In a house to house survey of oral cancer and precancerous conditions, comprising 10,169 villagers, 43·8% were reverse smokers; the female: male ratio being 1·7: 1. Ten previously undiagnosed cases of oral cancer...

journal_title：British journal of cancer

authors： Pindborg JJ,Mehta FS,Gupta PC,Daftary DK,Smith CJ

更新日期：1971-03-01 00:00:00

abstract：:We evaluated the therapeutic usefulness of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer (NSCLC). We also examined the relation between DNA ploidy pattern and the response to chemotherapy. A total of 267 patients with NSCLC (pathologically documented stage I, II, or IIIA) underw...

journal_title：British journal of cancer

authors： Nakagawa K,Tada H,Akashi A,Yasumitsu T,Iuchi K,Taki T,Kodama K,Osaka Lung Cancer Study Group, Japan.

更新日期：2006-10-09 00:00:00

abstract：BACKGROUND:Our previous study demonstrated that extracellular adenosine 5'-triphosphate (ATP) stimulated prostate cancer cell invasion via P2Y receptors. However, the purinergic receptor subtype(s) involved in this process remains unclear. Here we aimed to determine whether P2Y2, one subtype of P2Y receptors, was invol...

journal_title：British journal of cancer

authors： Li WH,Qiu Y,Zhang HQ,Liu Y,You JF,Tian XX,Fang WG

更新日期：2013-09-17 00:00:00

abstract：BACKGROUND:Random error in the numbers of avoidable deaths among cancer patients has not been considered in earlier studies. METHODS:Methods to obtain valid confidence intervals (CIs) for numbers of avoidable deaths were developed. The excess mortality rates were estimated for patients diagnosed with colon cancer in f...

journal_title：British journal of cancer

authors： Seppä K,Hakulinen T,Läärä E

更新日期：2012-05-22 00:00:00

abstract：:Meningiomas are tumours derived from the arachnoid and pia mater. During embryogenesis, these membranes develop from the migrating craniofacial neural crest. We have previously demonstrated that meningiomas have characteristic features of embryonic meninges. Craniofacial neural crest derivatives are affected during no...

journal_title：British journal of cancer

authors： Pereda MP,Hopfner U,Pagotto U,Renner U,Uhl E,Arzt E,Missale C,Stalla GK

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Determining the rate of breast cancer (BC) growth in vivo, which can predict prognosis, has remained elusive despite its relevance for treatment, screening recommendations and medicolegal practice. We developed a model that predicts the rate of in vivo tumour growth using a unique study cohort of BC patients...

journal_title：British journal of cancer

authors： Bhattarai S,Klimov S,Aleskandarany MA,Burrell H,Wormall A,Green AR,Rida P,Ellis IO,Osan RM,Rakha EA,Aneja R

更新日期：2019-09-01 00:00:00

abstract：:During the period 1943-1980 a significant increase in the incidence of neuroblastoma was seen in Denmark. The incidence increased from a level corresponding to that in Finland to a level corresponding to that in the USA, and the increase appears to be continuing. The increase relates to children aged under 5 years, an...

journal_title：British journal of cancer

authors： Carlsen NL

更新日期：1986-12-01 00:00:00

abstract：:5,6-Dimethylxanthenone-4-acetic acid, synthesised in this laboratory, reduces tumour blood flow, both in mice and in patients on Phase I trial. We used TUNEL (TdT-mediated dUTP nick end labelling) assays to investigate whether apoptosis induction was involved in its antivascular effect. 5,6-Dimethylxanthenone-4-acetic...

journal_title：British journal of cancer

authors： Ching LM,Cao Z,Kieda C,Zwain S,Jameson MB,Baguley BC

更新日期：2002-06-17 00:00:00

abstract：:Oestrogen receptor protein (ER) was detected in 9 of 11 samples of malignant breast tissue and 8 of 9 samples of normal breast tissue. Levels of cytosolic ER (ERc) in malignant breast were 21-1102 fmol mg-1 soluble protein (Kd 1.8 X 10(-9)-3.1 X 10(-8) mol l-1) and those of nucleosolic ER (ERn), 13-526 fmol mg-1 solub...

journal_title：British journal of cancer

authors： Iqbal MJ,Colletta AA,Houmayoun-Valyani SD,Baum M

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Lignans - oestrogenic substances present in various foods - are associated with postmenopausal breast cancer risk, but not much is known regarding their effects on survival. METHODS:In a follow-up study of 2653 postmenopausal breast cancer patients diagnosed between 2001 and 2005, vital status and causes of...

journal_title：British journal of cancer

authors： Buck K,Zaineddin AK,Vrieling A,Heinz J,Linseisen J,Flesch-Janys D,Chang-Claude J

更新日期：2011-10-11 00:00:00

abstract：:'de novo' carcinogenesis has been advocated besides 'adenoma carcinoma sequence' as another dominant pathway leading to colorectal carcinoma. Our recent study has demonstrated that the distribution of brain (fetal)-type glycogen phosphorylase (BGP) positive foci (BGP foci) has a close relationship with the location of...

journal_title：British journal of cancer

authors： Shimada S,Shiomori K,Tashima S,Tsuruta J,Ogawa M

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer. METHO...

journal_title：British journal of cancer

authors： Starzer AM,Steindl A,Mair MJ,Deischinger C,Simonovska A,Widhalm G,Gatterbauer B,Dieckmann K,Heller G,Preusser M,Berghoff AS

更新日期：2021-01-21 00:00:00

abstract：:A long term follow-up study has been undertaken in 33 patients with acute non-lymphoblastic leukaemia (ANLL) in order to establish whether a correlation exists between the clinical course and the immunologic pattern of lymphoid subpopulations. Peripheral blood lymphoid cells have been investigated longitudinally (each...

journal_title：British journal of cancer

authors： Pizzolo G,Trentin L,Vinante F,Agostini C,Zambello R,Masciarelli M,Feruglio C,Dazzi F,Todeschini G,Chilosi M

更新日期：1988-09-01 00:00:00

abstract：:Mediastinal masses include a wide variety of tumours and remain an interesting diagnostic challenge for radiologist. We performed positron emission tomography (PET) studies of primary mediastinal tumours in order to predict the malignancy of these tumours preoperatively. Twenty-two patients with primary mediastinal tu...

journal_title：British journal of cancer

authors： Kubota K,Yamada S,Kondo T,Yamada K,Fukuda H,Fujiwara T,Ito M,Ido T

更新日期：1996-04-01 00:00:00

abstract：:The objective of this study was to prospectively measure peri-diagnostic and surgical time intervals for patients with suspected colorectal, lung, or prostate cancer. Prospective eligible patients were referred to a regional hospital in Ottawa, Canada between February 2004 and February 2005 for diagnostic assessment o...

journal_title：British journal of cancer

authors： Grunfeld E,Watters JM,Urquhart R,O'Rourke K,Jaffey J,Maziak DE,Morash C,Patel D,Evans WK

更新日期：2009-01-13 00:00:00

abstract：BACKGROUND:Previous epidemiologic studies have shown inconsistent results for the association between alcohol intake and endometrial cancer risk. Most of the studies, however, assessed alcohol intake after cancer diagnosis, or measured alcohol intake at baseline only. METHODS:We prospectively examined the association ...

journal_title：British journal of cancer

authors： Je Y,De Vivo I,Giovannucci E

更新日期：2014-07-08 00:00:00