Production of transforming growth factor-alpha in human tumour cell lines.

abstract：:Darbepoetin alfa (Aranesp), Amgen) is a novel erythropoiesis-stimulating protein with a serum half-life longer than recombinant human erythropoietin (Epo), used in the treatment of cancer-associated anaemia. Anaemia is known to adversely affect prognosis and response to treatment in cancer patients. Solid tumours cont...

journal_title：British journal of cancer

authors： Shannon AM,Bouchier-Hayes DJ,Condron CM,Toomey D

更新日期：2005-07-25 00:00:00

abstract：BACKGROUND:FOXA1 expression is a good prognostic marker for endocrine therapy in hormone-positive breast cancer. We retrospectively examined breast cancer patients with luminal human epidermal growth factor receptor 2 (HER2)-negative tumours, as defined by immunohistochemistry, who received neo-adjuvant chemotherapy (N...

journal_title：British journal of cancer

authors： Horimoto Y,Arakawa A,Harada-Shoji N,Sonoue H,Yoshida Y,Himuro T,Igari F,Tokuda E,Mamat O,Tanabe M,Hino O,Saito M

更新日期：2015-01-20 00:00:00

abstract：:The study was originally set up to measure accurate cell kinetic parameters in two murine squamous cell carcinomas (scc) for comparison with radiobiological data on proliferation during radiotherapy. The tumours, AT84 and AT478, were both moderately well differentiated aneuploid scc. In the course of the study, severa...

journal_title：British journal of cancer

authors： Schultz-Hector S,Begg AC,Hofland I,Kummermehr J,Sund M

更新日期：1993-12-01 00:00:00

abstract：:The aim of this study was to evaluate serum midkine (S-MK) concentrations as a prognostic tumour marker in oral squamous cell carcinoma (OSCC). We measured S-MK concentrations in patients with OSCC and healthy volunteers. In addition, we performed real-time quantitative reverse transcription-PCR analysis and immunohis...

journal_title：British journal of cancer

authors： Ota K,Fujimori H,Ueda M,Shiniriki S,Kudo M,Jono H,Fukuyoshi Y,Yamamoto Y,Sugiuchi H,Iwase H,Shinohara M,Ando Y

更新日期：2008-08-19 00:00:00

abstract：BACKGROUND:Prescribing anti-programmed death-1 (PD-1) immunotherapy for advanced melanoma is currently not restricted by any biomarker assessment. Determination of programmed death-ligand-1 (PD-L1)-expression status is technically challenging and is not mandatory, because negative tumours also achieve therapeutic respo...

journal_title：British journal of cancer

authors： Dupuis F,Lamant L,Gerard E,Torossian N,Chaltiel L,Filleron T,Beylot-Barry M,Dutriaux C,Prey S,Gros A,Jullie ML,Meyer N,Vergier B

更新日期：2018-07-01 00:00:00

abstract：:Reports are available on the studies of the cell cycle of several normal cell populations and of neoplastic effusions in man and experimental animals in vitro and in vivo at various stages of the growth. In the present work the cell cycle of 5 solid human tumours in vitro and the duration of their various intermitotic...

journal_title：British journal of cancer

authors： Kucheria K

更新日期：1970-06-01 00:00:00

abstract：:Chemotherapy during a viable pregnancy may be associated with adverse perinatal outcomes. We conducted a prospective cohort study to examine the perinatal outcomes of babies born following in utero exposure to chemotherapy in Australia and New Zealand. Over 18 months we identified 24 births, of >400 g and/or >20-weeks...

journal_title：British journal of cancer

authors： Safi N,Anazodo A,Dickinson JE,Lui K,Wang AY,Li Z,Sullivan EA

更新日期：2019-10-01 00:00:00

abstract：:The endocrine effects of 125 mg (low dose) aminoglutethimide (AG) twice daily (b.d.) were compared with those of 125 mg AG + 20 mg hydrocortisone (HC) b.d. in 23 and 45 postmenopausal patients with advanced breast cancer, respectively. The patients in each group were drawn from two separate populations, but the mean a...

journal_title：British journal of cancer

authors： Dowsett M,Harris AL,Stuart-Harris R,Hill M,Cantwell BM,Smith IE,Jeffcoate SL

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Ovarian and endometrial high-grade serous carcinomas (HGSCs) have similar clinical and pathological characteristics; however, exhaustive protein expression profiling of these cancers has yet to be reported. METHODS:We performed protein expression profiling on 14 cases of HGSCs (7 ovarian and 7 endometrial) ...

journal_title：British journal of cancer

authors： Hiramatsu K,Yoshino K,Serada S,Yoshihara K,Hori Y,Fujimoto M,Matsuzaki S,Egawa-Takata T,Kobayashi E,Ueda Y,Morii E,Enomoto T,Naka T,Kimura T

更新日期：2016-03-01 00:00:00

abstract：:Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies u...

journal_title：British journal of cancer

authors： Romeijn P,Lenthall R,Stavrou D,Melcher D,Ladyman H,Ritter MA

更新日期：1994-11-01 00:00:00

abstract：:Human glioma usually shows intrinsic multidrug resistance because of the blood-brain barrier (BBB), in which membrane-associated P-glycoprotein (P-gp), encoded by the human multidrug resistance gene MDR1, plays a role. We studied drug sensitivity to vincristine (VCR), doxorubicin (DOX) and nimustine (ACNU) in both int...

journal_title：British journal of cancer

authors： Takamiya Y,Abe Y,Tanaka Y,Tsugu A,Kazuno M,Oshika Y,Maruo K,Ohnishi Y,Sato O,Yamazaki H,Kijima H,Ueyama Y,Tamaoki N,Nakamura M

更新日期：1997-01-01 00:00:00

abstract：:Canine transmissible venereal sarcoma (CTVS) is a naturally occurring contagious neoplasm which can be transplanted with intact viable cells across major histocompatibility (MHC) barriers within the species and even to other members of the canine family, such as foxes, coyotes, and wolves. After 2 to 4 months of progr...

journal_title：British journal of cancer

authors： Yang TJ,Chandler JP,Dunne-Anway S

更新日期：1987-02-01 00:00:00

abstract：:To understand the role of p53 tumour suppressor gene in the carcinogenesis of arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan, we collected tumour samples from 23 patients with Bowen's disease, seven patients with basal cell carcinomas (BCC) and nine patients with squamous cell carcinoma...

journal_title：British journal of cancer

authors： Hsu CH,Yang SA,Wang JY,Yu HS,Lin SR

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:The accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance (Mcm) 2-7 proteins is an early event in epithelial multistep carcinogenesis and thus MCM proteins represent powerful ca...

journal_title：British journal of cancer

authors： Dudderidge TJ,Kelly JD,Wollenschlaeger A,Okoturo O,Prevost T,Robson W,Leung HY,Williams GH,Stoeber K

更新日期：2010-08-24 00:00:00

abstract：BACKGROUND:To enhance the success rate of nanocarrier-mediated chemotherapy combined with an anti-angiogenic agent, it is crucial to identify parameters for tumour vasculature that can predict a response to the treatment of the anti-angiogenic agent. METHODS:To apply transforming growth factor (TGF)-beta type I recept...

journal_title：British journal of cancer

authors： Minowa T,Kawano K,Kuribayashi H,Shiraishi K,Sugino T,Hattori Y,Yokoyama M,Maitani Y

更新日期：2009-12-01 00:00:00

abstract：:The reaction patterns of eight antibodies directed against blood group substances A, B and H, respectively, against Lewis B antigen, difucosylated carbohydrate antigens (DFCA), gastrointestinal cancer antigen CA 19-9 (GICA), carcinoma-associated antigen CA-50 and CEA, were studied in 68 rectal carcinomas using the avi...

journal_title：British journal of cancer

authors： Enblad P,Glimelius B,Busch C,Pontén J,Påhlman L

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:We modified and evaluated an advance care planning (ACP) intervention, which had been shown to improve compliance with patient's end of life (EoL) wishes, in a different patient population. METHODS:Patients with incurable cancer, and a Family Member (FM), were randomised one-to-one to usual care or usual ca...

journal_title：British journal of cancer

authors： Johnson SB,Butow PN,Bell ML,Detering K,Clayton JM,Silvester W,Kiely BE,Clarke S,Vaccaro L,Stockler MR,Beale P,Fitzgerald N,Tattersall MHN

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Non-invasive biomarkers of disease progression in mice with cancer are lacking making it challenging to implement appropriate humane end points. We investigated whether body temperature, food and water consumption could be used to predict tumour burden. METHODS:Thirty-six male, wild-type C57Bl/6 mice were i...

journal_title：British journal of cancer

authors： Hunter JE,Butterworth J,Perkins ND,Bateson M,Richardson CA

更新日期：2014-02-18 00:00:00

abstract：:We analysed two case-control studies of women from Italy and Switzerland, including 195 cases of oral and pharyngeal cancers and 1113 controls. The multivariate odds ratio was 4.6 for heavy smokers and 2.7 for high alcohol intake. Vegetables, fruit, beta-carotene and wholegrain foods were inversely, butter and retinol...

journal_title：British journal of cancer

authors： Bosetti C,Negri E,Franceschi S,Conti E,Levi F,Tomei F,La Vecchia C

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:The role of processed meat in the aetiology of several cancers was explored in detail. METHODS:In the time period 1996-2004, a multisite case-control study was conducted in Montevideo, Uruguay. The study included 6 060 participants (3 528 cases and 2 532 controls) corresponding to cancers of the oral cavity...

journal_title：British journal of cancer

authors： De Stefani E,Boffetta P,Ronco AL,Deneo-Pellegrini H,Correa P,Acosta G,Mendilaharsu M,Luaces ME,Silva C

更新日期：2012-10-23 00:00:00

abstract：:Differences were seen in the ability of 2 strains of C. parvum to augment cytotoxicity attributable to NK cells towards a rat lymphoma. Furthermore, 2 batches of the same strain of C. parvum prepared by different methods also differed in their ability to augment cytotoxicity. Other factors influencing cytotoxicity wer...

journal_title：British journal of cancer

authors： Flexman JP,Shellam GR

更新日期：1980-07-01 00:00:00

abstract：:Many theories mention hypersensitive, promiscuous, outlaw or bypass signalling pathways to explain the acquisition of hormone independence in prostate cancer. Hormonal escape of prostate tumours is marked by many biological changes, including mucinous and neuroendocrine differentiation. Since expression of several muc...

journal_title：British journal of cancer

authors： Legrier ME,de Pinieux G,Boyé K,Arvelo F,Judde JG,Fontaine JJ,Bara J,Poupon MF

更新日期：2004-02-09 00:00:00

abstract：BACKGROUND:The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) is mainly related to human papillomavirus (HPV) infection. As OPSCCs are often diagnosed at an advanced stage, mortality and morbidity remain high. There are no diagnostic biomarkers for early detection of OPSCC. METHODS:Serum from 25...

journal_title：British journal of cancer

authors： Tuhkuri A,Saraswat M,Mäkitie A,Mattila P,Silén R,Dickinson A,Carpén T,Tohmola T,Joenväärä S,Renkonen S

更新日期：2018-07-01 00:00:00

abstract：:We have purified epithelial cells from human colonic tumours by velocity sedimentation in an isokinetic density gradient of Ficoll in tissue culture medium. In frozen sections of colonic carcinoma, histochemically demonstrable N-acetyl-beta-D-glucosaminidase (HDAG) was observed primarily in epithelial cells. We used t...

journal_title：British journal of cancer

authors： Brattain MG,Kimball PM,Pretlow TG 2nd,Pitts AM

更新日期：1977-06-01 00:00:00

abstract：:To assess the precise role of IGF1 in benign and malignant breast diseases, we analysed the tissular localisation, characterised, and quantified specific insulin-like growth factor 1 (IGF1) binding sites in these heterogenous tissues, using histo-autoradiographic analysis (HAA). The 125I-IGF1 binding was performed on ...

journal_title：British journal of cancer

authors： Jammes H,Peyrat JP,Ban E,Vilain MO,Haour F,Djiane J,Bonneterre J

更新日期：1992-08-01 00:00:00

abstract：:The syndecans, a family of cell-surface heparan sulphate proteoglycans, have been proposed to mediate cellular interactions with extracellular effector molecules, such as growth factors and components of the extracellular matrix, during critical phases of development. Transcripts of all four syndecans are expressed at...

journal_title：British journal of cancer

authors： Wong ZM,Choo B,Li M,Carey DJ,Cano-Gauci DF,Buick RN

更新日期：1998-03-01 00:00:00

abstract：:The sera from patients with advanced cancer were tested for their specific inhibitory effects on the cytotoxicity of autologous lymphocytes on tumour cells in a microculture assay. By adding a standard volume of the sera to suspensions of well-washed lymphocytes the inhibitory effect was quantitated by comparison with...

journal_title：British journal of cancer

authors： Currie GA

更新日期：1973-07-01 00:00:00

abstract：:Fifty-one patients with advanced non-small cell lung carcinoma were treated with a combination of mitomycin C, vinblastine and cis-platin (MVP). Most cycles were given on an out-patient basis. Major side effects were leukopenia and peripheral neurotoxicity; one patient died of sepsis while leukopenic. In 44 evaluable ...

journal_title：British journal of cancer

authors： Giaccone G,Bagatella M,Donadio M,Bonardi GM,Testore F,Ferrati P,Ciuffreda L,Calciati A

更新日期：1987-10-01 00:00:00

abstract：:We have investigated the effects of 50 min whole-body hyperthermia (WBH; 15 min equilibration followed by 41 degrees C for 35 min) on the toxicity and pharmacokinetics of the radiosensitizer Ro 03-8799 in mice. WBH markedly reduced Ro 03-8799 LD50/7d from 779 to 259 micrograms g-1 (P less than 0.001). Pharmacokinetics...

journal_title：British journal of cancer

authors： Walton MI,Bleehen NM,Workman P

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Malignancy alters cellular complex lipid metabolism and membrane lipid composition and turnover. Here, we investigated whether tumorigenesis in cancer-derived prostate epithelial cell lines influences protein kinase C-linked turnover of ethanolamine phosphoglycerides (EtnPGs) and alters the pattern of ethano...

journal_title：British journal of cancer

authors： Schmitt J,Noble A,Otsuka M,Berry P,Maitland NJ,Rumsby MG

更新日期：2014-10-14 00:00:00