An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma.

abstract：:Recombinant adeno-associated virus (rAAV) vectors have emerged as vehicles for gene therapy. In addition, anti-neoplastic properties have been attributed to wild-type AAV. To take advantage of both features and to overcome technical problems associated with rAAV preparation, we developed a production method in which r...

journal_title：British journal of cancer

authors： Vermeij J,Zeinoun Z,Neyns B,Teugels E,Bourgain C,De Grève J

更新日期：2001-11-16 00:00:00

abstract：:Preclinical studies have demonstrated the synergistic anti-tumour activity of combination therapy with the oral cytostatics, 5'-deoxy-5-fluorouridine (5'-DFUR) and cyclophosphamide (CPA), in human breast cancer xenograft models. This study was performed to evaluate the efficacy and safety of this oral combination chem...

journal_title：British journal of cancer

authors： Yoshimoto M,Tada K,Tokudome N,Kutomi G,Tanabe M,Goto T,Nishimura S,Makita M,Kasumi F

更新日期：2003-11-03 00:00:00

abstract：:T-lymphocyte maturation associated protein, MAL, has been described as a tumour-suppressor gene with diagnostic value in colorectal and oesophageal cancers, and can be inactivated by promoter hypermethylation. The aim of this study was to analyse the prevalence of MAL promoter hypermethylation and the association with...

journal_title：British journal of cancer

authors： Buffart TE,Overmeer RM,Steenbergen RD,Tijssen M,van Grieken NC,Snijders PJ,Grabsch HI,van de Velde CJ,Carvalho B,Meijer GA

更新日期：2008-12-02 00:00:00

abstract：BACKGROUND:The immune system has a central role in controlling cancer, and factors that influence protective antitumour immunity could therefore have a significant impact on the course of malignant disease. Opioids are essential for the management of cancer pain, and preclinical studies indicate that opioids have the p...

journal_title：British journal of cancer

authors： Boland JW,McWilliams K,Ahmedzai SH,Pockley AG

更新日期：2014-08-26 00:00:00

abstract：:The presence of specific and high affinity epidermal growth factor receptors (EGF-R) has been demonstrated in human prostate cancer (CaP). Scatchard analysis of the binding data revealed a linear plot consistent with a single class of binding sites with a mean dissociation constant (Kd) +/- s.d. = 1.6 +/- 0.4 nmol 1-1...

journal_title：British journal of cancer

authors： Maddy SQ,Chisholm GD,Busuttil A,Habib FK

更新日期：1989-07-01 00:00:00

abstract：:The relationship between circulating C-reactive protein concentrations and potential cytokine and receptor mediators (interleukin-6, leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), soluble IL-6 receptor, soluble gp130, soluble TNF receptor, interleukin-1 receptor antagonist and interleukin-8 (IL...

journal_title：British journal of cancer

authors： McKeown DJ,Brown DJ,Kelly A,Wallace AM,McMillan DC

更新日期：2004-12-13 00:00:00

abstract：BACKGROUND:The characterisation of desmoplastic reaction (DR) has emerged as a new, independent prognostic determinant in colorectal cancer. Herein, we report the validation of its prognostic value in a randomised controlled study (SACURA trial). METHODS:The study included 991 stage II colon cancer patients. DR was cl...

journal_title：British journal of cancer

authors： Ueno H,Ishiguro M,Nakatani E,Ishikawa T,Uetake H,Murotani K,Matsui S,Teramukai S,Sugai T,Ajioka Y,Maruo H,Kotaka M,Tsujie M,Munemoto Y,Yamaguchi T,Kuroda H,Fukunaga M,Tomita N,Sugihara K

更新日期：2021-01-07 00:00:00

abstract：:Pleural effusion fluid obtained from eleven patients with metastatic spread to the pleura was screened for the ability to cause the dispersal--'scattering'--of MDCK colonies in vitro. Four of these samples proved to be positive using this assay. Of these two had titres high enough to warrant further purification on a ...

journal_title：British journal of cancer

authors： Kenworthy P,Dowrick P,Baillie-Johnson H,McCann B,Tsubouchi H,Arakaki N,Daikuhara Y,Warn RM

更新日期：1992-08-01 00:00:00

abstract：:We have studied the ability of cyclosporin A (CsA) and a non-immunosuppressive analogue, O-acetyl cyclosporin A (OACsA, B3-243) to inhibit the growth of human lung cancer cells in vitro. Using continuous drug exposure and the MTT colorimetric assay to determine cell growth we found that CsA produced partial growth inh...

journal_title：British journal of cancer

authors： Twentyman PR,Wright KA,Wallace HM

更新日期：1992-03-01 00:00:00

abstract：:Studies of underground miners occupationally exposed to radon have consistently demonstrated an increased risk of lung cancer in both smokers and non-smokers. Radon exposure also occurs elsewhere, especially in houses, and estimates based on the findings for miners suggest that residential radon is responsible for abo...

journal_title：British journal of cancer

authors： Darby S,Whitley E,Silcocks P,Thakrar B,Green M,Lomas P,Miles J,Reeves G,Fearn T,Doll R

更新日期：1998-08-01 00:00:00

abstract：:Over a wide range of pH, the semiquinone free radicals formed by reduction of adriamycin exist as a form which is strongly stabilised by internal hydrogen bonding and resonance. They protonate with pKa = 2.9. Below this pH they exhibit absorption maxima at 430 nm (Emax = 13,200 dm3 mol-1 cm-1) and approximately 720 nm...

journal_title：British journal of cancer

authors： Land EJ,Mukherjee T,Swallow AJ,Bruce JM

更新日期：1985-04-01 00:00:00

abstract：:Preclinical models that can accurately predict outcomes in the clinic are much sought after in the field of cancer drug discovery and development. Existing models such as organoids and patient-derived xenografts have many advantages, but they suffer from the drawback of not contextually preserving human tumour archite...

journal_title：British journal of cancer

authors： Powley IR,Patel M,Miles G,Pringle H,Howells L,Thomas A,Kettleborough C,Bryans J,Hammonds T,MacFarlane M,Pritchard C

更新日期：2020-03-01 00:00:00

abstract：:ICI 182,780 (Fulvestrant) is the first in a new class of novel, steroidal, 'pure' antioestrogens--the oestrogen receptor (ER) down-regulators. Its unique mode of action and the absence of partial agonist activity make it a candidate for the treatment of advanced breast cancer in both pre- and postmenopausal women. Tam...

journal_title：British journal of cancer

authors： Robertson JF

更新日期：2001-11-01 00:00:00

abstract：:One hundred and one consecutive patients with newly diagnosed stage I Hodgkin's disease (HD) received treatment at St Bartholomew's Hospital, between 1968 and 1987, with a median follow-up of 12 years. Eleven patients have been excluded from detailed analysis because they either received involved field radiotherapy (R...

journal_title：British journal of cancer

authors： Ganesan TS,Wrigley PF,Murray PA,Stansfeld AG,d'Ardenne AJ,Arnott S,Jones A,Shand WS,Malpas JS,Lister TA

更新日期：1990-08-01 00:00:00

abstract：:The relationship of cytogenetic changes with the acquisition of an indefinite life span in vitro, the ability of cells to grow in soft agar and their tumourigenicity in syngeneic animals has been studied in control, trans-7,8-dihydrodiolbenzo(a)pyrene and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrah...

journal_title：British journal of cancer

authors： Connell JR

更新日期：1984-08-01 00:00:00

abstract：:We have previously reported that interleukin 10 (IL-10) signalling stimulated activation of a specific enhancer element, termed HTE-1, to promote tissue inhibitor of matrix metalloproteinase1 (TIMP-1) expression in human bone metastatic PC-3 subclone (PC-3 ML) cells. Recently, we have identified an IL-10 responsive si...

journal_title：British journal of cancer

authors： Wang M,Hu Y,Stearns ME

更新日期：2003-05-19 00:00:00

abstract：BACKGROUND:To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. METHODS:A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and ...

journal_title：British journal of cancer

authors： Feng X,Song M,Preston MA,Ma W,Hu Y,Pernar CH,Stopsack KH,Ebot EM,Fu BC,Zhang Y,Li N,Dai M,Liu L,Giovannucci EL,Mucci LA

更新日期：2020-08-01 00:00:00

abstract：:Exploring the fundamental mechanisms behind the low tumour uptake of labelled monoclonal antibodies (MoAbs) during in vivo immunotargeting, experiments were performed to estimate the in vivo value of the association constant (Ka) in an experimental targeting reaction. An artificial tumour model was utilised, based on ...

journal_title：British journal of cancer

authors： Fjeld JG,Benestad HB,Stigbrand T,Nustad K

更新日期：1992-07-01 00:00:00

abstract：:No published data are available concerning the activity and tolerability of intramuscularly administered granulocyte colony-stimulating factor (G-CSF) in humans. To fill this gap, 19 patients with advanced ovarian cancer previously treated with at least one first-line chemotherapy cycle received the following myelosup...

journal_title：British journal of cancer

authors： Di Leo A,Bajetta E,Nolè F,Biganzoli L,Ferrari L,Oriana S,Riboldi G,Bohm S,Spatti G,Raspagliesi F

更新日期：1994-05-01 00:00:00

abstract：:Variants of the melanocortin-1 receptor (MC1R) gene have been linked to sun-sensitive skin types and hair colour, and may independently play a role in susceptibility to cutaneous melanoma. To assess the role of MC1R variants in uveal melanoma, we have analysed a cohort of 350 patients for the changes within the major ...

journal_title：British journal of cancer

authors： Hearle N,Humphreys J,Damato BE,Wort R,Talaban R,Wixey J,Green H,Easton DF,Houlston RS

更新日期：2003-11-17 00:00:00

abstract：BACKGROUND:The distinct expression pattern of tumour-associated antigens (TAAs) might be a critical reason for the inefficacy of immunity-based treatments and heterogeneous postsurgical recovery in patients with solid tumours, including hepatocellular carcinoma (HCC). However, little is known about the clinical value o...

journal_title：British journal of cancer

authors： Liang J,Ding T,Guo ZW,Yu XJ,Hu YZ,Zheng L,Xu J

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, using available large transcriptomic datasets, aims to identify genes assoc...

journal_title：British journal of cancer

authors： Kurozumi S,Joseph C,Sonbul S,Alsaeed S,Kariri Y,Aljohani A,Raafat S,Alsaleem M,Ogden A,Johnston SJ,Aleskandarany MA,Fujii T,Shirabe K,Caldas C,Ashankyty I,Dalton L,Ellis IO,Desmedt C,Green AR,Mongan NP,Rakha EA

更新日期：2019-06-01 00:00:00

abstract：:Three hundred and ninety women participated in the quality of life (QL) study of ACCOG1, a high-dose vs conventional adjuvant chemotherapy breast cancer trial, for patients with a high risk of relapse. Patients completed the European Organisation for Research and Treatment of Cancer QLQ-C30, questions on menopausal sy...

journal_title：British journal of cancer

authors： Malinovszky KM,Gould A,Foster E,Cameron D,Humphreys A,Crown J,Leonard RC,Anglo Celtic Co-operative Oncology Group.

更新日期：2006-12-18 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. We tested megestrol acetate (MA) against placebo in the treatment of advanced HCC. METHODS:From 2002 through 2007, this randomised double-blind trial enrolled 204 patients with treatment-naive advanced HCC (Eastern Coopera...

journal_title：British journal of cancer

authors： Chow PK,Machin D,Chen Y,Zhang X,Win KM,Hoang HH,Nguyen BD,Jin MY,Lobo R,Findlay M,Lim CH,Tan SB,Gandhi M,Soo KC,Asia-Pacific Hepatocellular Carcinoma Trials Group.

更新日期：2011-09-27 00:00:00

abstract：:The childhood peak of common acute lymphoblastic leukaemia has been proposed as being a rare response to delayed exposure to a common infection. In this context, factors related to the child's immune system are of special interest. Information on such factors was obtained in a recent German case-control study comprisi...

journal_title：British journal of cancer

authors： Schüz J,Kaletsch U,Meinert R,Kaatsch P,Michaelis J

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Evidence suggests that dysregulation of energy-sensing pathways closely associates with renal cell carcinoma (RCC) development. The metabolic regulation is largely controlled by 5'-AMP activated protein kinase (AMPK) which is activated through phosphorylation by LKB1. METHODS:The expression of LKB1 was dete...

journal_title：British journal of cancer

authors： Duivenvoorden WC,Beatty LK,Lhotak S,Hill B,Mak I,Paulin G,Gallino D,Popovic S,Austin RC,Pinthus JH

更新日期：2013-02-05 00:00:00

abstract：BACKGROUND:Heterogeneity and low incidence comprise the biggest challenge in sarcoma diagnosis and treatment. Chemotherapy, although efficient for some sarcoma subtypes, generally results in poor clinical responses and is mostly recommended for advanced disease. Specific genomic aberrations have been identified in some...

journal_title：British journal of cancer

authors： Brodin BA,Wennerberg K,Lidbrink E,Brosjö O,Potdar S,Wilson JN,Ma L,Moens LN,Hesla A,Porovic E,Bernhardsson E,Papakonstantinou A,Bauer H,Tsagkozis P,von Sivers K,Wejde J,Östling P,Kallioniemi O,Stragliotto CL

更新日期：2019-02-01 00:00:00

abstract：:Gap junctions provide a route for small molecules to pass directly between cells. Toxic species may spread through junctions into 'bystander' cells, which may be exploited in chemotherapy and radiotherapy. However, this may be prevented by junction closure, and therefore an understanding of the dose-dependency of inhi...

journal_title：British journal of cancer

authors： Edwards GO,Botchway SW,Hirst G,Wharton CW,Chipman JK,Meldrum RA

更新日期：2004-04-05 00:00:00

abstract：BACKGROUND:OCT3/4 (POU5F1) is an established diagnostic immunohistochemical marker for specific histological variants of human malignant germ cell tumours (GCTs), including the seminomatous types and the stem cell component of non-seminomas, known as embryonal carcinoma. OCT3/4 is crucial for the regulation of pluripot...

journal_title：British journal of cancer

authors： Rijlaarsdam MA,van Herk HA,Gillis AJ,Stoop H,Jenster G,Martens J,van Leenders GJ,Dinjens W,Hoogland AM,Timmermans M,Looijenga LH

更新日期：2011-09-06 00:00:00

abstract：:A cytogenetic study was performed in 27 patients suspected of t-MDS or t-ANLL. In 12 patients the diagnosis of t-MDS or t-ANLL was confirmed by morphological, cytochemical and immunophenotypical analysis. The cases were classified as RA (one), RAEB (four), CMML (two), ANLL (five). They had received chemotherapy and/or...

journal_title：British journal of cancer

authors： Sozzi G,Miozzo M,Orazi A,Calderone C,Castellano M,Viviani S,Santoro A,Pierotti MA,Della Porta G

更新日期：1990-03-01 00:00:00